메뉴 건너뛰기




Volumn 7, Issue 3, 2013, Pages 196-202

Women's Health Initiative Hormone Therapy Trials: New Insights on Cardiovascular Disease from Additional Years of Follow up

Author keywords

Conjugated equine estrogens; Medroxyprogesterone acetate; Myocardial infarction; Stroke; Timing hypothesis

Indexed keywords

26 HYDROXYCHOLESTEROL; ADIPOCYTOKINE; BIOLOGICAL MARKER; BLOOD CLOTTING FACTOR 8; C REACTIVE PROTEIN; CONJUGATED ESTROGEN; D DIMER; ESTRADIOL; ESTROGEN; GESTAGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MATRIX METALLOPROTEINASE; MEDROXYPROGESTERONE ACETATE; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; VON WILLEBRAND FACTOR;

EID: 84877020162     PISSN: 19329520     EISSN: 19329563     Source Type: Journal    
DOI: 10.1007/s12170-013-0305-1     Document Type: Review
Times cited : (13)

References (46)
  • 2
    • 84944655238 scopus 로고
    • Estrogen use and all-cause mortality. Preliminary results from the Lipid Research Clinics Program follow-up study
    • Bush TL, Cowan LD, Barrett-Connor E, Criqui MH, Karon JM, Wallace RB, et al. Estrogen use and all-cause mortality. Preliminary results from the Lipid Research Clinics Program follow-up study. JAMA. 1983; 249: 903-6.
    • (1983) Jama , vol.249 , pp. 903-906
    • Bush, T.L.1    Cowan, L.D.2    Barrett-Connor, E.3    Criqui, M.H.4    Karon, J.M.5    Wallace, R.B.6
  • 3
    • 0023265766 scopus 로고
    • Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program follow-up study
    • Bush TL, Barrett-Connor E, Cowan LD, Criqui MH, Wallace RB, Suchindran CM, et al. Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program follow-up study. Circulation. 1987; 75: 1102-9.
    • (1987) Circulation , vol.75 , pp. 1102-1109
    • Bush, T.L.1    Barrett-Connor, E.2    Cowan, L.D.3    Criqui, M.H.4    Wallace, R.B.5    Suchindran, C.M.6
  • 4
    • 0037534909 scopus 로고    scopus 로고
    • Effect of estrogen plus progestin on stroke in postmenopausal women. The Women's Health Initiative: a randomized trial
    • Wassertheil-Smoller S, Hendrix SL, Limacher M, Heiss G, Kooperberg C, Baird A, et al. Effect of estrogen plus progestin on stroke in postmenopausal women. The Women's Health Initiative: a randomized trial. JAMA. 2003; 289: 2673-84.
    • (2003) Jama , vol.289 , pp. 2673-2684
    • Wassertheil-Smoller, S.1    Hendrix, S.L.2    Limacher, M.3    Heiss, G.4    Kooperberg, C.5    Baird, A.6
  • 6
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002; 288: 321-33.
    • (2002) Jama , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3    LaCroix, A.Z.4    Kooperberg, C.5    Stefanick, M.L.6
  • 7
    • 1842867053 scopus 로고    scopus 로고
    • Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    • Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004; 291: 1701-12.
    • (2004) Jama , vol.291 , pp. 1701-1712
    • Anderson, G.L.1    Limacher, M.2    Assaf, A.R.3    Bassford, T.4    Beresford, S.A.5    Black, H.6
  • 8
    • 84870533682 scopus 로고    scopus 로고
    • The role of personalized medicine in identifying appropriate candidates for menopausal estrogen therapy
    • Manson JE. The role of personalized medicine in identifying appropriate candidates for menopausal estrogen therapy. Metabolism. 2013; 62 Suppl 1: S15-9.
    • (2013) Metabolism , vol.62 , Issue.SUPPL. 1
    • Manson, J.E.1
  • 9
    • 6844255857 scopus 로고    scopus 로고
    • Design of the Women's Health Initiative Clinical Trial and Observational Study
    • Group TWsHIS
    • Group TWsHIS. Design of the Women's Health Initiative Clinical Trial and Observational Study. Control Clin Trials. 1998; 19: 61-109.
    • (1998) Control Clin Trials , vol.19 , pp. 61-109
  • 10
    • 79953743574 scopus 로고    scopus 로고
    • Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial
