Toll-like receptor ligands enhance the protective effects of vaccination against porcine reproductive and respiratory syndrome virus in swine

Veterinary Microbiology

Volumn 164, Issue 3-4, 2013, Pages 253-260

  Zhang, Lili ^a   Bai, Juan ^a   Liu, Jie ^a   Wang, Xiaoye ^a   Li, Yufeng ^a   Jiang, Ping ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

Adjuvants; Killed virus (KV) vaccine; PRRSV; TLR ligands

Indexed keywords

CL 097; DOUBLE STRANDED RNA; GAMMA INTERFERON; IMMUNOLOGIC AGENT; LIPOTEICHOIC ACID; POLYRIBOINOSINIC POLYRIBOCYTIDYLIC; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIVIRUS; ARTERIVIRUS INFECTION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; MOUSE; NONHUMAN; SWINE; T LYMPHOCYTE; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, VIRAL; IMIDAZOLES; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MICE; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; QUINOLINES; SWINE; VACCINES, INACTIVATED; VIRAL VACCINES;

ANIMALIA; MUS; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE;

EID: 84877106477     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2013.02.016     Document Type: Article

References (35)

1. Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4:499-511.
2. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
3. Beutler B., Jiang Z., Georgel P., Crozat K., Croker B., Rutschmann S., Du X., Hoebe K. Genetic analysis of host resistance: toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 2006, 24:353-389.
4. Cao Y., Lu Z., Li P., Sun P., Fu Y., Bai X., Bao H., Chen Y., Li D., Liu Z. Improved neutralising antibody response against foot-and-mouth-disease virus in mice inoculated with a multi-epitope peptide vaccine using polyinosinic and poly-cytidylic acid as an adjuvant. J. Virol. Methods 2012, 185:124-128.
5. Collins J.E., Benfield D.A., Christianson W.T., Harris L., Hennings J.C., Shaw D.P., Goyal S.M., McCullough S., Morrison R.B., Joo H.S., et al. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J. Vet. Diagn. Invest. 1992, 4:117-126.
6. Guo X., Zhang Q., Hou S., Zhai G., Zhu H., Sanchez-Vizcaino J.M. Plasmid containing CpG motifs enhances the efficacy of porcine reproductive and respiratory syndrome live attenuated vaccine. Vet. Immunol. Immunopathol. 2011, 144:405-409.
7. Halbur P.G., Miller L.D., Paul P.S., Meng X.J., Huffman E.L., Andrews J.J. Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs. Vet. Pathol. 1995, 32:200-204.
8. Jiang Y., Fang L., Xiao S., Li B., Pan Y., Luo R., Chen H. A suicidal DNA vaccine co-expressing two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus antigens induce protective responses. Biotechnol. Lett. 2009, 31:509-518.
9. Kawai T., Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int. Immunol. 2009, 21:317-337.
10. Lahiri A., Das P., Chakravortty D. Engagement of TLR signaling as adjuvant: towards smarter vaccine and beyond. Vaccine 2008, 26:6777-6783.
11. Li G., Jiang P., Li Y., Wang X., Huang J., Bai J., Cao J., Wu B., Chen N., Zeshan B. Inhibition of porcine reproductive and respiratory syndrome virus replication by adenovirus-mediated RNA interference both in porcine alveolar macrophages and swine. Antiviral Res. 2009, 82:157-165.
12. Li H., Willingham S.B., Ting J.P., Re F. Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J. Immunol. 2008, 181:17-21.
13. Li W., Liu H., Yang X., Zheng J., Wang Y., Si L. Development of prophylactic recombinant HPV58-attenuated Shigella live vector vaccine and evaluation of its protective efficacy and immunogenicity in the guinea pig keratoconjunctivitis model. Acta Biochim. Biophys. Sinica 2009, 41:137-145.
14. Li Y., Wang X., Bo K., Tang B., Yang B., Jiang W., Jiang P. Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China. Vet. J. 2007, 174:577-584.
15. Li Y., Wang X., Jiang P., Chen W. Genetic analysis of two porcine reproductive and respiratory syndrome viruses with different virulence isolated in China. Arch. Virol. 2008, 153:1877-1884.
16. Longhi M.P., Trumpfheller C., Idoyaga J., Caskey M., Matos I., Kluger C., Salazar A.M., Colonna M., Steinman R.M. Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant. J. Exp. Med. 2009, 206:1589-1602.
