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Volumn 154, Issue 5, 2013, Pages 1701-1710

Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; INSULIN RECEPTOR; PICROPODOPHYLLIN; S 961; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

EID: 84876778343     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-2263     Document Type: Article
Times cited : (23)

References (60)
  • 3
    • 2942520997 scopus 로고    scopus 로고
    • Diabetes mellitus as a predictor of cancer mortality in a large cohort of us adults
    • Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol. 2004;159:1160-1167.
    • (2004) Am J Epidemiol , vol.159 , pp. 1160-1167
    • Coughlin, S.S.1    Calle, E.E.2    Teras, L.R.3    Petrelli, J.4    Thun, M.J.5
  • 4
    • 79951991748 scopus 로고    scopus 로고
    • Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer
    • Erickson K, Patterson RE, Flatt SW, et al. Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. J Clin Oncol. 2011;29:54-60.
    • (2011) J Clin Oncol , vol.29 , pp. 54-60
    • Erickson, K.1    Patterson, R.E.2    Flatt, S.W.3
  • 5
    • 79951960884 scopus 로고    scopus 로고
    • Diabetes mellitus and breast cancer outcomes: A systematic review and meta-Analysis
    • Peairs KS, Barone BB, Snyder CF, et al. Diabetes mellitus and breast cancer outcomes: a systematic review and meta-Analysis. J Clin Oncol. 2011;29:40-46.
    • (2011) J Clin Oncol , vol.29 , pp. 40-46
    • Peairs, K.S.1    Barone, B.B.2    Snyder, C.F.3
  • 6
    • 84870244963 scopus 로고    scopus 로고
    • Epidemiological evidence of a relationship between type-1 diabetes mellitus and cancer: A review of the existing literature
    • Gordon-Dseagu VL, Shelton N, Mindell JS. Epidemiological evidence of a relationship between type-1 diabetes mellitus and cancer: a review of the existing literature. Int J Cancer. 2013;132:501-508.
    • (2013) Int J Cancer , vol.132 , pp. 501-508
    • Gordon-Dseagu, V.L.1    Shelton, N.2    Mindell, J.S.3
  • 7
    • 0030871903 scopus 로고    scopus 로고
    • Cancer and diabetes -A follow-up study of two population-based cohorts of diabetic patients
    • Hjalgrim H, Frisch M, Ekbom A, Kyvik K, Melbye M, Green A. Cancer and diabetes -A follow-up study of two population-based cohorts of diabetic patients. J Int Med. 1997;241:471-475.
    • (1997) J Int Med , vol.241 , pp. 471-475
    • Hjalgrim, H.1    Frisch, M.2    Ekbom, A.3    Kyvik, K.4    Melbye, M.5    Green, A.6
  • 8
    • 77954249988 scopus 로고    scopus 로고
    • Cancer risk among patients hospitalized for type 1 diabetes mellitus: A population-based cohort study in sweden
    • Shu X, Ji J, Li X, Sundquist J, Sundquist K, Hemminki K. Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population-based cohort study in Sweden. Diabet Med. 2010;27:791-797.
    • (2010) Diabet Med , vol.27 , pp. 791-797
    • Shu, X.1    Ji, J.2    Li, X.3    Sundquist, J.4    Sundquist, K.5    Hemminki, K.6
  • 10
    • 3242746896 scopus 로고    scopus 로고
    • Hyperinsulinaemia and increased risk of breast cancer: Findings from the british women's heart and health study
    • Lawlor DA, Smith GD, Ebrahim S. Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study. Cancer Causes Control. 2004;15:267-275.
    • (2004) Cancer Causes Control , vol.15 , pp. 267-275
    • Lawlor, D.A.1    Smith, G.D.2    Ebrahim, S.3
  • 11
    • 84855426420 scopus 로고    scopus 로고
    • Hyperinsulinemia enhances c-myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes
    • Ferguson RD, Novosyadlyy R, Fierz Y, et al. Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes. Breast Cancer Res. 2012;14:R8.
    • (2012) Breast Cancer Res , vol.14
    • Ferguson, R.D.1    Novosyadlyy, R.2    Fierz, Y.3
  • 12
    • 0028969852 scopus 로고
    • Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin
    • WuX, Fan Z, Masui H, Rosen N, Mendelsohn J. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest. 1995;95:1897.
