Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase

Nuclear Medicine and Biology

Volumn 40, Issue 4, 2013, Pages 554-560

  Da Costa Branquinho, Emilie ^a,b   Becker, Guillaume ^c,d   Bouteiller, Cédric ^a   Jean, Ludovic ^b   Renard, Pierre Yves ^b   Zimmer, Luc ^c,d  

^a Advanced Accelerator Applications ^*  (France)

^b UNIVERSITÉ DE ROUEN   (France)

^c UNIVERSITÉ LYON 1   (France)

^d CERMEP IMAGERIE DU VIVANT   (France)

Author keywords

Acetylcholinesterase; Cat; Huprine; P glycoprotein; PET; Rat

Indexed keywords

ACETYLCHOLINESTERASE; ALIPHATIC COMPOUND; CHOLINESTERASE INHIBITOR; CYCLOSPORIN; FLUORINATED HUPRINE DERIVATIVE F 18; FLUORINE 18; HUPRINE; MESYLIC ACID; MULTIDRUG RESISTANCE PROTEIN; TACRINE; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING COMPETITION; BRAIN MAPPING; CAT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PENETRATION; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

ACETYLCHOLINESTERASE; AMINOQUINOLINES; ANIMALS; AUTORADIOGRAPHY; CATS; CHOLINESTERASE INHIBITORS; COMPUTATIONAL BIOLOGY; HALOGENATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; MULTIMODAL IMAGING; QUALITY CONTROL; RADIOACTIVE TRACERS; RADIOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84876735614     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2013.02.004     Document Type: Article

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