Natural Killer Cell Function, an Important Target for Infection and Tumor Protection, Is Impaired in Type 2 Diabetes

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Berrou, Jeannig ^a,b   Fougeray, Sophie ^a,c   Venot, Marion ^a   Chardiny, Victor ^a   Gautier, Jean François ^b,c   Dulphy, Nicolas ^a,b,c,d   Toubert, Antoine ^a,b,c,d   Peraldi, Marie Noëlle ^a,b,c  

^a INSERM   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITÉ PARIS DIDEROT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HEMOGLOBIN A1C; INTERLEUKIN 15; MESSENGER RNA; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN DISULFIDE ISOMERASE; PROTEIN IRE1; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; T LYMPHOCYTE RECEPTOR; TUNICAMYCIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; KLRK1 PROTEIN, HUMAN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; NCR1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BINDING IMMUNOGLOBULIN PROTEIN GENE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMMUNE DYSREGULATION; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER T CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PROTEIN DISULFIDE ISOMERASE GENE; PROTEIN EXPRESSION; UNFOLDED PROTEIN RESPONSE; X BOX BINDING PROTEIN 1 GENE; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; INFECTION; METABOLISM; MIDDLE AGED; NATURAL KILLER CELL; NEOPLASM; YOUNG ADULT;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMANS; HYPERGLYCEMIA; INFECTION; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NEOPLASMS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; PHENOTYPE; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 84876743932     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062418     Document Type: Article

References (43)

