Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients

British Journal of Cancer

Volumn 108, Issue 8, 2013, Pages 1677-1683

  Szkandera, J ^a   Absenger, G ^a   Liegl Atzwanger, B ^a   Pichler, M ^a   Stotz, M ^a   Samonigg, H ^a   Glehr, M ^a   Zacherl, M ^a   Stojakovic, T ^a   Gerger, A ^a   Leithner, A ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ADJUVANT CHEMORADIOTHERAPY; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER LOCALIZATION; CANCER PATIENT; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SIZE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CELLULAR PARAMETERS; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FOLLOW UP; HISTOLOGY; HUMAN; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; NECROSIS; NEUTROPHIL; NEUTROPHIL LYMPHOCYTE RATIO; NUCLEAR MAGNETIC RESONANCE IMAGING; OVERALL SURVIVAL; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SOFT TISSUE SARCOMA; TUMOR INVASION; TUMOR MICROENVIRONMENT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; HUMANS; LYMPHOCYTES; MIDDLE AGED; NEUTROPHILS; PREOPERATIVE CARE; PROGNOSIS; SARCOMA; TREATMENT OUTCOME; TUMOR MICROENVIRONMENT; YOUNG ADULT;

EID: 84877057575     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.135     Document Type: Article

References (34)

1. An X, Ding PR, Li YH, Wang FH, Shi YX, Wang ZQ, He YJ, Xu RH, Jiang WQ (2010) Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer. Biomarkers 15: 516-522.
2. Borden EC, Baker LH, Bell RS, Bramwell V, Demetri GD, Eisenberg BL, Fletcher CD, Fletcher JA, Ladanyi M, Meltzer P, O'Sullivan B, Parkinson DR, Pisters PW, Saxman S, Singer S, Sundaram M, van Oosterom AT, Verweij J, Waalen J, Weiss SW, Brennan MF (2003) Soft tissue sarcomas of adults: state of the translational science. Clin Cancer Res 9: 1941-1956.
3. Chen Z, Gerhold-Ay A, Gebhard S, Boehm D, Solbach C, Lebrecht A, Battista M, Sicking I, Cotarelo C, Cadenas C, Marchan R, Stewart JD, Gehrmann M, Koelbl H, Hengstler JG, Schmidt M (2012) Immunoglobulin kappa C predicts overall survival in node-negative breast cancer. PLoS ONE 7: e44741.
4. Cho H, Hur HW, Kim SW, Kim SH, Kim JH, Kim YT, Lee K (2009) Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother 58: 15-23.
5. Clark EJ, Connor S, Taylor MA, Madhavan KK, Garden OJ, Parks RW (2007) Preoperative lymphocyte count as a prognostic factor in resected pancreatic ductal adenocarcinoma. HPB (Oxford) 9: 456-460.
6. Coindre JM (2006) Grading of soft tissue sarcomas: review and update. Arch Pathol Lab Med 130: 1448-1453.
7. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420: 860-867.
8. Di Carlo E, Forni G, Musiani P (2003) Neutrophils in the antitumoral immune response. Chem Immunol Allergy 83: 182-203.
9. El-Hag A, Clark RA (1987) Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system. J Immunol., 139, 2406-2413.
10. Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 106-120.
11. Fletcher CDM, Unni KK, Mertens F (2002) World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone 9-224. IARC Press: Lyon.
12. Gomez D, Farid S, Malik HZ, Young AL, Toogood GJ, Lodge JP, Prasad KR (2008) Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 32: 1757-1762.
13. Gousias K, Becker AJ, Simon M, Niehusmann P (2012) Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas. J Neurooncol 109: 545-553.
14. Idowu OK, Ding Q, Taktak AF, Chandrasekar CR, Yin Q (2012) Clinical implication of pretreatment neutrophil to lymphocyte ratio in soft tissue sarcoma. Biomarkers 17: 539-544.
15. Jackson JR, Seed MP, Kircher CH, Willoughby DA, Winkler JD (1997) The codependence of angiogenesis and chronic inflammation. FASEB J 11: 457-465.
16. Jaiswal M, LaRusso NF, Burgart LJ, Gores GJ (2000) Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res 60: 184-190.
17. Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK (2006) K-ras activation generates an inflammatory response in lung tumors. Oncogene 25: 2105-2112.
18. Jilma B, Blann A, Pernerstorfer T, Stohlawetz P, Eichler HG, Vondrovec B, Amiral J, Richter V, Wagner OF (1999) Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin. Am J Respir Crit Care Med 159: 857-863.
19. Jung MR, Park YK, Jeong O, Seon JW, Ryu SY, Kim DY, Kim YJ (2011) Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer. J Surg Oncol 104: 504-510.
20. Kattan MW, Leung DH, Brennan MF (2002) Postoperative nomogram for 12-year sarcoma-specific death. J Clin Oncol 20: 791-796.
21. Kim HS, Han KH, Chung HH, Kim JW, Park NH, Song YS, Kang SB (2010) Neutrophil to lymphocyte ratio for preoperative diagnosis of uterine sarcomas: a case-matched comparison. Eur J Surg Oncol 36: 691-698.
22. Lee YY, Choi CH, Kim HJ, Kim TJ, Lee JW, Lee JH, Bae DS, Kim BG (2012) Pretreatment neutrophil:lymphocyte ratio as a prognostic factor in cervical carcinoma. Anticancer Res 32: 1555-1561.
23. Liegl-Atzwanger B, Hofmann G, Leithner A, Beham A (2009) Undifferentiated high-grade pleomorphic sarcoma (UHPS): Diagnostic criteria, differential diagnosis, and treatment. An attempt to erasure the misnomer MFH. Eur Surg 41: 143-149.
24. Mallappa S, Sinha A, Gupta S, Chadwick S (2013) Preoperative neutrophil lymphocyte ratio greater than five is a prognostic factor for recurrent colorectal cancer. Colorectal Dis 15: 323-328.
25. Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454: 436-444.
26. Petrie HT, Klassen LW, Kay HD (1985) Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. J Immunol 134: 230-234.
27. Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, Lim E (2009) Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg 137: 425-428.
28. Schaider H, Oka M, Bogenrieder T, Nesbit M, Satyamoorthy K, Berking C, Matsushima K, Herlyn M (2003) Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8. Int J Cancer 103: 335-343.
29. Shamamian P, Schwartz JD, Pocock BJ, Monea S, Whiting D, Marcus SG, Mignatti P (2001) Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis. J Cell Physiol 189: 197-206.
30. Shau HY, Kim A (1988) Suppression of lymphokine-activated killer induction by neutrophils. J Immunol 141: 4395-4402.
31. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29.
32. Suzuki S, Toyabe S, Moroda T, Tada T, Tsukahara A, Iiai T, Minagawa M, Maruyama S, Hatakeyama K, Endoh K, Abo T (1997) Circadian rhythm of leucocytes and lymphocytes subsets and its possible correlation with the function of the autonomic nervous system. Clin Exp Immunol 110: 500-508.
33. Teramukai S, Kitano T, Kishida Y, Kawahara M, Kubota K, Komuta K, Minato K, Mio T, Fujita Y, Yonei T, Nakano K, Tsuboi M, Shibata K, Furuse K, Fukushima M (2009) Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer 45: 1950-1958.
34. Zhang H, Wang DW, Mahmoudi S, Adell G, Farnebo M, Sun XF (2012) WRAP53 is an independent prognostic factor in rectal cancer-a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients. BMC Cancer 12: 294.