A gene variation (rs12691) in the CCAT/enhancer binding protein α modulates glucose metabolism in metabolic syndrome

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 23, Issue 5, 2013, Pages 417-423

  Delgado Lista, J ^a,b   Perez Martinez, P ^a,b   Garcia Rios, A ^a,b   Phillips, C M ^c   Hall, W ^d   Gjelstad, I M F ^e,f   Lairon, D ^g   Saris, W ^h   Kiec Wilk B ⁱ   Karlstrom B ^j   Drevon, C A ^e   Defoort, C ^g   Blaak, E E ^h   Dembinska Kiec A ⁱ   Riserus U ^j   Lovegrove, J A ^d   Roche, H M ^c   Lopez Miranda, J ^a,b  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d UNIVERSITY OF READING   (United Kingdom)

^e UNIVERSITY OF OSLO   (Norway)

^f AKER UNIVERSITY HOSPITAL   (Norway)

^g INSERM   (France)

^h MAASTRICHT UNIVERSITY   (Netherlands)

ⁱ JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^j UPPSALA UNIVERSITY   (Sweden)

more..

Author keywords

C EBP ; CEBP ; Insulin resistance; Insulin secretion; Metabolic syndrome

Indexed keywords

ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, HUMAN; DNA; FATTY ACID; INSULIN; LEPTIN; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; RESISTIN; TRIACYLGLYCEROL;

ADULT; AGED; ALLELE; ARTICLE; BLOOD; BODY MASS; BODY WEIGHT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; FAT INTAKE; FEMALE; GENETICS; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; INTERVENTION STUDY; ISOLATION AND PURIFICATION; LIPID METABOLISM; MALE; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; SECRETION (PROCESS); SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONECTIN; ADULT; AGED; ALLELES; BLOOD GLUCOSE; BODY MASS INDEX; BODY WEIGHT; CCAAT-ENHANCER-BINDING PROTEINS; DIETARY FATS; DIETARY SUPPLEMENTS; DNA; FASTING; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, OMEGA-3; FEMALE; GENOTYPE; HUMANS; INSULIN; INSULIN RESISTANCE; INTERVENTION STUDIES; LEPTIN; LIPID METABOLISM; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RESISTIN; TRIGLYCERIDES;

EID: 84876815223     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2011.09.008     Document Type: Article

References (40)

