The appearance of renal cells cytoplasmic degeneration and nuclear destruction might be an indication of GNPs toxicity

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Abdelhalim, Mohamed Anwar K ^a   Jarrar, Bashir M ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b JOUF UNIVERSITY   (Saudi Arabia)

Author keywords

gold nanoparticles; histology; hydropic degeneration; nanotoxicity; renal tissue

Indexed keywords

GOLD NANOPARTICLE; GOLD; METAL NANOPARTICLE;

ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CELL INFILTRATION; CONTROLLED STUDY; HISTOLOGY; KIDNEY CELL; KIDNEY CORTEX; KIDNEY HEMORRHAGE; KIDNEY HYPERTROPHY; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE NECROSIS; MALE; NONHUMAN; RAT; VASODILATATION; ANIMAL; CELL ADHESION; CELL NUCLEUS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOPLASM; DRUG EFFECT; IMMUNOLOGY; INFUSION; INTERSTITIAL NEPHRITIS; KIDNEY; MATERIALS TESTING; NEUTROPHIL CHEMOTAXIS; PARTICLE SIZE; PATHOLOGY; RANDOMIZATION; TIME; ULTRASTRUCTURE; WISTAR KYOTO RAT;

ANIMALIA; RATTUS;

ANIMALS; CELL ADHESION; CELL NUCLEUS; CYTOPLASM; GOLD; INFUSIONS, PARENTERAL; KIDNEY; KIDNEY CORTEX; KIDNEY TUBULAR NECROSIS, ACUTE; KIDNEY TUBULES, PROXIMAL; MALE; MATERIALS TESTING; METAL NANOPARTICLES; NEPHRITIS, INTERSTITIAL; NEUTROPHIL INFILTRATION; PARTICLE SIZE; RANDOM ALLOCATION; RATS; RATS, INBRED WKY; TIME FACTORS;

EID: 80052035746     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-147     Document Type: Article

References (35)

1. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. Huang X, El-Sayed I, Qian W, El-Sayed M, J Am Chem Soc 2006 128 2115 20 10.1021/ja057254a 16464114 (Pubitemid 43277351)
2. Au nanoparticles target cancer. Jain P, El-Sayed I, El-Sayed M, Nanotoday 2007 2 18 29 (Pubitemid 46196541)
3. Therapeutic possibilitiesof plasmonically heated gold nanoparticles. Pissuwan D, Valenzuela S, Cortie MM, Trends in Biotechnol 2006 24 62 67 10.1016/j.tibtech.2005.12.004 (Pubitemid 43151977)
4. Nanotherapeutics for enhancing thermal therapy of cancer. Visaria R, Bischof J, Loren M, Williams B, Ebbini E, Paciotti G, Griffin R, Int J Hyperthermia 2007 23 6 501 511 10.1080/02656730701611241 17952764 (Pubitemid 350011520)
5. Hyperthermic effects of gold nanorods on tumor cells. Huff T, Tong L, Zhao Y, Hansen M, Cheng JX, Wei A, Nanomed 2007 2 125 132 10.2217/17435889.2.1. 125 (Pubitemid 46850567)
6. Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Chen J, Wang D, Xi J, Au L, Siekkinen A, Warsen A, Li Y, Zhang H, Xia Y, Li X, Nano Lett 2007 7 1318 1322 10.1021/nl070345g 17430005 (Pubitemid 46834416)
7. Biomedical applications and potential health risks of nanomaterials: molecular mechanisms. Lanone S, Boczkowski J, Curr Mol Med 2006 6 651 63 10.2174/156652406778195026 17022735 (Pubitemid 44377764)
8. Translocation and effects of gold nanoparticles after inhalation exposure in rats. Yu LE, Yung L-YL, Balasubramaniam KS, Hartono D, et al. Nanotoxicology 2007 1 3 235 42 10.1080/17435390701763108 (Pubitemid 350179071)
9. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD, Small 2005 1 3 325 327 10.1002/smll.200400093 17193451 (Pubitemid 43951781)
10. Modification of gold nanorods using phosphatidylcholineto reduce cytotoxicity. Takahashi H, Niidome Y, Niidome T, Kaneko K, Kawasaki H, Yamada S, Langmuir 2006 22 1 2 5 10.1021/la0520029 16378388 (Pubitemid 43063513)
11. Size-dependent cytotoxicity of gold nanoparticles. Neuss S, Leifert A, Fischler M, Wen F, Simon U, et al. Small 2007 3 11 1941 1949 10.1002/smll.200700378 17963284 (Pubitemid 350099867)
12. Mechanism of lung injury caused by PM10 and ultrafine particles with special reference to COPD. MacNee W, Donaldson K, Eur Respir J 2003 21 40 47S 51S 10.1183/09031936.03.00403203 (Pubitemid 36565582)
13. Potential oxidative stress of gold Nanoparticles by induced-NO releasing in serum. Jia HY, Liu Y, Zhang XJ, Han L, Du LB, Tian Q, et al. J am Chem Soc 2009 131 1 40 1 10.1021/ja808033w 19072650
14. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Chithrani BD, Chan WC, Nano Lett 2007 7 1542 1550 10.1021/nl070363y 17465586 (Pubitemid 47140422)
15. Size-dependent cytotoxicity of gold nanoparticles. Pan Y, Neuss S, Leifert A, Fischler M, Wen F, Simon U, Schmid G, Brandau W, Jahnen-Dechent W, Small 2007 3 1941 1949 10.1002/smll.200700378 17963284 (Pubitemid 350099867)
16. Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice. BarathManiKanth S, Kalishwaralal K, Sriram M, Pandian SRK, Youn H, SooHyun Eom S, Gurunathan S, Journal of Nanobiotechnology 2010 8 16 10.1186/1477-3155-8-16 20630072
17. In vitro toxicity of nanoparticles in BRL- 3A rat liver cells. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ, Toxicol in Vitro 2005 19 975 983 10.1016/j.tiv.2005.06.034 16125895 (Pubitemid 41563236)
18. Can silver nanoparticles be useful as potential biological labels? Schrand AM, Bradich-Stolle LK, Schlager JJ, Dai L, Hussain SM, Nanotechnology 2008 9 1 13
19. Perturbational profiling of nanomaterial biologic activity. Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R, Proc Natl Acad Sci USA 2008 105 7387 7392 10.1073/pnas.0802878105 18492802 (Pubitemid 351830027)
20. Paclitaxel-functionalized gold nanoparticles. Gibson JD, Khanal BP, Zubarev ER, J Am Chem Soc 2007 129 11653 11661 10.1021/ja075181k 17718495 (Pubitemid 47555582)
21. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. De Jong W, Hagens W, Krystek P, Burger M, Sips A, Geertsma R, Biomater 2008 29 12 1912 1919 10.1016/j.biomaterials.2007.12.037
22. Gum rabic as a phytochemical construct for the stabilization of gold nanoparticles: In vivo pharmacokinetics and x-ray-contrast-imaging studies. Kattumuri V, Katti K, Bhaskaran S, Boote E, Casteel S, Fent G, Robertson D, Chandrasekhar M, Kannan R, Katti K, Small 2007 3 333 341 10.1002/smll.200600427 17262759
23. Histochemistry. Theoritical and applied. Analytical technology. Pearse AE, Churchill-Livingstone, Edinburgh 4 1985 2
24. Tracking gold nanoparticles in the body. Terentyuk G, Maslyyakova G, Suleymanova L, Kogan B, Khlebtsov B, Akchurin G, Makisimova I, Shantrokha A, Tuchin V, J Biomedical Optics 2009 14 19 16
25. Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress. Inumaru J, Tanihar H, Umezawa k, Niwa S, Suzuki Y, Nakumura S, Ishimoto T, Takahashi E, Nagano O, Saya H, Genes Cells 2009 14 6 703 716 10.1111/j.1365-2443.2009.01303.x 19422420
26. A standard hepatotoxic model produced by paracetamol in rat. Pandey G, Srivastava DN, Madhuri S, Toxicology International 2008 15 1 69 70 (Pubitemid 351983822)
27. Inflammatory response, reactive oxygen species, programmed (necrotic-like and apoptotic) cell death and cancer. Johar D, Roth JC, Bay GH, Walker JN, Kroczak TJ, Los M, Rocz Akad Med Bialymst 2004 49 31 9 15638366
28. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Yen HJ, Hsu SH, Tsai CL, Small 2009 5 1553 1561 10.1002/smll.200900126 19326357
29. Size-dependent cytotoxicity of gold nanoparticles. Pan Y, Neuss S, Leifert A, Fischler M, Wen F, Simon U, Schmid G, Brandau W, Jahnen-Dechent W, Small 2007 3 1941 1949 10.1002/smll.200700378 17963284 (Pubitemid 350099867)
30. Drug delivery and nanoparticles: applications and hazards. De Jong WH, Borm P, Int J Nanomed 2008 3 133 149 (Pubitemid 352042401)
31. Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage. Tarnuzzer RW, Colon J, Patil S, Seal S, Nano Lett 2005 5 2573 2577 10.1021/nl052024f 16351218 (Pubitemid 43088915)
32. Toxic potential of materials at the nanolevel. Nel A, Xia T, Madler L, Li NB, Science 2006 311 622 627 10.1126/science.1114397 16456071 (Pubitemid 43191298)
33. A nanoproduct in medical application. Chen X, Schluesener HJ, Nanosilver V, Toxicol Lett 2008 176 1 12 10.1016/j.toxlet.2007.10.004 18022772 (Pubitemid 350251066)
34. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJ, Geertsma RE, Biomaterials 2008 29 1912 1919 10.1016/j.biomaterials.2007.12. 037 18242692
35. Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence. Florence AT, Hillery AM, Hussain N, Jani PU, J Drug Targe 1995 3 65 70 10.3109/10611869509015936