Platelet APP isoform ratios correlate with declining cognition in AD

Neurology

Volumn 54, Issue 10, 2000, Pages 1907-1909

  Baskin, F ^a,b   Rosenberg, R N ^a   Iyer, L ^a   Hynan, L ^b   Cullum, C M ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Alzheimer amyloid precursor protein; Mini Mental State Examination; Platelets

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FOLLOW UP; HUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SCORING SYSTEM;

EID: 0034705215     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.54.10.1907     Document Type: Article

References (19)

1. Rosenberg RN. A causal role for amyloid in Alzheimer's disease: the end of the beginning. Neurology 1993;43:851-856.
2. Selkoe DJ. Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol 1994;53:438-447.
3. Schlossmacher MG, Ostaszewski BL, Hecker LI, et al. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiol Aging 1992;13:421-434.
4. Li QX, Berndt MC, Bush AL, et al. Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelet and brain: surface expression on the activated human platelet. Blood 1994;84:133-142.
5. Chen M, Inestrosa NC, Ross GS, Fernandez HL. Platelets are the primary source of amyloid beta-peptide in human blood. Biochem Biophys Res Commun 1995;213:96-103.
6. Oltersdorf T, Fritz LC, Schenk DB, et al. The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin II. Nature 1989;341:144-147.
7. Fukutsu R, Tsuzuki K, Takamanu Y, et al. Is APP in cultured cells and platelets processed in multiple pathways? Soc Neurosci 1996;22:190. Abstract.
8. Bush AL, Whyte S, Thomas LD, et al. An abnormality of plasma amyloid protein precursor in Alzheimer's disease. Ann Neurol 1992;32:57-65.
9. Rosenberg RN, Baskin F, Fosmire JA, et al. Altered amyloid protein processing in platelets of patients with Alzheimer's disease. Arch Neurol 1997;54:139-144.
10. DiLuca M, Pastorino L, Cattabeni F, et al. Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down Syndrome. Arch Neurol 1996;53:1162-1166.
11. DiLuca M, Pastorino L, Bianchetti A, et al. Differential level of platelet amyloid beta precursor protein isoforms - an early marker for Alzheimer disease. Arch Neurol 1998;55:1195-1200.
12. Matsushima H, Shimohama S, Tanaka S, et al. Platelet protein kinase C levels in Alzheimer's disease. Neurobiol Aging 1994;15:671-674.
13. Hasitz M, Racz Z, Nagy A, Lipcsey A. Importance of platelet functions in Alzheimer's disease. Arch Gerontol Geriatr 1995; 21:53-61.
14. Davies TA, Fine RE, Johnson RJ, et al. Non-age-related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease. Biochem Biophys Res Commun 1993;194:537-543.
15. Davies TA, Long HJ, Rathbun WH, et al. Platelets from patients with Alzheimer's disease or other dementias exhibit disease-specific and apolipoprotein E correlatable defects. Amyloid Int J Exp Clin Invest 1996;3:13-19.
16. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group. Neurology 1984;34:939-944.
17. Weiner M, Bruhn M, Svetlik D, et al. Experiences with depression in a dementia clinic. J Clin Psychol 1991;52:234-238.
18. Huberman M, Shalit F, Roth-Deri I, et al. Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease state. J Neuroimmunol 1994;52:147-152.
19. Kowalska MA, Badellino K. Beta-amyloid protein induces platelet aggregation and supports platelet adhesion. Biochem Biophys Res Commun 1994;205:1829-1835.