Characterization of a new mPGES-1 inhibitor in rat models of inflammation

Prostaglandins and Other Lipid Mediators

Volumn 102-103, Issue , 2013, Pages 1-12

  Leclerc, Patrick ^a   Pawelzik, Sven Christian ^a   Idborg, Helena ^a,b   Spahiu, Linda ^a   Larsson, Charlotte ^b   Stenberg, Patric ^b,c   Korotkova, Marina ^a,b   Jakobsson, Per Johan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KDev Exploratory AB   (Sweden)

^c Nova SAID AB   (Sweden)

Author keywords

Adjuvant induced arthritis; Air pouch; Inflammation; Macrophage; mPGES 1 inhibition; Rat

Indexed keywords

ANTIINFECTIVE AGENT; CELECOXIB; DEXAMETHASONE; ISOMERASE INHIBITOR; MICROSOMAL PROSTAGLANDIN E SYNTHASE 1 INHIBITOR; PROSTAGLANDIN E SYNTHASE 1; PYRAZOLONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CELL CULTURE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; NONHUMAN; PERITONEUM; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DISEASE MODELS, ANIMAL; FIBROBLASTS; HUMANS; INFLAMMATION; MACROPHAGES, PERITONEAL; PAIN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLONES; RATS; SYNOVIAL FLUID;

EID: 84877051958     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2013.03.005     Document Type: Article

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