    • (1995) J Clin Invest , vol.95 , pp. 1897
    • WuX Fan, Z.1    Masui, H.2    Rosen, N.3    Mendelsohn, J.4
  • 13
    • 0033304934 scopus 로고    scopus 로고
    • The insulinrelated ovarian regulatory system in health and disease
    • Poretsky L, Cataldo NA, Rosenwaks Z, Giudice LC. The insulinrelated ovarian regulatory system in health and disease. Endocrine Rev. 1999;20:535-582.
    • (1999) Endocrine Rev , vol.20 , pp. 535-582
    • Poretsky, L.1    Cataldo, N.A.2    Rosenwaks, Z.3    Giudice, L.C.4
  • 14
    • 0031919552 scopus 로고    scopus 로고
    • Insulin signal transduction through protein kinase cascades
    • Avruch J. Insulin signal transduction through protein kinase cascades. Mol Cell Biochem. 1998;182:31-48.
    • (1998) Mol Cell Biochem , vol.182 , pp. 31-48
    • Avruch, J.1
  • 15
    • 0036550234 scopus 로고    scopus 로고
    • Signalling through igf-i and insulin receptors: Where is the specificity?
    • Kim JJ, Accili D. Signalling through IGF-I and insulin receptors: where is the specificity? Growth Horm IGF Res. 2002;12:84-90.
    • (2002) Growth Horm IGF Res , vol.12 , pp. 84-90
    • Kim, J.J.1    Accili, D.2
  • 17
    • 77957241580 scopus 로고    scopus 로고
    • The proliferating role of insulin and insulin-like growth factors in cancer
    • Gallagher EJ, LeRoith D. The proliferating role of insulin and insulin-like growth factors in cancer. Trends Endocrinol Metab. 2010; 21:610.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 610
    • Gallagher, E.J.1    LeRoith, D.2
  • 20
    • 76549136489 scopus 로고    scopus 로고
    • Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes
    • Novosyadlyy R, Lann DE, Vijayakumar A, et al. Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Res. 2010;70:741-751.
    • (2010) Cancer Res , vol.70 , pp. 741-751
    • Novosyadlyy, R.1    Lann, D.E.2    Vijayakumar, A.3
  • 21
    • 84863727860 scopus 로고    scopus 로고
    • Inhibiting pi3k reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia
    • Gallagher E, Fierz Y, Vijayakumar A, Haddad N, Yakar S, LeRoith D. Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia. Oncogene. 2012;31:3213-3222.
    • (2012) Oncogene , vol.31
    • Gallagher, E.1    Fierz, Y.2    Vijayakumar, A.3    Haddad, N.4    Yakar, S.5    LeRoith, D.6
  • 22
    • 7444250290 scopus 로고    scopus 로고
    • Mutation of the pik3ca gene in ovarian and breast cancer
    • Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res. 2004;64: 7678-7681.
    • (2004) Cancer Res , vol.64 , pp. 7678-7681
    • Campbell, I.G.1    Russell, S.E.2    Choong, D.Y.3
  • 23
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase akt pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 24
    • 84865585349 scopus 로고    scopus 로고
    • Identification of common and distinctive mechanisms of resistance to different anti-igf-ir agents in ewing's sarcoma
    • Garofalo C, Mancarella C, Grilli A, et al. Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma. Mol Endocrinol. 2012;26:1603-1616.
    • (2012) Mol Endocrinol , vol.26
    • Garofalo, C.1    Mancarella, C.2    Grilli, A.3
  • 25
    • 77953973648 scopus 로고    scopus 로고
    • Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to igf-1r targeted therapy
    • Ulanet DB, Ludwig DL, Kahn CR, Hanahan D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci. 2010;107:10791-10798.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 10791-10798
    • Ulanet, D.B.1    Ludwig, D.L.2    Kahn, C.R.3    Hanahan, D.4
  • 26
    • 43349088787 scopus 로고    scopus 로고
    • Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer
    • Yuen JSP, Macaulay VM. Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer. Expert Opin Ther Targets. 2008;12:589-603.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 589-603
    • Yuen, J.S.P.1    Macaulay, V.M.2
  • 27
    • 1642494838 scopus 로고    scopus 로고
    • Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth
    • Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004;64:236-242.
