Extract of Scutellaria baicalensis inhibits dengue virus replication

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Zandi, Keivan ^a   Lim, Tong Hye ^b   Rahim, Nor Aziyah ^a   Shu, Meng Hooi ^a   Teoh, Boon Teong ^a   Sam, Sing Sin ^a   Danlami, Mohammed Bashar ^a   Tan, Kim Kee ^a   Abubakar, Sazaly ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b Herbitec Sendirian Berhad ^*  (Malaysia)

Author keywords

Antiviral; Baicalein; Dengue; Flavonoids; Infectious disease; Scultellaria baicalensis

Indexed keywords

ANTIVIRUS AGENT; BAICALEIN; SCUTELLARIA BAICALENSIS EXTRACT; VIRUS RNA;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; COPY NUMBER VARIATION; CYTOTOXICITY; DENGUE; DENGUE VIRUS; DENGUE VIRUS 1; DENGUE VIRUS 2; DENGUE VIRUS 3; DENGUE VIRUS 4; IC 50; IN VITRO STUDY; MASS SPECTROMETRY; MICROWAVE RADIATION; NONHUMAN; PLANT ROOT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCUTELLARIA BAICALENSIS; VIRUS ATTACHMENT; VIRUS PARTICLE; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DENGUE; DENGUE VIRUS; HUMANS; PLANT EXTRACTS; SCUTELLARIA BAICALENSIS; VIRUS REPLICATION;

EID: 84876809800     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-91     Document Type: Article

References (33)

