Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans

Diabetic Medicine

Volumn 25, Issue 2, 2008, Pages 157-164

  Stegenga, M E ^a   Crabben, S N Van Der ^a   Dessing, M C ^a   Pater, J M ^a   Van Den Pangaart, P S ^a   De Vos, A F ^a   Tanck, M W ^a   Roos, D ^a   Sauerwein, H P ^a   Van Der Poll, T ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Cytokines; Hyperglycaemia; Hyperinsulinaemia; mRNA; Neutrophils

Indexed keywords

CYTOKINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; NUCLEAR FACTOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS INHIBITOR ALPHA PROTEIN; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HORMONE ACTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULINEMIA; LEUKOCYTE FUNCTION; MALE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHAGOCYTOSIS;

ADULT; DIABETES MELLITUS, TYPE 2; DNA-BINDING PROTEINS; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; INTERLEUKIN-1ALPHA; MALE; NEUTROPHILS; RNA, MESSENGER;

EID: 39749107384     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2007.02348.x     Document Type: Article

References (42)

1. Smitherman KO, Peacock JE Jr. Infectious emergencies in patients with diabetes mellitus. Med Clin North Am 1995 79 : 53 77.
2. McMahon MM, Bistrian BR. Host defenses and susceptibility to infection in patients with diabetes mellitus. Infect Dis Clin North Am 1995 9 : 1 9.
3. Joshi N, Caputo GM, Weitekamp MR, Karchmer AW. Infections in patients with diabetes mellitus. N Engl J Med 1999 341 : 1906 1912.
4. Turina M, Fry DE, Polk HC Jr. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Crit Care Med 2005 33 : 1624 1633.
5. Krogh-Madsen R, Plomgaard P, Keller P, Keller C, Pedersen BK. Insulin stimulates interleukin-6 and tumor necrosis factor-alpha gene expression in human subcutaneous adipose tissue. Am J Physiol Endocrinol Metab 2004 286 : E234 E238.
6. Geerlings SE, Hoepelman AI. Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol Med Microbiol 1999 26 : 259 265.
7. Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B. Impaired leucocyte functions in diabetic patients. Diabet Med 1997 14 : 29 34.
8. Wierusz-Wysocka B, Wysocki H, Wykretowicz A, Klimas R. The influence of increasing glucose concentrations on selected functions of polymorphonuclear neutrophils. Acta Diabetol Lat 1988 25 : 283 288.
9. Tater D, Tepaut B, Bercovici JP, Youinou P. Polymorphonuclear cell derangements in Type I diabetes. Horm Metab Res 1987 19 : 642 647.
10. Marhoffer W, Stein M, Maeser E, Federlin K. Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes. Diabetes Care 1992 15 : 256 260.
11. Balasoiu D, van Kessel KC, van Kats-Renaud HJ, Collet TJ, Hoepelman AI. Granulocyte function in women with diabetes and asymptomatic bacteriuria. Diabetes Care 1997 20 : 392 395.
12. Gallacher SJ, Thomson G, Fraser WD, Fisher BM, Gemmell CG, MacCuish AC. Neutrophil bactericidal function in diabetes mellitus: evidence for association with blood glucose control. Diabet Med 1995 12 : 916 920.
13. Nielson CP, Hindson DA. Inhibition of polymorphonuclear leukocyte respiratory burst by elevated glucose concentrations in vitro. Diabetes 1989 38 : 1031 1035.
14. Oldenborg PA, Sundqvist IM, Sehlin J. Different effects of glucose on extracellular and intracellular respiratory burst response in normal human neutrophils activated with the soluble agonist fMet-Leu-Phe. Diabet Med 2000 17 : 532 537.
15. Ortmeyer J, Mohsenin V. Inhibition of phospholipase D and superoxide generation by glucose in diabetic neutrophils. Life Sci 1996 59 : 255 262.
16. Perner A, Nielsen SE, Rask-Madsen J. High glucose impairs superoxide production from isolated blood neutrophils. Intensive Care Med 2003 29 : 642 645.
17. Mohanty P, Hamouda W, Garg R, Aljada A, Ghanim H, Dandona P. Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes. J Clin Endocrinol Metab 2000 85 : 2970 2973.
18. Mysliwska J, Zorena K, Bakowska A, Skuratowicz-Kubica A, Mysliwski A. Significance of tumor necrosis factor alpha in patients with long-standing Type-I diabetes mellitus. Horm Metab Res 1998 30 : 158 161.
