Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem

Perfusion (United Kingdom)

Volumn 28, Issue 3, 2013, Pages 184-193

  Hayes, R A ^a   Shekar, K ^a   Fraser, J F ^a  

^a THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

cardiorespiratory failure; extracorporeal membrane oxygenation; hyperoxaemia; platelet activation; reactive oxygen species; thrombosis

Indexed keywords

ACETYLCYSTEINE; ARACHIDONIC ACID; INTERCELLULAR ADHESION MOLECULE 1; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEART INFARCTION; ADULT RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; BLOOD CLOTTING TIME; CARDIOPULMONARY BYPASS; CARDIOPULMONARY INSUFFICIENCY; CONFORMATIONAL TRANSITION; ENERGY YIELD; EXTRACORPOREAL OXYGENATION; HEART FUNCTION; HUMAN; HYPERBARIC OXYGEN; HYPEROXIA; IATROGENIC DISEASE; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; LUNG CIRCULATION; NEUTROPHIL; OXIDATIVE STRESS; OXYGEN CONCENTRATION; OXYGEN TENSION; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RENAL PROTECTION; REPERFUSION INJURY; REVIEW; RISK FACTOR; TENSION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOSIS; TRAUMATIC BRAIN INJURY; UPPER EXTREMITY DEEP VEIN THROMBOSIS;

EXTRACORPOREAL MEMBRANE OXYGENATION; HEMORRHAGE; HUMANS; HYPEROXIA; PLATELET AGGREGATION; REACTIVE OXYGEN SPECIES; RISK FACTORS; THROMBOSIS;

EID: 84876725030     PISSN: 02676591     EISSN: 1477111X     Source Type: Journal    
DOI: 10.1177/0267659112473172     Document Type: Review

References (91)

