메뉴 건너뛰기




Volumn 39, Issue 5, 2013, Pages 518-524

Neoadjuvant therapy in resectable pancreatic cancer: A critical review

Author keywords

Chemotherapy; Neoadjuvant therapy; Pancreatic cancer; Radiotherapy; Resectable disease; Surgery

Indexed keywords

CISPLATIN; ERLOTINIB; FLUOROURACIL; GEMCITABINE; PACLITAXEL; TEGAFUR;

EID: 84877006160     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2012.09.008     Document Type: Review
Times cited : (37)

References (63)
  • 1
    • 0035212974 scopus 로고    scopus 로고
    • Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomized controlled trial
    • Neoptolemos J.P., Stocken D.D., Dunn J.A., et al. Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomized controlled trial. Ann Surg 2001, 234:758-768.
    • (2001) Ann Surg , vol.234 , pp. 758-768
    • Neoptolemos, J.P.1    Stocken, D.D.2    Dunn, J.A.3
  • 3
    • 70249099504 scopus 로고    scopus 로고
    • A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer
    • Ueno H., Kosuge T., Matsuyama Y., et al. A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer. Br J Cancer 2009, 101:908-915.
    • (2009) Br J Cancer , vol.101 , pp. 908-915
    • Ueno, H.1    Kosuge, T.2    Matsuyama, Y.3
  • 4
    • 33846405332 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial
    • Oettle H., Post S., Neuhaus P., et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 2007, 297:267-277.
    • (2007) JAMA , vol.297 , pp. 267-277
    • Oettle, H.1    Post, S.2    Neuhaus, P.3
  • 5
    • 42249102457 scopus 로고    scopus 로고
    • Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?
    • Schnelldorfer T., Ware A.L., Sarr M.G., et al. Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible?. Ann Surg 2008, 247:456-462.
    • (2008) Ann Surg , vol.247 , pp. 456-462
    • Schnelldorfer, T.1    Ware, A.L.2    Sarr, M.G.3
  • 6
    • 12144287320 scopus 로고    scopus 로고
    • A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    • Neoptolemos J.P., Stocken D.D., Friess H., et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 2004, 350:1200-1210.
    • (2004) N Engl J Med , vol.350 , pp. 1200-1210
    • Neoptolemos, J.P.1    Stocken, D.D.2    Friess, H.3
  • 7
    • 40449113435 scopus 로고    scopus 로고
    • Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial
    • Regine W.F., Winter K.A., Abrams R.A., et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial. JAMA 2008, 299:1019-1026.
    • (2008) JAMA , vol.299 , pp. 1019-1026
    • Regine, W.F.1    Winter, K.A.2    Abrams, R.A.3
  • 8
    • 77956416112 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial
    • Neoptolemos J., Stocken D.D., Bassi C., et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 2010, 304:1073-1081.
    • (2010) JAMA , vol.304 , pp. 1073-1081
    • Neoptolemos, J.1    Stocken, D.D.2    Bassi, C.3
  • 9
    • 0021867923 scopus 로고
    • Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection
    • Kalser M.H., Ellenberg S.S. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 1985, 120:899-903.
    • (1985) Arch Surg , vol.120 , pp. 899-903
    • Kalser, M.H.1    Ellenberg, S.S.2
  • 10
    • 0033497862 scopus 로고    scopus 로고
    • Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group
    • discussion 82-84
    • Klinkenbijl J.H., Jeekel J., Sahmoud T., et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 1999, 230:776-782. discussion 82-84.
    • (1999) Ann Surg , vol.230 , pp. 776-782
    • Klinkenbijl, J.H.1    Jeekel, J.2    Sahmoud, T.3
  • 11
    • 0031056942 scopus 로고    scopus 로고
    • Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas
    • Spitz F.R., Abbruzzese J.L., Lee J.E., et al. Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol 1997, 15:928-937.
