Structural modifications into diphenyl diselenide molecule do not cause toxicity in mice

Environmental Toxicology and Pharmacology

Volumn 27, Issue 2, 2009, Pages 271-276

  Savegnago, Lucielli ^a   Jesse, Cristiano R ^a   Nogueira, Cristina Wayne ^a  

^a Reatividade e Avaliacao Farmacologica e Toxicologica de Organocalcogenios   (Brazil)

Author keywords

Disubstituted diaryl diselenides; Mice; Pharmacology; Selenium; Toxicology

Indexed keywords

3,3' DITRIFLUOROMETHYLDIPHENYL DISELENIDE; 4,4' DICHLORODIPHENYLDISELENIDE; 4,4' DIMETHOXYLDIPHENYL DISELENIDE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ASCORBIC ACID; CATALASE; DIPHENYL DISELENIDE; PORPHOBILINOGEN SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; FLUID INTAKE; FOOD INTAKE; LD 50; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TOXICITY TESTING; WEIGHT GAIN;

MUS;

EID: 59649099665     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2008.11.007     Document Type: Article

References (42)

1. Aebi H. Catalase in vitro. Methods Enzymol. 105 (1984) 121-126
2. Barbosa N.B.V., Rocha J.B.T., Zeni G., Emanuelli T., Beque M.C., and Braga A.L. Effect of organic forms of Selenium on delta-aminolevulinate dehydratase from liver, kidney and brain of adult rats. Toxicol. Appl. Pharmacol. 149 (1998) 243-253
3. Bock A., Forchhammer K., Heider J., and Baron C. Selenoprotein synthesis: an expansion of the genetic code. Trends Biochem. Sci. 16 (1991) 463-467
4. +-ATPase activity in rats. Toxicology 215 (2005) 191-197
5. Borges L.P., Borges V.C., Moro A.V., Nogueira C.W., Rocha J.B.T., and Zeni G. Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats. Toxicology 210 (2005) 1-8
6. Borges L.P., Nogueira C.W., Panatieri R.B., Rocha J.B.T., and Zeni G. Acute liver damage induced by 2-nitropropane in rats: effect of diphenyl diselenide on antioxidant defenses. Chem. Biol. Interact. 160 (2006) 99-107
7. Borges L.P., Brandão R., Godoi B., Nogueira C.W., and Zeni G. Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats. Chem. Biol. Interact. 171 (2008) 15-25
8. Burk R.F., and Lane J.M. Modification of chemical toxicity by selenium deficiency. Fundam. Appl. Toxicol. 3 (1983) 218-221
9. Carfagna M.A., Douglas Ponsler G., and Muhoberac B.B. Inhibition of ATPase activity in rat synaptic plasma membranes by simultaneous exposure to metals. Chem. Biol. Interact. 100 (1996) 53-65
10. Daiber A., Zou M., Bachschmid M., and Ullrich V. Ebselen as a peroxynitrite scavenger in vitro and ex vivo. Biochem. Pharmacol. 59 (2000) 153-160
11. De Bem A.F., Portella R.L., Perottoni J., Becker E., Bohrer D., Paixão M.W., Nogueira C.W., Zeni G., and Rocha J.B.T. Changes in biochemical parameters in rabbits blood after oral exposure to diphenyl diselenide for long periods. Chem. Biol. Interact. 162 (2006) 1-10
12. Farina M., Brandão R., Lara F.S., Soares F.A., Souza D.O., and Rocha J.B. Mechanisms of the inhibitory effects of selenium and Mercury on the activity of delta-aminolevulinate dehydratease form mouse liver, kidney and brain. Toxicol. Lett. 139 (2003) 55-66
13. Fiske C.H., and Subbarow Y.J. The colorimetric determination of phosphorus. Biol. Chem. 66 (1925) 375-381
14. +-ATPase but not on δ-aminolevulinate dehydratase in mice. Toxicology 153 (2004) 333-341
15. Jacques-Silva M.C., Nogueira C.W., Broch L.C., and Rocha J.B.T. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in brain of mice. Pharmacol. Toxicol. 88 (2001) 119-125
16. Jaffe M.Z. Methods determining creatinine. Physiol. Chem. 10 (1886) 39-40
17. +)-ATPase from outer medulla of mammalian kidney. Biochem. Biophys. Acta 860 (1986) 570-576
18. Lowry O.H., Rosebrough A.L., Farr A.L., and Randall R. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
19. Maciel E.N., Bolzan R.C., Braga A., and Rocha J.B.T. Diphenyl diselenide and diphenyl ditelluride affect delta-aminolevulinate dehydratase from liver, kidney and brain of mice. J. Biochem. Mol. Toxicol. 14 (2000) 310-319
