Reduced expression of transcription factor AP-2α is associated with gastric adenocarcinoma prognosis

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Wang, Wei ^a   Lv, Lin ^a   Pan, Ke ^a   Zhang, Yu ^a,b   Zhao, Jing jing ^a   Chen, Ju gao ^a   Chen, Yi bing ^a   Li, Yong qiang ^a   Wang, Qi jin ^a   He, Jia ^a   Chen, Shi ping ^a   Zhou, Zhi wei ^a   Xia, Jian chuan ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR AP 2ALPHA; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; TUMOR DIFFERENTIATION; TUMOR VOLUME; WESTERN BLOTTING; ADENOCARCINOMA; DOWN REGULATION; FOLLOW UP; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR;

ADENOCARCINOMA; ADULT; AGED; BLOTTING, WESTERN; DOWN-REGULATION; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; TRANSCRIPTION FACTOR AP-2; YOUNG ADULT;

EID: 80053135656     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024897     Document Type: Article

References (22)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225-249.
3. Ajani JA, Barthel JS, Bekaii-Saab T, (2010) NCCN Clinical Practice Guidelines in Oncology, Gastric cancer, v.2.2010. Available: www.nccn.org. Accessed 2010 July 26.
4. Chen CN, Lin JJ, Chen JJ, Lee PH, Yang CY, et al. (2005) Gene expression profile predicts patient survival of gastric cancer after surgical resection. J Clin Oncol 23: 7286-7295.
5. Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, et al. (2005) Molecular-pathological prognostic factors of gastric cancer: a review. Gastric Cancer 8: 86-94.
6. Lee HS, Cho SB, Lee HE, Kim MA, Kim JH, et al. (2007) Protein expression profiling and molecular classification of gastric cancer by the tissue array method. Clin Cancer Res 13: 4154-4163.
7. Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, et al. (2004) Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res 64: 2397-2405.
8. Hippo Y, Taniguchi H, Tsutsumi S, Machida N, Chong JM, et al. (2002) Global gene expression analysis of gastric cancer by oligonucleotide microarrays. Cancer Res 62: 233-240.
9. Yasui W, Oue N, Sentani K, Sakamoto N, Motoshita J, (2009) Transcriptome dissection of gastric cancer: identification of novel diagnostic and therapeutic targets from pathology specimens. Pathol Int 59: 121-136.
10. Karjalainen JM, Kellokoski JK, Eskelinen MJ, Alhava EM, Kosma VM, (1998) Downregulation of transcription factor AP-2 predicts poor survival in stage I cutaneous malignant melanoma. J Clin Oncol 16: 3584-3591.
11. Motley AM, Berg N, Taylor MJ, Sahlender DA, Hirst J, et al. (2006) Functional analysis of AP-2 alpha and mu2 subunits. Mol Biol Cell 17: 5298-5308.
12. Pellikainen J, Kataja V, Ropponen K, Kellokoski J, Pietilainen T, et al. (2002) Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer. Clin Cancer Res 8: 3487-3495.
13. Ropponen KM, Kellokoski JK, Pirinen RT, Moisio KI, Eskelinen MJ, et al. (2001) Expression of transcription factor AP-2 in colorectal adenomas and adenocarcinomas; comparison of immunohistochemistry and in situ hybridisation. J Clin Pathol 54: 533-538.
14. Bar-Eli M, (1999) Role of AP-2 in tumor growth and metastasis of human melanoma. Cancer Metastasis Rev 18: 377-385.
15. Ruiz M, Pettaway C, Song R, Stoeltzing O, Ellis L, et al. (2004) Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells. Cancer Res 64: 631-638.
16. Douglas DB, Akiyama Y, Carraway H, Belinsky SA, Esteller M, et al. (2004) Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer. Cancer Res 64: 1611-1620.
17. Anttila MA, Kellokoski JK, Moisio KI, Mitchell PJ, Saarikoski S, et al. (2000) Expression of transcription factor AP-2alpha predicts survival in epithelial ovarian cancer. Br J Cancer 82: 1974-1983.
18. Heimberger AB, McGary EC, Suki D, Ruiz M, Wang H, et al. (2005) Loss of the AP-2alpha transcription factor is associated with the grade of human gliomas. Clin Cancer Res 11: 267-272.
19. Gee JM, Robertson JF, Ellis IO, Nicholson RI, Hurst HC, (1999) Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer. J Pathol 189: 514-520.
20. Lipponen P, Aaltomaa S, Kellokoski J, Ala-Opas M, Kosma V, (2000) Expression of activator protein 2 in prostate cancer is related to tumor differentiation and cell proliferation. Eur Urol 37: 573-578.
21. Ropponen KM, Kellokoski JK, Lipponen PK, Pietilainen T, Eskelinen MJ, et al. (1999) p22/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis. Br J Cancer 81: 133-140.
22. Japanese Gastric Cancer A (1998) Japanese Classification of Gastric Carcinoma- 2nd English Edition. Gastric Cancer 1: 10-24.