Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to smoothened-targeting Hedgehog inhibition

Journal of Biological Chemistry

Volumn 288, Issue 17, 2013, Pages 11824-11833

  Das, Shamik ^a   Samant, Rajeev S ^a,b   Shevde, Lalita A ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELLS; DRUG RESISTANCE; FEED-FORWARD; HEDGEHOG SIGNALING; INFLAMMATORY CYTOKINES; MULTIDRUG RESISTANCE; SUBCELLULAR DISTRIBUTION; TUMORIGENICITY;

BIOACTIVITY; LIGANDS; SIGNALING; TRANSCRIPTION FACTORS; TUMORS;

CELL SIGNALING;

BREAST CANCER RESISTANCE PROTEIN; CYCLOPAMINE; GLYCOGEN SYNTHASE KINASE 3BETA; MULTIDRUG RESISTANCE PROTEIN 1; OSTEOPONTIN; PROTEIN KINASE B; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ABCG2 GENE; ARTICLE; CANCER CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; INHIBITION KINETICS; MULTIDRUG RESISTANCE PROTEIN 1 GENE; PHENOTYPIC PLASTICITY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HEDGEHOG PROTEINS; HUMANS; OSTEOPONTIN; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

ERINACEIDAE;

EID: 84876895507     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.432302     Document Type: Article

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