    • Provides evidence for effect modification by age, which became stronger for some outcomes with inclusion of post-intervention follow up, and suggests a potential role for age in risk stratification
    • • LaCroix A, Chlebowski RT, Manson JE, Aragaki A, Johnson KC, Martin L, et al. Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. JAMA. 2011; 305: 1305-14. Provides evidence for effect modification by age, which became stronger for some outcomes with inclusion of post-intervention follow up, and suggests a potential role for age in risk stratification.
    • (2011) Jama , vol.305 , pp. 1305-1314
    • LaCroix, A.1    Chlebowski, R.T.2    Manson, J.E.3    Aragaki, A.4    Johnson, K.C.5    Martin, L.6
  • 11
    • 40449104676 scopus 로고    scopus 로고
    • Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin
    • Heiss G, Wallace R, Anderson GL, Aragaki A, Beresford SA, Brzyski R, et al. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA. 2008; 299: 1036-45.
    • (2008) Jama , vol.299 , pp. 1036-1045
    • Heiss, G.1    Wallace, R.2    Anderson, G.L.3    Aragaki, A.4    Beresford, S.A.5    Brzyski, R.6
  • 13
    • 68749108089 scopus 로고    scopus 로고
    • Using basic science to design a clinical trial: baseline characteristics of women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)
    • Miller VM, Black DM, Brinton EA, Budoff MJ, Cedars MI, Hodis HN, et al. Using basic science to design a clinical trial: baseline characteristics of women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). J Cardiovasc Transl Res. 2009; 2: 228-39.
    • (2009) J Cardiovasc Transl Res , vol.2 , pp. 228-239
    • Miller, V.M.1    Black, D.M.2    Brinton, E.A.3    Budoff, M.J.4    Cedars, M.I.5    Hodis, H.N.6
  • 14
    • 79952311372 scopus 로고    scopus 로고
    • A "window of opportunity:" the reduction of coronary heart disease and total mortality with menopausal therapies is age and time dependent
    • Hodis HN, Bauer HJ, Rawlins DB, Mack WJ. A "window of opportunity:" the reduction of coronary heart disease and total mortality with menopausal therapies is age and time dependent. Brain Res. 2011; 1379: 244-52.
    • (2011) Brain Res , vol.1379 , pp. 244-252
    • Hodis, H.N.1    Bauer, H.J.2    Rawlins, D.B.3    Mack, W.J.4
  • 15
    • 34047237367 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
    • Rossouw J, Prentice R, Manson J, Wu L, Barad D, Barnabei V, et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA. 2007; 297: 1465.
    • (2007) Jama , vol.297 , pp. 1465
    • Rossouw, J.1    Prentice, R.2    Manson, J.3    Wu, L.4    Barad, D.5    Barnabei, V.6
  • 18
    • 56149101806 scopus 로고    scopus 로고
    • Prophylactic oophorectomy in premenopausal women and long-term health
    • Shuster LT, Gostout BS, Grossardt BR, Rocca WA. Prophylactic oophorectomy in premenopausal women and long-term health. Menopause Int. 2008; 14: 111-6.
    • (2008) Menopause Int , vol.14 , pp. 111-116
    • Shuster, L.T.1    Gostout, B.S.2    Grossardt, B.R.3    Rocca, W.A.4
  • 20
    • 39549093148 scopus 로고    scopus 로고
    • General cardiovascular risk profile for use in primary care: the Framingham Heart Study
    • D'Agostino Sr RB, Vasan RS, Pencina MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation. 2008; 117: 743-53.
    • (2008) Circulation , vol.117 , pp. 743-753
    • D'Agostino Sr., R.B.1    Vasan, R.S.2    Pencina, M.J.3
  • 21
    • 43549116334 scopus 로고    scopus 로고
    • Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary events
    • Bray PF, Larson JC, Lacroix AZ, Manson J, Limacher MC, Rossouw JE, et al. Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary events. Am J Cardiol. 2008; 101: 1599-605.
    • (2008) Am J Cardiol , vol.101 , pp. 1599-1605
    • Bray, P.F.1    Larson, J.C.2    Lacroix, A.Z.3    Manson, J.4    Limacher, M.C.5    Rossouw, J.E.6
  • 22
    • 84857034450 scopus 로고    scopus 로고
    • Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS)
    • Unique assessment of various fat depots and their relationship to coronary arterial calcification
    • •• Huang G, Wang D, Zeb I, Budoff MJ, Harman SM, Miller V, et al. Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS). Atherosclerosis. 2012; 221: 198-205. Unique assessment of various fat depots and their relationship to coronary arterial calcification.
    • (2012) Atherosclerosis , vol.221 , pp. 198-205
    • Huang, G.1    Wang, D.2    Zeb, I.3    Budoff, M.J.4    Harman, S.M.5    Miller, V.6
  • 23
    • 84866739535 scopus 로고    scopus 로고
    • Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy
    • Rossouw JE, Prentice RL, Manson JE, Aragaki AK, Hsia J, Martin LW, et al. Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy. Circulation. 2012; 126: 1577-86.
    • (2012) Circulation , vol.126 , pp. 1577-1586
    • Rossouw, J.E.1    Prentice, R.L.2    Manson, J.E.3    Aragaki, A.K.4    Hsia, J.5    Martin, L.W.6
  • 24
    • 85027923654 scopus 로고    scopus 로고
    • Coronary heart disease events in the Women's Health Initiative hormone trials: effect modification by metabolic syndrome: a nested case-control study within the Women's Health Initiative randomized clinical trials
    • Provides evidence that the constellation of clinical characteristics defining metabolic syndrome can help establish risk for use of menopausal hormone therapy. Although these data are derived from women on average ten years past menopause, the findings suggest that metabolic syndrome phenotype may be useful in stratifying women's coronary risk on MHT
    • •• Wild RA, Wu C, Curb JD, Martin LW, Phillips L, Stefanick M, et al. Coronary heart disease events in the Women's Health Initiative hormone trials: effect modification by metabolic syndrome: a nested case-control study within the Women's Health Initiative randomized clinical trials. Menopause. 2013; 20(3): 254-60. Provides evidence that the constellation of clinical characteristics defining metabolic syndrome can help establish risk for use of menopausal hormone therapy. Although these data are derived from women on average ten years past menopause, the findings suggest that metabolic syndrome phenotype may be useful in stratifying women's coronary risk on MHT.
    • (2013) Menopause , vol.20 , Issue.3 , pp. 254-260
    • Wild, R.A.1    Wu, C.2    Curb, J.D.3    Martin, L.W.4    Phillips, L.5    Stefanick, M.6
  • 25
    • 81855176108 scopus 로고    scopus 로고
    • Alterations in platelet function and cell-derived microvesicles in recently menopausal women: relationship to metabolic syndrome and atherogenic risk
    • Jayachandran M, Litwiller RD, Lahr BD, Bailey KR, Owen WG, Mulvagh SL, et al. Alterations in platelet function and cell-derived microvesicles in recently menopausal women: relationship to metabolic syndrome and atherogenic risk. J Cardiovasc Transl Res. 2011; 4: 811-22.
    • (2011) J Cardiovasc Transl Res , vol.4 , pp. 811-822
    • Jayachandran, M.1    Litwiller, R.D.2    Lahr, B.D.3    Bailey, K.R.4    Owen, W.G.5    Mulvagh, S.L.6
  • 26
    • 55949128552 scopus 로고    scopus 로고
    • Inflammatory, lipid, thrombotic, and genetic markers of coronary heart disease risk in the women's health initiative trials of hormone therapy
    • Rossouw JE, Cushman M, Greenland P, Lloyd-Jones DM, Bray P, Kooperberg C, et al. Inflammatory, lipid, thrombotic, and genetic markers of coronary heart disease risk in the women's health initiative trials of hormone therapy. Arch Intern Med. 2008; 168: 2245-53.
    • (2008) Arch Intern Med , vol.168 , pp. 2245-2253
    • Rossouw, J.E.1    Cushman, M.2    Greenland, P.3    Lloyd-Jones, D.M.4    Bray, P.5    Kooperberg, C.6
  • 27
    • 84860892245 scopus 로고    scopus 로고
    • Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: cross-sectional analyses from the KEEPS Study
