Is subnanomolar binding affinity required for the in vivo imaging of acetylcholinesterase? Studies on 18F-labeled G379

Nuclear Medicine and Biology

Volumn 33, Issue 1, 2006, Pages 91-94

  Lee, Sang Yoon ^a   Choe, Yearn Seong ^a   Ryu, Eun Kyoung ^a   Iimura, Yoichi ^b   Choi, Yong ^a   Lee, Kyung Han ^a   Kim, Byung Tae ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b EISAI CO LTD   (Japan)

Author keywords

18F; Acetylcholinesterase; Alzheimer's disease; G379; IC 50

Indexed keywords

1 (4 FLUOROBENZYL) 4 [(5,6 DIMETHOXY 1 OXOINDAN 2 FLUORO 2 YL)METHYL]PIPERIDINE; ACETYLCHOLINESTERASE; DONEPEZIL; FLUORINE 18; N BENZYLPIPERIDINE LACTAM BENZISOXALE; PIPERIDINE; RADIOLIGAND; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; IC 50; IN VIVO STUDY; MALE; METABOLISM; MOUSE; NONHUMAN; RADIOCHEMISTRY; TISSUE DISTRIBUTION;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; FLUORINE RADIOISOTOPES; INDANS; ISOTOPE LABELING; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED ICR; MICROCHEMISTRY; NANOTECHNOLOGY; PIPERIDINES; PROTEIN BINDING; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 31844440695     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2005.10.003     Document Type: Article

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