The Association of Genetic Polymorphisms in Sex Hormone Biosynthesis and Action with Insulin Sensitivity and Diabetes Mellitus in Women at Midlife

American Journal of Medicine

Volumn 119, Issue 9 SUPPL. 1, 2006, Pages

  Lo, Joan C ^a   Zhao, Xinhua ^b   Scuteri, Angelo ^c   Brockwell, Sarah ^b   Sowers, MaryFran R ^d  

^a DIVISION OF RESEARCH   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

17 Hydroxysteroid dehydrogenase; Diabetes mellitus; Genetics; Haplotype; Insulin sensitivity; Metabolic syndrome

Indexed keywords

AROMATASE; DNA; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOSE; INSULIN; SEX HORMONE; TESTOSTERONE 17BETA DEHYDROGENASE;

ADULT; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; CHINESE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIABETES MELLITUS; ETHNOLOGY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; PREVALENCE; PRIORITY JOURNAL; RACE; RISK;

17-HYDROXYSTEROID DEHYDROGENASES; ADULT; AROMATASE; CONTINENTAL POPULATION GROUPS; DIABETES MELLITUS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GONADAL STEROID HORMONES; HEALTH SURVEYS; HUMANS; INSULIN RESISTANCE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 33747877248     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2006.07.009     Document Type: Article

References (32)

1. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 18 (1997) 774-800
2. Ehrmann D.A. Polycystic ovary syndrome. N Engl J Med 352 (2005) 1223-1236
3. Taylor J.A., Lewis K.J., and Lubahn D.B. Estrogen receptor mutations. Mol Cell Endocrinol 145 (1998) 61-66
4. Grumbach M.M., and Auchus R.J. Estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab 84 (1999) 4677-4694
5. Isomaa B., Almgren P., Tuomi T., et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24 (2001) 683-689
6. Scuteri A., Najjar S.S., Morrel C.H., and Lakatta E.G. The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study. Diabetes Care 28 (2005) 882-887
7. Eckel R.H., Grundy S.M., and Zimmet P.Z. The metabolic syndrome. Lancet 365 (2005) 1415-1428
8. Howard G., O'Leary D.H., Zaccaro D., et al., Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Insulin sensitivity and atherosclerosis. Circulation 93 (1996) 1809-1817
9. Jones M.E., Thorburn A.W., Britt K.L., et al. Aromatase-deficient (ArKO) mice accumulate excess adipose tissue. J Steroid Biochem Mol Biol 79 (2001) 3-9
10. Jones M.E., Thorburn A.W., Britt K.L., et al. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci U S A 97 (2000) 12735-12740
11. Heine P.A., Taylor J.A., Iwamoto G.A., Lubahn D.B., and Cooke P.S. Increased adipose tissue in male and female estrogen receptor-α knockout mice. Proc Natl Acad Sci USA 97 (2000) 12729-12734
12. Sowers M., Crawford S., Sternfeld B., et al. Design, survey, sampling and recruitment methods of SWAN: a multicenter, multiethnic, community-based cohort study of women and the menopausal transition. In: Lobo R.A., Kelsey J., and Marcus R. (Eds). Menopause: Biology and Pathobiology (2000), Academic Press, San Diego, CA 175-188
13. Myers G.L., Cooper G.R., Winn C.L., and Smith S.J. The Centers for Disease Control-National Heart, Lung, and Blood Institute Lipid Standardization Program: an approach to accurate and precise lipid measurements. Clin Lab Med 9 (1989) 105-135
14. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
15. Levy J.C., Matthews D.R., and Hermans M.P. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21 (1998) 2191-2192
16. Wallace T.M., Levy J.C., and Matthews D.R. Use and abuse of HOMA modeling. Diabetes Care 27 (2004) 1487-1495
17. Warnick G.R., and Albers J.J. A comprehensive evaluation of the heparin manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res 19 (1978) 65-76
18. World Health Organization Department of Noncommunicable Disease Surveillance. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation (1999), World Health Organization, Geneva Publication WHO/NCD/99.2
19. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285 (2001) 2486-2497
20. Steering Committee of the Western Pacific Region of the World Health Organization, the International Association for the Study of Obesity, and the International Obesity Task Force. The Asia-Pacific perspective: redefining obesity and its treatment. Melbourne, Australia: Health Communications Australia Pty Limited, 2000. Available at: http://www.diabetes.com.au/pdf/obesity_report.pdf. Accessed October 25, 2005.
21. Ferris B. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis 118 (1978) 1-120
22. Baecke J.A., Burema J., and Fritjers J.E. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 36 (1982) 936-942
23. Sternfeld B., Ainsworth B.E., and Quesenberry C.J. Physical activity patterns in a diverse population of women. Prev Med 28 (1999) 313-323
24. Torréns J.I., Skurnick J., Davidow A.L., et al. Ethnic differences in insulin sensitivity and β-cell function in premenopausal or early perimenopausal women without diabetes: Study of Women's Health Across the Nation (SWAN). Diabetes Care 27 (2004) 354-361
25. Hosmer D.W., and Lemeshow S. Applied Logistic Regression (1989), John Wiley and Sons, New York
26. Baghaei F., Rosmond R., Westberg L., et al. The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women. Obesity Res 11 (2003) 578-585
27. Sowers M.F.R., Wilson A.L., Kardia S.R., Chu J., and Ferrell R. Aromatase gene (CYP 19) polymorphisms and endogenous androgen concentrations in a multiethnic/multiracial, multisite study of women at mid-life. Am J Med 119 suppl 9A (2006) S23-S30
28. Chen Z., Bassford T., Green S.B., et al. Postmenopausal hormone therapy and body composition-a substudy of the estrogen plus progestin trial of the Women's Health Initiative. Am J Clin Nutr 82 (2005) 651-656
29. Godsland I.F. Oestrogens and insulin secretion. Diabetologia 48 (2005) 2213-2220
30. Kanaya A.M., Herrington D., Vittinghoff E., et al. Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 138 (2003) 1-9
31. Zhang J., Rowe W.L., Clark A.G., and Buetow K.H. Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations. Am J Hum Genet 73 (2003) 1073-1081
32. Riancho J.A., Zarrabeitia M.T., Valero C., et al. Aromatase gene and osteoporosis: relationship of ten polymorphic loci with bone mineral density. Bone 36 (2005) 917-925