    • (1997) J Clin Oncol , vol.15 , pp. 928-937
    • Spitz, F.R.1    Abbruzzese, J.L.2    Lee, J.E.3
  • 12
    • 34250816847 scopus 로고    scopus 로고
    • A randomized phase 2 trial of neoadjuvant chemotherapy in resectable pancreatic cancer: gemcitabine alone versus gemcitabine combined with cisplatin
    • Palmer D.H., Stocken D.D., Hewitt H., et al. A randomized phase 2 trial of neoadjuvant chemotherapy in resectable pancreatic cancer: gemcitabine alone versus gemcitabine combined with cisplatin. Ann Surg Oncol 2007, 14:2088-2096.
    • (2007) Ann Surg Oncol , vol.14 , pp. 2088-2096
    • Palmer, D.H.1    Stocken, D.D.2    Hewitt, H.3
  • 13
    • 49049102131 scopus 로고    scopus 로고
    • Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head
    • Varadhachary G.R., Wolff R.A., Crane C.H., et al. Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008, 26:3487-3495.
    • (2008) J Clin Oncol , vol.26 , pp. 3487-3495
    • Varadhachary, G.R.1    Wolff, R.A.2    Crane, C.H.3
  • 14
    • 49049101358 scopus 로고    scopus 로고
    • Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head
    • Evans D.B., Varadhachary G.R., Crane C.H., et al. Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008, 26:3496-3502.
    • (2008) J Clin Oncol , vol.26 , pp. 3496-3502
    • Evans, D.B.1    Varadhachary, G.R.2    Crane, C.H.3
  • 15
    • 0031972708 scopus 로고    scopus 로고
    • Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: an Eastern Cooperative Oncology Group Study
    • Hoffman J.P., Lipsitz S., Pisansky T., Weese J.L., Solin L., Benson A.B. Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: an Eastern Cooperative Oncology Group Study. J Clin Oncol 1998, 16:317-323.
    • (1998) J Clin Oncol , vol.16 , pp. 317-323
    • Hoffman, J.P.1    Lipsitz, S.2    Pisansky, T.3    Weese, J.L.4    Solin, L.5    Benson, A.B.6
  • 16
    • 18244369036 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiation for localized adenocarcinoma of the pancreas
    • White R.R., Hurwitz H.I., Morse M.A., et al. Neoadjuvant chemoradiation for localized adenocarcinoma of the pancreas. Ann Surg Oncol 2001, 8:758-765.
    • (2001) Ann Surg Oncol , vol.8 , pp. 758-765
    • White, R.R.1    Hurwitz, H.I.2    Morse, M.A.3
  • 17
    • 4544257275 scopus 로고    scopus 로고
    • Assessment of pathologic response after preoperative chemoradiotherapy and surgery in pancreatic adenocarcinoma
    • Moutardier V., Magnin V., Turrini O., et al. Assessment of pathologic response after preoperative chemoradiotherapy and surgery in pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys 2004, 60:437-443.
    • (2004) Int J Radiat Oncol Biol Phys , vol.60 , pp. 437-443
    • Moutardier, V.1    Magnin, V.2    Turrini, O.3
  • 18
    • 0027946783 scopus 로고
    • Is the long-term survival rate improved by preoperative irradiation prior to Whipple's procedure for adenocarcinoma of the pancreatic head?
    • Ishikawa O., Ohigashi H., Imaoka S., et al. Is the long-term survival rate improved by preoperative irradiation prior to Whipple's procedure for adenocarcinoma of the pancreatic head?. Arch Surg 1994, 129:1075-1080.
    • (1994) Arch Surg , vol.129 , pp. 1075-1080
    • Ishikawa, O.1    Ohigashi, H.2    Imaoka, S.3
  • 19
    • 0026454511 scopus 로고
    • Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas
    • Evans D.B., Rich T.A., Byrd D.R., et al. Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. Arch Surg 1992, 127:1335-1339.
    • (1992) Arch Surg , vol.127 , pp. 1335-1339
    • Evans, D.B.1    Rich, T.A.2    Byrd, D.R.3
  • 20
    • 0032421150 scopus 로고    scopus 로고
    • Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma
    • Pisters P.W., Abbruzzese J.L., Janjan N.A., et al. Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. J Clin Oncol 1998, 16:3843-3850.