    • (2004) Cancer Res , vol.64 , pp. 236-242
    • Girnita, A.1    Girnita, L.2    Del Prete, F.3    Bartolazzi, A.4    Larsson, O.5    Axelson, M.6
  • 28
    • 2942558349 scopus 로고    scopus 로고
    • Explant-cell culture of primary mammary tumors from mmtv-c-myc transgenic mice
    • Pei XF, Noble MS, Davoli MA, et al. Explant-cell culture of primary mammary tumors from MMTV-c-Myc transgenic mice. In Vitro Cell Dev Biol Anim. 2004;40:14-21.
    • (2004) Vitro Cell Dev Biol Anim , vol.40 , pp. 14-21
    • Pei, X.F.1    Noble, M.S.2    Davoli, M.A.3
  • 29
    • 0035425234 scopus 로고    scopus 로고
    • Functional inactivation of the igf-i and insulin receptors in skeletal muscle causes type 2 diabetes
    • FernándezAM,KimJK, Yakar S, et al. Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev. 2001;15:1926-1934.
    • (2001) Genes Dev , vol.15 , pp. 1926-1934
    • Fernández, A.M.1    Kim, J.K.2    Yakar, S.3
  • 30
    • 84864917469 scopus 로고    scopus 로고
    • Cancer risk in type 2 diabetes mellitus: Metabolic links and therapeutic considerations
    • Sun G, Kashyap SR. Cancer risk in type 2 diabetes mellitus: metabolic links and therapeutic considerations. J Nutr Metab. 2011; 2011:708183.
    • (2011) J Nutr Metab , vol.2011 , pp. 708183
    • Sun, G.1    Kashyap, S.R.2
  • 31
    • 58549084793 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factor-i, and risk of breast cancer in postmenopausal women
    • Gunter MJ, Hoover DR, Yu H, et al. Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 2009;101:48-60.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 48-60
    • Gunter, M.J.1    Hoover, D.R.2    Yu, H.3
  • 32
    • 0036721523 scopus 로고    scopus 로고
    • Activation of themapkpathway enhances sensitivity ofmcf-7breast cancer cells to the mitogenic effect of estradiol
    • Yue W, Wang JP, Conaway M, Masamura S, Li Y, Santen RJ. Activation of theMAPKpathway enhances sensitivity ofMCF-7breast cancer cells to the mitogenic effect of estradiol. Endocrinology. 2002;143:3221-3229.
    • (2002) Endocrinology , vol.143 , pp. 3221-3229
    • Yue, W.1    Wang, J.P.2    Conaway, M.3    Masamura, S.4    Li, Y.5    Santen, R.J.6
  • 33
    • 79958272949 scopus 로고    scopus 로고
    • Mechanism of the mitogenic influence of hyperinsulinemia
    • Draznin B. Mechanism of the mitogenic influence of hyperinsulinemia. Diabetol Metab Syndr. 2011;3:10.
    • (2011) Diabetol Metab Syndr , vol.3 , pp. 10
    • Draznin, B.1
  • 34
    • 0014056238 scopus 로고
    • Cell proliferation induced by insulin in organ culture of rat mammary carcinoma
    • Heuson JC, Coune A, Heimann R. Cell proliferation induced by insulin in organ culture of rat mammary carcinoma. Exp Cell Res. 1967;45:351-360.
    • (1967) Exp Cell Res , vol.45 , pp. 351-360
    • Heuson, J.C.1    Coune, A.2    Heimann, R.3
  • 35
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4:579-591.
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 36
    • 0035138167 scopus 로고    scopus 로고
    • Reducing bioavailable sex hormones through a comprehensive change in diet: The diet and androgens (diana) randomized trial
    • Berrino F, Bellati C, Secreto G, et al. Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial. Cancer Epidemiol Biomarkers Prev. 2001;10:25-33.
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , pp. 25-33
    • Berrino, F.1    Bellati, C.2    Secreto, G.3
  • 37
    • 0029970843 scopus 로고    scopus 로고
    • Nutrition, hormones, and breast cancer: Is insulin the missing link?
    • Kaaks R. Nutrition, hormones, and breast cancer: is insulin the missing link? Cancer Causes Control. 1996;7:605-625.
