Decrease of reported adverse events to injectable polylactic acid after recommending an increased dilution: 8-year results from the Injectable Filler Safety study

Journal of Cosmetic Dermatology

Volumn 8, Issue 1, 2009, Pages 14-18

  Rossner, Florian ^a   Rossner, Mathias ^a   Hartmann, Vanessa ^a   Erdmann, Ricardo ^a   Wiest, Luitgard G ^b   Rzany, Berthold ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b NONE

Author keywords

Adverse events; Filler; Nodules; Polylactic acid

Indexed keywords

POLYLACTIC ACID; SCULPTURA; UNCLASSIFIED DRUG; BIOMATERIAL; LACTIC ACID; POLYMER;

ADULT; AGED; ALLERGIC RHINITIS; ARTICLE; CIGARETTE SMOKING; CLINICAL ARTICLE; CLINICAL ASSESSMENT; DILUTION; DISEASE DURATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SAFETY; FEMALE; HUMAN; INFLAMMATION; INJECTION SITE ABSCESS; INJECTION SITE INFLAMMATION; INJECTION SITE NODULE; INJECTION SITE PAIN; INJECTION SITE PRURITUS; INJECTION SITE SWELLING; INJECTION SITE ULCER; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK FACTOR; SIDE EFFECT; SKIN NODULE; SKIN PIGMENTATION; TREATMENT DURATION; COHORT ANALYSIS; CUTANEOUS PARAMETERS; DRUG EFFECT; ESTHETIC SURGERY; ESTHETICS; FOREIGN BODY REACTION; GEL; INCIDENCE; MIDDLE AGED; PHYSIOLOGY; REGISTER; REJUVENATION; RISK ASSESSMENT; SAFETY; SUBCUTANEOUS DRUG ADMINISTRATION; TIME; TREATMENT OUTCOME;

ADULT; BIOCOMPATIBLE MATERIALS; COHORT STUDIES; COSMETIC TECHNIQUES; ESTHETICS; FEMALE; FOREIGN-BODY REACTION; GELS; HUMANS; INCIDENCE; INJECTIONS, SUBCUTANEOUS; LACTIC ACID; MALE; MIDDLE AGED; POLYMERS; REGISTRIES; REJUVENATION; RISK ASSESSMENT; SAFETY; SKIN AGING; TIME FACTORS; TREATMENT OUTCOME;

EID: 67049114737     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/j.1473-2165.2009.00417.x     Document Type: Article

References (20)

1. Humble G, Mest D. Soft tissue augmentation using sculptra. Facial Plast Surg 2004; 20: 157-63.
2. Burgess CM, Quiroga RM. Assessment of the safety and efficacy of poly-L-lactic acid for the treatment of HIV-associated facial lipoatrophy. J Am Acad Dermatol 2005; 52: 233-9.
3. Valantin MA, Aubron-Olivier C, Ghosn J et al. Polylactic acid implants (New-Fill) to correct facial lipoatrophy in HIV-infected patients: results of the open-label study VEGA. AIDS 2003; 17: 2471-7.
4. Woerle B, Hanke CW, Sattler G. Poly-L-lactic acid: A temporary filler for soft tissue augmentation. J Drugs Dermatol 2004; 3: 385-9.
5. Cheonis N. New-Fill to treat facial wasting. Beta 2002; 15: 10-5.
6. Rotunda AM, Narins RS. Poly-L-lactic acid: A new dimension in soft tissue augmentation. Dermatol Ther 2006; 19: 151-8.
7. Zielke H, Wölber L, Wiest L et al. Risk profiles of different injectable fillers: Results from the Injectable Filler Safety Study (IFS Study). Dermatol Surg 2008; 34: 326-35; discussion 35.
8. Fix Orphan Lowe NJ, Maxwell CA, Patnaik R. Adverse reactions to dermal fillers: Review. Dermatol Surg 2005; 31: 1616-25.
9. Vochelle D. The use of poly-L-lactic acid in the management of soft-tissue augmentation: A five-year experience. Semin Cutan Med Surg 2004; 23: 223-6.
10. Mest DR, Humble G. Safety and efficacy of poly-L-lactic acid injections in persons with HIV-associated lipoatrophy: The US experience. Dermatol Surg 2006; 32: 1336-45.
11. Moyle GJ, Lysakova L, Brown S et al. A randomized open-label study of immediate versus delayed polylactic acid injections for the cosmetic management of facial lipoatrophy in persons with HIV infection. HIV Med 2004; 5: 82-7.
12. Vleggaar D. Facial volume tric correction with injectable poly-L-lactic acid. Dermatol Surg 2005; 31: 1511-7; discussion 17-8.
13. Lemperle G, Gauthier-Hazan N, Wolters M. [Complications after dermal fillers and their treatment]. Handchir Mikrochir Plast Chir 2006; 38: 354-69.
14. Lombardi T, Samson J, Plantier F et al. Orofacial granulomas after injection of cosmetic fillers. Histopathologic and clinical study of 11 cases. J Oral Pathol Med 2004; 33: 115-20.
15. Dijkema SJ, van der Lei B, Kibbelaar RE. New-fill injections may induce late-onset foreign body granulomatous reaction. Plast Reconstr Surg 2005; 115: 76e-78e.
16. Jackson EM. The sensitization potential of methyl methacrylate and ethyl methacrylate. Am J Contact Dermat 1999; 10: 49-50.
17. Kanerva L, Alanko K. Allergic contact dermatitis from 2-hydroxyethyl methacrylate in an adhesive on an electrosurgical earthing plate. Eur J Dermatol 1998; 8: 521-4.
18. Morhenn VB, Lemperle G, Gallo RL. Phagocytosis of different particulate dermal filler substances by human macrophages and skin cells. Dermatol Surg 2002; 28: 484-90.
19. Lemperle G, Morhenn V, Charrier U. Human histology and persistence of various injectable filler substances for soft tissue augmentation. Aesthetic Plast Surg 2003; 27: 354-66; discussion 67.
20. Lemperle G, Gauthier-Hazan N, Lemperle M. PMMA-Microspheres (Artecoll) for long-lasting correction of wrinkles: Refinements and statistical results. Aesthetic Plast Surg 1998; 22: 356-65.