1. Tang LI, Ling AP, Koh RY, Chye SM, Voon KG. Screening of anti-dengue activity in methanolic extracts of medicinal plants. BMC Complement Altern Med. 2012, 12:3. 10.1186/1472-6882-12-3, 3269354, 22244370.
2. Zandi K, Ramedani E, Mohammadi K, Tajbakhsh S, Deilami I, Rastian Z, Fouladvand M, Yousefi F, Farshadpour F. Evaluation of antiviral activities of curcumin derivatives against HSV-1 in Vero cell line. Nat Prod Commun. 2010, 5:1935-1938.
3. Astani A, Reichling J, Schnitzler P. Screening for antiviral activities of isolated compounds from essential oils. Evid Based Complement Altern Med 2011, 2011:253643.
4. Han H, He W, Wang W, Gao B. Inhibitory effect of aqueous dandelion extract on HIV-1 replication and reverse transcriptase activity. BMC Complement Alternat Med. 2011, 11:112.
5. He W, Han H, Wang W, Gao B. Anti-influenza virus effect of aqueous extracts from dandelion. Virol J. 2011, 8:538. 10.1186/1743-422X-8-538, 3265450, 22168277.
6. Li J, Huang H, Feng M, Zhou W, shi X, Zhou P. In vitro and in vivo anti-hepatitis B virus activities of a plant extract from Geranium carolinianum L. Antiviral Res. 2008, 79:114-120. 10.1016/j.antiviral.2008.03.001, 18423640.
7. Yang Y, Zhang L, Fan X, Qin C, Liu J. Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo. Bioorg Med Chem Lett. 2012, 22:2209-2211. 10.1016/j.bmcl.2012.01.102, 22342145.
8. Hudson JB. Applications of the phytomedicine Echinacea purpurea (purple coneflower) in infectious diseases. J Biomed Biotechnol 2012, 2012:769896. 3205674, 22131823.
9. Chen L, Dou J, Su Z, Zhou H, Wang H, Zhou W, Guo Q, Zhou C. Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res. 2011, 91:314-320. 10.1016/j.antiviral.2011.07.008, 21782851.
10. Chingwaru W, Majinda RT, Yeboah SO, Jackson JC, Kapewangolo PT, Kandawa-Schulz M, Cencic A. Tylosema esculentum (Marama) tuber and bean extracts are strong antiviral agents against rotavirus infection. Evid Based Complement Alternat Med. 2011, 2011:284795. 3057194, 21423688.
11. Ge H, Wang YF, Xu J, Gu Q, Liu HB, Xiao PG, Zhou J, Liu Y, Yang Z, Su H. Anti-influenza agents from traditional Chinese medicine. Nat Prod Rep. 2010, 27:1758-1780. 10.1039/c0np00005a, 20941447.
12. An X, Zhang AL, May BH, Lin L, Xu Y, Xue CC. Oral Chinese herbal medicine for improvement of quality of life in patients with stable chronic obstructive pulmonary disease: a systematic review. J Alternat Complement Med. 2012, 18:731-743.
13. Scheck AC, Perry K, Hank NC, Clark WD. Anticancer activity of extracts derived from the mature roots of S. baicalensis on human malignant brain tumor cells. BMC Complement Alternat Med 2006, 16:27.
14. Zhang N, Van Crombruggen K, Holtappels G, Bachert C. A herbal composition of S. Baicalensis and eleutherococcus senticosus shows potent anti-inflammatory effects in an Ex vivo human mucosal tissue model. Evid Based Complement Alternat Med 2012, 2012:673145. 3261630, 22272213.
15. Li HB, Chen F, Chen F. Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant S. baicalensis by high-speed counter-current chromatography. J Chromatogr A 2005, 1074:107-110. 10.1016/j.chroma.2005.03.088, 15941045.
16. Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR, Abubakar S. In vitro antiviral activity of fisetin, rutin and naringenin against dengue virus type-2. J Med Plants Res. 2011, 5:5534-5539.
17. Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR, Abubakar S. Antiviral activity of four types of bioflavonoid against dengue virus type-2. Virol J. 2011, 8:560. 10.1186/1743-422X-8-560, 3271998, 22201648.
18. Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR, Abubakar S. Novel antiviral activity of baicalein against dengue virus. BMC Complement Alternat Med. 2012, 12:3.
19. Gubler DJ. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002, 10:100-103. 10.1016/S0966-842X(01)02288-0, 11827812.
20. Kuno G. Research on dengue and dengue-like illness in east Asia and the western pacific during the first half of the 20th century. Rev Med Virol. 2007, 17:327-341. 10.1002/rmv.545, 17562529.
21. Che P, Wang L, Li Q. The development, optimization and validation of an assay for high throughput antiviral drug screening against Dengue virus. Int J Clin Exp Med 2009, 2:363-373. 2802053, 20057980.
22. Zandi K, Lani R, Wong PF, Teoh BT, Sam SS, Johari J, Mustafa MR, AbuBakar S. Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in Vero cells. Molecules. 2012, 17:2437-2445. 10.3390/molecules17032437, 22374315.
23. Wong SS, Abd-Jamil J, Abubakar S. Antibody neutralization and viral virulence in recurring dengue virus type 2 outbreaks. Viral Immunol. 2007, 20:359-368. 10.1089/vim.2006.0100, 17931106.
24. Nagai T, Suzuki Y, Tomimori T, Yamada H. Antiviral activity of plant flavonoid, 5,7,4'-trihydroxy-8-methoxyflavone, from the roots of S. baicalensis against influenza A (H3N2) and B viruses. Biol Pharm Bull 1995, 18:295-299. 10.1248/bpb.18.295, 7742801.
25. Yu K, Gong Y, Lin Z, Cheng Y. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of S. baicalensis Georgi using capillary electrophoresis. J Pharm Biomed Anal 2007, 43:540-548. 10.1016/j.jpba.2006.08.011, 16989969.
26. Burnett BP, Jia Q, Zhao Y, Levy RM. A medicinal extract of Scutellari abaicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food. 2007, 10:442-451. 10.1089/jmf.2006.255, 17887937.
27. Lu Y, Joerger R, Wu C. Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of S. baicalensis Georgi. J Agric Food Chem 2011, 59:10934-10942. 10.1021/jf202741x, 21866919.
28. Nagai T, Moriguchi R, Suzuki Y, Tomimori T, Yamada H. Mode of action of the anti-influenza virus activity of plant flavonoid, 5,7,4'-trihydroxy-8-methoxyflavone, from the roots of Scutellaria baicalensis. Antiviral Res. 1995, 26:11-25. 10.1016/0166-3542(94)00062-D, 7741518.
29. Kiat TS, Pippen R, Yusof R, Ibrahim H, Khalid N, Rahman NA. Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease. Bioorg Med Chem Lett 2006, 16:3337-3340. 10.1016/j.bmcl.2005.12.075, 16621533.
30. Ahn HC, Lee SY, Kim JW, Son WS, Shin CG, Lee BJ. Binding aspects of baicalein to HIV-1 integrase. Mol Cells. 2001, 12:127-130.
31. Shinozuka K, Kikuchi Y, Nishino C, Mori A, Tawata S. Inhibitory effect of flavonoids on DNA-dependent DNA and RNA polymerases. Experientia. 1998, 44:882-885.
32. Nafisi S, Shadaloi A, Feizbakhsh A, Tajmir-Riahi HA. RNA binding to antioxidant flavonoids. J Photochem Photobiol B. 2009, 94:1-7. 10.1016/j.jphotobiol.2008.08.001, 18922698.
33. Sun Y, Bi S, Song D, Qiao C, Mu D, Zhang H. Study on the interaction mechanism between DNA and the main active components in S. baicalensis Georgi. Sensor Actuat B 2008, 129:799-810.