20. Machado M.S., Rosa R.M., Dantas A.S., Reolon G.K., Appelt H.R., Braga A.L., Henrique J.A.P., and Roesler R. An organic selenium compound attenuates apomorphine-induced stereotypy in mice. Neurosci. Lett. 410 (2006) 198-202
21. Mackay E.M., and Mackay L.L. Methods determining urea. J. Clin. Invest. 4 (1927) 295-296
22. Meotti F.C., Borges V.C., Zeni G., Rocha J.B.T., and Nogueira C.W. Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and ebselen for rats and mice. Toxicol. Lett. 143 (2003) 9-16
23. Meotti F.C., Stangherlin E., Zeni G., Nogueira C.W., and Rocha J.B.T. Protective role of aryl and alkyl diselenide on lipid peroxidation. Environ. Res. 94 (2004) 276-282
24. Meotti F.C., Borges V.C., Perottoni J., and Nogueira C.W. Toxicological evaluation of subchronic exposure to diphenyl diselenide in rats. J. Appl. Toxicol. 25 (2008) 638-644
25. Moro A.V., Nogueira C.W., Barbosa N.B.V., Menezes P.H., Rocha J.B.T., and Zeni G. Highly stereoselective one-pot producers to prepare bis- and tris chalcogenide alkenes via addition of disulfides and diselenides to terminal alkynes. J. Org. Chem. 70 (2005) 5257-5268
26. Muller A., Cadenas E., Graf P., and Sies H. A novel biologically active seleno-organic compound I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ51 (Ebselen). Biochem. Pharmacol. 33 (1984) 3235-3239
27. Nogueira C.W., Quinhones E.B., Jung E.A.C., Zeni G., and Rocha J.B.T. Anti-inflammatory and antinociceptive activity of diphenyl diselenide. Inflamm. Res. 52 (2003) 56-63
28. Nogueira C.W., Zeni G., and Rocha J.B.T. Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem. Rev. 104 (2004) 6255-6285
29. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
30. Parnham M.J., and Graf E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem. Pharmacol. 36 (1987) 3095-3102
31. Paulmier C. Selenium reagents and intermediates. Organic Synthesis (1986), Pergamon, Oxford
32. Prigol M., Wilhelm E.A., Schneider C.C., Rocha J.B.T., Nogueira C.W., and Zeni G. Involvement of oxidative stress in seizures induced by diphenyl diselenide in rat pups. Brain Res. 1147 (2007) 226-232
33. Reitman S., and Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 28 (1957) 56-63
34. Rocha J.B., Pereira M.E., Emanuelli T., Christofari R.S., and Souza D.O. Effect of treatment with Mercury chloride and lead acetate during the second stage of rapid postnatal brain growth on delta-aminolevulinic acid dehydratase (ALA-D) activity in brain, liver, kidney and blood of suckling rats. Toxicology 100 (1995) 27-37
35. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., and Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 179 (1973) 588-590
36. Sassa S. Delta-aminolevulinic acid dehydratase assay. Enzyme 28 (1982) 133-145
37. Savegnago L., Trevisan M., Alves D., Rocha J.B.T., Nogueira C.W., and Zeni G. Antisecretory and antiulcer effects of diphenyl diselenide. Environ. Toxicol. Pharmacol. 21 (2006) 86-92
38. Savegnago L., Pinto L.G., Jesse C.R., Alves D., Rocha J.B.T., Nogueira C.W., and Zeni G. Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action. Eur. J. Pharmacol. 555 (2007) 129-138
39. Savegnago L., Jesse C.R., Pinto L.G., Rocha J.B.T., Nogueira C.W., and Zeni G. Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (2007) 1261-1269
40. Schewe T. Molecular actions of ebselen-an anti-inflammatory antioxidant. Gen. Pharmacol. 26 (1995) 1153-1169
41. Sies H., and Arteel G.E. Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics. Free Radic. Biol. Med. 28 (2000) 1451-1455
42. Tsukamoto I., Yoshinaga T., and Sano S. The role of zinc with special reference to the essential thiol groups in delta-aminolevulinic acid dehydratase of bovine liver. Biochem. Biophys. Res. Commun. 570 (1979) 167-178