Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Mulay, Vishwaroop ^a   Wood, Peta ^a   Manetsch, Melanie ^a   Darabi, Masoud ^a   Cairns, Rose ^a   Hoque, Monira ^a   Chan, Karen Cecilia ^a   Reverter, Meritxell ^b   Álvarez Guaita, Anna ^b   Rye, Kerry Anne ^c,d   Rentero, Carles ^b   Heeren, Joerg ^e   Enrich, Carlos ^b   Grewal, Thomas ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HEART RESEARCH INSTITUTE   (Australia)

^d University of Sydney   (Australia)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; CELL PROTEIN; H RAS PROTEIN; HIGH DENSITY LIPOPROTEIN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN KINASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCG1 PROTEIN, HUMAN; CHOLESTEROL;

ANIMAL CELL; ARTICLE; CELL SURFACE; CHO CELL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LIPID TRANSPORT; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; METABOLISM; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL;

CRICETULUS GRISEUS;

ANIMALS; ATP BINDING CASSETTE TRANSPORTER 1; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE INHIBITORS; PROTEIN STABILITY; PROTEOLYSIS; RAS PROTEINS;

EID: 84876727729     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062667     Document Type: Article

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