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Volumn 14, Issue 2, 2013, Pages 60-66

An automated approach to solving Pharma's cardiac toxicity conundrum

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ALFUZOSIN; ASTEMIZOLE; CAFFEINE; CHLOROQUINE; CISAPRIDE; CITALOPRAM; CLEMASTINE; CLOMIFENE; DOFETILIDE; FLUOXETINE; MOXIFLOXACIN; POTASSIUM CHANNEL HERG; QUINIDINE; RANOLAZINE; TERFENADINE; VERAPAMIL;

EID: 84877075182     PISSN: 14694344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (22)
  • 1
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I, Landis, J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 2004; 3(8):711-715. (Pubitemid 39173511)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.8 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 2
  • 3
    • 84856375492 scopus 로고    scopus 로고
    • The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery
    • Thomas, CE, Will, Y. The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery. Expert Opin Drug Discov 2012; 7(2):109-122.
    • (2012) Expert Opin Drug Discov , vol.7 , Issue.2 , pp. 109-122
    • Thomas, C.E.1    Will, Y.2
  • 4
    • 63249109982 scopus 로고    scopus 로고
    • High-throughput screening for analysis of in vitro toxicity
    • Schoonen, WG, Westerink, WM, Horbach, GJ. High-throughput screening for analysis of in vitro toxicity. EXS 2009; 99:401-452.
    • (2009) EXS , vol.99 , pp. 401-452
    • Schoonen, W.G.1    Westerink, W.M.2    Horbach, G.J.3
  • 5
    • 84861493873 scopus 로고    scopus 로고
    • Automated electrophysiology makes the pace for cardiac ion channel safety screening
    • Moller, C, Witchel, H. Automated electrophysiology makes the pace for cardiac ion channel safety screening. Front Pharmacol 2011; 2:73.
    • (2011) Front Pharmacol , vol.2 , pp. 73
    • Moller, C.1    Witchel, H.2
  • 6
    • 79958021542 scopus 로고    scopus 로고
    • How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
    • Laverty, H, Benson, C, Cartwright, E, Cross, M, Garland, C, Hammond, T et al. How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? Br J Pharmacol 2011; 163(4):675-693.
    • (2011) Br J Pharmacol , vol.163 , Issue.4 , pp. 675-693
    • Laverty, H.1    Benson, C.2    Cartwright, E.3    Cross, M.4    Garland, C.5    Hammond, T.6
  • 8
    • 77950939863 scopus 로고    scopus 로고
    • Report and recommendations of the workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity
    • Stummann, TC, Beilmann, M, Duker, G, Dumotier, B, Fredriksson, JM, Jones, RL et al. Report and recommendations of the workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity. Cardiovasc Toxicol 2009; 9(3): 107-125.
    • (2009) Cardiovasc Toxicol , vol.9 , Issue.3 , pp. 107-125
    • Stummann, T.C.1    Beilmann, M.2    Duker, G.3    Dumotier, B.4    Fredriksson, J.M.5    Jones, R.L.6
  • 9
    • 84865980135 scopus 로고    scopus 로고
    • Toward a New Gold Standard for Early Safety: Automated Temperature- Controlled hERG Test on the PatchLiner
    • Polonchuk, L. Toward a New Gold Standard for Early Safety: Automated Temperature- Controlled hERG Test on the PatchLiner. Front Pharmacol 2012; 3:3.
    • (2012) Front Pharmacol , vol.3 , pp. 3
    • Polonchuk, L.1
  • 10
    • 80555130144 scopus 로고    scopus 로고
    • Introduction of a modular automated voltage-clamp platform and its correlation with manual human Ether-a- go-go related gene voltage-clamp data
    • Scheel, O, Himmel, H, Rascher-Eggstein, G, Knott, T. Introduction of a modular automated voltage-clamp platform and its correlation with manual human Ether-a- go-go related gene voltage-clamp data. Assay Drug Dev Technol 2011; 9(6):600-607.
    • (2011) Assay Drug Dev Technol , vol.9 , Issue.6 , pp. 600-607
    • Scheel, O.1    Himmel, H.2    Rascher-Eggstein, G.3    Knott, T.4
  • 11
    • 84861502604 scopus 로고    scopus 로고
    • State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials and High Throughput in Ion Channel Screening
    • Stoelzle, S, Obergrussberger, A, Bruggemann, A, Haarmann, C, George, M, Kettenhofen, R et al. State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials and High Throughput in Ion Channel Screening. Front Pharmacol 2011; 2:76.
    • (2011) Front Pharmacol , vol.2 , pp. 76
    • Stoelzle, S.1    Obergrussberger, A.2    Bruggemann, A.3    Haarmann, C.4    George, M.5    Kettenhofen, R.6
  • 12
    • 84877067260 scopus 로고    scopus 로고
    • Cardiac drug safety and hERG channel
    • Yang, N. Cardiac drug safety and hERG channel. T Bio/Phar Ind 2012; 1:30-35.
    • (2012) T Bio/Phar Ind , vol.1 , pp. 30-35
    • Yang, N.1
  • 13
    • 0033553504 scopus 로고    scopus 로고
    • Mechanism of block and identification of the verapamil binding domain to HERG potassium channels
    • Zhang, S, Zhou, Z, Gong, Q, Makielski, JC, January, CT Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ Res 1999; 84(9):989-998. (Pubitemid 29227678)
    • (1999) Circulation Research , vol.84 , Issue.9 , pp. 989-998
    • Zhang, S.1    Zhou, Z.2    Gong, Q.3    Makielski, J.C.4    January, C.T.5
  • 17
    • 0037070199 scopus 로고    scopus 로고
    • Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents
    • DOI 10.1016/S0014-5793(01)03320-8, PII S0014579301033208
    • Witchel, HJ, Pabbathi, VK, Hofmann, G, Paul, AA, Hancox, JC. Inhibitory actions of the selective serotonin re-uptake inhibitor Citalopram on HERG and ventricular L-type calcium currents. FEBS Lett 2002; 512(1-3):59-66. (Pubitemid 34164451)
    • (2002) FEBS Letters , vol.512 , Issue.1-3 , pp. 59-66
    • Witchel, H.J.1    Pabbathi, V.K.2    Hofmann, G.3    Paul, A.A.4    Hancox, J.C.5
  • 22
    • 79151474418 scopus 로고    scopus 로고
    • An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation
    • Gintant, G. An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation. Pharmacol Ther 2011; 129(2):109-119.
    • (2011) Pharmacol Ther , vol.129 , Issue.2 , pp. 109-119
    • Gintant, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.