    • (1998) J Clin Oncol , vol.16 , pp. 3843-3850
    • Pisters, P.W.1    Abbruzzese, J.L.2    Janjan, N.A.3
  • 22
    • 0037092960 scopus 로고    scopus 로고
    • Preoperative paclitaxel and concurrent rapid-fractionation radiation for resectable pancreatic adenocarcinoma: toxicities, histologic response rates, and event-free outcome
    • Pisters P.W., Wolff R.A., Janjan N.A., et al. Preoperative paclitaxel and concurrent rapid-fractionation radiation for resectable pancreatic adenocarcinoma: toxicities, histologic response rates, and event-free outcome. J Clin Oncol 2002, 20:2537-2544.
    • (2002) J Clin Oncol , vol.20 , pp. 2537-2544
    • Pisters, P.W.1    Wolff, R.A.2    Janjan, N.A.3
  • 23
    • 3843119127 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiation with tegafur in cancer of the pancreas: initial analysis of clinical tolerance and outcome
    • Calvo F.A., Matute R., Garcia-Sabrido J.L., et al. Neoadjuvant chemoradiation with tegafur in cancer of the pancreas: initial analysis of clinical tolerance and outcome. Am J Clin Oncol 2004, 27:343-349.
    • (2004) Am J Clin Oncol , vol.27 , pp. 343-349
    • Calvo, F.A.1    Matute, R.2    Garcia-Sabrido, J.L.3
  • 24
    • 0028878540 scopus 로고
    • A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas
    • discussion 7-8
    • Hoffman J.P., Weese J.L., Solin L.J., et al. A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas. Am J Surg 1995, 169:71-77. discussion 7-8.
    • (1995) Am J Surg , vol.169 , pp. 71-77
    • Hoffman, J.P.1    Weese, J.L.2    Solin, L.J.3
  • 25
    • 0036704413 scopus 로고    scopus 로고
    • A phase II single institutional experience with preoperative radiochemotherapy in pancreatic adenocarcinoma
    • Moutardier V., Giovannini M., Lelong B., et al. A phase II single institutional experience with preoperative radiochemotherapy in pancreatic adenocarcinoma. Eur J Surg Oncol 2002, 28:531-539.
    • (2002) Eur J Surg Oncol , vol.28 , pp. 531-539
    • Moutardier, V.1    Giovannini, M.2    Lelong, B.3
  • 26
    • 0242500947 scopus 로고    scopus 로고
    • Neoadjuvant preoperative chemoradiation in patients with pancreatic cancer
    • Magnin V., Moutardier V., Giovannini M.H., et al. Neoadjuvant preoperative chemoradiation in patients with pancreatic cancer. Int J Radiat Oncol Biol Phys 2003, 55:1300-1304.
    • (2003) Int J Radiat Oncol Biol Phys , vol.55 , pp. 1300-1304
    • Magnin, V.1    Moutardier, V.2    Giovannini, M.H.3
  • 27
    • 65449156920 scopus 로고    scopus 로고
    • Neoadjuvant 5 fluorouracil-cisplatin chemoradiation effect on survival in patients with resectable pancreatic head adenocarcinoma: a ten-year single institution experience
    • Turrini O., Viret F., Moureau-Zabotto L., et al. Neoadjuvant 5 fluorouracil-cisplatin chemoradiation effect on survival in patients with resectable pancreatic head adenocarcinoma: a ten-year single institution experience. Oncology 2009, 76:413-419.
    • (2009) Oncology , vol.76 , pp. 413-419
    • Turrini, O.1    Viret, F.2    Moureau-Zabotto, L.3
  • 28
    • 33746702065 scopus 로고    scopus 로고
    • Feasibility of preoperative combined radiation therapy and chemotherapy with 5-fluorouracil and cisplatin in potentially resectable pancreatic adenocarcinoma: The French SFRO-FFCD 97-04 Phase II trial
    • Mornex F., Girard N., Scoazec J.Y., et al. Feasibility of preoperative combined radiation therapy and chemotherapy with 5-fluorouracil and cisplatin in potentially resectable pancreatic adenocarcinoma: The French SFRO-FFCD 97-04 Phase II trial. Int J Radiat Oncol Biol Phys 2006, 65:1471-1478.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 1471-1478
    • Mornex, F.1    Girard, N.2    Scoazec, J.Y.3
  • 29
    • 45149091560 scopus 로고    scopus 로고
    • Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head
    • Heinrich S., Pestalozzi B.C., Schafer M., et al. Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008, 26:2526-2531.
