Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells

Journal of Lipid Research

Volumn 54, Issue 5, 2013, Pages 1457-1465

  Martin, Maria Laura ^a   Liebisch, Gerhard ^b   Lehneis, Stefan ^b   Schmitz, Gerd ^b   Alonso Sande, María ^a   Bestard Escalas, Joan ^a   Lopez, Daniel H ^a   García Verdugo, José Manuel ^c   Soriano Navarro, Mario ^c   Busquets, Xavier ^a   Escribá, Pablo V ^a   Barceló Coblijn, Gwendolyn ^a  

^a Department of Biology   (Spain)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Antitumor drug; Mass spectroscopy; Sphingolipid metabolism

Indexed keywords

2 HYDROXYOLEIC ACID; CELL ENZYME; CERAMIDE DERIVATIVE; CERAMIDE HEXOSIDE; DIHYDROSPHINGOMYELIN; LACTOSYLCERAMIDE; MESSENGER RNA; PHOSPHOLIPID; RICINOLEIC ACID; SPHINGANINE; SPHINGOLIPID; SPHINGOMYELIN SYNTHASE; SPHINGOSINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER MORPHOLOGY; CELL VIABILITY; CERAMIDE S1 GENE; CERAMIDE S5 GENE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; GENE; GENE EXPRESSION REGULATION; GLIOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID COMPOSITION; LIPID METABOLISM; LIPIDOSIS; LYSOSOME; MASS SPECTROMETRY; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL;

CELL LINE, TUMOR; CELL SURVIVAL; CERAMIDES; GLIOMA; HUMANS; OLEIC ACIDS; SPHINGOLIPIDOSES; SPHINGOLIPIDS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 84876816072     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M036749     Document Type: Article

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