The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertension

Turkish Journal of Gastroenterology

Volumn 18, Issue 2, 2007, Pages 95-99

  Akyüz, Filiz ^a   Yekeler, Ensar ^a   Kaymakoǧlu, Sabahattin ^a   Horasanli, Sibel ^a   Ibrişim, Duygu ^a   Demir, Kadir ^a   Aksoy, Nevzat ^a   Poturoǧlu, Şule ^a   Badur, Selim ^a   Ökten, Atilla ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Portal hypertension; Thrombocytopenia; Thrombopoietin

Indexed keywords

HYALURONIC ACID; THROMBOPOIETIN;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGAN SIZE; PORTAL HYPERTENSION; PROTEIN FUNCTION; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADULT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYALURONIC ACID; HYPERTENSION, PORTAL; LIVER CIRRHOSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PLATELET COUNT; PROSPECTIVE STUDIES; SPLEEN; SPLENOMEGALY; THROMBOCYTOPENIA; THROMBOPOIETIN;

EID: 43549107928     PISSN: 13004948     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Shah SHA, Hayes PC, Allan P, et al. Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis. Am J Gastroenterol 1996; 91: 2580-3.
2. Adinolfi LE, Giordano MG, Andreana A, et al. Hepatic fibrosis plays a central role in the pathogenesis of thrombocytopenia in patients with chronic viral hepatitis. Br J Haematol 2001; 113: 590-5.
3. Sanjo A, Satoi J, Ohnishi A, et al. Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. J Gastroenterol Hepatol 2003; 18: 638-44.
4. Sezai S, Kamisaka K, Ikegami F, et al. Regulation of hepatic thrombopoietin production by portal hemodynamics in liver cirrhosis. Am J Gastroenterol 1998; 93: 80-2.
5. Freni MA, Spadaro A, Ajello A, et al. Serum thrombopoietin in chronic liver disease: relation to severity of the disease and spleen size. Hepatogastroenterology 2002; 49: 1382-5.
6. Koruk M, Onuk MD, Akcay F, Savas MC. Serum thrombopoietin levels in patients with chronic hepatitis and liver cirrhosis, and its relationship with circulating thrombocyte counts. Hepatogastroenterology 2002; 49: 1645-8.
7. Kawasaki T, Takeshita A, Souda K, et al. Serum thrombopoietin levels in patients with chronic hepatitis and liver cirrhosis. Am J Gastroenterol 1999; 94: 1918-22.
8. Schiodt FV, Balko J, Schilsky M, et al. Acute Liver Failure Study Group. Thrombopoietin in acute liver failure. Hepatology 2003; 37: 558-61.
9. Rios R, Sangro B, Herroro I, et al. The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis. Am J Gastroenterol 2005; 100: 1311-6.
10. Giannini E, Botta F, Borro P, et al. Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection. Am J Gastroenterol 2003; 98: 2516-20.
11. Pugh RHN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-9.
12. nd ed. Edinburg: Churchill Livingstone, 1986; 93-108.
13. Ferrara J, Ellison EC, Martin EW Jr, Cooperman M. Correction of hypersplenism following distal splenorenal shunt. Surgery 1979; 86: 4068-71.
14. Alvarez OA, Lopera GA, Patel V, et al. Improvement of thrombocytopenia due to hypertension after transjugular intrahepatic portosystemic shunt placement in cirrhotic patients. Am J Gastroenterol 1996; 91: 134-7.
15. Peck-Radosavljevic M, Zacherl J, Meng YG, et al. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 1997; 27: 127-31.
16. Wolber EM, Ganshow R, Burdelski M, Jelkman W. Hepatic thrombopoietin mRNA levels in acute and chronic liver failure of childhood. Hepatology 1999; 29: 1739-42.
17. Martin TG, Somberg KA, Meng YG, et al. Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation. Ann Intern Med 1997; 127: 285-8.
18. Ishikawa T, Ichida T, Matsuda Y, et al. Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis. J Gastroenterol Hepatol 1998; 13: 907-13.
19. Kato T, Matsumoto A, Ogami K, et al. Native thrombopoietin: structure and function. Stem Cells 1998; 16: 322-8.
20. Plevris JN, Haydon GH, Simpson KJ, et al. Serum hyaluronan - a non-invasive test for diagnosing liver cirrhosis. Eur J Gastroenterol Hepatol 2000; 12: 1121-7.
21. Guechot J, Serfaty L, Bonnand AM, et al. Prognostic value of serum hyaluronan in patients with compensated HCV cirrhosis. J Hepatol 2000; 32: 447-52.
22. Murata K, Ochiai Y, Akashio K. Polydispersity of acidic glycosaminoglycan components in human liver and the changes at different stages in liver cirrhosis. Gastroenterology 1985; 89: 1248-57.
23. Yamashita Y, Shiota A, Fujise N, et al. Effects of the deleted form of hepatocyte growth factor on serum hyaluronate levels in rats with liver cirrhosis. J Vet Med Sci 1998; 60: 359-60.
24. Shimada Y, Kato T, Ogami K, et al. Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines. Exp Hematol 1995; 23: 1388-96.
25. Schiodt FV, Balko J, Schilsky M, et al. Thrombopoietin in acute liver failure. Hepatology 2003; 37: 558-61.