Liver disease as a cause of thrombocytopenia

QJM: An International Journal of Medicine

Volumn 106, Issue 5, 2013, Pages 425-431

  Hancox, S H ^a   Smith, B C ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; INTERFERON;

ADULT; AGED; ARTICLE; BILIRUBIN BLOOD LEVEL; DISEASE ASSOCIATION; FEMALE; HEPATITIS C; HOSPITAL PATIENT; HUMAN; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; OUTPATIENT; PANCYTOPENIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPLEEN SIZE; SPLENOMEGALY; TERTIARY HEALTH CARE; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

EID: 84877043690     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcs239     Document Type: Article

References (32)

1. Reardon Jr J, Marques M. Evaluation of thrombocytopenia. Lab Med 2006; 37:248-50.
2. Mehta AB, McIntyre N. Haematological disorders in liver disease. Forum 1998; 8:8-25.
3. Giannini EG. Review article: thrombocytopenia in chronic liver disease and pharmacologic treatment options. Aliment Pharmacol Ther 2006; 23:1055-65.
4. Peck-Radosavljevic M. Thrombocytopenia in liver disease. Can J Gastroenterol 2000; 14(Suppl. D):60-66.
5. Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, et al. Thrombocytopenia associated with chronic liver disease. J Hepatol 2008; 48:1000-7.
6. Aster RH. Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia. J Clin Invest 1966; 45:645-57.
7. Olariu M, Olariu C, Olteanu D. Thrombocytopenia in chronic hepatitis C. J Gastrointestin Liver Dis 2010; 19:381-5.
8. Sekhon SS, Roy V. Thrombocytopenia in adults: a practical approach to evaluation and management. Southern Med J 2006; 99:491-98.
9. Feudjo-Tepie MA, Robinson NJ, Bennett D. Prevalence of diagnosed chronic immune thrombocytopenic purpura in the US: analysis of a large US claim database: a rebuttal. J Thromb Haemost 2008; 6:711-2, author reply 713.
10. Levene AP, Goldin RD. The epidemiology, pathogenesis and histopathology of fatty liver disease. Histopathology 2012; 61:141-52.
11. Office for National Statistics. Death Rates From Alcoholrelated Diseases. http://www.ons.gov.uk (22 May 2012, date last accessed).
12. Health Protection Agency Centre for Infections, London. Hepatitis C in the UK 2009.http://www.hpa.org.uk/web/HPAweb&HPAwebStandard/HPAweb_C/1259152221168 (22 May 2012, date last accessed).
13. Bain B. Normal Ranges. Blood Cells-A Practical Guide, 4th edn. UK, Gower Medical Publishing, 2006, 203p.
14. Hobson H, Venning J. Imperial Pathology User GuideMarch 2012. http://www.imperial.nhs.uk/prdcons/groups/public/@corporate/@communications/documents/doc/id_014046. pdf (22 May 2012, date last accessed).
15. Hruby E, Garamvolgyi Z, Gorbe E, Hajdu J, Rigo J. Incidence and causes of maternal thrombocytopenia in triplet gestation. J Perinatal Med 2012; 40:229-35.
16. Biino G, Gasparini P, D'Adamo P, Ciullo M, Nutile T, Toniolo D, et al. Influence of age, sex and ethnicity on platelet count in five Italian geographic isolates: mild thrombocytopenia may be physiological. Br J Haematol 2012; 157:384-7.
17. Lai SW, Huang CY, Lai HC, Liao KF, Lai YM, Liu CS, et al. Thrombocytopenia and its related factors: A hospital-based, cross-sectional study. Ann Acad Med 2010; 39:9-12.
18. Siemensma NP, Bathal PS, Penington DG. The effect of massive liver resection on platelet kinetics in the rat. J Laboratory Clin Med 1975; 86:817-33.
19. McCormick PA, Murphy KM. Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. Bailliere's best practice & research. Clin Gastroenterol 2000; 14:1009-31.
20. Newland A. Thrombopoietin: too much or too little. Hematology 2012; 17(Suppl. 1):166-8.
21. Peck-Radosavljevic M, Zacherl J, Meng YG, Pidlich J, Lipinski E, Längle F, et al. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 1997; 27:127-31.
22. Martin TG III, Somberg KA, Meng YG, Cohen RL, Heid CA, de Sauvage FJ, et al. Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation. Ann Intern Med 1997; 127:285-8.
23. Ogasawara F, Fusegawa H, Haruki Y, Shiraishi K, Watanabe N, Matsuzaki S. Platelet activation in patients with alcoholic liver disease. Tokai J Exp Clin Med 2005; 30:41-8.
24. Fusegawa H, Shiraishi K, Ogasawara F, Shimizu M, Haruki Y, Miyachi H, et al. Platelet activation in patients with chronic hepatitis C. Tokai J Exp Clin Med 2002; 27:101-6.
25. Ballard HS. The hematological complications of alcoholism. Alcohol Health Res World 1997; 21:42-52.
26. Weiss HJ. Platelet physiology and abnormalities of platelet function (first of two parts). New Engl J Med 1975; 293:531-41.
27. Bennett D, Hodgson ME, Shukla A, Logie JW. Prevalence of diagnosed adult immune thrombocytopenia in the United Kingdom. Adv Ther 2011; 28:1096-1104.
28. Akyuz F, Yekeler E, Kaymakoglu S, Horasanli S, Ibrisim D, Demir K, et al. The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension. Turk J Gastroenterol 2007; 18:95-98.
29. Phillips GB. The lipid composition of serum in patients with liver disease. J Clin Invest 1960; 39:1639-50.
30. Abraham SC, Poterucha JJ, Rosen CB, Demetris AJ, Krasinskas AM. Histologic abnormalities are common in protocol liver allograft biopsies from patients with normal liver function tests. Am J Surg Pathol 2008; 32:965-73.
31. Ashraf S, Naeem S. Frequency of hypersplenism in chronic liver disease patients presenting with pancytopenia. Ann King Edward Med Univ 2010; 16:108-10.
32. Baranova A, Lal P, Birerdinc A, Younossi ZM. Non-invasive markers for hepatic fibrosis. BMC Gastroenterol 2011; 11:91.