17. Matsumoto M., Funami K., Oshiumi H., Seya T. Toll-like receptor 3: a link between toll-like receptor, interferon and viruses. Microbiol. Immunol. 2004, 48:147-154.
18. Quan Z., Qin Z.G., Zhen W., Feng X.Z., Hong J., Fei Z.H. Plasmid containing CpG oligodeoxynucleotides can augment the immune responses of pigs immunized with porcine reproductive and respiratory syndrome killed virus vaccine. Vet. Immunol. Immunopathol. 2010, 136:257-264.
19. Salem M.L., El-Naggar S.A., Kadima A., Gillanders W.E., Cole D.J. The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. Vaccine 2006, 24:5119-5132.
20. San Roman B., De Andres X., Munoz P.M., Obregon P., Asensio A.C., Garrido V., Mansilla C., Arribillaga L., Lasarte J.J., De Andres D., Amorena B., Grillo M.J. The extradomain A of fibronectin (EDA) combined with poly(I:C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model. Vaccine 2012, 30:2564-2569.
21. Spranger S., Javorovic M., Burdek M., Wilde S., Mosetter B., Tippmer S., Bigalke I., Geiger C., Schendel D.J., Frankenberger B. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J. Immunol. 2010, 185:738-747.
22. Stahl-Hennig C., Eisenblatter M., Jasny E., Rzehak T., Tenner-Racz K., Trumpfheller C., Salazar A.M., Uberla K., Nieto K., Kleinschmidt J., Schulte R., Gissmann L., Muller M., Sacher A., Racz P., Steinman R.M., Uguccioni M., Ignatius R. Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques. PLoS Pathog. 2009, 5:e1000373.
23. Stevceva L. Toll-like receptor agonists as adjuvants for HIV vaccines. Curr. Med. Chem. 2011, 18:5079-5082.
24. Sun H.X., Pan H.J. Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice. Vaccine 2006, 24:1914-1920.
25. Tian K., Yu X., Zhao T., Feng Y., Cao Z., Wang C., Hu Y., Chen X., Hu D., Tian X., Liu D., Zhang S., Deng X., Ding Y., Yang L., Zhang Y., Xiao H., Qiao M., Wang B., Hou L., Wang X., Yang X., Kang L., Sun M., Jin P., Wang S., Kitamura Y., Yan J., Gao G.F. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One 2007, 2:e526.
26. Tian Z.J., An T.Q., Zhou Y.J., Peng J.M., Hu S.P., Wei T.C., Jiang Y.F., Xiao Y., Tong G.Z. An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS. Vet. Microbiol. 2009, 138:34-40.
27. Tong G., Zhou Y., Hao X., Tian Z., An T., Qiu H. Highly pathogenic porcine reproductive and respiratory syndrome, China. Emerg. Infect Dis. 2007, 13:1434-1436.
28. Trumpfheller C., Caskey M., Nchinda G., Longhi M.P., Mizenina O., Huang Y., Schlesinger S.J., Colonna M., Steinman R.M. The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:2574-2579.
29. Wang Y., Liang Y., Han J., Burkhart K.M., Vaughn E.M., Roof M.B., Faaberg K.S. Attenuation of porcine reproductive and respiratory syndrome virus strain MN184 using chimeric construction with vaccine sequence. Virology 2008, 371:418-429.
30. Wensvoort G., Terpstra C., Pol J.M., ter Laak E.A., Bloemraad M., de Kluyver E.P., Kragten C., van Buiten L., den Besten A., Wagenaar F., et al. Mystery swine disease in The Netherlands: the isolation of Lelystad virus. Vet. Quart. 1991, 13:121-130.
31. Wille-Reece U., Flynn B.J., Lore K., Koup R.A., Kedl R.M., Mattapallil J.J., Weiss W.R., Roederer M., Seder R.A. HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+T cell responses in nonhuman primates. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:15190-15194.
32. Zhou Y., Hao X., Tian Z., Tong G., Yoo D., An T., Zhou T., Li G., Qiu H., Wei T. Highly virulent porcine reproductive and respiratory syndrome virus emerged in China. Transbound. Emerg. Dis. 2008, 55:152-164.
33. Zhou Y.J., Hao X.F., Tian Z.J., Tong G.Z., Yoo D., An T.Q., Zhou T., Li G.X., Qiu H.J., Wei T.C., Yuan X.F. Highly virulent porcine reproductive and respiratory syndrome virus emerged in China. Transbound. Emerg. Dis. 2008, 55:152-164.
34. Zhu Q., Egelston C., Gagnon S., Sui Y., Belyakov I.M., Klinman D.M., Berzofsky J.A. Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice. J. Clin. Investig. 2010, 120:607-616.
35. Zhu Q., Egelston C., Vivekanandhan A., Uematsu S., Akira S., Klinman D.M., Belyakov I.M., Berzofsky J.A. Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:16260-16265.