    • (1996) Cancer Causes Control , vol.7 , pp. 605-625
    • Kaaks, R.1
  • 38
    • 0035961202 scopus 로고    scopus 로고
    • Breast cancer: Hormones and other risk factors
    • discussion 113-116
    • Hulka BS, Moorman PG. Breast cancer: hormones and other risk factors. Maturitas. 2001;38:103-113; discussion 113-116.
    • (2001) Maturitas , vol.38 , pp. 103-113
    • Hulka, B.S.1    Moorman, P.G.2
  • 39
    • 57149143868 scopus 로고    scopus 로고
    • Growth hormone and insulin-like growth factor-i in the transition from normal mammary development to preneoplastic mammary lesions
    • Kleinberg DL, Wood TL, Furth PA, Lee AV. Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocrine Rev. 2009;30:51-74.
    • (2009) Endocrine Rev , vol.30 , pp. 51-74
    • Kleinberg, D.L.1    Wood, T.L.2    Furth, P.A.3    Lee, A.V.4
  • 40
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor i receptor
    • LeRoith D, Werner H, Beitner-Johnson D, Roberts AT. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocrine Rev. 1995;16:143-163.
    • (1995) Endocrine Rev , vol.16
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts, A.T.4
  • 41
    • 33751290510 scopus 로고    scopus 로고
    • Classification of breast cancer using genetic algorithms and tissue microarrays
    • Dolled-Filhart M, Rydén L, Cregger M, et al. Classification of breast cancer using genetic algorithms and tissue microarrays. Clin Cancer Res. 2006;12:6459-6468.
    • (2006) Clin Cancer Res , vol.12 , pp. 6459-6468
    • Dolled-Filhart, M.1    Rydén, L.2    Cregger, M.3
  • 42
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R, Wang X, Chen GY, et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells.NEngl J Med. 2007; 356:217-226.
    • (2007) NEngl J Med , vol.356 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3
  • 43
    • 52949099133 scopus 로고    scopus 로고
    • Anovel high-Affinity peptide antagonist to the insulin receptor
    • Schäffer L, Brand CL, Hansen BF, et al.Anovel high-Affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun. 2008;376:380-383.
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 380-383
    • Schäffer, L.1    Brand, C.L.2    Hansen, B.F.3
  • 44
    • 77955058188 scopus 로고    scopus 로고
    • S961, an insulin receptor antagonist causes hyperinsulinemia, insulin-resistance and depletion of energy stores in rats
    • Vikram A, Jena G. S961, an insulin receptor antagonist causes hyperinsulinemia, insulin-resistance and depletion of energy stores in rats. Biochem Biophys Res Commun. 2010;398:260-265.
    • (2010) Biochem Biophys Res Commun , vol.398 , pp. 260-265
    • Vikram, A.1    Jena, G.2
  • 45
    • 34047270772 scopus 로고    scopus 로고
    • Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-i receptor
    • Linder S, Shoshan MC, Gupta RS. Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor. Cancer Res. 2007;67:2899.
    • (2007) Cancer Res , vol.67 , pp. 2899
    • Linder, S.1    Shoshan, M.C.2    Gupta, R.S.3
  • 46
    • 77950354885 scopus 로고    scopus 로고
    • Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression
    • Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D. Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Diabetes. 2010;59:686-693.
    • (2010) Diabetes , vol.59 , pp. 686-693
    • Fierz, Y.1    Novosyadlyy, R.2    Vijayakumar, A.3    Yakar, S.4    LeRoith, D.5
  • 47
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7:606-619.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 48
    • 78649816080 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes
    • Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D.Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes. Endocr Relat Cancer. 2010;17:941-951.
    • (2010) Endocr Relat Cancer , vol.17 , pp. 941-951
    • Fierz, Y.1    Novosyadlyy, R.2    Vijayakumar, A.3    Yakar, S.4    LeRoith, D.5
  • 49
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev. 2009;30:586-623.
    • (2009) Endocr Rev , vol.30 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca, L.4    Vigneri, R.5
  • 50
    • 33846458639 scopus 로고    scopus 로고
    • Down-regulation of type i insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
    • Zhang H, Pelzer AM, Kiang DT, Yee D. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res. 2007;67:391-397.
