ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 17, 2013, Pages 6871-6876

  Radke, Joshua B ^a   Lucas, Olivier ^a,e   De Silva, Erandi K ^b   Ma, Yanfen ^c   Sullivan, William J ^d   Weiss, Louis M ^c   Llinas, Manuel ^b   White, Michael W ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ILLUMINA INC   (United States)

Author keywords

Apicomplexa; Gene expression; Gene regulation

Indexed keywords

ANTIGEN; BRADYZOITE ANTIGEN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR APIAP2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYZOITE; DNA BINDING; DNA SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; TACHYZOITE; TOXOPLASMA; TOXOPLASMOSIS;

ANIMALIA; APICOMPLEXA; TOXOPLASMA;

EID: 84876870137     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300059110     Document Type: Article

References (39)

1. Dubey JP, Miller NL, Frenkel JK (1970) Toxoplasma gondii life cycle in cats. J Am Vet Med Assoc 157(11):1767-1770.
2. Kruszon-Moran D, McQuillan GM (2005) Seroprevalence of six infectious diseases among adults in the United States by race/ethnicity: Data from the third national health and nutrition examination survey, 1988-94. Adv Data (352):1-9.
3. Jones JL, Kruszon-Moran D, Sanders-Lewis K, Wilson M (2007) Toxoplasma gondii infection in the United States, 1999 2004, decline from the prior decade. Am J Trop Med Hyg 77(3):405-410.
4. Bahia-Oliveira LM, et al. (2003) Highly endemic, waterborne toxoplasmosis in north Rio de Janeiro state, Brazil. Emerg Infect Dis 9(1):55-62.
5. Adomako-Ankomah Y, Wier GM, Boyle JP (2012) Beyond the genome: Recent advances in Toxoplasma gondii functional genomics. Parasite Immunol 34(2-3):80-89.
6. Jerome ME, Radke JR, Bohne W, Roos DS, White MW (1998) Toxoplasma gondii bradyzoites form spontaneously during sporozoite-initiated development. Infect Immun 66(10):4838-4844.
7. Radke JR, Guerini MN, Jerome M, White MW (2003) A change in the premitotic period of the cell cycle is associated with bradyzoite differentiation in Toxoplasma gondii. Mol Biochem Parasitol 131(2):119-127.
8. Behnke MS, et al. (2010) Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii. PLoS ONE 5(8):e12354.
9. Bozdech Z, et al. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 1(1):E5.
10. Balaji S, Babu MM, Iyer LM, Aravind L (2005) Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. Nucleic Acids Res 33(13):3994-4006.
11. Altschul SF, Wootton JC, Zaslavsky E, Yu YK (2010) The construction and use of log-odds substitution scores for multiple sequence alignment. PLOS Comput Biol 6(7): e1000852.
12. Campbell TL, De Silva EK, Olszewski KL, Elemento O, Llinás M (2010) Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. PLoS Pathog 6(10):e1001165.
13. Iwanaga S, Kaneko I, Kato T, Yuda M (2012) Identification of an AP2-family protein that is critical for malaria liver stage development. PLoS ONE 7(11):e47557.
14. Walker R, et al. (2013) The Toxoplasma nuclear factor TgAP2XI-4 controls bradyzoite gene expression and cyst formation. Mol Microbiol 87(3):641-655.
15. Yuda M, Iwanaga S, Shigenobu S, Kato T, Kaneko I (2010) Transcription factor AP2-Sp and its target genes in malarial sporozoites. Mol Microbiol 75(4):854-863.
16. Yuda M, et al. (2009) Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. Mol Microbiol 71(6):1402-1414.
17. Flueck C, et al. (2010) A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. PLoS Pathog 6(2):e1000784.
18. Behnke MS, Radke JB, Smith AT, Sullivan WJ, Jr., White MW (2008) The transcription of bradyzoite genes in Toxoplasma gondii is controlled by autonomous promoter elements. Mol Microbiol 68(6):1502-1518.
19. Bohne W, Parmley SF, Yang S, Gross U (1996) Bradyzoite-specific genes. Curr Top Microbiol Immunol 219:81-91.
20. Fox BA, et al. (2011) type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection. Eukaryot Cell 10(9):1193-1206.
21. Buchholz KR, et al. (2011) Identification of tissue cyst wall components by tran-scriptome analysis of in vivo and in vitro Toxoplasma gondii bradyzoites. Eukaryot Cell 10(12):1637-1647.
22. Bohne W, Roos DS (1997) Stage-specific expression of a selectable marker in Toxo-plasma gondii permits selective inhibition of either tachyzoites or bradyzoites. Mol Biochem Parasitol 88(1-2):115-126.
23. Bohne W, et al. (1998) Targeted disruption of the bradyzoite-specific gene BAG1 does not prevent tissue cyst formation in Toxoplasma gondii. Mol Biochem Parasitol 92(2): 291-301.
24. Herm-Götz A, et al. (2007) Rapid control of protein level in the apicomplexan Toxo-plasma gondii. Nat Methods 4(12):1003-1005.
25. Bohne W, Heesemann J, Gross U (1994) Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: A possible role for nitric oxide in triggering stage conversion. Infect Immun 62(5):1761-1767.
26. Bahl A, et al. (2010) A novel multifunctional oligonucleotide microarray for Toxo-plasma gondii. BMC Genomics 11:603.
27. Yant L, Mathieu J, Schmid M (2009) Just say no: Floral repressors help Arabidopsis bide the time. Curr Opin Plant Biol 12(5):580-586.
28. Song CP, et al. (2005) Role of an Arabidopsis AP2/EREBP-type transcriptional repressor in abscisic acid and drought stress responses. Plant Cell 17(8):2384-2396.
29. Dubey JP (1976) Reshedding of Toxoplasma oocysts by chronically infected cats. Nature 262(5565):213-214.
30. Dubey JP (1997) Bradyzoite-induced murine toxoplasmosis: Stage conversion, path-ogenesis, and tissue cyst formation in mice fed bradyzoites of different strains of Toxoplasma gondii. J Eukaryot Microbiol 44(6):592-602.
31. Dubey JP (2001) Oocyst shedding by cats fed isolated bradyzoites and comparison of infectivity of bradyzoites of the VEG strain Toxoplasma gondii to cats and mice. J Parasitol 87(1):215-219.
32. Dubey JP (2005) Unexpected oocyst shedding by cats fed Toxoplasma gondii tachy-zoites: in Vivo stage conversion and strain variation. Vet Parasitol 133(4):289-298.
33. Göndör A, Ohlsson R (2009) Replication timing and epigenetic reprogramming of gene expression: A two-way relationship? Nat Rev Genet 10(4):269-276.
34. Henery CC, Miranda M, Wiekowski M, Wilmut I, DePamphilis ML (1995) Repression of gene expression at the beginning of mouse development. Dev Biol 169(2):448-460.
35. Rook F, Hadingham SA, Li Y, Bevan MW (2006) Sugar and ABA response pathways and the control of gene expression. Plant Cell Environ 29(3):426-434.
36. Arroyo A, Bossi F, Finkelstein RR, León P (2003) Three genes that affect sugar sensing (abscisic acid insensitive 4, abscisic acid insensitive 5, and constitutive triple response 1) are differentially regulated by glucose in Arabidopsis. Plant Physiol 133(1):231-242.
37. Radke JR, et al. (2005) The transcriptome of Toxoplasma gondii. BMC Biol 3:26.
38. Gentleman RC, et al. (2004) Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol 5(10):R80.
39. Gissot M, Kelly KA, Ajioka JW, Greally JM, Kim K (2007) Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii. PLoS Pathog 3(6): e77.