-
1
-
-
84858735072
-
The noncanonical NF-κB pathway
-
Sun SC. The noncanonical NF-κB pathway. Immunol. Rev. 246(1), 125-140 (2012).
-
(2012)
Immunol. Rev.
, vol.246
, Issue.1
, pp. 125-140
-
-
Sun, S.C.1
-
2
-
-
0034607655
-
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
-
Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288(5467), 874-877 (2000).
-
(2000)
Science
, vol.288
, Issue.5467
, pp. 874-877
-
-
Yang, Y.1
Fang, S.2
Jensen, J.P.3
Weissman, A.M.4
Ashwell, J.D.5
-
3
-
-
0034745420
-
NF-κBinducing kinase regulates the processing of NF-κB2 p100
-
Xiao G, Harhaj EW, Sun SC. NF-κBinducing kinase regulates the processing of NF-κB2 p100. Mol. Cell 7(2), 401-409 (2001).
-
(2001)
Mol. Cell
, vol.7
, Issue.2
, pp. 401-409
-
-
Xiao, G.1
Harhaj, E.W.2
Sun, S.C.3
-
4
-
-
85046913982
-
Constitutive non-canonical NFκB signaling in pancreatic cancer cells
-
Wharry CE, Haines KM, Carroll RG, May MJ. Constitutive non-canonical NFκB signaling in pancreatic cancer cells. Cancer Biol. Ther. 8(16), 1567-1576 (2009).
-
(2009)
Cancer Biol. Ther.
, vol.8
, Issue.16
, pp. 1567-1576
-
-
Wharry, C.E.1
Haines, K.M.2
Carroll, R.G.3
May, M.J.4
-
5
-
-
1842850737
-
Increased expression of NF-κB subunits in human pancreatic cancer cells
-
Chandler NM, Canete JJ, Callery MP. Increased expression of NF-κB subunits in human pancreatic cancer cells. J. Surg. Res. 118(1), 9-14 (2004).
-
(2004)
J. Surg. Res.
, vol.118
, Issue.1
, pp. 9-14
-
-
Chandler, N.M.1
Canete, J.J.2
Callery, M.P.3
-
6
-
-
68949097479
-
NIK is involved in constitutive activation of the alternative NF-κB pathway and proliferation of pancreatic cancer cells
-
Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J. NIK is involved in constitutive activation of the alternative NF-κB pathway and proliferation of pancreatic cancer cells. Biochem. Biophys. Res. Commun. 388(1), 96-101 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.388
, Issue.1
, pp. 96-101
-
-
Nishina, T.1
Yamaguchi, N.2
Gohda, J.3
Semba, K.4
Inoue, J.5
-
7
-
-
84871862001
-
Downregulation of TRAF2 mediates NIKinduced pancreatic cancer cell proliferation and tumorigenicity
-
Döppler H, Liou GY, Storz P. Downregulation of TRAF2 mediates NIKinduced pancreatic cancer cell proliferation and tumorigenicity. PLoS ONE 8(1), e53676 (2013).
-
(2013)
PLoS ONE 8
, vol.1
-
-
Döppler, H.1
Liou, G.Y.2
Storz, P.3
-
8
-
-
33748052706
-
IKKα controls p52/RelB at the skp2 gene promoter to regulate G1-to S-phase progression
-
Schneider G, Saur D, Siveke JT, Fritsch R, Greten FR, Schmid RM. IKKα controls p52/RelB at the skp2 gene promoter to regulate G1-to S-phase progression. EMBO J. 25(16), 3801-3812 (2006).
-
(2006)
EMBO J.
, vol.25
, Issue.16
, pp. 3801-3812
-
-
Schneider, G.1
Saur, D.2
Siveke, J.T.3
Fritsch, R.4
Greten, F.R.5
Schmid, R.M.6
-
9
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata CM, Davis RE, Demchenko Y et al. Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 12(2), 115-130 (2007).
-
(2007)
Cancer Cell
, vol.12
, Issue.2
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
-
10
-
-
34547126428
-
The inhibitors of apoptosis (IAPs) as cancer targets
-
Hunter AM, LaCasse EC, Korneluk RG. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12(9), 1543-1568 (2007).
-
(2007)
Apoptosis
, vol.12
, Issue.9
, pp. 1543-1568
-
-
Hunter, A.M.1
Lacasse, E.C.2
Korneluk, R.G.3
-
11
-
-
77955426473
-
NF-κB inducing kinase (NIK) inhibitors: Identification of new scaffolds using virtual screening
-
Mortier J, Masereel B, Remouchamps C, Ganeff C, Piette J, Frederick R. NF-κB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening. Bioorg. Med. Chem. Lett. 20(15), 4515-4520 (2010).
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.15
, pp. 4515-4520
-
-
Mortier, J.1
Masereel, B.2
Remouchamps, C.3
Ganeff, C.4
Piette, J.5
Frederick, R.6
-
12
-
-
84867339398
-
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site
-
de Leon-Boenig G, Bowman KK, Feng JA et al. The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site. Structure 20(10), 1704-1714 (2012).
