Efficacy and safety of imiquimod versus podophyllotoxin in the treatment of anogenital warts

Sexually Transmitted Diseases

Volumn 38, Issue 3, 2011, Pages 216-218

  Komericki, Peter ^a   Akkilic Materna, Merve ^a   Strimitzer, Tanja ^b   Aberer, Werner ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b AUSTRIAN AGENCY FOR HEALTH AND FOOD SAFETY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

IMIQUIMOD; PODOPHYLLOTOXIN;

ADULT; ARTICLE; CHLAMYDIA TRACHOMATIS; CLINICAL ARTICLE; CONDYLOMA ACUMINATUM; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FEMALE; HUMAN; MALE; MYCOPLASMA HOMINIS; NEISSERIA GONORRHOEAE; NONHUMAN; RANDOMIZED CONTROLLED TRIAL; SKIN INFLAMMATION; TREATMENT OUTCOME; UREAPLASMA UREALYTICUM;

ADJUVANTS, IMMUNOLOGIC; ADOLESCENT; ADULT; AMINOQUINOLINES; CONDYLOMATA ACUMINATA; FEMALE; HUMANS; INTENTION TO TREAT ANALYSIS; KERATOLYTIC AGENTS; MALE; MIDDLE AGED; PODOPHYLLOTOXIN; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79951681876     PISSN: 01485717     EISSN: None     Source Type: Journal    
DOI: 10.1097/OLQ.0b013e3181f68ebb     Document Type: Article

References (18)

1. Sexually transmitted diseases treatment guidelines 2002. Centers for Disease Control and Prevention. MMWR Recomm Rep 2002; 51: 1-78.
2. Fleischer AB, Parrish CA, Glenn R, et al. Condylomata acuminate (genital warts): Patient demographics and treating physicians. Sex Transm Dis 2001; 28:643-647. (Pubitemid 33055108)
3. Scheinfeld N, Lehmann DS. An evidence-based review of medical and surgical treatments of genital warts. Dermatol Online J 2006; 12:5.
4. Beutner KR, Ferenczy A. Therapeutic approaches to genital warts. Am J Med 1997; 102:28-37. (Pubitemid 127695957)
5. Kaplan IW. Condylomata acuminate. New Orleans Med Surg J 1942; 94:388-390.
6. Von Krogh, Maibach HI. Cutaneous cytodestructive potency of lignans. A comparative evaluation of influence on epidermal and dermal DNA synthesis and on dermal microcirculation in the hairless mouse. Arch Dermatol Res 1982; 274:9-20.
7. Von Krogh G. Penile condylomata acuminata: An experimental model for evaluation of topical self-treatment with 0.5%-1% ethanolic preparations of podophyllotoxin for 3 days. Sex Transm Dis 1981; 8:179-184.
8. Lacey CJ, Goodall RL, Ragnarson Tennvall G, et al. Randomised controlled trial and economic evaluation of podophyllotoxin solution, podophyllotoxin cream, and podophyllin in the treatment of genital warts. Sex Transm Infect 2003; 79:270-275. (Pubitemid 37026341)
9. Tyring S, Edwards L, Cherry LK, et al. Safety and efficacy of 0.5% podofilox gel in the treatment of angenital warts. Arch Dermatol 1998; 134:33-38. (Pubitemid 28087110)
10. Von Krogh G, Hellberg D. Self-treatment using a 0.5% podo-phyllotoxin cream of external genital condylomata acuminata in women: A placebo-controlled, double-blind study. Sex Transm Dis 1992; 19:170-174.
11. Sayed TA, Lundin S, Ahmad SA. Topical 0.3% and 0.5% podo-phyllotoxin cream for self-treatment of condylomata acuminata in women: A placebo-controlled, double-blind study. Dermatology 1994; 189:142-145. (Pubitemid 24162318)
12. Beutner KR, Tyring SK, Trofatter KF Jr, et al. Imiquimod, a patient-applied immune-response modifier for treatment of external genital warts. Antimicrob Agents Chemother 1998; 42:789-794. (Pubitemid 28216355)
13. Gotovtseva EP, Kapadia AS, Smolensky MH, et al. Optimal frequency of imiquimod (Aldara) 5% cream for the treatment of external genital warts in immunocompetent adults: A meta-anal-ysis. Sex Transm Dis 2008; 35:346-351. (Pubitemid 351440773)
14. Beutner KR, Spruance SL, Hougham AJ, et al. Treatment of genital warts with an immune-response modifier (imiquimod). J Am Acad Dermatol 1998; 38:230-239. (Pubitemid 28100838)
15. Edwards L, Ferenczy A, Eron L, et al. Self-administered topical 5% imiquimod cream for external anogenital warts. HPV Study Group: Human Papillomavirus. Arch Dermatol 1998; 134:25-30. (Pubitemid 28087109)
16. Arican O, Guneri F, Bilgic K, et al. Topical imiquimod 5% cream in external anogenital warts: A randomized double-blind, placebo-controlled study. J Dermatol 2004; 31:627-631. (Pubitemid 39243785)
17. Yan J, Chen SL, Wang HN, et al. Meta-analysis of 5% imiquimod and 0.5% podophyllotoxin in the treatment of condylomata acuminata. Dermatology 2006; 213:218-223. (Pubitemid 44567832)
18. Lassus A. Comparison of podophyllotoxin and podophyllin in the treatment of genital warts. Lancet 1987; 2:512-513. (Pubitemid 17126759)