    • Huang G, Wang D, Khan UI, Zeb I, Manson JE, Miller V, et al. Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: cross-sectional analyses from the KEEPS Study. Cardiovasc Diabetol. 2012; 11(1): 52.
    • (2012) Cardiovasc Diabetol , vol.11 , Issue.1 , pp. 52
    • Huang, G.1    Wang, D.2    Khan, U.I.3    Zeb, I.4    Manson, J.E.5    Miller, V.6
  • 28
    • 34047111681 scopus 로고    scopus 로고
    • Circulating microparticles: pathophysiology and clinical implications
    • Piccin A, Murphy WG, Smith OP. Circulating microparticles: pathophysiology and clinical implications. Blood Rev. 2007; 21: 157-71.
    • (2007) Blood Rev , vol.21 , pp. 157-171
    • Piccin, A.1    Murphy, W.G.2    Smith, O.P.3
  • 29
    • 84855354256 scopus 로고    scopus 로고
    • Methodology for isolation, identification and characterization of microvesicles in peripheral blood
    • Provides methodological parameters for isolation and characterization of blood borne cell membrane-derived micorvesicles that if applied would help to standardize and enable analysis of microvesicles among studies
    • •• Jayachandran M, Miller VM, Heit JA, Owen WG. Methodology for isolation, identification and characterization of microvesicles in peripheral blood. J Immunol Methods. 2012; 375: 207-14. Provides methodological parameters for isolation and characterization of blood borne cell membrane-derived micorvesicles that if applied would help to standardize and enable analysis of microvesicles among studies.
    • (2012) J Immunol Methods , vol.375 , pp. 207-214
    • Jayachandran, M.1    Miller, V.M.2    Heit, J.A.3    Owen, W.G.4
  • 30
    • 61949284701 scopus 로고    scopus 로고
    • Circulating microparticles and endogenous estrogen in newly menopausal women
    • Jayachandran M, Litwiller RD, Owen WG, Miller VM. Circulating microparticles and endogenous estrogen in newly menopausal women. Climacteric. 2009; 12: 177-84.
    • (2009) Climacteric , vol.12 , pp. 177-184
    • Jayachandran, M.1    Litwiller, R.D.2    Owen, W.G.3    Miller, V.M.4
  • 34
    • 84872864855 scopus 로고    scopus 로고
    • Genetic polymorphisms associated carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study
    • doi:10.1152/physiolgenomics.00114.2012.34
    • Miller VM, Petterson TM, Jeavons EN, Lnu AS, Rider DN, Heit JA, et al. Genetic polymorphisms associated carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study. Physiol Genomics. 2013; 45(2): 79-88. doi: 10. 1152/physiolgenomics. 00114. 2012. 34.
    • (2013) Physiol Genomics , vol.45 , Issue.2 , pp. 79-88
    • Miller, V.M.1    Petterson, T.M.2    Jeavons, E.N.3    Lnu, A.S.4    Rider, D.N.5    Heit, J.A.6
  • 35
    • 33747893585 scopus 로고    scopus 로고
    • Vasomotor symptom prevalence is associated with polymorphisms in sex steroid-metabolizing enzymes and receptors
    • Crandall CJ, Crawford SL, Gold EB. Vasomotor symptom prevalence is associated with polymorphisms in sex steroid-metabolizing enzymes and receptors. Am J Med. 2006; 119: S52-60.
    • (2006) Am J Med , vol.119
    • Crandall, C.J.1    Crawford, S.L.2    Gold, E.B.3
  • 36
    • 33747872891 scopus 로고    scopus 로고
    • Sex steroid hormone pathway genes and health-related measures in women of 4 races/ethnicities: the Study of Women's Health Across the Nation (SWAN)
    • Sowers MR, Wilson AL, Karvonen-Gutierrez CA, Kardia. Sex steroid hormone pathway genes and health-related measures in women of 4 races/ethnicities: the Study of Women's Health Across the Nation (SWAN). Am J Med. 2006; 119: S103-10.
    • (2006) Am J Med , vol.119
    • Sowers, M.R.1    Wilson, A.L.2    Karvonen-Gutierrez, C.A.3    Kardia4
  • 37
    • 33747877248 scopus 로고    scopus 로고
    • The association of genetic polymorphisms in sex hormone biosynthesis and action with insulin sensitivity and diabetes mellitus in women at midlife