19. Pickup JC, Crook MA. Is Type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998 41 : 1241 1248.
20. Zozulinska D, Majchrzak A, Sobieska M, Wiktorowicz K, Wierusz-Wysocka B. Serum interleukin-8 level is increased in diabetic patients. Diabetologia 1999 42 : 117 118.
21. Orlinska U, Newton RC. Role of glucose in interleukin-1 beta production by lipopolysaccharide-activated human monocytes. J Cell Physiol 1993 157 : 201 208.
22. Iida KT, Shimano H, Kawakami Y, Sone H, Toyoshima H, Suzuki S et al. Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway. J Biol Chem 2001 276 : 32531 32537.
23. Kirwan JP, Krishnan RK, Weaver JA, Del Aguila LF, Evans WJ. Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia. Am J Physiol Endocrinol Metab 2001 281 : E1137 1143.
24. Satomi N, Sakurai A, Haranaka K. Relationship of hypoglycemia to tumor necrosis factor production and antitumor activity: role of glucose, insulin, and macrophages. J Natl Cancer Inst 1985 74 : 1255 1260.
25. Fraker DL, Merino MJ, Norton JA. Reversal of the toxic effects of cachectin by concurrent insulin administration. Am J Physiol 1989 256 : E725 731.
26. Shanmugam N, Reddy MA, Guha M, Natarajan R. High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 2003 52 : 1256 1264.
27. Zhang L, Zalewski A, Liu Y, Mazurek T, Cowan S, Martin JL et al. Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries. Circulation 2003 108 : 472 478.
28. Stegenga ME, van der Crabben SN, Levi M, de Vos AF, Tanck MW, Sauerwein HP et al. Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans. Diabetes 2006 55 : 1807 1812.
29. Spek CA, Verbon A, Aberson H, Pribble JP, McElgunn CJ, Turner T et al. Treatment with an anti-CD14 monoclonal antibody delays and inhibits lipopolysaccharide-induced gene expression in humans in vivo. J Clin Immunol 2003 23 : 132 140.
30. Wettinger SB, Doggen CJ, Spek CA, Rosendaal FR, Reitsma PH. High throughput mRNA profiling highlights associations between myocardial infarction and aberrant expression of inflammatory molecules in blood cells. Blood 2005 105 : 2000 2006.
31. Maris NA, de Vos AF, Dessing MC, Spek CA, Lutter R, Jansen HM et al. Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers. Am J Respir Crit Care Med 2005 172 : 878 884.
32. Weijer S, Sewnath ME, de Vos AF, Florquin S, van der Sluis K, Gouma DJ et al. Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis. Infect Immun 2003 71 : 5488 5497.
33. Wan CP, Park CS, Lau BH. A rapid and simple microfluorometric phagocytosis assay. J Immunol Methods 1993 162 : 1 7.
34. Conover WJ, Iman RL. Analysis of covariance using the rank transformation. Biometrics 1982 38 : 715 724.
35. Hansen L, Gaster M, Oakeley EJ, Brusgaard K, Damsgaard Nielsen EM, Beck-Nielsen H et al. Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and Type 2 diabetes. Biochem Biophys Res Commun 2004 323 : 685 695.
36. Aljada A, Friedman J, Ghanim H, Mohanty P, Hofmeyer D, Chaudhuri A et al. Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects. Metabolism 2006 55 : 1177 1185.
37. Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002 106 : 2067 2072.
38. Pickup JC, Chusney GD, Thomas SM, Burt D. Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in Type 2 diabetes. Life Sci 2000 67 : 291 300.
39. Mishima Y, Kuyama A, Tada A, Takahashi K, Ishioka T, Kibata M. Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus. Diabetes Res Clin Pract 2001 52 : 119 123.
40. Krogh-Madsen R, Moller K, Dela F, Kronborg G, Jauffred S, Pedersen BK. Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-alpha, and FFAs to low-dose endotoxemia in humans. Am J Physiol Endocrinol Metab 2004 286 : E766 E772.
41. Soop M, Duxbury H, Agwunobi AO, Gibson JM, Hopkins SJ, Childs C et al. Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans. Am J Physiol Endocrinol Metab 2002 282 : E1276 1285.
42. Fejfarova V, Jirkovska A, Lupinkova J, Kovar J, Kalanin J, Striz I et al. Effect of acute hyperglycemia and/or hyperinsulinemia on polymorphonuclear functions in healthy subjects. Metabolism 2006 55 : 811 818.