Abnormal platelet amyloid-β protein precursor (aβpp) metabolism in Alzheimer's disease: Identification and characterization of a new AβPP isoform as potential biomarker

Journal of Alzheimer's Disease

Volumn 35, Issue 2, 2013, Pages 285-295

  Jelic, Vesna ^a   Hagman, Göran ^a   Yamamoto, Natsuko Goto ^b   Teranishi, Yasuhiro ^b   Nishimura, Takeshi ^b   Winblad, Bengt ^a   Pavlov, Pavel F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Alzheimer's disease; amyloid protein precursor; biomarker; platelets

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MONOCLONAL ANTIBODY;

AGED; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; FEMALE; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84877137763     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-122122     Document Type: Article

References (40)

1. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944
2. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G,Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol 6, 734-746
3. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 3, 263-269
4. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH (2011) Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 3, 280-292
5. Humpel C (2011) Identifying and validating biomarkers for Alzheimer's disease. Trends Biotechnol 1, 26-32
6. Blennow K, Hampel H,Weiner M, Zetterberg H (2010) Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 6, 131-144
7. Tamaoka A, Fukushima T, Sawamura N, Ishikawa K, Oguni E, Komatsuzaki Y, Shoji S (1996) Amyloid beta protein in plasma from patients with sporadic Alzheimer's disease. J Neurol Sci 141, 65-68
8. Fukumoto H, Tennis M, Locascio JJ, Hyman BT, Growdon JH, Irizarry MC (2003) Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. Arch Neurol 60, 958-964
9. Korolainen MA, Nyman TA, Aittokallio T, Pirttilä T (2010) An update on clinical proteomics in Alzheimer's research. J Neurochem 112, 1386-1414
10. Rye PD, Booij BB, Grave G, Lindahl T, Kristiansen L, Andersen HM, Horndalsveen PO, Nygaard HA, Naik M, Hoprekstad D, Wetterberg P, Nilsson C, Aarsland D, Sharma P, Lönneborg A (2011) A novel blood test for the early detection of Alzheimer's disease. J Alzheimers Dis 23, 121-129
11. Rosenberg RN, Baskin F, Fosmire JA, Risser R, Adams P, Svetlik D, Honig LS, Cullum CM, Weiner MF (1997) Altered amyloid protein processing in platelets of patients with Alzheimer disease. Arch Neurol 54, 139-144
12. Di Luca M, Pastorino L, Cattabeni F, Zanardi R, Sae S, Racagni G, Smeraldi E, Perez J (1996) Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome. Arch Neurol 53, 1162-1166
13. Di Luca M, Pastorino L, Bianchetti A, Perez J, Vignolo LA, Lenzi GL, Trabucchi M, Cattabeni F, Padovani A (1998) Differential level of platelet amyloid beta precursor protein isoforms: An early marker for Alzheimer disease. Arch Neurol 55, 1195-1200
14. Baskin F, Rosenberg RN, Iyer L, Hynan L, CullumCM(2000) Platelet APP isoform ratios correlate with declining cognition in AD. Neurology 54, 1907-1909
15. Baskin F, Rosenberg RN, Iyer L, Schellenberg GD, Hynan L, Nee LE (2001) Platelet APP isoform ratios in asymptomatic young adults expressing an AD-related presenilin-1 mutation. J Neurol Sci 183, 85-88
16. Borroni B, Colciaghi F, Pastorino L, Pettenati C, Cottini E, Rozzini L, Monastero R, Lenzi GL, Cattabeni F, Di Luca M, Padovani A (2001) Amyloid precursor protein in platelets of patients with Alzheimer disease: Effect of acetylcholinesterase inhibitor treatment. Arch Neurol 58, 442-446
17. Borroni B, Colciaghi F, Corsini P, Akkawi N, Rozzini L, Del Zotto E, Talarico G, Cattabeni F, Lenzi GL, Di Luca M, Padovani A (2002) Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms. Neurol Sci 5, 207-210
18. Padovani A, Borroni B, Colciaghi F, Pettenati C, Cottini E, Agosti C, Lenzi GL, Caltagirone C, Trabucchi M, Cattabeni F, Di Luca M (2002) Abnormalities in the pattern of platelet amyloid precursor protein forms in patients with mild cognitive impairment and Alzheimer disease. Arch Neurol 59, 71-75
19. Baskin F, Rosenberg RN, Fang X, Hynan LS, Moore CB, Weiner M, Vega GL (2003) Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients. Neurology 60, 2006-2007
