Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: Cross-sectional analyses from the KEEPS study

Cardiovascular Diabetology

Volumn 11, Issue , 2012, Pages

  Huang, Gary ^a   Wang, Dan ^a   Khan, Unab I ^a   Zeb, Irfan ^b   Manson, JoAnn E ^c   Miller, Virginia ^d   Hodis, Howard N ^e   Budoff, Matthew J ^b   Merriam, George R ^f   Harman, Mitchell S ^g   Brinton, Eliot A ^h   Cedars, Marcelle I ⁱ   Su, Yali ^j   Lobo, Rogerio A ^k   Naftolin, Frederick ^l   Santoro, Nanette ^m   Taylor, Hugh S ⁿ   Wildman, Rachel P ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^g Kronos Longevity Research Institute   (United States)

^h UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j SliverCreek Technologies   (United States)

^k Columbia University College of Medicine ^*  (United States)

^l NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

ⁿ YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Retinol binding protein 4; Risk factors; Subclinical atherosclerosis; Women

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; GLUCOSE; INSULIN; RETINOL BINDING PROTEIN 4; TRIACYLGLYCEROL; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; LIPID; PLASMA RETINOL BINDING PROTEIN; RBP4 PROTEIN, HUMAN;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD PRESSURE; CARDIOMETABOLIC RISK; CHOLESTEROL BLOOD LEVEL; CONFIDENCE INTERVAL; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY CALCIFICATION; CORRELATION COEFFICIENT; CROSS-SECTIONAL STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GOLD STANDARD; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MULTICENTER STUDY; POSTMENOPAUSE; PROTEIN BLOOD LEVEL; PROTEIN HOMEOSTASIS; RACE; SCREENING; SMOKING; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING; AGED; ANALYSIS; ATHEROSCLEROSIS; BLOOD; CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; HORMONE SUBSTITUTION; LIFESTYLE; MIDDLE AGED; OBESITY; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

ADULT; AGED; ATHEROSCLEROSIS; BIOMARKERS; BLOOD GLUCOSE; BLOOD PRESSURE; C-REACTIVE PROTEIN; CAROTID INTIMA-MEDIA THICKNESS; CORONARY DISEASE; CROSS-SECTIONAL STUDIES; DOUBLE-BLIND METHOD; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; INSULIN; LIFE STYLE; LIPIDS; MIDDLE AGED; OBESITY; POSTMENOPAUSE; RETINOL-BINDING PROTEINS, PLASMA; RISK FACTORS;

EID: 84860892245     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-11-52     Document Type: Article

References (38)

