Weaker ligands can dominate an odor blend due to syntopic interactions

Chemical Senses

Volumn 38, Issue 4, 2013, Pages 293-304

  Münch, Daniel ^a   Schmeichel, Benjamin ^a   Silbering, Ana F ^b   Galizia, C Giovanni ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Drosophila melanogaster; Mixture interaction; Mixture processing; Olfaction; Olfactory receptor neuron; Or22a

Indexed keywords

CALCIUM ION;

ANIMAL EXPERIMENT; ARTICLE; BANANA; BINDING SITE; CHEMICAL INTERACTION; CONTROLLED STUDY; DENDRITE; DROSOPHILA MELANOGASTER; EVOKED RESPONSE; FEMALE; LIGAND BINDING; MASS FRAGMENTOGRAPHY; NONHUMAN; ODOR; OLFACTORY RECEPTOR; PRIORITY JOURNAL; RECEPTOR BINDING; SENSORY NERVE CELL; STIMULUS RESPONSE;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; ODORS; OLFACTORY RECEPTOR NEURONS; PERFUME; RECEPTORS, ODORANT; SMELL;

DROSOPHILA MELANOGASTER;

EID: 84876818968     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjs138     Document Type: Article

References (49)

1. Araneda RC, Kini AD, Firestein S. 2000. The molecular receptive range of an odorant receptor. Nat Neurosci. 3(12):1248-1255.
2. Asahina K, Louis M, Piccinotti S, Vosshall LB. 2009. A circuit supporting concentration-invariant odor perception in Drosophila. J Biol. 8(1):9.
3. Bell GA, Laing DG, Panhuber H. 1987. Odour mixture suppression: evidence for a peripheral mechanism in human and rat. Brain Res. 426(1):8-18.
4. Boekhoff I, Michel WC, Breer H, Ache BW. 1994. Single odors differentially stimulate dual second messenger pathways in lobster olfactory receptor cells. J Neurosci. 14:3304-3309.
5. Brodin M, Laska M, Olsson MJ. 2009. Odor interaction between Bourgeonal and its antagonist undecanal. Chem Senses. 34(7):625-630.
6. Chaput MA, El Mountassir F, Atanasova B, Thomas-Danguin T, Le Bon AM, Perrut A, Ferry B, Duchamp-Viret P. 2012. Interactions of odorants with olfactory receptors and receptor neurons match the perceptual dynamics observed for woody and fruity odorant mixtures. Eur J Neurosci. 35(4):584-597.
7. Cleland TA, Chen S-YT, Hozer KW, Ukatu HN, Wong KJ, Zheng F. 2012. Sequential mechanisms underlying concentration invariance in biological olfaction. Front Neuroeng. 4:1-12.
8. Cometto-Muñiz JE, Cain WS, Abraham MH. 2003. Quantification of chemical vapors in chemosensory research. Chem Senses. 28(6):467-477.
9. Cromarty SI, Derby CD. 1997. Multiple excitatory receptor types on individual olfactory neurons: implications for coding of mixtures in the spiny lobster. J Comp Physiol A. 180(5):481-491.
10. Cromarty SI, Derby CD. 1998. Inhibitory receptor binding events among the components of complex mixtures contribute to mixture suppression in responses of olfactory receptor neurons of spiny lobsters. J Comp Physiol A. 183(6):699-707.
11. de Bruyne M, Clyne PJ, Carlson JR. 1999. Odor coding in a model olfactory organ: the Drosophila maxillary palp. J Neurosci. 19:4520-4532.
12. de Bruyne M, Foster K, Carlson JR. 2001. Odor Coding in the Drosophila Antenna. Neuron. 30:537-552.
13. Dobritsa AA, van der Goes van Naters W, Warr CG, Steinbrecht RA, Carlson JR. 2003. Integrating the molecular and cellular basis of odor coding in the Drosophila antenna. Neuron. 37(5):827-841.
14. Duchamp-Viret P, Duchamp A, Chaput MA. 2003. Single olfactory sensory neurons simultaneously integrate the components of an odour mixture. Eur J Neurosci. 18(10):2690-2696.
15. French AS, Torkkeli PH, Schuckel J. 2011. Dynamic characterization of Drosophila antennal olfactory neurons indicates multiple opponent signaling pathways in odor discrimination. J Neurosci. 31(3):861-869.
16. Galizia CG, Münch D, Strauch M, Nissler A, Ma S. 2010. Integrating heterogeneous odor response data into a common response model: A DoOR to the complete olfactome. Chem Senses. 35(7):551-563.
17. Giraudet P, Berthommier F, Chaput M. 2002. Mitral cell temporal response patterns evoked by odor mixtures in the rat olfactory bulb. J Neurophysiol. 88(2):829-838.
18. Hallem EA, Carlson JR. 2006. Coding of odors by a receptor repertoire. Cell. 125(1):143-160.
19. Hallem EA, Ho MG, Carlson JR. 2004. The molecular basis of odor coding in the Drosophila antenna. Cell. 117(7):965-979.
20. Hillier NK, Vickers NJ. 2011. Mixture interactions in moth olfactory physiology: examining the effects of odorant mixture, concentration, distal stimulation, and antennal nerve transection on sensillar responses. Chem Senses. 36(1):93-108.
21. Ignell R, Root CM, Birse RT, Wang JW, Nässel DR, Winther AM. 2009. Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila. Proc Natl Acad Sci USA. 106(31):13070-13075.
22. Jinks A, Laing DG. 2001. The analysis of odor mixtures by humans: evidence for a configurational process. Physiol Behav. 72(1-2):51-63.