    • (2008) J Clin Oncol , vol.26 , pp. 2526-2531
    • Heinrich, S.1    Pestalozzi, B.C.2    Schafer, M.3
  • 30
    • 0035425508 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma
    • Philip P.A., Zalupski M.M., Vaitkevicius V.K., et al. Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma. Cancer 2001, 92:569-577.
    • (2001) Cancer , vol.92 , pp. 569-577
    • Philip, P.A.1    Zalupski, M.M.2    Vaitkevicius, V.K.3
  • 31
    • 31544438080 scopus 로고    scopus 로고
    • A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma
    • Talamonti M.S., Small W., Mulcahy M.F., et al. A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma. Ann Surg Oncol 2006, 13:150-158.
    • (2006) Ann Surg Oncol , vol.13 , pp. 150-158
    • Talamonti, M.S.1    Small, W.2    Mulcahy, M.F.3
  • 32
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore M.J., Goldstein D., Hamm J., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007, 25:1960-1966.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 33
    • 77955914277 scopus 로고    scopus 로고
    • Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
    • Philip P.A., Benedetti J., Corless C.L., et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol 2010, 28:3605-3610.
    • (2010) J Clin Oncol , vol.28 , pp. 3605-3610
    • Philip, P.A.1    Benedetti, J.2    Corless, C.L.3
  • 34
    • 79952036599 scopus 로고    scopus 로고
    • Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
    • Kindler H.L., Ioka T., Richel D.J., et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol 2011, 12:256-262.
    • (2011) Lancet Oncol , vol.12 , pp. 256-262
    • Kindler, H.L.1    Ioka, T.2    Richel, D.J.3
  • 35
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler H.L., Friberg G., Singh D.A., et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 2005, 23:8033-8040.
    • (2005) J Clin Oncol , vol.23 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3
  • 36
    • 0027323902 scopus 로고
    • Neoadjuvant chemoradiation in pancreatic and duodenal carcinoma. A phase II Study
    • Yeung R.S., Weese J.L., Hoffman J.P., et al. Neoadjuvant chemoradiation in pancreatic and duodenal carcinoma. A phase II Study. Cancer 1993, 72:2124-2133.
    • (1993) Cancer , vol.72 , pp. 2124-2133
    • Yeung, R.S.1    Weese, J.L.2    Hoffman, J.P.3
  • 37
    • 84865142675 scopus 로고    scopus 로고
    • Adjuvant PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) or gemcitabine followed by chemoradiation in pancreatic cancer: a randomized phase II trial
    • Reni M., Balzano G., Aprile G., et al. Adjuvant PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) or gemcitabine followed by chemoradiation in pancreatic cancer: a randomized phase II trial. Ann Surg Oncol 2012, 19:2256-2263.
    • (2012) Ann Surg Oncol , vol.19 , pp. 2256-2263
    • Reni, M.1    Balzano, G.2    Aprile, G.3
  • 38
    • 79251579661 scopus 로고    scopus 로고
    • Multicenter phase II trial of adjuvant therapy for resected pancreatic cancer using cisplatin, 5-fluorouracil, and interferon-alfa-2b-based chemoradiation: ACOSOG Trial Z05031
    • Picozzi V.J., Abrams R.A., Decker P.A., et al. Multicenter phase II trial of adjuvant therapy for resected pancreatic cancer using cisplatin, 5-fluorouracil, and interferon-alfa-2b-based chemoradiation: ACOSOG Trial Z05031. Ann Oncol 2011, 22:348-354.