20. Borroni B, Colciaghi F, Lenzi GL, Caimi L, Cattabeni F, Di Luca M, Padovani A (2003) High cholesterol affects platelet APP processing in controls and in AD patients. Neurobiol Aging 5, 631-636
21. Borroni B, Colciaghi F, Caltagirone C, Rozzini L, Broglio L, Cattabeni F, Di Luca M, Padovani A (2003) Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: A 2-year follow-up study. Arch Neurol 60, 1740-1744
22. Borroni B, Colciaghi F, Archetti S, Marcello E, Caimi L, Di Luca M, Padovani A (2004) Predicting cognitive decline in Alzheimer disease. Role of platelet amyloid precursor protein. Alzheimer Dis Assoc Disord 18, 32-34
23. Liu HC, Chi CW, Ko SY,Wang HC, Hong CJ, Lin KN,Wang PN, Liu TY (2005) Cholinesterase inhibitor affects the amyloid precursor protein isoforms in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 19, 345-348
24. Liu HC, Wang HC, Ko SY, Wang PN, Chi CW, Hong CJ, Lin KN, Liu TY (2007) Correlation between platelet amyloid precursor protein isoform ratio and cognition in Alzheimer's disease. J Alzheimers Dis 11, 77-84
25. Zainaghi IA, Forlenza OV, Gattaz WF (2007) Abnormal APP processing in platelets of patients with Alzheimer's disease: Correlations with membrane fluidity and cognitive decline. Psychopharmacology (Berl) 192, 547-553
26. Bush AI, Tanzi RE (1998) Alzheimer disease-related abnormalities of amyloid beta precursor protein isoforms in the platelet: The brain's delegate in the periphery? Arch Neurol 55, 1179-1180
27. Potempska A, Styles J, Mehta P, Kim KS, Miller DL (1991) Purification and tissue level of the beta-Amyloid peptide precursor of rat brain. J Biol Chem 266, 8464-8469
28. Multhaup G, Mechler H, Masters CL (1995) Characterization of the high affinity heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP) and its enhancement by zinc (II). J Mol Recognit 8, 247-257
29. Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD (1990) Protease nexin-II (amyloid beta-protein precursor): A platelet alpha-granule protein. Science 248, 745-748
30. Smith RP, Broze GJ Jr (1992) Characterization of plateletreleasable forms of beta-Amyloid precursor proteins: The effect of thrombin. Blood 80, 2252-2260
31. Bush AI, Martins RN, Rumble B (1990) The amyloid precursor protein of Alzheimer's disease is released by human platelets. J Biol Chem 265, 15977-15983
32. Schmaier AH, Dahl LD, Rozemuller AJM, Roos RAC,Wagner SL, Chung R, Van Nostrand WE (1993) Protease nexin-2 amyloid protein precursor: A tight-biding inhibitor of coagulation factor IXa. J Clin Invest 92, 2540-2545
33. Tanzi RE, Gusella JF, Watkins PC, Bruns GAP, St George-Hyslop P, Van Patterson D, Pagan S, Kurnit DM, Neve RL (1987) Amyloid protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer's disease. Science 235, 880-884
34. Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ (1992) Detection of distinct isoform patterns of the beta-Amyloid precursor protein in human platelets and lymphocytes. Neurobiol Aging 13, 421-434
35. Li QX, Berndt MC, Bush AI, Rumble B, Mackenzie I, Friedhuber A, Beyreuther K, Masters CL (1994) Membraneassociated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: Surface expression on the activated human platelet. Blood 84, 133-142
36. Li QX, Evin G, Small DH, Multhaup G, Beyreuther K, Masters CL (1995) Proteolytic processing of Alzheimer's disease -A4 Amyloid precursor protein in human platelets. J Biol Chem 270, 14140-14147
37. Colciaghi F, Marcello E, Borroni B, Zimmermann M, Caltagirone C, Cattabeni F, Padovani A, Di LucaM(2004) Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease. Neurology 62, 498-501
38. Tang K, Hynan LS, Baskin F, Rosenberg RN (2006) Platelet amyloid precursor protein processing: A bio-marker for Alzheimer's disease. J Neurol Sci 240, 53-58
39. Georgopoulou N, McLaughlin M, McFarlane I, Breen KC (2001) The role of post-Translational modification in betaamyloid precursor protein processing. Biochem Soc Symp 67, 23-36
40. Galbete JL, Martin TR, Peressini E, Modena P, Bianchi R, Forloni G (2000) Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway. Biochem J 348, 307-313