What is more damaging to vascular endothelial function: Diabetes, age, high BMI, or all of the above?

Medical Science Monitor

Volumn 19, Issue 1, 2013, Pages 257-263

  Petrofsky, Jerrold S ^a   Alshammari, Faris ^a   Bains, Gurinder Singh ^a   Khowailed, Iman Akef ^a   Lee, Haneul ^a   Kuderu, Yashvanth Nagarajamurthy ^a   Lodha, Riya D ^a   Rodrigues, Sophia ^a   Nguyen, Diamond ^a   Potnis, Pooja Ashok ^a   Deshpande, Pooja P ^a   Yim, Jong Eun ^b   Berk, Lee ^a  

^a LOMA LINDA UNIVERSITY   (United States)

^b Sahmyook University   (South Korea)

Author keywords

Cardiovascular; Diabetes; Heat

Indexed keywords

HEMOGLOBIN A1C;

ADULT; AGED; ARTICLE; BLOOD FLOW; BLOOD VESSEL INJURY; BODY MASS; DATA ANALYSIS; DIABETES MELLITUS; DOPPLER FLOWMETRY; FEMALE; HUMAN; MALE; SKIN BLOOD FLOW; SKIN TEMPERATURE; THERMAL EXPOSURE; VASCULAR ENDOTHELIUM;

EID: 84876854006     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.883878     Document Type: Article

References (58)