1. Allen S, Holena D, McCunn M, et al. A review of the fundamental principles and evidence base in the use of extracorporeal membrane oxygenation (ECMO) in critically ill adult patients. J Intensive Care Med. 2011 ; 26: 13-26
2. Bartlett RH, Gattinoni L. Current status of extracorporeal life support (ECMO) for cardiopulmonary failure. Minerva Anestesiol. 2010 ; 76: 534-540
3. Lindstrom SJ, Pellegrino VA, Butt WW. Extracorporeal membrane oxygenation. Med J Aust. 2009 ; 191: 178-182
4. Fraser JF, Shekar K, Diab S, et al. ECMO - the clinician's view. ISBT Sci Series. 2012 ; 7: 82-88
5. Garcia JP, Kon ZN, Evans C, et al. Ambulatory veno-venous extracorporeal membrane oxygenation: innovation and pitfalls. J Thorac Cardiovasc Surg. 2011 ; 142: 755-761
6. Marasco SF, Lukas G, McDonald M, et al. Review of ECMO (extra corporeal membrane oxygenation) support in critically ill adult patients. Heart Lung Circ. 2008 ; 17: S41-47
7. Stulak JM, Dearani JA, Burkhart HM, et al. ECMO cannulation controversies and complications. Semin Cariothorac Vasc Anesth. 2009 ; 13: 176-182
8. Vasavada R, Feng Qiu, Undar A. Current status of pediatric/neonatal extracorporeal life support: clinical outcomes, circuit evolution, and translational research. Perfusion. 2011 ; 26: 294-301
9. Ferraris VA, Brown JR, Despotis GJ, et al. 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg. 2011 ; 91: 944-982
10. Sievert A, Uber W, Laws S, et al. Improvement in long-term ECMO by detailed monitoring of anticoagulation: a case report. Perfusion. 2011 ; 26: 59-64
11. Muntean W. Coagulation and anticoagulation in extracorporeal membrane oxygenation. Artif Organs. 1999 ; 23: 979-983
12. Klinger G, Beyene J, Shah P, et al. Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia?. Arch Dis Child Fetal Neonatal Ed. 2005 ; 90: F49-52
13. Davis DP, Meade W, Sise MJ, et al. Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma. 2009 ; 26: 2217-2223
14. Bellomo R, Bailey M, Eastwood GM, et al. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care. 2011 ; 15: R90
15. Spurlock DJ, Toomasian JM, Romano MA, et al. A simple technique to prevent limb ischemia during veno-arterial ECMO using the femoral artery: the posterior tibial approach. Perfusion. 2012 ; 27: 141-145
16. Shekar K, Fraser JF, Smith MT, et al. Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. J Crit Care. 2012 ; 27: 741
17. Nakamura T, Takata M, Arai M, et al. The effect of left-to-right shunting on coronary oxygenation during extracorporeal membrane oxygenation. J Pediatr Surg. 1999 ; 34: 981-985 (Pubitemid 29277918)
18. Joachimsson PO, Sjöberg F, Forsman M, et al. Adverse effects of hyperoxemia during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1996 ; 112: 812-819 (Pubitemid 26347039)
19. Kilgannon JH, Jones AE, Shapiro NI, et al. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA. 2010 ; 303: 2165-2171
20. Tsangaris H, Pneumatikos J, Sdranis J, et al. The effect of hyperoxaemia on erythropoietin secretion in anaemic patients. Monaldi Arch Chest Dis. 1999 ; 54: 120-125 (Pubitemid 29329223)
21. Kilgannon JH, Jones AE, Parrillo JE, et al. Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation. 2011 ; 123: 2717-2722
22. Ferguson LP, Durward A, Tibby SM. Relationship between arterial partial oxygen pressure after resuscitation from cardiac arrest and mortality in children. Circulation. 2012 ; 126: 335-342
23. Brenner M, Stein D, Hu P, et al. Association between early hyperoxia and worse outcomes after traumatic brain injury. Arch Surg. 2012 ; 147: 1-5
24. De Jonge E, Peelen L, Keijzers PJ, et al. Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care. 2008 ; 12: R156
25. Mach WJ, Thimmesch AR, Pierce JT, et al. Consequences of hyperoxia and the toxicity of oxygen in the lung. Nurs Res Pract. 2011 ; 2011: 260482
26. Bartorelli AL. Hyperoxemic perfusion for treatment of reperfusion microvascular ischemia in patients with myocardial infarction. Am J Cardiovasc Drugs. 2003 ; 3: 253-263 (Pubitemid 37069837)
27. Bigdeli MR, Asheghabadi M, Khalili A. Time course of neuroprotection induced by normobaric hyperoxia in focal cerebral ischemia. Neurol Res. 2012 ; 34: 439-446
28. Auer RN. Non-pharmacologic (physiologic) neuroprotection in the treatment of brain ischemia. Ann N Y Acad Sci. 2001 ; 939: 271-282 (Pubitemid 32620077)
29. Stub D, Smith K, Bernard S, et al. A randomized controlled trial of oxygen therapy in acute myocardial infarction Air Verses Oxygen In myocarDial infarction study (AVOID Study). Am Heart J. 2012 ; 163: 339-345
30. Miyamoto O, Auer RN. Hypoxia, hyperoxia, ischemia, and brain necrosis. Neurology. 2000 ; 54: 362-371 (Pubitemid 30078067)
31. Meyhoff CS, Staehr AK, Rasmussen LS. Rational use of oxygen in medical disease and anesthesia. Curr Opin Anaesthesiol. 2012 ; 25: 363-370