1. Dey DK, Rothenberg E, Sundh V, Bosaeus I, Steen B. Waist circumference, body mass index, and risk for stroke in older people: a 15 year longitudinal population study of 70- year-olds. J Am Geriatr Soc 2002, 50(9):1510-1518. 10.1046/j.1532-5415.2002.50406.x, 12383148.
2. Li TY, Rana JS, Manson JE, Willett WC, Stampfer MJ, Colditz GA, Rexrode KM, Hu FB. Obesity as compared with physical activity in predicting risk of coronary heart disease in women. Circulation 2006, 113(4):499-506. 10.1161/CIRCULATIONAHA.105.574087, 3210835, 16449729.
3. Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 2002, 162(16):1867-1872. 10.1001/archinte.162.16.1867, 12196085.
4. Blaner WS. Retinol-binding protein: the serum transport protein for vitamin A. Endocr Rev 1989, 10(3):308-316. 10.1210/edrv-10-3-308, 2550213.
5. McTernan PG, Kumar S. Editorial: retinol binding protein 4 and pathogenesis of diabetes. J Clin Endocrinol Metab 2007, 92(7):2430-2432. 10.1210/jc.2007-1054, 17616636.
6. Wolf G. Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes. Nutr Rev 2007, 65(5):251-256. 10.1111/j.1753-4887.2007.tb00302.x, 17566551.
7. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005, 436(7049):356-362. 10.1038/nature03711, 16034410.
8. Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH, Lee HK, Park KS. Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care 2006, 29(11):2457-2461. 10.2337/dc06-0360, 17065684.
9. Gavi S, Stuart LM, Kelly P, Melendez MM, Mynarcik DC, Gelato MC, McNurlan MA. Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes. J Clin Endocrinol Metab 2007, 92(5):1886-1890. 10.1210/jc.2006-1815, 17299074.
10. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006, 354(24):2552-2563. 10.1056/NEJMoa054862, 16775236.
11. Jia W, Wu H, Bao Y, Wang C, Lu J, Zhu J, Xiang K. Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. J Clin Endocrinol Metab 2007, 92(8):3224-3229. 10.1210/jc.2007-0209, 17550959.
12. Kowalska I, Straczkowski M, Adamska A, Nikolajuk A, Karczewska-Kupczewska M, Otziomek E, Gorska M. Serum retinol binding protein 4 is related to insulin resistance and nonoxidative glucose metabolism in lean and obese women with normal glucose tolerance. J Clin Endocrinol Metab 2008, 93(7):2786-2789. 10.1210/jc.2008-0077, 18430770.
13. Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu FB, Franco OH, Wang J, Li H, Liu Y, et al. Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab 2007, 92(12):4827-4834. 10.1210/jc.2007-1219, 17878249.
14. Takebayashi K, Suetsugu M, Wakabayashi S, Aso Y, Inukai T. Retinol binding protein-4 levels and clinical features of type 2 diabetes patients. J Clin Endocrinol Metab 2007, 92(7):2712-2719. 10.1210/jc.2006-1249, 17440021.
15. Broch M, Vendrell J, Ricart W, Richart C, Fernandez-Real JM. Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects. Diabetes Care 2007, 30(7):1802-1806. 10.2337/dc06-2034, 17416795.
16. Janke J, Engeli S, Boschmann M, Adams F, Bohnke J, Luft FC, Sharma AM, Jordan J. Retinol-binding protein 4 in human obesity. Diabetes 2006, 55(10):2805-2810. 10.2337/db06-0616, 17003346.
17. Lewis JG, Shand BI, Frampton CM, Elder PA, Scott RS. Plasma retinol-binding protein is not a marker of insulin resistance in overweight subjects: a three year longitudinal study. Clin Biochem 2008, 41(13):1034-1038. 10.1016/j.clinbiochem.2008.06.002, 18588869.
18. Graham TE, Wason CJ, Bluher M, Kahn BB. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia 2007, 50(4):814-823. 10.1007/s00125-006-0557-0, 17294166.
19. Selzer RH, Mack WJ, Lee PL, Kwong-Fu H, Hodis HN. Improved common carotid elasticity and intima-media thickness measurements from computer analysis of sequential ultrasound frames. Atherosclerosis 2001, 154(1):185-193. 10.1016/S0021-9150(00)00461-5, 11137099.
20. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990, 15(4):827-832. 10.1016/0735-1097(90)90282-T, 2407762.
21. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips D, Maruyama H, Kraus BJ, et al. RBP4 inhibits insulin signaling in adipocytes by inducing pro-inflammatory cytokines in macrophages through a JNK- and TLR4-dependent and retinol-independent mechanism. Mol Cell Biol 2012,
22. Gavi S, Qurashi S, Stuart LM, Lau R, Melendez MM, Mynarcik DC, McNurlan MA, Gelato MC. Influence of age on the association of retinol-binding protein 4 with metabolic syndrome. Obesity (Silver Spring) 2008, 16(4):893-895.
23. Staels B. Regulation of lipid and lipoprotein metabolism by retinoids. J Am Acad Dermatol 2001, 45(5):S158-167. 10.1067/mjd.2001.113718, 11606948.
24. Erikstrup C, Mortensen OH, Pedersen BK. Retinol-binding protein 4 and insulin resistance. N Engl J Med 2006, 355(13):1393-1394. author reply 1394-1395.
25. Kashyap SR, Diab DL, Baker AR, Yerian L, Bajaj H, Gray-McGuire C, Schauer PR, Gupta M, Feldstein AE, Hazen SL, et al. Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort. Obesity (Silver Spring) 2009, 17(9):1696-1701.
26. Lin CC, Lai MM, Li TC, Li CI, Liu CS, Chen CC, Wu MT. Relationship between serum retinol-binding protein 4 and visfatin and the metabolic syndrome. Diabetes Res Clin Pract 2009, 85(1):24-29. 10.1016/j.diabres.2009.03.016, 19403191.
27. Wang SN, Yeh YT, Wang ST, Chen YL, Chuang SC, Ker CG, Lee KT. Decreased retinol binding protein 4 concentrations are associated with cholesterol gallstone disease. J Formos Med Assoc 2010, 109(6):422-429. 10.1016/S0929-6646(10)60073-3, 20610143.
28. Shim CY, Park S, Kim JS, Shin DJ, Ko YG, Kang SM, Choi D, Ha JW, Jang Y, Chung N. Association of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients. Yonsei Med J 2010, 51(3):375-384. 10.3349/ymj.2010.51.3.375, 2852793, 20376890.
29. Takashima N, Tomoike H, Iwai N. Retinol-binding protein 4 and insulin resistance. N Engl J Med 2006, 355(13):1392. author reply 1394-1395.
30. Shin JY, Lee HR, Lee DC. Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetes. Cardiovasc Diabetol 2011, 10:30. 10.1186/1475-2840-10-30, 3098149, 21492487.
31. Bobbert T, Raila J, Schwarz F, Mai K, Henze A, Pfeiffer AF, Schweigert FJ, Spranger J. Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness. Atherosclerosis 2010, 213(2):549-551. 10.1016/j.atherosclerosis.2010.07.063, 20832065.
32. Ingelsson E, Lind L. Circulating retinol-binding protein 4 and subclinical cardiovascular disease in the elderly. Diabetes Care 2009, 32(4):733-735. 10.2337/dc08-1656, 2660453, 19114616.
33. Solini A, Santini E, Madec S, Rossi C, Muscelli E. Retinol-binding protein-4 in women with untreated essential hypertension. Am J Hypertens 2009, 22(9):1001-1006. 10.1038/ajh.2009.116, 19556974.
34. Cabre A, Lazaro I, Girona J, Manzanares J, Marimon F, Plana N, Heras M, Masana L. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes. J Intern Med 2007, 262(4):496-503. 10.1111/j.1365-2796.2007.01849.x, 17875187.
35. Gerstein HC, Miller ME, Genuth S, Ismail-Beigi F, Buse JB, Goff DC, Probstfield JL, Cushman WC, Ginsberg HN, Bigger JT, et al. Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med 2011, 364(9):818-828.
36. von Eynatten M, Lepper PM, Liu D, Lang K, Baumann M, Nawroth PP, Bierhaus A, Dugi KA, Heemann U, Allolio B, et al. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease. Diabetologia 2007, 50(9):1930-1937. 10.1007/s00125-007-0743-8, 17639305.
37. Newman AB, Naydeck BL, Ives DG, Boudreau RM, Sutton-Tyrrell K, O'Leary DH, Kuller LH. Coronary artery calcium, carotid artery wall thickness, and cardiovascular disease outcomes in adults 70 to 99 years old. Am J Cardiol 2008, 101(2):186-192. 10.1016/j.amjcard.2007.07.075, 2213559, 18178404.
38. Folsom AR, Kronmal RA, Detrano RC, O'Leary DH, Bild DE, Bluemke DA, Budoff MJ, Liu K, Shea S, Szklo M, et al. Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med 2008, 168(12):1333-1339. 10.1001/archinte.168.12.1333, 2555989, 18574091.