1. van Tubergen A, van der Linden S: A brief history of spa therapy. Ann Rheum Dis, 2002; 61(3): 273-75
2. McKemy DD, Neuhausser WM, Julius D: Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature, 2002; 416(6876): 52-58
3. Peier AM et al: A TRP channel that senses cold stimuli and menthol. Cell, 2002; 108(5): 705-15
4. Reid G: ThermoTRP channels and cold sensing: what are they really up to? Pflugers Arch, 2005; 451(1): 250-63
5. Voets T et al: Sensing with TRP channels. Nat Chem Biol, 2005; 1(2): 85-92
6. Mergler S et al: Thermosensitive transient receptor potential channels (thermo-TRPs) in human corneal epithelial cells. J Cell Physiol, 2010
7. Owsianik G et al: Permeation and selectivity of TRP channels. Annu Rev Physiol, 2006; 68: 685-717
8. Pedersen SF, Owsianik G, Nilius B: TRP channels: an overview. Cell Calcium, 2005; 38(3-4): 233-52
9. Ramsey IS, Delling M, Clapham DE: An introduction to TRP channels. Annu Rev Physiol, 2006; 68: 619-47
10. Nilius B et al: Transient receptor potential cation channels in disease. Physiol Rev, 2007; 87(1): 165-217
11. Venkatachalam K, Montell C: TRP channels. Annu Rev Biochem, 2007; 76: 387-417
12. Benham CD, Davis JB, Randall AD: Vanilloid and TRP channels: a family of lipid-gated cation channels. Neuropharmacology, 2002; 42(7): 873-88
13. Nilius B et al: TRPV4 calcium entry channel: a paradigm for gating diversity. Am J Physiol Cell Physiol, 2004; 286(2): 195-205
14. Nilius B, Watanabe H, Vriens J: The TRPV4 channel: structure-function relationship and promiscuous gating behaviour. Pflugers Arch, 2003; 446(3): 298-303
15. Everaerts W, Nilius B, Owsianik G: The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol, 2010; 103(1): 2-17
16. Caterina MJ et al: The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 1997; 389(6653): 816-24
17. Caterina MJ, Julius D: The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci, 2001; 24: 487-517
18. Tominaga M: The Role of TRP Channels in Thermosensation. 2007
19. Tominaga M et al: The cloned capsaicin receptor integrates multiple painproducing stimuli. Neuron, 1998; 21(3): 531-43
20. Cesare P et al: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. Neuron, 1999; 23(3): 617-24
21. Liedtke W et al: Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell, 2000; 103(3): 525-35
22. Strotmann R et al: OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol, 2000; 2(10): 695-702
23. Wissenbach U et al: Trp12, a novel Trp related protein from kidney. FEBS Lett, 2000; 485(2-3): 127-34
24. Kellogg DL Jr. et al: Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol, 1999; 86(4): 1185-90
25. Minson CT, Berry LT, Joyner MJ: Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol, 2001; 91(4): 1619-26
26. Minson CT et al: Decreased nitric oxide- and axon reflex-mediated cutaneous vasodilation with age during local heating. J Appl Physiol, 2002; 93(5): 1644-49
27. Namer B et al: Chemically and electrically induced sweating and flare reaction. Auton Neurosci, 2004; 114(1-2): 72-82
28. Petrofsky JS, Al-Malty AM, Prowse M: Relationship between multiple stimuli and skin blood flow. Med Sci Monit, 2008; 14(8): CR399-405
29. Sauerstein K et al: Electrically evoked neuropeptide release and neurogenic inflammation differ between rat and human skin. J Physiol, 2000; 529: 803-10
30. Almalty AM et al: An effective method for skin blood flow measurement using local heat combined with electrical stimulation. J Med Eng Technol, 2009; 33(8): 663-69
31. Rowell LB: Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev, 1974; 54(1): 75-159
32. Rowell LB: Reflex control of the cutaneous vasculature. J Invest Dermatol, 1977; 69(1): 154-66
33. Petrofsky J et al: The interrealtionship between locally applied heat, ageing and skin blood flow on heat transfer into and from the skin. J Med Eng Technol, 2011; 35(5): 262-74
34. Petrofsky J et al: The ability of different areas of the skin to absorb heat from a locally applied heat source: the impact of diabetes. Diabetes Technol Ther, 2011; 13(3): 365-72
35. Petrofsky J et al: The ability of the skin to absorb heat; the effect of repeated exposure and age. Med Sci Monit, 2011; 17(1): CR1-8
36. Vecchini A et al: Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells. J Lipid Res, 2004; 45(2): 308-16
37. Wong BJ, Fieger SM: Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans. J Physiol, 2010; 588 (Pt 21): 4317-26
38. Petrofsky J et al: Dry heat, moist heat and body fat: are heating modalities really effective in people who are overweight? J Med Eng Technol, 2009; 33(5): 361-69
39. Farage M, Miller K, Maibach H (eds.): Influence of Race, Gender, Age and Diabetes on the Skin Circluation. Text Book of Ageing Skin. 2010, Springer Berlin Heidelberg
40. Bui C et al: Acute effect of a single high-fat meal on forearm blood flow, blood pressure and heart rate in healthy male Asians and Caucasians: a pilot study. Southeast Asian J Trop Med Public Health, 2010; 41(2): 490-500
41. Yim J et al: Differences in endothelial function between Korean-Asians and Caucasians. Med Sci Monit, 2012; 18(6): CR337-43
42. Calder PC et al: Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr, 2011; 106(Suppl.3): S5-78
43. de Heredia FP, Gomez-Martinez S, Marcos A: Obesity, inflammation and the immune system. Proc Nutr Soc, 2012; 71(2): 332-38
44. Yim J et al: Protective effect of anti-oxidants on endothelial function in young Korean-Asians compared to Caucasians. Med Sci Monit, 2012; 18(8): CR467-79
45. [Practical study of the establishment of menus in general hospital, with a view to a diet balanced and adapted to different categories of hospitalized patients.]. Terramycine Informations, 1960; 16: 49-52
46. Petrofsky JS, Laymon M, Lee H et al: The Effect of Coenzyme Q-10 on Endothelial Function in a Young Population Physical Therapy Rehabilitation Science, 2012; 1: 6-12
47. Higdon JV, Frei B: Obesity and oxidative stress: a direct link to CVD? Arterioscler Thromb Vasc Biol, 2003; 23(3): 365-67
48. Middleton E Jr., Kandaswami C, Theoharides TC: The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev, 2000; 52(4): 673-751
49. Powers SK, Jackson MJ: Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev, 2008; 88(4): 1243-76
50. Petrofsky JS: Resting blood flow in the skin: does it exist, and what is the influence of temperature, aging, and diabetes? J Diabetes Sci Technol, 2012; 6(3): 674-85
51. Petrofsky JS et al: Reduced endothelial function in the skin in Southeast Asians compared to Caucasians. Med Sci Monit, 2012; 18(1): CR1-8
52. Babu PV, Liu D: Green tea catechins and cardiovascular health: an update. Curr Med Chem, 2008; 15(18): 1840-50
53. Babu PV, Sabitha KE, Shyamaladevi CS: Effect of green tea extract on advanced glycation and cross-linking of tail tendon collagen in streptozotocin induced diabetic rats. Food Chem Toxicol, 2008; 46(1): 280-85
54. Powers SK, Talbert EE, Adhihetty PJ: Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle. J Physiol, 2011; 589(Pt 9): 2129-38
55. Baskurt OK, Ulker P, Meiselman HJ: Nitric oxide, erythrocytes and exercise. Clin Hemorheol Microcirc, 2011; 49(1-4): 175-81
56. Peternelj TT Coombes JS: Antioxidant Supplementation during Exercise Training: Beneficial or Detrimental? Sports Med, 2011; 41(12): 1043-69
57. Wray DW et al: Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension, 2012; 59(4): 818-24
58. Tare M et al: Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats. J Physiol, 2011; 589(Pt 19): 4777-86