    • (2011) Ann Oncol , vol.22 , pp. 348-354
    • Picozzi, V.J.1    Abrams, R.A.2    Decker, P.A.3
  • 39
    • 77954802691 scopus 로고    scopus 로고
    • CapRI: final results of the open-label, multicenter, randomized phase III trial of adjuvant chemoradiation plus interferon-α2b (CRI) versus 5-FU alone for patients with resected pancreatic adenocarcinoma (PAC)
    • (abstr LBA4012)
    • Marten A., Schmidt J., Debus J., et al. CapRI: final results of the open-label, multicenter, randomized phase III trial of adjuvant chemoradiation plus interferon-α2b (CRI) versus 5-FU alone for patients with resected pancreatic adenocarcinoma (PAC). J Clin Oncol 2010, 28:18s. (abstr LBA4012).
    • (2010) J Clin Oncol , vol.28
    • Marten, A.1    Schmidt, J.2    Debus, J.3
  • 40
    • 77951709577 scopus 로고    scopus 로고
    • Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages
    • Gillen S., Schuster T., Meyer Zum Buschenfelde C., Friess H., Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med 2010, 7:e1000267.
    • (2010) PLoS Med , vol.7
    • Gillen, S.1    Schuster, T.2    Meyer Zum Buschenfelde, C.3    Friess, H.4    Kleeff, J.5
  • 41
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • Burris H.A., Moore M.J., Andersen J., et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997, 15:2403-2413.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3
  • 42
    • 0037099604 scopus 로고    scopus 로고
    • Multicenter randomized phase III trial comparing protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin in inoperable pancreatic cancer
    • Maisey N., Chau I., Cunningham D., et al. Multicenter randomized phase III trial comparing protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin in inoperable pancreatic cancer. J Clin Oncol 2002, 20:3130-3136.
    • (2002) J Clin Oncol , vol.20 , pp. 3130-3136
    • Maisey, N.1    Chau, I.2    Cunningham, D.3
  • 43
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale
    • Colucci G., Giuliani F., Gebbia V., et al. Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer 2002, 94:902-910.
    • (2002) Cancer , vol.94 , pp. 902-910
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3
  • 44
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial
    • Louvet C., Labianca R., Hammel P., et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 2005, 23:3509-3516.
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3
  • 45
    • 0033635935 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer
    • Heinemann V., Wilke H., Mergenthaler H.G., et al. Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer. Ann Oncol 2000, 11:1399-1403.
    • (2000) Ann Oncol , vol.11 , pp. 1399-1403
    • Heinemann, V.1    Wilke, H.2    Mergenthaler, H.G.3
  • 46
    • 77950498286 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study
    • Colucci G., Labianca R., Di Costanzo F., et al. Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study. J Clin Oncol 2010, 28:1645-1651.
    • (2010) J Clin Oncol , vol.28 , pp. 1645-1651
    • Colucci, G.1    Labianca, R.2    Di Costanzo, F.3
  • 47
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group
    • Poplin E., Feng Y., Berlin J., et al. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2009, 27:3778-3785.
    • (2009) J Clin Oncol , vol.27 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3
  • 48
    • 41149159801 scopus 로고    scopus 로고
    • Biweekly triple combination chemotherapy with gemcitabine, oxaliplatin, levofolinic acid and 5-fluorouracil (GOLF) is a safe and active treatment for patients with inoperable pancreatic cancer
    • Correale P., Montagnani F., Miano S., et al. Biweekly triple combination chemotherapy with gemcitabine, oxaliplatin, levofolinic acid and 5-fluorouracil (GOLF) is a safe and active treatment for patients with inoperable pancreatic cancer. J Chemother 2008, 20:119-125.
    • (2008) J Chemother , vol.20 , pp. 119-125
    • Correale, P.1    Montagnani, F.2    Miano, S.3
  • 49
    • 1842503065 scopus 로고    scopus 로고
    • Phase II study of cisplatin, gemcitabine and 5-fluorouracil in advanced pancreatic cancer
    • Novarino A., Chiappino I., Bertelli G.F., et al. Phase II study of cisplatin, gemcitabine and 5-fluorouracil in advanced pancreatic cancer. Ann Oncol 2004, 15:474-477.
