Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer

Journal of Surgical Oncology

Volumn 104, Issue 5, 2011, Pages 504-510

  Jung, Mi Ran ^a   Park, Young Kyu ^a   Jeong, Oh ^a   Seon, Jang Won ^a   Ryu, Seong Yeob ^a   Kim, Dong Yi ^a   Kim, Young Jin ^a  

^a Chonnam National University   (South Korea)

Author keywords

disease free survival; gastric cancer; inflammation; neutrophil to lymphocyte ratio; prognostic factor

Indexed keywords

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HUMAN; LYMPHOCYTE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; NEUTROPHIL COUNT; OVERALL SURVIVAL; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; STOMACH CANCER;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; FOLLOW-UP STUDIES; GASTRECTOMY; HUMANS; LYMPHATIC METASTASIS; LYMPHOCYTES; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEUTROPHILS; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 80955180024     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21986     Document Type: Article

References (35)

1. Parkin DM, Bray F, Ferlay J, et al.: Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108. (Pubitemid 40372904)
2. Balkwill F, Mantovani A,: Inflammation and cancer: Back to Virchow? Lancet 2001; 357: 539-545. (Pubitemid 32173595)
3. Coussens LM, Werb Z,: Inflammation and cancer. Nature 2002; 420: 860-867. (Pubitemid 36019639)
4. Jaiswal M, LaRusso NF, Burgart LJ, et al.: Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res 2000; 60: 184-190. (Pubitemid 30058750)
5. Jackson JR, Seed MP, Kircher CH, et al.: The codependence of angiogenesis and chronic inflammation. FASEB J 1997; 11: 457-465. (Pubitemid 27259987)
6. Kawata A, Une Y, Hosokawa M, et al.: Tumor-infiltrating lymphocytes and prognosis of hepatocellular carcinoma. Jpn J Clin Oncol 1992; 22: 256-263.
7. Yamashita J, Ogawa M, Shirakusa T,: Free-from neutrophil elastase is an independent marker predicting recurrence in primary breast cancer. J Leukoc Biol 1995; 57: 375-378.
8. Ueda E, Osaki T, Yoneda K, et al.: Suppression of leukocyte function by treatment for head and neck carcinomas: Mainly on influence to reactive oxygen generation of neutrophils. J Jpn SOC Cancer Ther 1992; 27: 1925-1936.
9. Satomi A, Murakami S, Ishida K, et al.: Significance of increased neutrophils in patients with advanced colorectal cancer. Acta Oncol 1995; 34: 69-73.
10. Schmidt H, Suciu S, Punt CJ, et al.: Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with American joint committee on cancer stage IV melanoma: Results of the EORTC 18951 Biochemotherapy trial. J Clin Oncol 2007; 25: 1562-1569. (Pubitemid 46733083)
11. Donskov F, Bennedsgaard KM, Hokland M, et al.: Leukocyte orchestration in blood and tumour tissue following interleukin-2 based immunotherapy in metastatic renal cell carcinoma. Cancer Immunol Immunother 2004; 53: 729-739. (Pubitemid 38962067)
12. Teramukai S, Kitano T, Kishida Y, et al.: Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: An analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer 2009; 45: 1950-1958.
13. Clark EJ, Connor S, Taylor MA, et al.: Preoperative lymphocyte count as a prognostic factors in resected pancreatic ductal adenocarcinoma. HPB (Oxford) 2007; 9: 456-460. (Pubitemid 350215042)
14. Kitayama J, Yasuda K, Kawai K, et al.: Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer. Radiat Oncol 2010; 5: 47.
15. Walsh SR, Cook EJ, Goulder F, et al.: Neutrophil-lymphocyte ratio as a prognostic factors in colorectal cancer. J Surg Oncol 2005; 91: 181-184. (Pubitemid 41254421)
16. Liu H, Liu G, Bao Q, et al.: The baseline ratio of neutrophil to lymphocytes is associated with patient prognosis in rectal carcinoma. J Gastrointest Cancer 2010; 41: 116-120.
17. Gomez D, Morris-Stiff G, Toogood GJ, et al.: Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol 2008; 97: 513-518. (Pubitemid 351631430)
18. Gomez D, Farid S, Malik HZ, et al.: Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 2008; 32: 1757-1762.
19. An X, Ding PR, Li YH, et al.: Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer. Biomarkers 2010; 15: 516-522.
20. Hirashima M, Higuchi S, Sakamoto K, et al.: The ratio of neutrophils to lymphocytes and the pehnotypes of neutrophils in patients with early gastric cancer. J Cancer Res Clin Oncol 1998; 124: 329-334. (Pubitemid 28332916)
21. Yamanaka T, Matsumoto S, Teramukai S, et al.: The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007; 73: 215-220. (Pubitemid 351630053)
22. Mohri Y, Tanaka K, Ohi M, et al.: Prognostic significance of host- and tumor-related factors in patients with gastric cancer. World J Surg 2010; 34: 285-290.
23. Nagtegaal ID, Marijnen CA, Kranenberg EK, et al.: Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific response as only a systemic effecta-A histopathological and immunohistochemical study. BMC Cancer 2001; 1: 7.
24. Bruckner HW, Lavin PT, Plaxe SC, et al.: Absolute granulocyte, lymphocyte, and monocyte counts. Useful determinants of prognosis for patients with metastatic cancer of the stomach. JAMA 1982; 247: 1004-1006. (Pubitemid 12162304)
25. Aliustaoglu M, Bilici A, Ustaalioglu BB, et al.: The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment. Med Oncol 2010; 27: 1060-1065.
26. Di Carlo E, Forni G, Musiani P,: Neutrophils in the antitumoral immune response. Chem Immunol Allergy 2003; 83: 182-203. (Pubitemid 37522418)
27. Shamamian P, Schwartz JD, Pocock BJ, et al.: Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: A role for inflammatory cells in tumor invasion and angiogenesis. J Cell Physiol 2001; 189: 197-206. (Pubitemid 32946031)
28. Petrie HT, Klassen LW, Kay HD,: Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. J Immunol 1985; 134: 230-234. (Pubitemid 15191502)
29. el-Hag A, Clark RA,: Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system. J Immunol 1987; 139: 2406-2413. (Pubitemid 17152141)
30. McMillan DC,: Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 2009; 12: 223-226.
31. Halazun KJ, Aldoori A, Malik HZ, et al.: Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol 2008; 34: 55-60. (Pubitemid 350296756)
32. Varon JA, Sandler RS,: Nonsteroidal anti-inflammatory drugs and cancer prevention. Annu Rev Med 2000; 51: 511-523. (Pubitemid 30216052)
33. Garcia-Rodriguez LA, Huerta-Alvarez C,: Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiflammatory drugs. Epidemiology 2001; 12: 88-93. (Pubitemid 32006467)
34. Langman MJ, Cheng KK, Gilman EA, et al.: Effect of anti-inflammatory drugs on overall risk of common cancer: Case-control study in general practice research database. BMJ 2000; 320: 1642-1646. (Pubitemid 30364636)
35. Lesterhuis WJ, de Vries IJ, Schuurhuis DH, et al.: Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: Antigen-specific T cell responses in DTH skin test. Ann Oncol 2006; 17: 974-980. (Pubitemid 43778989)