32. Schultz JM, Karamlou T, Shen I, et al. Cardiac output augmentation during hypoxemia improves cerebral metabolism after hypothermic cardiopulmonary bypass. Ann Thorac Surg. 2006 ; 81: 625-632
33. Toraman F, Evrenkaya S, Senay S, et al. Adjusting oxygen fraction to avoid hyperoxemia during cardiopulmonary bypass. Asian Cardiovasc Thorac Ann. 2007 ; 15: 303-306 (Pubitemid 47377179)
34. Lambert AJ, Brand MD. Reactive oxygen species production by mitochondria. Methods Mol Biol. 2009 ; 554: 165-181
35. Nishikawa T, Araki E. Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications. Antioxid Redox Signal. 2007 ; 9: 343-353 (Pubitemid 46150966)
36. Ralph SJ, Rodríguez-Enríquez S, Neuzil J, et al. The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy. Mol Aspects Med. 2010 ; 31: 145-170
37. Neumar RW. Optimal oxygenation during and after cardiopulmonary resuscitation. Curr Opin Crit Care. 2011 ; 17: 236-240
38. Ang AL, Teo D, Lim CH, et al. Blood transfusion requirements and independent predictors of increased transfusion requirements among adult patients on extracorporeal membrane oxygenation - a single centre experience. Vox Sang. 2009 ; 96: 34-43
39. Mangalmurti NS, Chatterjee S, Cheng G, et al. Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products. Transfusion. 2010 ; 50: 2353-2361
40. McDonald CI, Fung YL, Fraser JF. Antioxidant trace element reduction in an in vitro cardiopulmonary bypass circuit. ASAIO J. 2012 ; 58: 217-222
41. Förstermann U.. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med. 2008 ; 5: 338-349 (Pubitemid 351761708)
42. Klotz LO, Kröncke KD, Buchczyk DP, et al. Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress. J Nutr. 2003 ; 133: 1448S - 451S (Pubitemid 36548723)
43. Perkowski S, Scherpereel A, Murciano JC, et al. Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2006 ; 291: L1050-1058
44. Fung YL, Fraser JF, Wood P, et al. The systemic inflammatory response syndrome induces functional changes and relative hyporesponsiveness in neutrophils. J Crit Care. 2008 ; 23: 542-549
45. Ciapetti M, Cianchi G, Zagli G, et al. Feasibility of inter-hospital transportation using extra-corporeal membrane oxygenation (ECMO) support of patients affected by severe swine-flu(H1N1)-related ARDS. Scand J Trauma Resusc Emerg Med. 2011 ; 19: 32
46. Noah MA, Peek GJ, Finney SJ, et al. Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1). JAMA. 2011 ; 306: 1659-1668
47. Kaminski KA, Bonda TA, Korecki J, et al. Oxidative stress and neutrophil activation-the two keystones of ischemia/reperfusion injury. Int J Cardiol. 2002 ; 86: 41-59 (Pubitemid 35247882)
48. Fontana L, Giagulli C, Minuz P, et al. 8-Iso-PGF2 alpha induces beta 2-integrin-mediated rapid adhesion of human polymorphonuclear neutrophils: a link between oxidative stress and ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol. 2001 ; 21: 55-60 (Pubitemid 32061927)
49. Tung JP, Fraser JF, Wood P, et al. Respiratory burst function of ovine neutrophils. BMC Immunol. 2009 ; 10: 25
50. Basili S, Pignatelli P, Tanzilli G, et al. Anoxia-reoxygenation enhances platelet thromboxane A2 production via reactive oxygen species-generated NOX2: effect in patients undergoing elective percutaneous coronary intervention. Arterioscler Thromb Vasc Biol. 2011 ; 31: 1766-1771
51. De Biase L, Pignatelli P, Lenti L, et al. Enhanced TNF alpha and oxidative stress in patients with heart failure: effect of TNF alpha on platelet O2- production. Thromb Haemost. 2003 ; 90: 317-125
52. Adrian K, Mellgren K, Skogby M, et al. Cytokine release during long-term extracorporeal circulation in an experimental model. Artif Organs. 1998 ; 22: 859-863 (Pubitemid 28471277)
53. Fortenberry JD, Bhardwaj V, Niemer P, et al. Neutrophil and cytokine activation with neonatal extracorporeal membrane oxygenation. J Pediatr. 1996 ; 128: 670-678 (Pubitemid 26137726)
54. Schaible T, Veit M, Tautz J, et al. Serum cytokine levels in neonates with congenital diaphragmatic hernia. Klin Pädiatr. 2011 ; 223: 414-418
55. McIlwain RB, Timpa JG, Kurundkar AR, et al. Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine. Lab Invest. 2010 ; 90: 128-139
56. Caudrillier A, Kessenbrock K, Gilliss BM, et al. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 ; 122: 2661-2671
57. Caudrillier A, Looney MR. Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury. Curr Pharm Des. 2012 ; 18: 3260-3266
58. Begonja AJ, Gambaryan S, Geiger J, et al. Platelet NAD(P)H-oxidase- generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. Blood. 2005 ; 106: 2757-2760 (Pubitemid 41510751)
59. Chlopicki S, Olszanecki R, Janiszewski M, et al. Functional role of NADPH oxidase in activation of platelets. Antioxid Redox Signal. 2004 ; 6: 691-698 (Pubitemid 38890785)
