메뉴 건너뛰기




Volumn 522, Issue 1, 2013, Pages 96-101

Influence of MDR1 C1236T polymorphism on lopinavir plasma concentration and virological response in HIV-1-infected children

Author keywords

HAART; HIV 1 pediatric infection; Lopinavir; Single nucleotide polymorphism

Indexed keywords

AMPRENAVIR; CD4 ANTIGEN; LOPINAVIR; MULTIDRUG RESISTANCE PROTEIN 1; RITONAVIR;

EID: 84877005223     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.03.020     Document Type: Article
Times cited : (18)

References (38)
  • 1
    • 23744464363 scopus 로고    scopus 로고
    • Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver
    • Albermann N., et al. Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem. Pharmacol. 2005, 70(6):949-958.
    • (2005) Biochem. Pharmacol. , vol.70 , Issue.6 , pp. 949-958
    • Albermann, N.1
  • 2
    • 0035051412 scopus 로고    scopus 로고
    • MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
    • Ameyaw M.M., et al. MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity. Pharmacogenetics 2001, 11(3):217-221.
    • (2001) Pharmacogenetics , vol.11 , Issue.3 , pp. 217-221
    • Ameyaw, M.M.1
  • 3
    • 77949543949 scopus 로고    scopus 로고
    • MDR1 3435T and 1236T alleles delay disease progression to pediatric AIDS but have no effect on HIV-1 vertical transmission
    • Bellusci C.P., et al. MDR1 3435T and 1236T alleles delay disease progression to pediatric AIDS but have no effect on HIV-1 vertical transmission. AIDS 2010, 24(6):833-840.
    • (2010) AIDS , vol.24 , Issue.6 , pp. 833-840
    • Bellusci, C.P.1
  • 4
    • 0037307357 scopus 로고    scopus 로고
    • Frequency distribution of C3435T mutation in exon 26 of the MDR1 gene in a Spanish population
    • Bernal M.L., Sinues B., Fanlo A., Mayayo E. Frequency distribution of C3435T mutation in exon 26 of the MDR1 gene in a Spanish population. Ther. Drug Monit. 2003, 25(1):107-111.
    • (2003) Ther. Drug Monit. , vol.25 , Issue.1 , pp. 107-111
    • Bernal, M.L.1    Sinues, B.2    Fanlo, A.3    Mayayo, E.4
  • 5
    • 3042689560 scopus 로고    scopus 로고
    • Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR study)
    • Breilh D., et al. Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR study). AIDS 2004, 18(9):1305-1310.
    • (2004) AIDS , vol.18 , Issue.9 , pp. 1305-1310
    • Breilh, D.1
  • 6
    • 0037462209 scopus 로고    scopus 로고
    • Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response
    • Brumme Z.L., et al. Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response. AIDS 2003, 17(2):201-208.
    • (2003) AIDS , vol.17 , Issue.2 , pp. 201-208
    • Brumme, Z.L.1
  • 7
    • 0035104031 scopus 로고    scopus 로고
    • Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
    • Cascorbi I., et al. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin. Pharmacol. Ther. 2001, 69(3):169-174.
    • (2001) Clin. Pharmacol. Ther. , vol.69 , Issue.3 , pp. 169-174
    • Cascorbi, I.1
  • 8
    • 0000771140 scopus 로고
    • Revised classification system for human immunodeficiency virus (HIV) infection in children under 13years of age
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC) Revised classification system for human immunodeficiency virus (HIV) infection in children under 13years of age. MMWR Morb. Mortal. Wkly Rep. 1994, 43(RR-12):1-10.
    • (1994) MMWR Morb. Mortal. Wkly Rep. , vol.43 , Issue.RR 12 , pp. 1-10
  • 9
    • 42049093456 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein
    • Cianfriglia M., et al. HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein. Retrovirology 2007, 4:17.
    • (2007) Retrovirology , vol.4 , pp. 17
    • Cianfriglia, M.1
  • 10
    • 57049102316 scopus 로고    scopus 로고
    • Pharmacokinetic study of the variability of indinavir drug levels when boosted with ritonavir in HIV-infected children
    • Curras V., et al. Pharmacokinetic study of the variability of indinavir drug levels when boosted with ritonavir in HIV-infected children. Pharmacology 2009, 83(1):59-66.
    • (2009) Pharmacology , vol.83 , Issue.1 , pp. 59-66
    • Curras, V.1
  • 11
    • 0038103469 scopus 로고    scopus 로고
    • Simultaneous determination of the HIV drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite M8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography
    • Droste J.A., Verweij-Van Wissen C.P., Burger D.M. Simultaneous determination of the HIV drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite M8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography. Ther. Drug Monit. 2003, 25(3):393-399.
    • (2003) Ther. Drug Monit. , vol.25 , Issue.3 , pp. 393-399
    • Droste, J.A.1    Verweij-Van Wissen, C.P.2    Burger, D.M.3
  • 13
    • 0037022006 scopus 로고    scopus 로고
    • Swiss HIV Cohort Study. Cohort Study. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
