Influence of age, sex and ethnicity on platelet count in five Italian geographic isolates: Mild thrombocytopenia may be physiological

British Journal of Haematology

Volumn 157, Issue 3, 2012, Pages 384-387

  Biino, Ginevra ^a   Gasparini, Paolo ^b   D'Adamo, Pio ^b   Ciullo, Marina ^c   Nutile, Teresa ^c   Toniolo, Daniela ^a,d   Sala, Cinzia ^d   Minelli, Cosetta ^e   Gögele, Martin ^e   Balduini, Carlo L ^f  

^a CNR   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

^e INSTITUTE FOR RENEWABLE ENERGY   (Italy)

^f UNIVERSITY OF PAVIA   (Italy)

Author keywords

Geographic isolates; Platelet count; Thrombocytopenia

Indexed keywords

ADOLESCENT; ADULT; AGE; AGED; BLOOD ANALYSIS; BLOOD SAMPLING; CHILD; CONTROLLED STUDY; DEMOGRAPHY; ETHNIC DIFFERENCE; FEMALE; GENETIC TRAIT; HUMAN; INFANT; ITALY; LETTER; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; PHYSICAL EXAMINATION; POPULATION RESEARCH; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEX DIFFERENCE; SOCIAL STATUS; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; ITALY; MALE; MIDDLE AGED; PLATELET COUNT; REFERENCE VALUES; SEX DISTRIBUTION; THROMBOCYTOPENIA; YOUNG ADULT;

EID: 84859502866     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08981.x     Document Type: Letter

References (10)

1. Abrahamson, P.E., Hall, S.A., Feudjo-Tepie, M., Mitrani-Gold, F.S. & Logie, J. (2009) The incidence of idiopathic thrombocytopenic purpura among adults: a population-based study and literature review. European Journal of Haematology, 83, 83-89.
2. Biino, G., Balduini, C.L., Casula, L., Cavallo, P., Vaccargiu, S., Parracciani, D., Serra, D., Portas, L., Murgia, F. & Pirastu, M. (2011) Analysis of 12, 517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits. Haematologica, 96, 96-101.
3. Girotto, G., Pirastu, N., Sorice, R., Biino, G., Campbell, H., d'Adamo, A.P., Hastie, N.D., Nutile, T., Polasek, O., Portas, L., Rudan, I., Ulivi, S., Zemunik, T., Wright, A.F., Ciullo, M., Hayward, C., Pirastu, M. & Gasparini, P. (2011) Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways. Journal of Medical Genetics, 48, 369-374.
4. Pattaro, C., Marroni, F., Riegler, A., Mascalzoni, D., Pichler, I., Volpato, C.B., Dal Cero, U., De Grandi, A., Egger, C., Eisendle, A., Fuchsberger, C., Gogele, M., Pedrotti, S., Pinggera, G.K., Stefanov, S.A., Vogl, F.D., Wiedermann, C.J., Meitinger, T. & Pramstaller, P.P. (2007) The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives. BMC Med Genet, 8, 29.
5. Santimone, I., Di Castelnuovo, A., De Curtis, A., Spinelli, M., Cugino, D., Gianfagna, F., Zito, F., Donati, M.B., Cerletti, C., de Gaetano, G. & Iacoviello, L. (2011) White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project. Haematologica, 96, 1180-1188.
6. Siervo, M., Ruggiero, D., Sorice, R., Nutile, T., Aversano, M., Stephan, B.C. & Ciullo, M. (2010) Angiogenesis and biomarkers of cardiovascular risk in adults with metabolic syndrome. Journal of Internal Medicine, 268, 338-347.
7. Soranzo, N., Spector, T.D., Mangino, M., Kuhnel, B., Rendon, A., Teumer, A., Willenborg, C., Wright, B., Chen, L., Li, M., Salo, P., Voight, B.F., Burns, P., Laskowski, R.A., Xue, Y., Menzel, S., Altshuler, D., Bradley, J.R., Bumpstead, S., Burnett, M.S., Devaney, J., Doring, A., Elosua, R., Epstein, S.E., Erber, W., Falchi, M., Garner, S.F., Ghori, M.J., Goodall, A.H., Gwilliam, R., Hakonarson, H.H., Hall, A.S., Hammond, N., Hengstenberg, C., Illig, T., Konig, I.R., Knouff, C.W., McPherson, R., Melander, O., Mooser, V., Nauck, M., Nieminen, M.S., O'Donnell, C.J., Peltonen, L., Potter, S.C., Prokisch, H., Rader, D.J., Rice, C.M., Roberts, R., Salomaa, V., Sambrook, J., Schreiber, S., Schunkert, H., Schwartz, S.M., Serbanovic-Canic, J., Sinisalo, J., Siscovick, D.S., Stark, K., Surakka, I., Stephens, J., Thompson, J.R., Volker, U., Volzke, H., Watkins, N.A., Wells, G.A., Wichmann, H.E., Van Heel, D.A., Tyler-Smith, C., Thein, S.L., Kathiresan, S., Perola, M., Reilly, M.P., Stewart, A.F., Erdmann, J., Samani, N.J., Meisinger, C., Greinacher, A., Deloukas, P., Ouwehand, W.H. & Gieger, C. (2009) A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature Genetics, 41, 1182-1190.
8. Stasi, R., Amadori, S., Osborn, J., Newland, A.C. & Provan, D. (2006) Long-term outcome of otherwise healthy individuals with incidentally discovered borderline thrombocytopenia. PLoS Med, 3, e24.
9. Tepper, B.J., Koelliker, Y., Zhao, L., Ullrich, N.V., Lanzara, C., d'Adamo, P., Ferrara, A., Ulivi, S., Esposito, L. & Gasparini, P. (2008) Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. Obesity (Silver Spring), 16, 2289-2295.
10. Traglia, M., Sala, C., Masciullo, C., Cverhova, V., Lori, F., Pistis, G., Bione, S., Gasparini, P., Ulivi, S., Ciullo, M., Nutile, T., Bosi, E., Sirtori, M., Mignogna, G., Rubinacci, A., Buetti, I., Camaschella, C., Petretto, E. & Toniolo, D. (2009) Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes. PLoS ONE, 4, e7554.