23. Johnson BA, Ong J, Leon M. 2010. Glomerular activity patterns evoked by natural odor objects in the rat olfactory bulb are related to patterns evoked by major odorant components. J Comp Neurol. 518(9):1542-1555.
24. Jordán MJ, Tandon K, Shaw PE, Goodner KL. 2001. Aromatic profile of aqueous banana essence and banana fruit by gas chromatographymass spectrometry (GC-MS) and gas chromatography-olfactometry (GC-O). J Agric Food Chem. 49(10):4813-4817.
25. Kang J, Caprio J. 1997. In vivo responses of single olfactory receptor neurons of channel catfish to binary mixtures of amino acids. J Neurophysiol. 77(1):1-8.
26. Knudsen JT, Tollsten L, Bergström LG. 1993. Floral scents-a checklist of volatile compounds isolated by head-space techniques. Phytochemistry. 33:253-280.
27. Kuebler LS, Olsson SB, Weniger R, Hansson BS. 2011. Neuronal processing of complex mixtures establishes a unique odor representation in the moth antennal lobe. Front Neural Circuits. 5:7.
28. Lei H, Vickers N. 2008. Central processing of natural odor mixtures in insects. J Chem Ecol. 34(7):915-927.
29. Nakai J, Ohkura M, Imoto K. 2001. A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein. Nat Biotechnol. 19(2):137-141.
30. Neubig RR, Spedding M, Kenakin T, Christopoulos A. 2003. International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacol Rev. 55(4):597-606.
31. Ochieng SA, Park KC, Baker TC. 2002. Host plant volatiles synergize responses of sex pheromone-specific olfactory receptor neurons in male Helicoverpa zea. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 188(4):325-333.
32. Oka Y, Omura M, Kataoka H, Touhara K. 2004. Olfactory receptor antagonism between odorants. EMBO J. 23(1):120-126.
33. Olsen SR, Wilson RI. 2008. Lateral presynaptic inhibition mediates gain control in an olfactory circuit. Nature. 452(7190):956-960.
34. Pelz D. 2005. Functional Characterization of Drosophila melanogaster Olfactory Receptor Neurons. Freie Universität Berlin. http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000001732.
35. Pelz D, Roeske T, Syed Z, de Bruyne M, Galizia CG. 2006. The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a). J Neurobiol. 66(14):1544-1563.
36. Reinhard J, Sinclair M, Srinivasan MV, Claudianos C. 2010. Honeybees learn odour mixtures via a selection of key odorants. PLoS ONE. 5(2):e9110.
37. Root CM, Masuyama K, Green DS, Enell LE, Nässel DR, Lee CH, Wang JW. 2008. A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron. 59(2):311-321.
38. Rospars JP, Lansky P, Chaput M, Duchamp-Viret P. 2008. Competitive and noncompetitive odorant interactions in the early neural coding of odorant mixtures. J Neurosci. 28(10):2659-2666.
39. Sachse S, Galizia CG. 2002. Role of inhibition for temporal and spatial odor representation in olfactory output neurons: a calcium imaging study. J Neurophysiol. 87(2):1106-1117.
40. Sachse S, Galizia CG. 2003. The coding of odour-intensity in the honeybee antennal lobe: local computation optimizes odour representation. Eur J Neurosci. 18(8):2119-2132.
41. Schuckel J, Torkkeli PH, French AS. 2009. Two interacting olfactory transduction mechanisms have linked polarities and dynamics in Drosophila melanogaster antennal basiconic sensilla neurons. J Neurophysiol. 102(1):214-223.
42. Silbering AF, Galizia CG. 2007. Processing of odor mixtures in the Drosophila antennal lobe reveals both global inhibition and glomerulus-specific interactions. J Neurosci. 27(44):11966-11977.
43. Stensmyr MC, Giordano E, Balloi A, Angioy AM, Hansson BS. 2003. Novel natural ligands for Drosophila olfactory receptor neurones. J Exp Biol. 206:715-724.
44. Su CY, Menuz K, Reisert J, Carlson JR. 2012. Non-synaptic inhibition between grouped neurons in an olfactory circuit. Nature. 492(7427):66-71.
45. Tabor R, Yaksi E, Weislogel JM, Friedrich RW. 2004. Processing of odor mixtures in the zebrafish olfactory bulb. J Neurosci. 24(29):6611-6620.
46. Turner SL, Ray A. 2009. Modification of CO2 avoidance behaviour in Drosophila by inhibitory odorants. Nature. 461(7261):277-281.
47. Uchida N, Mainen ZF. 2007. Odor concentration invariance by chemical ratio coding. Front Syst Neurosci. 1:3.
48. Vermeulen A, Rospars JP. 2004. Why are insect olfactory receptor neurons grouped into sensilla? The teachings of a model investigating the effects of the electrical interaction between neurons on the transepithelial potential and the neuronal transmembrane potential. Eur Biophys J. 33(7):633-643.
49. Wang JW, Wong AM, Flores J, Vosshall LB, Axel R. 2003. Two-photon calcium imaging reveals an odor-evoked map of activity in the fly brain. Cell. 112(2):271-282.