    • Lo JC, Zhao X, Scuteri A, Brockwell S, Sowers MR. The association of genetic polymorphisms in sex hormone biosynthesis and action with insulin sensitivity and diabetes mellitus in women at midlife. Am J Med. 2006; 119: S69-78.
    • (2006) Am J Med , vol.119
    • Lo, J.C.1    Zhao, X.2    Scuteri, A.3    Brockwell, S.4    Sowers, M.R.5
  • 38
    • 33747873901 scopus 로고    scopus 로고
    • Sex steroid hormone polymorphisms, high-density lipoprotein cholesterol, and apolipoprotein A-1 from the Study of Women's Health Across the Nation (SWAN)
    • Sowers MR, Symons JP, Jannausch ML, Chu J, Kardia SR. Sex steroid hormone polymorphisms, high-density lipoprotein cholesterol, and apolipoprotein A-1 from the Study of Women's Health Across the Nation (SWAN). Am J Med. 2006; 119: S61-8.
    • (2006) Am J Med , vol.119
    • Sowers, M.R.1    Symons, J.P.2    Jannausch, M.L.3    Chu, J.4    Kardia, S.R.5
  • 39
    • 33747892232 scopus 로고    scopus 로고
    • CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal
    • Sowers MR, Wilson AL, Kardia SR, Chu J, McConnell DS. CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal. Am J Med. 2006; 119: S44-51.
    • (2006) Am J Med , vol.119
    • Sowers, M.R.1    Wilson, A.L.2    Kardia, S.R.3    Chu, J.4    McConnell, D.S.5
  • 41
    • 33847102281 scopus 로고    scopus 로고
    • Are some types of hormone therapy safer than others? Lessons from the Estrogen and Thromboembolism Risk study
    • Rexrode KM, Manson JE. Are some types of hormone therapy safer than others? Lessons from the Estrogen and Thromboembolism Risk study. Circulation. 2007; 115: 820-2.
    • (2007) Circulation , vol.115 , pp. 820-822
    • Rexrode, K.M.1    Manson, J.E.2
  • 42
    • 0042737410 scopus 로고    scopus 로고
    • Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk
    • Scarabin PY, Oger E, Plu-Bureau G. Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk. Lancet. 2003; 362: 428-32.
    • (2003) Lancet , vol.362 , pp. 428-432
    • Scarabin, P.Y.1    Oger, E.2    Plu-Bureau, G.3
  • 43
    • 0037695801 scopus 로고    scopus 로고
    • Investigators atS differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein
    • Lacut K, Oger E, Le Gal G, Blouch M-T, Abgrall J-F, Kerlan V, et al. Investigators atS differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein. Thromb Haemost. 2003; 90: 124-31.
    • (2003) Thromb Haemost , vol.90 , pp. 124-131
    • Lacut, K.1    Oger, E.2    Le Gal, G.3    Blouch, M.-T.4    Abgrall, J.-F.5    Kerlan, V.6
  • 44
    • 33749593535 scopus 로고    scopus 로고
    • Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women
    • Ho JY-P, Chen M-J, Sheu WH-H, Yi Y-C, Tsai AC-W, Guu H-F, et al. Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women. Hum Reprod. 2006; 21: 2715-20.
    • (2006) Hum Reprod , vol.21 , pp. 2715-2720
    • Ho, J.Y.-P.1    Chen, M.-J.2    Sheu, W.H.-H.3    Yi, Y.-C.4    Tsai, A.C.-W.5    Guu, H.-F.6
  • 45
    • 33847116637 scopus 로고    scopus 로고
    • Estrogen and Thromboembolism Risk (ESTHER) Study Group. Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study
    • Canonico M, Oger E, Plu-Bureau G, Conard J, Meyer G, Levesque H, et al. Estrogen and Thromboembolism Risk (ESTHER) Study Group. Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study. Circulation. 2007; 115: 840-5.
    • (2007) Circulation , vol.115 , pp. 840-845
    • Canonico, M.1    Oger, E.2    Plu-Bureau, G.3    Conard, J.4    Meyer, G.5    Levesque, H.6
  • 46
    • 84857508749 scopus 로고    scopus 로고
    • The 2012 Hormone Therapy Position Statement of The North American Menopause Society
    • The 2012 Hormone Therapy Position Statement of The North American Menopause Society. Menopause. 2012; 19: 257-71.
    • (2012) Menopause , vol.19 , pp. 257-271


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.