Single olfactory sensory neurons simultaneously integrate the components of an odour mixture

European Journal of Neuroscience

Volumn 18, Issue 10, 2003, Pages 2690-2696

  Duchamp Viret, Patricia ^a   Duchamp, André ^a   Chaput, Michel A ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

In vivo single unit recordings; Odour coding; Odour concentration; Odour mixture; Olfaction; Olfactory sensory neurons; Rat

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; NONHUMAN; ODOR; OLFACTORY DISCRIMINATION; OLFACTORY NERVE; OLFACTORY SYSTEM; PERCEPTION; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION;

ACTION POTENTIALS; ANIMALS; CAMPHOR; CYCLIC AMP; CYCLOHEXANOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; MONOTERPENES; NEURAL INHIBITION; NITRILES; ODORS; OLFACTORY BULB; OLFACTORY RECEPTOR NEURONS; PHOSPHORIC MONOESTER HYDROLASES; RATS; RATS, WISTAR; SMELL; STIMULATION, CHEMICAL;

EID: 0346120428     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2003.03001.x     Document Type: Article

References (43)

1. Ache, B. (1994) Towards a common strategy for transducing olfactory information. Semin. Cell. Biol., 5, 55-63.
2. Bell, G.A., Laing, D.G. & Panhuber, H. (1987) Odour mixture suppression: evidence for a peripheral mechanism in human and rat. Brain Res., 426, 8-18.
3. Breer, H. & Boekhoff, I. (1991) Odorants of the same odor class activate different 2nd messenger pathways. Chem. Senses, 16, 19-29.
4. Buck, L. & Axel, R. (1991) A novel multigene family may encode odorant receptors - a molecular basis for odor recognition. Cell, 65, 175-187.
5. Burgess, M., Olson, K., Derby, C. & Daniel, P. (1994) Relationship between inhibition of odorant-receptor binding and physiological binary mixture interactions for glutamate, taurine and 5′AMP receptors in the olfactory organ of the spiny lobster. Chem. Senses, 19, 448.
6. Chen, S., Lane, A.P., Bock, R., Leinders-Zufall, T. & Zufall, F. (2000) Blocking adenylyl cyclase inhibits olfactory generator currents induced by 'IP (3)-odors'. J. Neurophysiol., 84, 575-580.
7. Chess, A., Buck, L., Dowling, M.M., Axel, R. & Ngai, J. (1992) Molecular biology of smell - expression of the multigene family encoding putative odorant receptors. Cold Spring Harbor Symposia Quantitative Biol., 57, 505-516.
8. Cometto-Muniz, J.E., Cain, W.S., Abraham, M.H. & Gola, J.M. (1999) Chemosensory detectability of 1-butanol and 2-heptanone singly and in binary mixtures. Physiol. Behav., 67, 269-276.
9. Cromarty, S.I. & Derby, C.D. (1997) Multiple excitatory receptor types on individual olfactory neurons: implications for coding of mixtures in the spiny lobster. J. Comp. Physiol. [a], 180, 481-491.
10. Cromarty, S.I. & Derby, C.D. (1998) Inhibitory receptor binding events among the components of complex mixtures contribute to mixture suppression in responses of olfactory receptor neurons of spiny lobsters. J. Comp. Physiol. [a] Sensory Neural Behav. Physiol., 183, 699-707.
11. Daniel, P.C., Burgess, M.F. & Derby, C.D. (1996) Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable using a noncompetitive model that incorporates excitatory and inhibitory transduction pathways. J. Comp Physiol. [a], 178, 523-536.
12. Derby, C.D. (2000) Learning from spiny lobsters about chemosensory coding of mixtures. Physiol. Behav., 69, 203-209.
13. Duchamp-Viret, P. (1988) Le codage intensitif du stimulus olfactif: rôle des neurorécepteurs et de deutoneurones, étude électrophysiologique chez la grenouille. PhD Thesis. Université Claude Bernard, Lyon, France.
14. Duchamp-Viret, P., Chaput, M.A. & Duchamp, A. (1999) Odor response properties of rat olfactory receptor neurons. Science, 284, 2171-2174.
15. Duchamp-Viret, P. & Duchamp, A. (1997) Odor processing in the frog olfactory system. Prog. Neurobiol., 53, 561-602.
16. Duchamp-Viret, P., Duchamp, A. & Chaput, M.A. (2000) Peripheral odor coding in the rat and frog: Quality and intensity specification. J. Neurosci., 20, 2383-2390.
17. Duchamp-Viret, P., Duchamp, A. & Vigouroux, M. (1989) Amplifying role of convergence in olfactory system. A comparative study of receptor cell and second order neuron sensitivities. J. Neurophysiol., 61, 1085-1094.