1. Shaw D.I., Hall W.L., Williams C.M. Metabolic syndrome: what is it and what are the implications?. Proc Nutr Soc 2005, 64:349-357.
2. Alberti K.G., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645.
3. Sundstrom J., Riserus U., Byberg L., Zethelius B., Lithell H., Lind L. Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ 2006, 332:878-882.
4. Mottillo S., Filion K.B., Genest J., Joseph L., Pilote L., Poirier P., et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010, 56:1113-1132.
5. Sattar N., Gaw A., Scherbakova O., Ford I., O'Reilly D.S., Haffner S.M., et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland coronary prevention study. Circulation 2003, 108:414-419.
6. Roche H.M., Phillips C., Gibney M.J. The metabolic syndrome: the crossroads of diet and genetics. Proc Nutr Soc 2005, 64:371-377.
7. Phillips C., Lopez-Miranda J., Perez-Jimenez F., McManus R., Roche H.M. Genetic and nutrient determinants of the metabolic syndrome. Curr Opin Cardiol 2006, 21:185-193.
8. Warensjo E., Riserus U., Vessby B. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. Diabetologia 2005, 48:1999-2005.
9. Zabaneh D., Balding D.J. A genome-wide association study of the metabolic syndrome in Indian Asian men. PLoS One 2010, 5:e11961.
10. Delgado-Lista J., Perez-Martinez P., Garcia-Rios A., Phillips C.M., Williams C.M., Gulseth H.L., et al. Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study. Atherosclerosis 2011, 214:110-116.
11. Bennett C.E., Nsengimana J., Bostock J.A., Cymbalista C., Futers T.S., Knight B.L., et al. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the leeds family study. Diab Vasc Dis Res 2010, 7:195-203.
12. El-Jack A.K., Hamm J.K., Pilch P.F., Farmer S.R. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha. J Biol Chem 1999, 274:7946-7951.
13. Olofsson L.E., Orho-Melander M., William-Olsson L., Sjoholm K., Sjostrom L., Groop L., et al. CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides. J Clin Endocrinol Metab 2008, 93:4880-4886.
14. Tan E.H., Hooi S.C., Laban M., Wong E., Ponniah S., Wee A., et al. CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. Cancer Res 2005, 65:10330-10337.
15. Bacher U., Schnittger S., Haferlach T. Molecular genetics in acute myeloid leukemia. Curr Opin Oncol 2010, 22:646-655.
16. Reckzeh K., Cammenga J. Molecular mechanisms underlying deregulation of C/EBPalpha in acute myeloid leukemia. Int J Hematol 2010, 91:557-568.
17. Gregoire F.M. Adipocyte differentiation: from fibroblast to endocrine cell. Exp Biol Med (Maywood) 2001, 226:997-1002.
18. Barb C.R., Hausman G.J., Houseknecht K.L. Biology of leptin in the pig. Domest Anim Endocrinol 2001, 21:297-317.
19. Galic S., Oakhill J.S., Steinberg G.R. Adipose tissue as an endocrine organ. Mol Cell Endocrinol 2010, 316:129-139.
20. Rosen E.D., MacDougald O.A. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 2006, 7:885-896.
21. Perez-Martinez P., Lopez-Miranda J., Cruz-Teno C., Delgado-Lista J., Jimenez-Gomez Y., Fernandez J.M., et al. Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men. J Nutr 2008, 138:1609-1614.
22. Lopez-Miranda J., Perez-Martinez P., Marin C., Fuentes F., Delgado J., Perez-Jimenez F. Dietary fat, genes and insulin sensitivity. J Mol Med 2007, 85:213-226.
23. Ferguson J.F., Phillips C.M., Tierney A.C., Perez-Martinez P., Defoort C., Helal O., et al. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr 2010, 91:794-801.
24. Perez-Martinez P., Moreno-Conde M., Cruz-Teno C., Ruano J., Fuentes F., Delgado-Lista J., et al. Dietary fat differentially influences regulatory endothelial function during the postprandial state in patients with metabolic syndrome: from the LIPGENE study. Atherosclerosis 2010, 209:533-538.
25. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Jama 2001, 285:2486-2497.
26. Shaw D.I., Tierney A.C., McCarthy S., Upritchard J., Vermunt S., Gulseth H.L., et al. LIPGENE food-exchange model for alteration of dietary fat quantity and quality in free-living participants from eight European countries. Br J Nutr 2009, 101:750-759.
27. Mancia G., De Backer G., Dominiczak A., Cifkova R., Fagard R., Germano G., et al. 2007 ESH-ESC practice guidelines for the management of arterial hypertension: ESH-ESC task force on the management of arterial hypertension. J Hypertension 2007, 25:1751-1762.
28. Gulseth H.L., Gjelstad I.M., Tierney A.C., Lovegrove J., Defoort C., Blaak E.E., et al. Serum Vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome. Diabetes Care 2010, 33:923-925.
29. Ramji D.P., Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J 2002, 365:561-575.
30. Friedman A.D., Keefer J.R., Kummalue T., Liu H., Wang Q.F., Cleaves R. Regulation of granulocyte and monocyte differentiation by CCAAT/enhancer binding protein alpha. Blood Cells Mol Dis 2003, 31:338-341.
31. Faiola F., Wu Y.T., Pan S., Zhang K., Farina A., Martinez E. Max is acetylated by p300 at several nuclear localization residues. Biochem J 2007, 403:397-407.
32. Huang M.J., Cheng Y.C., Liu C.R., Lin S., Liu H.E. A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp Hematol 2006, 34:1480-1489.
33. Hurlin P.J., Huang J. The MAX-interacting transcription factor network. Semin Cancer Biol 2006, 16:265-274.
34. Kasper L.H., Boussouar F., Ney P.A., Jackson C.W., Rehg J., van Deursen J.M., et al. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 2002, 419:738-743.
35. Kong S., Kim S.J., Sandal B., Lee S.M., Gao B., Zhang D.D., et al. The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation. J Biol Chem 2011, 286:16967-16975.
36. Pasqualucci L., Dominguez-Sola D., Chiarenza A., Fabbri G., Grunn A., Trifonov V., et al. Inactivating mutations of acetyl transferase genes in B-cell lymphoma. Nature 2011, 471:189-195.
37. Tomkin G.H. Atherosclerosis, diabetes and lipoproteins. Expert Rev Cardiovasc Ther 2010, 8:1015-1029.
38. Qiao L., Zou C., Shao P., Schaack J., Johnson P.F., Shao J. Transcriptional regulation of fatty acid translocase/CD36 expression by CCAAT/enhancer-binding protein alpha. J Biol Chem 2008, 283:8788-8795.
39. Qiao L., MacLean P.S., You H., Schaack J., Shao J. knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology 2006, 147:3060-3069.
40. Wei E., Lehner R., Vance D.E. C/EBPalpha activates the transcription of triacylglycerol hydrolase in 3T3-L1 adipocytes. Biochem J 2005, 388:959-966.