1. Joshi N, Caputo GM, Weitekamp MR, Karchmer AW, (1999) Infections in patients with diabetes mellitus. N Engl J Med. 341: 1906-1912.
2. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, et al. (2010) Diabetes and cancer: a consensus report. Diabetes Care. 33: 1674-1685.
3. Morgan CL, Peters JR, Currie CJ, (2010) The changing prevalence of diagnosed diabetes and its associated vascular complications in a large region of the UK. Diabet. Med. 27: 673-678.
4. Stegenga ME, van der Crabben SN, Blümer RM, Levi M, Meijers JC, et al. (2008) Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood. 112: 82-89.
5. Stegenga ME, van der Crabben SN, Dessing MC, Pater JM, van den Pangaart PS, et al. (2008) Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans. Diabet Med. 25: 157-164.
6. Hand WL, Hand DL, Vasquez Y, (2007) Increased polymorphonuclear leucocyte respiratory burst function in type 2 diabetes. Diabetes Res Clin Pract. 76: 44-50.
7. Peraldi MN, Berrou J, Dulphy N, Seidowsky A, Haas P, et al. (2009) Oxidative stress mediates a reduced expression of the activating receptor NKG2D in NK cells from end-stage renal disease patients. J Immunol. 182: 1696-1705.
8. Zhang K, Kaufman RJ, (2008) From endoplasmic reticulum stress to the inflammatory response. Nature. 454: 455-462.
9. Lynch LA, O'Connel JM, Kwasnik AK, Cawood TJ, O'Farrely C, et al. (2009) Are Natural Killer cells protecting the metabolically healthy obese patient? Obesity. 17: 601-605.
10. Moretta A, Bottino C, Mingari MC, Biassoni R, Moretta L, (2002) What is a natural killer cell? Nat Immunol. 3: 6-8.
11. Colucci F, Caligiuri MA, Di Santo JP, (2003) What does it take to make a natural killer? Nat Rev Immunol. 3: 413-425.
12. Bauer S, Groh V, Wu J, Steinle A, Philips Jh, et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285: 727-729.
13. Vivier E, Nunes JA, Vely JF, (2004) Natural Killer cells signalling pathways. Science. 306: 1517-1519.
14. Raulet DH, (2003) Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 3: 781-785.
15. Zwimmer NW, Dole K, Stastny N, (1999) Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes and monocytes. Hum Immunol. 60: 323-330.
16. Eagle RA, Trowsdale J, (2007) Promiscuity and the single receptor NKG2D. Nat Rev Immunol. 7: 737-744.
17. Tieng V, Le Bouguenec C, Du Merle L, Bertheau P, Desreumaux P, et al. (2002) Binding of Escherichia Coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-relate molecule MICA. Proc Natl Acad Sci USA. 99: 2977-2982.
18. Biassoni R, Cantoni C, Pende D, Sivori S, Parolini S, et al. (2001) Human natural killer cell receptors and co-receptors. Immunol Rev. 181: 203-214.
19. Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, et al. (2009) NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. J Clin Invest. 119: 1251-1263.
20. Gazit R, Gruda R, Elboim M, Arnon TI, Katz G, et al. (2006) Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol. 7: 517-523.
21. Zhong Y, Li J, Chen Y, Wang JJ, Ratan R, et al. (2012) Activation of endoplasmic reticulum stress by hyperglycemia is essential for Muller cell-derived inflammatory cytokine production in diabetes. Diabetes. 61: 492-504.
22. He B, (2006) Viruses, endoplasmic reticulum stress, and interferon responses. Cell Death Differ. 13: 393-403.
23. Kuznetsov G, Bush KT, Zhang PL, Nigam SK, (1996) Perturbations in maturation of secretory proteins and their association with endoplasmic reticulum chaperones in a cell culture model for epithelial ischemia. Proc Natl Acad Sci U S A. 93: 8584-8589.
24. Basha B, Samuel SM, Triggle CR, Ding H, (2012) Endothelial dysfunction in Diabetes Mellitus: possible involvment of Endoplasmic reticulum stress? Experimental diabetes Research. 48: 1-14.
25. Tang C, Koulajian K, Schuiki I, Zhang L, Desai T, et al. (2012) Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress. Diabetologia. 55: 1366-1379.
26. Stevens LA, Schmid CH, Zhang YL, Coresh J, Manzi J, et al. (2010) Development and validation of GFR-estimating equations using diabetes, transplant and weight. Nephrol Dial Transplant. 25: 449-457.
27. Fisher L, Penack O, Gentilini C, Nogai A, Muessig A, et al. (2006) The anti-lymphoma effect of antibody-mediated immunotherapy is based on an increased degranulation of peripheral blood natural killer (NK) cells. Experimental Hematol. 34: 753-759.
28. Cooper MA, Fehniger TA, Caligiuri MA, (2001) The biology of human natural killer-cell subsets. Trends Immunol. 22: 633-640.
29. Alter G, Teigen N, Davis BT, Addo MM, Suscovich TJ, et al. (2005) Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood. 106: 3366-3369.
30. Claus M, Greil J, Watzl C, (2009) Comprehensive analysis of NK cell function in whole blood samples. J Immunol Methods. 34: 154-164.
31. Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, et al. (2009) IL-15 trans-presentation promotes human NK cells development and differentiation in vivo. J Exp Med. 206: 25-34.
32. Huntington ND, Vosshenrich CA, Di Santo JP, (2007) Developmental pathways that generate natural-killer-cell diversity in mice and humans. Nat. Rev. Immunol. 7: 703-714.
33. American Diabetes Association, (2009) Standards of medical care in the diabetes-2009. Diabetes Care. 32(suppl 1): 13-61.
34. Veiga-Fernandes H, Kloussis D, Coles M, (2010) Natural Killers receptors: the burden of a name. J Exp Med. 207: 269-272.
35. Moretta A, Bottino C, Vitale M, Pendi D, Cantoni C, et al. (2001) Activating receptors and co-receptors involved in human natural killer-cell mediated cytolysis. Annu Rev Immunol. 19: 197-223.
36. Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, et al. (2005) Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunol. 6: 928-937.
37. Rodacki M, Svoren B, Butty V, Besse W, Laffel L, et al. (2007) Altered natural killer cells in type 1 diabetic patients. Diabetes. 56: 177-185.
38. Gur C, Porgador A, Elboim M, Gazit R, Mizrahi S, et al. (2010) The activating receptor NKp46 is essential for the development of type 1 diabetes. Nat Immunol. 11: 121-128.
39. Akesson C, Uvebrant K, Oderup C, Lynch K, Harris RA, et al. (2010) Altered natural killer (NK) cell frequency and phenotype in latent autoimmune diabetes in adults (LADA) prior to insulin deficiency. Clin Exp Immunol. 161: 48-56.
40. Schröder M, Kaufman RJ, (2005) The mammalian unfolded protein response. Ann Rev Biochem. 74: 739-789.
41. Lin JH, Walter P, Yen TSB, (2008) Endoplasmic Reticulum stress in disease pathogenesis. Ann Rev Pathol. 3: 399-425.
42. Nakayama Y, Endo M, Tsukano H, Mori M, Oike Y, et al. (2010) Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway. J Biochem. 147: 471-483.
43. Xia M, Guerra N, Sukhova GK, Yang K, Miller CK, et al. (2011) Immune activation resulting from NKG2D/Ligand interaction promotes atherosclerosis. Circulation. 124: 2933-2943.