    • (2004) Ann Oncol , vol.15 , pp. 474-477
    • Novarino, A.1    Chiappino, I.2    Bertelli, G.F.3
  • 50
    • 33846498534 scopus 로고    scopus 로고
    • Gemcitabine, oxaliplatin and weekly high-dose 5-FU as 24-h infusion in chemonaive patients with advanced or metastatic pancreatic adenocarcinoma: a multicenter phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    • Wagner A.D., Buechner-Steudel P., Wein A., et al. Gemcitabine, oxaliplatin and weekly high-dose 5-FU as 24-h infusion in chemonaive patients with advanced or metastatic pancreatic adenocarcinoma: a multicenter phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Ann Oncol 2007, 18:82-87.
    • (2007) Ann Oncol , vol.18 , pp. 82-87
    • Wagner, A.D.1    Buechner-Steudel, P.2    Wein, A.3
  • 51
    • 78649490178 scopus 로고    scopus 로고
    • Combining gemcitabine, oxaliplatin and capecitabine (GEMOXEL) for patients with advanced pancreatic carcinoma (APC): a phase I/II trial
    • Hess V., Pratsch S., Potthast S., et al. Combining gemcitabine, oxaliplatin and capecitabine (GEMOXEL) for patients with advanced pancreatic carcinoma (APC): a phase I/II trial. Ann Oncol 2010, 21:2390-2395.
    • (2010) Ann Oncol , vol.21 , pp. 2390-2395
    • Hess, V.1    Pratsch, S.2    Potthast, S.3
  • 52
    • 34848896905 scopus 로고    scopus 로고
    • The gemcitabine, docetaxel, and capecitabine (GTX) regimen for metastatic pancreatic cancer: a retrospective analysis
    • Fine R.L., Fogelman D.R., Schreibman S.M., et al. The gemcitabine, docetaxel, and capecitabine (GTX) regimen for metastatic pancreatic cancer: a retrospective analysis. Cancer Chemother Pharmacol 2008, 61:167-175.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 167-175
    • Fine, R.L.1    Fogelman, D.R.2    Schreibman, S.M.3
  • 53
    • 20044374358 scopus 로고    scopus 로고
    • Irinotecan plus oxaliplatin and leucovorin-modulated fluorouracil in advanced pancreatic cancer-a Groupe Tumeurs Digestives of the Federation Nationale des Centres de Lutte Contre le Cancer study
    • Conroy T., Paillot B., Francois E., et al. Irinotecan plus oxaliplatin and leucovorin-modulated fluorouracil in advanced pancreatic cancer-a Groupe Tumeurs Digestives of the Federation Nationale des Centres de Lutte Contre le Cancer study. J Clin Oncol 2005, 23:1228-1236.
    • (2005) J Clin Oncol , vol.23 , pp. 1228-1236
    • Conroy, T.1    Paillot, B.2    Francois, E.3
  • 54
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T., Desseigne F., Ychou M., et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011, 364:1817-1825.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 55
    • 33846702197 scopus 로고    scopus 로고
    • Pooled efficacy analysis from a phase I-II study of biweekly irinotecan in combination with gemcitabine, 5-fluorouracil, leucovorin and cisplatin in patients with metastatic pancreatic cancer
    • Goel A., Grossbard M.L., Malamud S., et al. Pooled efficacy analysis from a phase I-II study of biweekly irinotecan in combination with gemcitabine, 5-fluorouracil, leucovorin and cisplatin in patients with metastatic pancreatic cancer. Anticancer Drugs 2007, 18:263-271.
    • (2007) Anticancer Drugs , vol.18 , pp. 263-271
    • Goel, A.1    Grossbard, M.L.2    Malamud, S.3
  • 56
    • 19944409357 scopus 로고    scopus 로고
    • Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre phase III trial
    • Reni M., Cordio S., Milandri C., et al. Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre phase III trial. Lancet Oncol 2005, 6:369-376.
