Identification of an AP2-family Protein That Is Critical for Malaria Liver Stage Development

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Iwanaga, Shiroh ^a   Kaneko, Izumi ^a   Kato, Tomomi ^a   Yuda, Masao ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR AP 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DNA MICROARRAY; ERYTHROCYTE; GENE; GENE EXPRESSION; IN VITRO STUDY; LIVER; LIVER CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PARASITE MIGRATION; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PROTEIN LOCALIZATION; SALIVARY GLAND; SCHIZONT; SLARP GENE; SPOROZOITE; TRANSGENIC ORGANISM; TROPHOZOITE;

AMINO ACID SEQUENCE; ANIMALS; ANOPHELES; CELL NUCLEUS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HEP G2 CELLS; HEPATOCYTES; HOST-PARASITE INTERACTIONS; HUMANS; LIVER; MALARIA; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE ANNOTATION; MOLECULAR SEQUENCE DATA; PLASMODIUM BERGHEI; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; RATS; SALIVARY GLANDS; SCHIZONTS; SPOROZOITES; TRANSCRIPTION FACTORS; TROPHOZOITES;

PLASMODIUM BERGHEI; RODENTIA;

EID: 84868693369     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047557     Document Type: Article

References (20)

1. Hoffman SL, Goh LML, Luke TC, Schneider I, Le TP, et al. (2002) Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. Journal of Infectious Diseases 185: 1155-1164.
2. Mueller AK, Labaied M, Kappe SH, Matuschewski K, (2005) Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature 433: 164-167.
3. Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, et al. (2011) Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host Microbe 9: 451-462.
4. Tarun AS, Dumpit RF, Camargo N, Labaied M, Liu P, et al. (2007) Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells. J Infect Dis 196: 608-616.
5. White KL, Snyder HL, Krzych U, (1996) MHC class I-dependent presentation of exoerythrocytic antigens to CD8+ T lymphocytes is required for protective immunity against Plasmodium berghei. J Immunol 156: 3374-3381.
6. Schofield L, Villaquiran J, Ferreira A, Schellekens H, Nussenzweig R, et al. (1987) Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites. Nature 330: 664-666.
7. Tarun AS, Peng X, Dumpit RF, Ogata Y, Silva-Rivera H, et al. (2008) A combined transcriptome and proteome survey of malaria parasite liver stages. Proc Natl Acad Sci U S A 105: 305-310.
8. Balaji S, Babu MM, Iyer LM, Aravind L, (2005) Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. Nucleic Acids Res 33: 3994-4006.
9. Painter HJ, Campbell TL, Llinas M, (2011) The Apicomplexan AP2 family: integral factors regulating Plasmodium development. Mol Biochem Parasitol 176: 1-7.
10. Iyer LM, Anantharaman V, Wolf MY, Aravind L, (2008) Comparative genomics of transcription factors and chromatin proteins in parasitic protists and other eukaryotes. Int J Parasitol 38: 1-31.
11. Yuda M, Iwanaga S, Shigenobu S, Kato T, Kaneko I, (2010) Transcription factor AP2-Sp and its target genes in malarial sporozoites. Mol Microbiol 75: 854-863.
12. Yuda M, Iwanaga S, Shigenobu S, Mair GR, Janse CJ, et al. (2009) Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. Mol Microbiol 71: 1402-1414.
13. Ishino T, Chinzei Y, Yuda M, (2005) Two proteins with 6-cys motifs are required for malarial parasites to commit to infection of the hepatocyte. Mol Microbiol 58: 1264-1275.
14. Mueller AK, Camargo N, Kaiser K, Andorfer C, Frevert U, et al. (2005) Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface. Proc Natl Acad Sci U S A 102: 3022-3027.
15. Janse CJ, Franke-Fayard B, Mair GR, Ramesar J, Thiel C, et al. (2006) High efficiency transfection of Plasmodium berghei facilitates novel selection procedures. Mol Biochem Parasitol 145: 60-70.
16. Silvie O, Goetz K, Matuschewski K, (2008) A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development. PLoS Pathog 4: e1000086.
17. Aly AS, Mikolajczak SA, Rivera HS, Camargo N, Jacobs-Lorena V, et al. (2008) Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection. Mol Microbiol 69: 152-163.
18. Aly AS, Lindner SE, MacKellar DC, Peng X, Kappe SH, (2011) SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages. Mol Microbiol 79: 929-939.
19. Campbell TL, De Silva EK, Olszewski KL, Elemento O, Llinas M, (2010) Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. PLoS Pathog 6: e1001165.
20. Ishino T, Yano K, Chinzei Y, Yuda M, (2004) Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer. PLoS Biol 2: E4.