-
1
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I, Landis, J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 2004; 3(8):711-715. (Pubitemid 39173511)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.8
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
2
-
-
79957889347
-
The productivity crisis in pharmaceutical R&D
-
Pammolli, F, Magazzini, L, Riccaboni, M. The productivity crisis in pharmaceutical R&D. Nat Rev Drug Discov 2011; 10(6):428-438.
-
(2011)
Nat Rev Drug Discov
, vol.10
, Issue.6
, pp. 428-438
-
-
Pammolli, F.1
Magazzini, L.2
Riccaboni, M.3
-
3
-
-
84856375492
-
The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery
-
Thomas, CE, Will, Y. The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery. Expert Opin Drug Discov 2012; 7(2):109-122.
-
(2012)
Expert Opin Drug Discov
, vol.7
, Issue.2
, pp. 109-122
-
-
Thomas, C.E.1
Will, Y.2
-
4
-
-
63249109982
-
High-throughput screening for analysis of in vitro toxicity
-
Schoonen, WG, Westerink, WM, Horbach, GJ. High-throughput screening for analysis of in vitro toxicity. EXS 2009; 99:401-452.
-
(2009)
EXS
, vol.99
, pp. 401-452
-
-
Schoonen, W.G.1
Westerink, W.M.2
Horbach, G.J.3
-
5
-
-
84861493873
-
Automated electrophysiology makes the pace for cardiac ion channel safety screening
-
Moller, C, Witchel, H. Automated electrophysiology makes the pace for cardiac ion channel safety screening. Front Pharmacol 2011; 2:73.
-
(2011)
Front Pharmacol
, vol.2
, pp. 73
-
-
Moller, C.1
Witchel, H.2
-
6
-
-
79958021542
-
How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
-
Laverty, H, Benson, C, Cartwright, E, Cross, M, Garland, C, Hammond, T et al. How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? Br J Pharmacol 2011; 163(4):675-693.
-
(2011)
Br J Pharmacol
, vol.163
, Issue.4
, pp. 675-693
-
-
Laverty, H.1
Benson, C.2
Cartwright, E.3
Cross, M.4
Garland, C.5
Hammond, T.6
-
8
-
-
77950939863
-
Report and recommendations of the workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity
-
Stummann, TC, Beilmann, M, Duker, G, Dumotier, B, Fredriksson, JM, Jones, RL et al. Report and recommendations of the workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity. Cardiovasc Toxicol 2009; 9(3): 107-125.
-
(2009)
Cardiovasc Toxicol
, vol.9
, Issue.3
, pp. 107-125
-
-
Stummann, T.C.1
Beilmann, M.2
Duker, G.3
Dumotier, B.4
Fredriksson, J.M.5
Jones, R.L.6
-
9
-
-
84865980135
-
Toward a New Gold Standard for Early Safety: Automated Temperature- Controlled hERG Test on the PatchLiner
-
Polonchuk, L. Toward a New Gold Standard for Early Safety: Automated Temperature- Controlled hERG Test on the PatchLiner. Front Pharmacol 2012; 3:3.
-
(2012)
Front Pharmacol
, vol.3
, pp. 3
-
-
Polonchuk, L.1
-
10
-
-
80555130144
-
Introduction of a modular automated voltage-clamp platform and its correlation with manual human Ether-a- go-go related gene voltage-clamp data
-
Scheel, O, Himmel, H, Rascher-Eggstein, G, Knott, T. Introduction of a modular automated voltage-clamp platform and its correlation with manual human Ether-a- go-go related gene voltage-clamp data. Assay Drug Dev Technol 2011; 9(6):600-607.
-
(2011)
Assay Drug Dev Technol
, vol.9
, Issue.6
, pp. 600-607
-
-
Scheel, O.1
Himmel, H.2
Rascher-Eggstein, G.3
Knott, T.4
-
11
-
-
84861502604
-
State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials and High Throughput in Ion Channel Screening
-
Stoelzle, S, Obergrussberger, A, Bruggemann, A, Haarmann, C, George, M, Kettenhofen, R et al. State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials and High Throughput in Ion Channel Screening. Front Pharmacol 2011; 2:76.
-
(2011)
Front Pharmacol
, vol.2
, pp. 76
-
-
Stoelzle, S.1
Obergrussberger, A.2
Bruggemann, A.3
Haarmann, C.4
George, M.5
Kettenhofen, R.6
-
12
-
-
84877067260
-
Cardiac drug safety and hERG channel
-
Yang, N. Cardiac drug safety and hERG channel. T Bio/Phar Ind 2012; 1:30-35.