-
(2012)
Structure
, vol.20
, Issue.10
, pp. 1704-1714
-
-
De Leon-Boenig, G.1
Bowman, K.K.2
Feng, J.A.3
-
13
-
-
84864971029
-
Structure of the nuclear factor κb-inducing kinase (NIK) kinase domain reveals a constitutively active conformation
-
Liu J, Sudom A, Min X et al. Structure of the nuclear factor κB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. J. Biol. Chem. 287(33), 27326-27334 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, Issue.33
, pp. 27326-27334
-
-
Liu, J.1
Sudom, A.2
Min, X.3
-
14
-
-
38349153572
-
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
-
Zhang T, Hamza A, Cao X et al. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol. Cancer Ther. 7(1), 162-170 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, Issue.1
, pp. 162-170
-
-
Zhang, T.1
Hamza, A.2
Cao, X.3
-
15
-
-
34250886966
-
Hsp90 regulates processing of NF-κ B2 p100 involving protection of NF-κ B-inducing kinase (NIK) from autophagy-mediated degradation
-
Qing G, Yan P, Qu Z, Liu H, Xiao G. Hsp90 regulates processing of NF-κ B2 p100 involving protection of NF-κ B-inducing kinase (NIK) from autophagy-mediated degradation. Cell Res. 17(6), 520-530 (2007).
-
(2007)
Cell Res.
, vol.17
, Issue.6
, pp. 520-530
-
-
Qing, G.1
Yan, P.2
Qu, Z.3
Liu, H.4
Xiao, G.5
-
16
-
-
4143144401
-
TNAP, a novel repressor of NF-κB-inducing kinase, suppresses NF-κB activation
-
Hu WH, Mo XM, Walters WM, Brambilla R, Bethea Jr. TNAP, a novel repressor of NF-κB-inducing kinase, suppresses NF-κB activation. J. Biol. Chem. 279(34), 35975-35983 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.34
, pp. 35975-35983
-
-
Hu, W.H.1
Mo, X.M.2
Walters, W.M.3
Brambilla, R.4
Bethea, J.R.5
-
17
-
-
33645737411
-
Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
-
Nawrocki ST, Carew JS, Pino MS et al. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res. 66(7), 3773-3781 (2006).
-
(2006)
Cancer Res.
, vol.66
, Issue.7
, pp. 3773-3781
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
-
18
-
-
59449102891
-
Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis
-
Dai Y, Liu M, Tang W et al. Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis. Clin. Cancer Res. 14(23), 7701-7710 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.23
, pp. 7701-7710
-
-
Dai, Y.1
Liu, M.2
Tang, W.3
-
19
-
-
77954520406
-
NFκB: A promising target for natural products in cancer chemoprevention
-
Luqman S, Pezzuto JM. NFκB: a promising target for natural products in cancer chemoprevention. Phytother. Res. 24(7), 949-963 (2010).
-
(2010)
Phytother. Res.
, vol.24
, Issue.7
, pp. 949-963
-
-
Luqman, S.1
Pezzuto, J.M.2
-
20
-
-
77951744260
-
The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
-
Fendrich V, Chen NM, Neef M et al. The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. Gut 59(5), 630-637 (2010).
-
(2010)
Gut 59
, vol.5
, pp. 630-637
-
-
Fendrich, V.1
Chen, N.M.2
Neef, M.3
-
21
-
-
53349118240
-
SN52, a novel nuclear factor-κB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation
-
Xu Y, Fang F, St Clair DK, Sompol P, Josson S, St Clair WH. SN52, a novel nuclear factor-κB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol. Cancer Ther. 7(8), 2367-2376 (2008).
-
(2008)
Mol. Cancer Ther.
, vol.7
, Issue.8
, pp. 2367-2376
-
-
Xu, Y.1
Fang, F.2
St Clair, D.K.3
Sompol, P.4
Josson, S.5
St Clair, W.H.6
-
22
-
-
33750446341
-
Inhibitors of NF-κB signaling: 785 and counting
-
Gilmore TD, Herscovitch M. Inhibitors of NF-κB signaling: 785 and counting. Oncogene 25(51), 6887-6899 (2006).
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6887-6899
-
-
Gilmore, T.D.1
Herscovitch, M.2
-
23
-
-
77956407149
-
NF-κB inducing kinase: A key regulator in the immune system and in cancer
-
Thu YM, Richmond A. NF-κB inducing kinase: a key regulator in the immune system and in cancer. Cytokine Growth Factor Rev. 21(4), 213-226 (2010).
-
(2010)
Cytokine Growth Factor Rev.
, vol.21
, Issue.4
, pp. 213-226
-
-
Thu, Y.M.1
Richmond, A.2
-
24
-
-
58149202128
-
Is NF-κB a good target for cancer therapy? Hopes and pitfalls
-
Baud V, Karin M. Is NF-κB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug Discov. 8(1), 33-40 (2009).
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, Issue.1
, pp. 33-40
-
-
Baud, V.1
Karin, M.2
-
26
-
-
84887262463
-
-
Majid TN, Hopkins C, Pedgrift BL, Collar N, Wirtz-Brugger F, Merrill J. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders. US-7132428-B2 (2006).
-
(2006)
Pyrazoloisoquinoline Derivative As Kinase Inhibitors for the Treatment of Various Disorders. US-7132428-B2
-
-
Majid, T.N.1
Hopkins, C.2
Pedgrift, B.L.3
Collar, N.4
Wirtz-Brugger, F.5
Merrill, J.6
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