60. Arita H, Nakano T, Hanasaki K. Thromboxane A2: its generation and role in platelet activation. Prog Lipid Res. 1989 ; 28: 273-301
61. Olas B, Wachowicz B. Role of reactive nitrogen species in blood platelet functions. Platelets. 2007 ; 18: 555-565 (Pubitemid 350179037)
62. Freedman JE. Oxidative stress and platelets. Arterioscler Thromb Vasc Biol. 2008 ; 28: s11-16
63. Iuliano L, Colavita AR, Leo R, et al. Oxygen free radicals and platelet activation. Free Radic Biol Med. 1997 ; 22: 999-1006 (Pubitemid 27084137)
64. Michelson AD. Methods for the measurement of platelet function. Am J Cardiol. 2009 ; 103: 20A - 26A
65. Kim C, Ye F, Ginsberg MH. Regulation of integrin activation. Ann Rev Cell Dev Biol. 2011 ; 27: 321-345
66. Offermanns S. Activation of platelet function through G protein-coupled receptors. Circ Res. 2006 ; 99: 1293-1304 (Pubitemid 44949665)
67. Smyth SS, McEver RP, Weyrich AS, et al. Platelet functions beyond hemostasis. J Thromb Haemost. 2009 ; 7: 1759-1766
68. Lazar DA, Cass DL, Olutoye OO, et al. Venovenous cannulation for extracorporeal membrane oxygenation using a bicaval dual-lumen catheter in neonates. J Pediatr Surg. 2012 ; 47: 430-434
69. Jacobson J. Nitric oxide: platelet protectant properties during cardiopulmonary bypass/ECMO. J Extra Corpor Technol. 2002 ; 34: 144-147 (Pubitemid 35434283)
70. Frenckner B, Radell P. Respiratory failure and extracorporeal membrane oxygenation. Semin Pediatr Surg. 2008 ; 17: 34-41 (Pubitemid 350297997)
71. Konkle BA. Acquired disorders of platelet function. Hematology Am Soc Hematol Educ Program. 2011 ; 2011: 391-396
72. Samama CM, Diaby M, Fellahi JL, et al. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology. 1995 ; 83: 56-65
73. Lowson SM, Hassan HM, Rich GF. The effect of nitric oxide on platelets when delivered to the cardiopulmonary bypass circuit. Anesth Analg. 1999 ; 89: 1360-1365
74. Rauch ED, Stammers AH, Mejak BL, et al. The effects of nitric oxide on coagulation during simulated extracorporeal membrane oxygenation. J Extra Corpor Technol. 2000 ; 32: 214-219 (Pubitemid 32016849)
75. Afshari A, Brok J, Møller AM, et al. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults. Cochrane Database Syst Rev. 2010 ;:
76. Adhikari NK, Burns KE, Friedrich JO, et al. Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ. 2007 ; 334: 779
77. Forceville X, Vitoux D, Gauzit R, et al. Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients. Crit Care Med. 1998 ; 26: 1536-1544 (Pubitemid 28450362)
78. Hayes GL, McKinzie BP, Bullington WM, et al. Nutritional supplements in critical illness. AACN Adv Crit Care. 2011 ; 22: 301-316
79. Sadowska AM, Manuel-Y-Keenoy B, De Backer WA. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm Pharmacol Ther. 2007 ; 20: 9-22 (Pubitemid 44648802)
80. Allegra L, Dal Sasso M, Bovio C, et al. Human neutrophil oxidative bursts and their in vitro modulation by different N-acetylcysteine concentrations. Arzneimittelforschung. 2002 ; 52: 669-676
81. Buyukhatipoglu H, Sezen Y, Yildiz A, et al. N-acetylcysteine fails to prevent renal dysfunction and oxidative stress after noniodine contrast media administration during percutaneous coronary interventions. Pol Arch Med Wewn. 2010 ; 120: 383-389
82. Adabag AS, Ishani A, Bloomfield HE, et al. Efficacy of N-acetylcysteine in preventing renal injury after heart surgery: a systematic review of randomized trials. Eur Heart J. 2009 ; 30: 1910-1917
83. Akca S, Haji-Michael P, De Mendonça A, et al. Time course of platelet counts in critically ill patients. Crit Care Med. 2002 ; 30: 753-756 (Pubitemid 34297789)
84. Nguyen TC, Carcillo JA. Bench-to-bedside review: thrombocytopenia- associated multiple organ failure-a newly appreciated syndrome in the critically ill. Critical care. 2006 ; 10: 235
85. Hsu LC. Heparin-coated cardiopulmonary bypass circuits: current status. Perfusion. 2001 ; 16: 417-428
86. Gourlay T. Biomaterial development for cardiopulmonary bypass. Perfusion. 2001 ; 16: 381-390 (Pubitemid 32834432)
87. Shafii AE, Brown CR, Murthy SC, et al. High incidence of upper-extremity deep vein thrombosis with dual-lumen venovenous extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg. 2012 ; 144: 988-989
88. Meyer AD, Wiles AA, Rivera O, et al. Hemolytic and thrombocytopathic characteristics of extracorporeal membrane oxygenation systems at simulated flow rate for neonates. Pediatr Crit Care Med. 2012 ; 13: e255 - e261
89. Toomasian JM, Bartlett RH. Hemolysis and ECMO pumps in the 21st Century. Perfusion. 2011 ; 26: 5-6
90. Shekar K, Fung YL, Diab S, et al. Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care Resusc. 2012 ; 14: 105-111
91. Fung YL, Diab S, Dunster K, et al. Extracorporeal lessons from sheep. ISBT Sci Series. 2012 ; 7: 92-95