-
(2012)
T Bio/Phar Ind
, vol.1
, pp. 30-35
-
-
Yang, N.1
-
13
-
-
0033553504
-
Mechanism of block and identification of the verapamil binding domain to HERG potassium channels
-
Zhang, S, Zhou, Z, Gong, Q, Makielski, JC, January, CT Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ Res 1999; 84(9):989-998. (Pubitemid 29227678)
-
(1999)
Circulation Research
, vol.84
, Issue.9
, pp. 989-998
-
-
Zhang, S.1
Zhou, Z.2
Gong, Q.3
Makielski, J.C.4
January, C.T.5
-
14
-
-
2142773127
-
Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene - Without QT interval prolongation
-
DOI 10.1016/j.bbrc.2004.04.063, PII S0006291X04007909
-
Yuill, KH, Borg, JJ, Ridley, JM, Milnes, JT, Witchel, HJ, Paul, AA et al. Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene-without QT interval prolongation. Biochem Biophys Res Commun 2004; 318(2):556-561. (Pubitemid 38553815)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.318
, Issue.2
, pp. 556-561
-
-
Yuill, K.H.1
Borg, J.J.2
Ridley, J.M.3
Milnes, J.T.4
Witchel, H.J.5
Paul, A.A.6
Kozlowski, R.Z.7
Hancox, J.C.8
-
15
-
-
29444432234
-
+ channel
-
DOI 10.1016/j.yjmcc.2005.09.017, PII S0022282805003111
-
Ridley, JM, Milnes, JT, Hancox, JC, Witchel, HJ. Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel. J Mol Cell Cardiol 2006; 40(1):107-118. (Pubitemid 43012122)
-
(2006)
Journal of Molecular and Cellular Cardiology
, vol.40
, Issue.1
, pp. 107-118
-
-
Ridley, J.M.1
Milnes, J.T.2
Hancox, J.C.3
Witchel, H.J.4
-
16
-
-
0033956657
-
Electrophysiological effects of fluoxetine in mammalian cardiac tissues
-
DOI 10.1007/s002109900154
-
Pacher, P, Magyar, J, Szigligeti, P, Banyasz, T, Pankucsi, C, Korom, Z et al. Electrophysiological effects of fluoxetine in mammalian cardiac tissues. Naunyn Schmiedebergs Arch Pharmacol 2000; 361(1):67-73. (Pubitemid 30064656)
-
(2000)
Naunyn-Schmiedeberg's Archives of Pharmacology
, vol.361
, Issue.1
, pp. 67-73
-
-
Pacher, P.1
Magyar, J.2
Szigligeti, P.3
Banyasz, T.4
Pankucsi, C.5
Korom, Z.6
Ungvari, Z.7
Kecskemeti, V.8
Nanasi, P.P.9
-
17
-
-
0037070199
-
Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents
-
DOI 10.1016/S0014-5793(01)03320-8, PII S0014579301033208
-
Witchel, HJ, Pabbathi, VK, Hofmann, G, Paul, AA, Hancox, JC. Inhibitory actions of the selective serotonin re-uptake inhibitor Citalopram on HERG and ventricular L-type calcium currents. FEBS Lett 2002; 512(1-3):59-66. (Pubitemid 34164451)
-
(2002)
FEBS Letters
, vol.512
, Issue.1-3
, pp. 59-66
-
-
Witchel, H.J.1
Pabbathi, V.K.2
Hofmann, G.3
Paul, A.A.4
Hancox, J.C.5
-
18
-
-
35448977328
-
Invitro experimental models for the risk assessment of antibiotic-induced QT prolongation
-
Lu, HR, Vlaminckx, E, Van de Water, A, Rohrbacher, J, Hermans, A, Gallacher, DJ. Invitro experimental models for the risk assessment of antibiotic-induced QT prolongation. Eur J Pharmacol 2007; 577(1-3):222-232.
-
(2007)
Eur J Pharmacol
, vol.577
, Issue.1-3
, pp. 222-232
-
-
Lu, H.R.1
Vlaminckx, E.2
Van De Water, A.3
Rohrbacher, J.4
Hermans, A.5
Gallacher, D.J.6
-
19
-
-
4344577023
-
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
-
DOI 10.1161/01.CIR.0000139333.83620.5D
-
Antzelevitch, C, Belardinelli, L, Zygmunt, AC, Burashnikov, A, Di Diego, JM, Fish, JM et al. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 2004; 110(8):904-910. (Pubitemid 39136212)
-
(2004)
Circulation
, vol.110
, Issue.8
, pp. 904-910
-
-
Antzelevitch, C.1
Belardinelli, L.2
Zygmunt, A.C.3
Burashnikov, A.4
Di, D.J.M.5
Fish, J.M.6
Cordeiro, J.M.7
Thomas, G.8
-
20
-
-
38749139218
-
Alfuzosin delays cardiac repolarization by a novel mechanism
-
DOI 10.1124/jpet.107.128405
-
Lacerda, AE, Kuryshev, YA, Chen, Y, Renganathan, M, Eng, H, Danthi, SJ et al. Alfuzosin delays cardiac repolarization by a novel mechanism. J Pharmacol Exp Ther 2008; 324(2):427-433. (Pubitemid 351185830)
-
(2008)
Journal of Pharmacology and Experimental Therapeutics
, vol.324
, Issue.2
, pp. 427-433
-
-
Lacerda, A.E.1
Kuryshev, Y.A.2
Chen, Y.3
Renganathan, M.4
Eng, H.5
Danthi, S.J.6
Kramer, J.W.7
Yang, T.8
Brown, A.M.9
-
21
-
-
39549090639
-
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel
-
DOI 10.1073/pnas.0708153105
-
Rodriguez-Menchaca, AA, Navarro-Polanco, RA, Ferrer-Villada, T, Rupp, J, Sachse, FB, Tristani-Firouzi, M et al. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci U SA 2008; 105(4): 1364-1368. (Pubitemid 351397059)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.4
, pp. 1364-1368
-
-
Rodriguez-Menchaca, A.A.1
Navarro-Polanco, R.A.2
Ferrer-Villada, T.3
Rupp, J.4
Sachse, F.B.5
Tristani-Firouzi, M.6
Sanchez-Chapula, J.A.7
-
22
-
-
79151474418
-
An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation
-
Gintant, G. An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation. Pharmacol Ther 2011; 129(2):109-119.
-
(2011)
Pharmacol Ther
, vol.129
, Issue.2
, pp. 109-119
-
-
Gintant, G.1
|