    • Fellay J., et al. Swiss HIV Cohort Study. Cohort Study. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 2002, 359(9300):30-36.
    • (2002) Lancet , vol.359 , Issue.9300 , pp. 30-36
    • Fellay, J.1
  • 14
    • 0037374415 scopus 로고    scopus 로고
    • A simplified approach to determining P-glycoprotein expression in peripheral blood mononuclear cell subsets
    • Ford J., Hoggard P.G., Owen A., Khoo S.H., Back D.J. A simplified approach to determining P-glycoprotein expression in peripheral blood mononuclear cell subsets. J. Immunol. Methods 2003, 274(1-2):129-137.
    • (2003) J. Immunol. Methods , vol.274 , Issue.1-2 , pp. 129-137
    • Ford, J.1    Hoggard, P.G.2    Owen, A.3    Khoo, S.H.4    Back, D.J.5
  • 15
    • 18644367631 scopus 로고    scopus 로고
    • Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease
    • Furuno T., et al. Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease. Pharmacogenetics 2002, 12(7):529-534.
    • (2002) Pharmacogenetics , vol.12 , Issue.7 , pp. 529-534
    • Furuno, T.1
  • 16
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
    • Geick A., Eichelbaum M., Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 2001, 276(18):14581-14587.
    • (2001) J. Biol. Chem. , vol.276 , Issue.18 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 17
    • 0242664934 scopus 로고    scopus 로고
    • MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study
    • Haas D.W., et al. MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study. J. Acquir. Immune Defic. Syndr. 2003, 34(3):295-298.
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.34 , Issue.3 , pp. 295-298
    • Haas, D.W.1
  • 18
    • 47049097878 scopus 로고    scopus 로고
    • Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survival
    • Hendrickson S.L., et al. Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survival. J. Acquir. Immune Defic. Syndr. 2008, 48(3):263-271.
    • (2008) J. Acquir. Immune Defic. Syndr. , vol.48 , Issue.3 , pp. 263-271
    • Hendrickson, S.L.1
  • 19
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer S., et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. U. S. A. 2000, 97(7):3473-3478.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , Issue.7 , pp. 3473-3478
    • Hoffmeyer, S.1
  • 20
    • 3042772026 scopus 로고    scopus 로고
    • Identification of functionally variant MDR1 alleles among European Americans and African Americans
    • Kim R.B., et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin. Pharmacol. Ther. 2001, 70(2):189-199.
    • (2001) Clin. Pharmacol. Ther. , vol.70 , Issue.2 , pp. 189-199
    • Kim, R.B.1
  • 21
    • 33744986097 scopus 로고    scopus 로고
    • MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer
    • Komoto C., et al. MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer. Drug Metab. Pharmacokinet. 2006, 21(2):126-132.
    • (2006) Drug Metab. Pharmacokinet. , vol.21 , Issue.2 , pp. 126-132
    • Komoto, C.1
  • 22
    • 34548691243 scopus 로고    scopus 로고
    • The effect of ABCB1 polymorphism on the pharmacokinetics of saquinavir alone and in combination with ritonavir
    • la Porte C.J., et al. The effect of ABCB1 polymorphism on the pharmacokinetics of saquinavir alone and in combination with ritonavir. Clin. Pharmacol. Ther. 2007, 82(4):389-395.
    • (2007) Clin. Pharmacol. Ther. , vol.82 , Issue.4 , pp. 389-395
    • la Porte, C.J.1
  • 23
    • 37549010733 scopus 로고    scopus 로고
    • Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression
    • Lamba J., Lamba V., Strom S., Venkataramanan R., Schuetz E. Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression. Drug Metab. Dispos. 2008, 36(1):169-181.
    • (2008) Drug Metab. Dispos. , vol.36 , Issue.1 , pp. 169-181
    • Lamba, J.1    Lamba, V.2    Strom, S.3    Venkataramanan, R.4    Schuetz, E.5
  • 24
    • 0032540001 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter
    • Lee C.G., et al. HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry 1998, 37(11):3594-3601.
    • (1998) Biochemistry , vol.37 , Issue.11 , pp. 3594-3601
    • Lee, C.G.1
  • 25
    • 33947607426 scopus 로고    scopus 로고
    • Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir in patients with HIV
    • Ma Q., et al. Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir in patients with HIV. Pharmacogenomics 2007, 8(3):227-235.
    • (2007) Pharmacogenomics , vol.8 , Issue.3 , pp. 227-235
    • Ma, Q.1
  • 26
    • 0042127239 scopus 로고    scopus 로고
    • MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients
    • Nasi M., et al. MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients. AIDS 2003, 17(11):1696-1698.
    • (2003) AIDS , vol.17 , Issue.11 , pp. 1696-1698
    • Nasi, M.1
  • 27
    • 6344294111 scopus 로고    scopus 로고
    • Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4
    • Owen A., et al. Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4. J. Virol. 2004, 78(21):12022-12029.
    • (2004) J. Virol. , vol.78 , Issue.21 , pp. 12022-12029
    • Owen, A.1
  • 28
    • 67649517091 scopus 로고    scopus 로고
    • A pharmacogenetic study of CD4 recovery in response to HIV antiretroviral therapy in two South African population groups
    • Parathyras J., Gebhardt S., Hillermann-Rebello R., Grobbelaar N., Venter M., Warnich L. A pharmacogenetic study of CD4 recovery in response to HIV antiretroviral therapy in two South African population groups. J. Hum. Genet. 2009, 54(5):261-265.
    • (2009) J. Hum. Genet. , vol.54 , Issue.5 , pp. 261-265
    • Parathyras, J.1    Gebhardt, S.2    Hillermann-Rebello, R.3    Grobbelaar, N.4    Venter, M.5    Warnich, L.6
  • 29
    • 80051792323 scopus 로고    scopus 로고
    • CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children
    • Rakhmanina N.Y., et al. CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children. Ther. Drug Monit. 2011, 33(4):417-424.
    • (2011) Ther. Drug Monit. , vol.33 , Issue.4 , pp. 417-424
    • Rakhmanina, N.Y.1
  • 30
    • 15944414161 scopus 로고    scopus 로고
    • An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    • Saitoh A., et al. An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children. AIDS 2005, 19(4):371-380.
    • (2005) AIDS , vol.19 , Issue.4 , pp. 371-380
    • Saitoh, A.1
  • 31
    • 78649673343 scopus 로고    scopus 로고
    • Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance
    • Schipani A., et al. Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance. Antimicrob. Agents Chemother. 2010, 54(12):5242-5250.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.12 , pp. 5242-5250
    • Schipani, A.1
  • 32
    • 53349160769 scopus 로고    scopus 로고
    • Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C->T) with reduced concentrations of unboosted atazanavir
    • Siccardi M., et al. Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C->T) with reduced concentrations of unboosted atazanavir. Clin. Infect. Dis. 2008, 47(9):1222-1225.
    • (2008) Clin. Infect. Dis. , vol.47 , Issue.9 , pp. 1222-1225
    • Siccardi, M.1
  • 33
    • 0034997034 scopus 로고    scopus 로고
    • Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene
    • Tanabe M., et al. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J. Pharmacol. Exp. Ther. 2001, 297(3):1137-1143.
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , Issue.3 , pp. 1137-1143
    • Tanabe, M.1
  • 34
    • 42049111861 scopus 로고    scopus 로고
    • Use of therapeutic drug monitoring in HIV disease
    • van Luin M., Kuks P.F., Burger D.M. Use of therapeutic drug monitoring in HIV disease. Curr. Opin. HIV AIDS 2008, 3(3):266-271.
    • (2008) Curr. Opin. HIV AIDS , vol.3 , Issue.3 , pp. 266-271
    • van Luin, M.1    Kuks, P.F.2    Burger, D.M.3
  • 35
    • 27944466136 scopus 로고    scopus 로고
    • Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy
    • Verstuyft C., et al. Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy. AIDS 2005, 19(18):2127-2131.
    • (2005) AIDS , vol.19 , Issue.18 , pp. 2127-2131
    • Verstuyft, C.1
  • 36
    • 3142751539 scopus 로고    scopus 로고
    • No influence of the P-glycoprotein genotype (MDR1 C3435T) on plasma levels of lopinavir and efavirenz during antiretroviral treatment
    • Winzer R., et al. No influence of the P-glycoprotein genotype (MDR1 C3435T) on plasma levels of lopinavir and efavirenz during antiretroviral treatment. Eur. J. Med. Res. 2003, 8(12):531-534.
    • (2003) Eur. J. Med. Res. , vol.8 , Issue.12 , pp. 531-534
    • Winzer, R.1
  • 37
    • 23144442403 scopus 로고    scopus 로고
    • No influence of the P-glycoprotein polymorphisms MDR1 G2677T/A and C3435T on the virological and immunological response in treatment naïve HIV-positive patients
    • Winzer R., et al. No influence of the P-glycoprotein polymorphisms MDR1 G2677T/A and C3435T on the virological and immunological response in treatment naïve HIV-positive patients. Ann. Clin. Microbiol. Antimicrob. 2005, 4:3.
    • (2005) Ann. Clin. Microbiol. Antimicrob. , vol.4 , pp. 3
    • Winzer, R.1
  • 38
    • 19944418250 scopus 로고    scopus 로고
    • Influence of single-nucleotide polymorphisms in the multidrug resistance-1 gene on the cellular export of nelfinavir and its clinical implication for highly active antiretroviral therapy
    • Zhu D., et al. Influence of single-nucleotide polymorphisms in the multidrug resistance-1 gene on the cellular export of nelfinavir and its clinical implication for highly active antiretroviral therapy. Antivir. Ther. 2004, 9(6):929-935.
    • (2004) Antivir. Ther. , vol.9 , Issue.6 , pp. 929-935
    • Zhu, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.