18. Fadool, D.A. & Ache, B.W. (1992) Plasma membrane inositol 1,4,5-trisphosphate-activated channels mediate signal transduction in lobster olfactory receptor neurons. Neuron, 9, 907-918.
19. Firestein, S. & Shepherd, G.M. (1991) A kinetic model of the odor response in single olfactory receptor neurons. J. Steroid Biochem. Mol. Biol., 39, 615-620.
20. Gold, G.H. (1999) Controversial issues in vertebrate olfactory transduction. Annu. Rev. Physiol., 61, 857-871.
21. Hatt, H. & Ache, B.W. (1994) Cyclic nucleotide-and inositol phosphate-gated ion channels in lobster olfactory receptor neurons. Proc. Natl Acad. Sci. USA, 91, 6264-6268.
22. Jinks, A., Laing, D.G. & Hutchinson, I. (2001) A psychophysical study of the relationship between temporal processing in odor mixtures and transduction pathways. Brain Res. Cogn. Brain Res., 12, 273-288.
23. Kajiya, K., Inaki, K., Tanaka, M., Haga, T., Kataoka, H. & Touhara, K. (2001) Molecular bases of odor discrimination: Reconstitution of olfactory receptors that recognize overlapping sets of odorants. J. Neurosci., 21, 6018-6025.
24. Kang, J. & Caprio, J. (1997) In vivo responses of single olfactory receptor neurons of channel catfish to binary mixtures of amino acids. J. Neurophysiol., 77, 1-8.
25. Kishimoto, J., Cox, H., Keverne, E.B. & Emson, P.C. (1994) Cellular localization of putative odorant receptor mRNAs in olfactory and chemosensory neurons: a non radioactive in situ hybridization study. Mol. Brain Res., 23, 33-39.
26. Kurahashi, T., Lowe, G. & Gold, G.H. (1994) Suppression of odorant responses by odorants in olfactory receptor cells. Science, 265, 118-120.
27. Laing, D.G., Panhuber, H. & Slotnick, B.M. (1989) Odor masking in the rat. Physiol. Behav., 45, 689-694.
28. Laing, D.G., Panhuber, H., Willcox, M.E. & Pittman, E.A. (1984) Quality and intensity of binary odor mixtures. Physiol. Behav., 33, 309-319.
29. Laska, M. & Hudson, R. (1993) Discriminating parts from the whole - determinants of odor mixture perception in squirrel monkeys, Saimirisciureus. J. Comp. Physiol. [a] - Sensory Neural Behav. Physiol., 173, 249-256.
30. Malnic, B., Hirono, J., Sato, T. & Buck, L.B. (1999) Combinatorial receptor codes for odors. Cell, 96, 713-723.
31. McClintock, T.S. & Ache, B.W. (1989) Hyperpolarizing receptor potentials in lobster olfactory receptor cells - implications for transduction and mixture suppression. Chem. Senses, 14, 637-647.
32. Michel, W.C. & Ache, B.W. (1992) Cyclic nucleotides mediate an odor-evoked potassium conductance in lobster olfactory receptor cells. J. Neurosci., 12, 3979-3984.
33. Michel, W.C. & Ache, B.W. (1994) Odor-evoked inhibition in primary olfactory receptor neurons. Chem. Senses, 19, 11-24.
34. Michel, W.C., McClintock, T.S. & Ache, B.W. (1991) Inhibition of lobster olfactory receptor cells by an odor-activated potassium conductance. J. Neurophysiol., 65, 446-453.
35. Ngai, J., Chess, A., Dowling, M.M. & Axel, R. (1993) Expression of odorant receptor genes in the catfish olfactory epithelium. Chem. Senses, 18, 209-216.
36. Noe, J. & Breer, H. (1998) Functional and molecular characterization of individual olfactory neurons. J. Neurochem., 71, 2286-2293.
37. Olson, K.S. & Derby, C.D. (1995) Inhibition of taurine and 5′AMP olfactory receptor sites of the spiny lobster Panulirus argus by odorant compounds and mixtures. J. Comp. Physiol. [a], 176, 527-540.
38. Sklar, P.B., Anholt, R.R.H. & Snyder, S.H. (1986) The odorant-sensitive adenylate cyclase of olfactory receptor cells. J. Biol. Chem., 261, 15538-15543.
39. Spehr, M., Wetzel, C.H., Hatt, H. & Ache, B.W. (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron, 33, 731-739.
40. Touhara, K. (2002) Odor discrimination by G protein-coupled olfactory receptors. Microscopy Res. Technique, 58, 135-141.
41. Touhara, K., Sengoku, S., Inaki, K., Tsuboi, A., Hirono, J., Sato, T., Sakano, H. & Haga, T. (1999) Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc. Natl Acad. Sci. USA, 96, 4040-4045.
42. Vigouroux, M., Viret, P. & Duchamp, A. (1988) A wide concentration range olfactometer for delivery of short reproducible odor pulses. J. Neurosci. Meth, 24, 57-63.
43. Wong, S.T., Trinh, K., Hacker, B., Chan, G.C., Lowe, G., Gaggar, A., Xia, Z., Gold, G.H. & Storm, D.R. (2000) Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron, 27, 487-497.