Human schistosomiasis mansoni: Intensity of infection differentially affects the production of interleukin-10, interferon-γ and interleukin-13 by soluble egg antigen or adult worm antigen stimulated cultures

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 98, Issue 9, 2004, Pages 514-519

  Silveira, Alda M S ^a   Gazzinelli, Giovanni ^b,g   Alves Oliveira, Lúcia F ^a   Bethony, Jeffrey ^c   Gazzinelli, Andrea ^d   Carvalho Queiroz, Claudia ^e   Alvarez, Maria Carolina B ^b   Lima Silva, Francisco C ^b   Prata, Aluizio ^f   LoVerde, Philip T ^e   Correa Oliveira, Rodrigo ^g  

^a UNIVERSIDADE VALE DO RIO DOCE   (Brazil)

^b Santa Casa Hospital   (Brazil)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^e UNIVERSITY AT BUFFALO   (United States)

^f FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

^g INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Brazil; Interferon ; Interleukin 10; Interleukin 13; Schistosoma mansoni; Schistosomiasis

Indexed keywords

ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13;

ADULT; ARTICLE; CELL CULTURE; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDEMIC DISEASE; FEMALE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL; WORM EGG;

ADULT; AGE FACTORS; ANIMALS; ANTIGENS, HELMINTH; BRAZIL; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; ENDEMIC DISEASES; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-13; LEUKOCYTES, MONONUCLEAR; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SEVERITY OF ILLNESS INDEX;

SCHISTOSOMA; SCHISTOSOMA MANSONI;

EID: 3342977308     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2003.11.009     Document Type: Article

References (18)

1. Arap-Siongok T.K. Mahmoud A.A.F. Ouma J.H. Warren K.E. Muller A.E. Handa A.K. Houser H.B. Morbidity in schistosomiasis mansoni in relation to intensity of infection: study of a community in Machakos, Kenya Am. J. Trop. Med. Hyg. 25 1976 273-284
2. Bethony J. Silveira A.M.S. Alves-Oliveira L.F. Thakur A. Gazzinelli G. Correa-Oliveira R. LoVerde P.T. Familial resemblance in humoral immune response to defined and crude Schistosoma mansoni antigens in an endemic area in Brazil J. Infect. Dis. 173 1999 1665-1673
3. Butterworth A.E. Capron M. Cordingley J.S. Dalton P.R. Dunne D.W. Kariuki H.C. Kimani G. Koech D. Mugambi M. Ouma J.H. Prentice M.A. Richardson B.A. Arap-Siongok T.K. Taylor D.W. Immunity after treatment of human schistosomiasis mansoni. II. Identification of resistant individuals, and analysis of their immune response. Trans R. Soc. Trop. Med. Hyg. 79 1985 393-408
4. Chiaramonte M.G. Mentink-Kane M. Jacobson B.A. Cheever A.W. Whitters M.J. Goad M.E. Wong A. Collins M. Donaldson D.D. Grusby M.J. Wynn T.A. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response J. Exp. Med. 197 2003 675-679
5. Dessein A.J. Couissinier P. Demeure C. Rihet P. Kohlstaedt S. Carneiro-Carvalho D. Ouattara M. Goudot-Crozel V. Dessein H. Bourgois A. Environmental genetic and immunological factors in human resistance to Schistosoma mansoni Immunol. Invest. 21 1992 423-453
6. Gazzinelli A. Bethony J. Alves-Oliveira L.F. LoVerde P.T. Correa-Oliveira R. Kloos H. Exposure to Schistosoma mansoni infection in a rural area of Brazil Part I: Water contact Trop. Med. Int. Health 6 2001 126-135
7. Gryseels B. Human resistance to Schistosoma infections: age or experience? Parasitol. Today 10 1994 380-384
8. Gryzch J.M. Pearce E.J. Cheever A.W. Caulada Z.A. Caspar P. Hieny S. Lewis A.Sher A.Egg deposition is a major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni J. Immunol. 146 1991 1322-1327
9. Katz N. Chaves A. Pellegrino J. A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni Rev. Inst. Med. Trop. São Paulo 14 1972 397-400
10. King C.L. Medhat A. Malhotra I. Nafeh M. Helmy A. Khaudary J. Ibrahim S. El-Sherbiny M. Zaky S. Stupi R.J. Brustoski K. Shehata M. Shata M.T. Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity J. Immunol. 156 1996 4715-4721
11. Malaquias L.C.C. Falcão P.L. Silveira A.M.S. Gazzinelli G. Prata A. Coffmann R.L. Pizziolo V.R. Corrêa-Oliveira R. Cytokine regulation of human response to Schistosoma mansoni: analysis of the role of IL-4, IL-5 and IL-10 on peripheral blood mononuclear cells responses Scand. J. Immunol. 46 1997 393-398
12. Montenegro S.M.L. Miranda P. Mahanty S. Abath F.G.C. Teixeira K.M. Coutinho E.M. Brinkman J. Gonçalves I. Domingues L.A.W. Domingues A.L. Sher A. Wynn T.A. Cytokine production in acute versus chronic human schistosomiasis mansoni: the cross-regulatory role of interferon-γ and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens J. Inf. Dis. 179 1999 1502-1514
13. Pearce E.J. Caspar P. Gryzch J.M. Lewis F.A. Sher A. Down regulation of Th1 cytocine production accompanies induction of Th2 responses by a helminth, Schistosoma mansoni J. Exp. Med. 173 1991 159-166
14. Sher A. Fiorentino D. Caspar P. Pearce E. Mosmann T. Production of IL-10 by CD4+ T lymphocytes corelates with downregulation of Th1 cytokine synthesis in helminth infection J. Immunol. 147 1991 2713-2716
15. Silveira A.M.S. Bethony J. Gazzinelli A. Kloos H. Alves-Oliveira L.F. Alves M.C.B. Prata A. Guerra H.A. Loverde P.T. Correa-Oliveira R. Gazzinelli G. High levels of IgG4 to Schistosoma mansoni egg antigens are observed in individuals with periportal fibrosis Am. J. Trop. Med. Hyg. 66 2002 542-549
16. Viana I.R.C. Sher A. Carvalho O.S. Massara C.L. Eloi-Santos S.M. Pearce E.J. Colley D.G. Gazzinelli G. Correa-Oliveira R. Interferon-γ production by peripheral blood mononuclear cells from residents of an area endemic for Schistosoma mansoni Trans. R. Soc. Trop. Med. Hyg. 88 1994 466-470
17. + Th2 response induced by Schistosoma mansoni eggs rapidly develops through an early, transient Th0-like stage J. Immunol. 148 1992 2283-2290
18. Zwingenberger K. Hohmann A. Cardoso de Brito M. Ritter M. Impaired balance of interleukin-4 and interferon-γ production in infections with Schistosoma mansoni and intestinal nematodes Scand. J. Immunol. 34 1991 234-251