High doses of 2,2'-dithienyl diselenide cause systemic toxicity in rats: An in vitro and in vivo study

Journal of Applied Toxicology

Volumn 33, Issue 6, 2013, Pages 480-487

  Chagas, Pietro Maria ^a   Bortolatto, Cristiani Folharini ^a   Wilhelm, Ethel Antunes ^a   Nogueira, Cristina Wayne ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

ALA D; 2,2' dithienyl diselenide; Na+ K+ ATPase; Organoselenium; Sulfhydryl; Toxicity

Indexed keywords

2,2 DITHIENYL DISELENIDE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALANINE AMINOTRANSFERASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; CREATININE; PORPHOBILINOGEN SYNTHASE; SELENIUM DERIVATIVE; SUPEROXIDE DISMUTASE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BRAIN HOMOGENATE; CHEMICAL STRUCTURE; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FLUID INTAKE; FOOD INTAKE; IC 50; LETHALITY; LIPID PEROXIDATION; MALE; MOLECULAR INTERACTION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS; UREA BLOOD LEVEL; VITAMIN BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BRAIN; CATALASE; CHLORIDES; DRINKING; DRUG-INDUCED LIVER INJURY; EATING; ENZYME INHIBITORS; FEMALE; GLUTATHIONE; KIDNEY DISEASES; LIPID PEROXIDATION; MALE; ORGANOSELENIUM COMPOUNDS; OXIDOREDUCTASES ACTING ON SULFUR GROUP DONORS; PORPHOBILINOGEN SYNTHASE; RATS; RATS, WISTAR; SODIUM-POTASSIUM-EXCHANGING ATPASE; SUPEROXIDE DISMUTASE; THIOPHENES; WEIGHT GAIN; ZINC COMPOUNDS;

RATTUS;

EID: 84876735996     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1777     Document Type: Article

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