    • (2005) Lancet Oncol , vol.6 , pp. 369-376
    • Reni, M.1    Cordio, S.2    Milandri, C.3
  • 57
    • 0035873947 scopus 로고    scopus 로고
    • Definitive results of a phase II trial of cisplatin, epirubicin, continuous-infusion fluorouracil, and gemcitabine in stage IV pancreatic adenocarcinoma
    • Reni M., Passoni P., Panucci M.G., et al. Definitive results of a phase II trial of cisplatin, epirubicin, continuous-infusion fluorouracil, and gemcitabine in stage IV pancreatic adenocarcinoma. J Clin Oncol 2001, 19:2679-2686.
    • (2001) J Clin Oncol , vol.19 , pp. 2679-2686
    • Reni, M.1    Passoni, P.2    Panucci, M.G.3
  • 58
    • 36248954607 scopus 로고    scopus 로고
    • Dose-intense PEFG (cisplatin, epirubicin, 5-fluorouracil, gemcitabine) in advanced pancreatic adenocarcinoma: a dose-finding study
    • Reni M., Cereda S., Bonetto E., et al. Dose-intense PEFG (cisplatin, epirubicin, 5-fluorouracil, gemcitabine) in advanced pancreatic adenocarcinoma: a dose-finding study. Cancer Invest 2007, 25:594-598.
    • (2007) Cancer Invest , vol.25 , pp. 594-598
    • Reni, M.1    Cereda, S.2    Bonetto, E.3
  • 59
    • 33845909834 scopus 로고    scopus 로고
    • Dose-intense PEFG (cisplatin, epirubicin, 5-fluorouracil, gemcitabine) in advanced pancreatic adenocarcinoma
    • Reni M., Cereda S., Bonetto E., et al. Dose-intense PEFG (cisplatin, epirubicin, 5-fluorouracil, gemcitabine) in advanced pancreatic adenocarcinoma. Cancer Chemother Pharmacol 2007, 59:361-367.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 361-367
    • Reni, M.1    Cereda, S.2    Bonetto, E.3
  • 60
    • 84856696460 scopus 로고    scopus 로고
    • A randomized phase II trial of two different 4-drug combinations in advanced pancreatic adenocarcinoma: cisplatin, capecitabine, gemcitabine plus either epirubicin or docetaxel (PEXG or PDXG regimen)
    • Reni M., Cereda S., Rognone A., et al. A randomized phase II trial of two different 4-drug combinations in advanced pancreatic adenocarcinoma: cisplatin, capecitabine, gemcitabine plus either epirubicin or docetaxel (PEXG or PDXG regimen). Cancer Chemother Pharmacol 2012, 69:115-123.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 115-123
    • Reni, M.1    Cereda, S.2    Rognone, A.3
  • 61
    • 67649220204 scopus 로고    scopus 로고
    • Carbohydrate antigen 19-9 change during chemotherapy for advanced pancreatic adenocarcinoma
    • Reni M., Cereda S., Balzano G., et al. Carbohydrate antigen 19-9 change during chemotherapy for advanced pancreatic adenocarcinoma. Cancer 2009, 115:2630-2639.
    • (2009) Cancer , vol.115 , pp. 2630-2639
    • Reni, M.1    Cereda, S.2    Balzano, G.3
  • 62
    • 77949415358 scopus 로고    scopus 로고
    • An Italian study on treatment trends and outcomes of patients with stage III pancreatic adenocarcinoma in the gemcitabine era: is it time to change?
    • Reni M., Sartori N., Mambrini A., et al. An Italian study on treatment trends and outcomes of patients with stage III pancreatic adenocarcinoma in the gemcitabine era: is it time to change?. Anticancer Drugs 2010, 21:459-464.
    • (2010) Anticancer Drugs , vol.21 , pp. 459-464
    • Reni, M.1    Sartori, N.2    Mambrini, A.3
  • 63
    • 79551489954 scopus 로고    scopus 로고
    • Treatment trends in metastatic pancreatic cancer patients: is it time to change?
    • Reni M., Pasetto L.M., Passardi A., et al. Treatment trends in metastatic pancreatic cancer patients: is it time to change?. Dig Liver Dis 2011, 43:225-230.
    • (2011) Dig Liver Dis , vol.43 , pp. 225-230
    • Reni, M.1    Pasetto, L.M.2    Passardi, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.