    • (2007) Cancer Res , vol.67 , pp. 391-397
    • Zhang, H.1    Pelzer, A.M.2    Kiang, D.T.3    Yee, D.4
  • 51
    • 0029011218 scopus 로고
    • The mapk signaling cascade
    • Seger R, Krebs E. The MAPK signaling cascade. FASEB J. 1995;9: 726-735.
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.2
  • 52
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration byjnkand p38mapk pathways in cancer development
    • Wagner EF, Nebreda AR. Signal integration byJNKand p38MAPK pathways in cancer development. Nat Rev Cancer. 2009;9:537-549.
    • (2009) Nat Rev Cancer , vol.9 , pp. 537-549
    • Wagner, E.F.1    Nebreda, A.R.2
  • 53
    • 56849114259 scopus 로고    scopus 로고
    • Oral picropodophyllin (ppp) is well tolerated in vivo and inhibits igf-1r expression and growth of uveal melanoma
    • Economou MA, Andersson S, Vasilcanu D, et al. Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma. Acta Ophthalmol. 2008;86:35-41.
    • (2008) Acta Ophthalmol , vol.86 , pp. 35-41
    • Economou, M.A.1    Andersson, S.2    Vasilcanu, D.3
  • 54
    • 33644751770 scopus 로고    scopus 로고
    • The insulin-like growth factor-i receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells
    • Girnita A, All-Ericsson C, Economou MA, et al. The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells. Clin Cancer Res. 2006;12:1383-1391.
    • (2006) Clin Cancer Res , vol.12
    • Girnita, A.1    All-Ericsson, C.2    Economou, M.A.3
  • 55
    • 79952672340 scopus 로고    scopus 로고
    • Clinical phase i study with an insulin-like growth factor-1 receptor inhibitor: Experiences in patients with squamous non-small cell lung carcinoma
    • Ekman S, Frödin JE, Harmenberg J, et al. Clinical phase I study with an insulin-like growth factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma. Acta Oncol. 2011;50:441-447.
    • (2011) Acta Oncol , vol.50 , pp. 441-447
    • Ekman, S.1    Frödin, J.E.2    Harmenberg, J.3
  • 56
    • 79961004321 scopus 로고    scopus 로고
    • Signalling by insulin and igf receptors: Supporting acts and new players
    • Siddle K. Signalling by insulin and IGF receptors: supporting acts and new players. J Mol Endocrinol. 2011;47:R1-R10.
    • (2011) J Mol Endocrinol , vol.47
    • Siddle, K.1
  • 57
    • 52449092107 scopus 로고    scopus 로고
    • Breast tumor cells with pi3k mutation or her2 amplification are selectively addicted to akt signaling
    • She Q-B, Chandarlapaty S, Ye Q, et al. Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS One. 2008;3:e3065.
    • (2008) PLoS One , vol.3
    • She, Q.-B.1    Chandarlapaty, S.2    Ye, Q.3
  • 58
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: Increased estrogen receptor-her2/neu cross-talk in er/ her2-positive breast cancer
    • Shou J, Massarweh S, Osborne CK, et al. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/ HER2-positive breast cancer. J Natl Cancer Inst. 2004;96:926-935.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3
  • 59
    • 0032549570 scopus 로고    scopus 로고
    • Overexpression of egfr and c-erbb2 causes enhanced cell migration in human breast cancer cells and nih3t3 fibroblasts
    • Verbeek BS, Adriaansen-Slot SS, Vroom TM, Beckers T, Rijksen G. Overexpression of EGFR and c-erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblasts. FEBS Lett. 1998;425:145-150.
    • (1998) FEBS Lett , vol.425 , pp. 145-150
    • Verbeek, B.S.1    Adriaansen-Slot, S.S.2    Vroom, T.M.3    Beckers, T.4    Rijksen, G.5
  • 60
    • 77951879658 scopus 로고    scopus 로고
    • Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation
    • Zhang H, Fagan DH, Zeng X, Freeman KT, Sachdev D, Yee D. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene. 2010;29:2517-2527.
    • (2010) Oncogene , vol.29 , pp. 2517-2527
    • Zhang, H.1    Fagan, D.H.2    Zeng, X.3    Freeman, K.T.4    Sachdev, D.5    Yee, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.