Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure - A newly appreciated syndrome in the critically ill

Critical Care

Volumn 10, Issue 6, 2006, Pages

  Nguyen, Trung C ^a   Carcillo, Joseph A ^b  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; ANTITHROMBIN III; APROTININ; FIBRINOLYTIC AGENT; FRESH FROZEN PLASMA; GLYCERYL TRINITRATE; HEPARIN; MILRINONE; PENTOXIFYLLINE; PROSTACYCLIN; PROTEIN C; STEROID; STREPTOKINASE; TRANEXAMIC ACID; UROKINASE; VINCRISTINE; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

BLEEDING; BLOOD CLOTTING; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; CRYOPRECIPITATE; DISEASE ASSOCIATION; DISSEMINATED INTRAVASCULAR CLOTTING; ENZYME ACTIVITY; HUMAN; INTENSIVE CARE; MULTIPLE CYCLE TREATMENT; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PLASMAPHERESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SEPSIS; SHOCK; SURVIVAL; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOSIS; THROMBOTIC THROMBOCYTOPENIC PURPURA; VON WILLEBRAND DISEASE; COMPLICATION; PROGNOSIS; SYNDROME;

CRITICAL ILLNESS; HUMANS; MULTIPLE ORGAN FAILURE; PLASMA EXCHANGE; PROGNOSIS; PROTEIN C; SYNDROME; THROMBOCYTOPENIA;

EID: 34247550937     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc5064     Document Type: Review

References (51)

1. Akca S Haji-Michael P de Mendonca A Suter P Levi M Vincent JL Time course of platelet counts in critically ill patients Crit Care Med 2002 30 753-756 10.1097/00003246-200204000-00005 11940740
2. Baughman RP Lower EE Flessa HC Tollerud DJ Thrombocytopenia in the intensive care unit Chest 1993 104 1243-1247 8404200
3. Brun-Buisson C Doyon F Carlet J Dellamonica P Gouin F Lepoutre A Mercier JC Offenstadt G Regnier B Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis JAMA 1995 274 968-974 10.1001/jama.274.12.968 7674528
4. Lee KH Hui KP Tan WC Thrombocytopenia in sepsis: A predictor of mortality in the intensive care unit Singapore Med J 1993 34 245-246 8266183
5. Nguyen TC Han YY Watson S Carcillo JA Kiss J Thrombocytopenia is associated with multiple organ failure and death in children Crit Care Med 2000 28S A50
6. Sprung CL Peduzzi PN Shatney CH Schein RM Wilson MF Sheagren JN Hinshaw LB Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group Crit Care Med 1990 18 801-806 10.1097/00003246-199001000-00034 2379391
7. Stephan F Hollande J Richard O Cheffi A Maier-Redelsperger M Flahault A Thrombocytopenia in a surgical ICU Chest 1999 115 1363-1370 10.1378/ chest.115.5.1363 10334154
8. Vanderschueren S De Weerdt A Malbrain M Vankersschaever D Frans E Wilmer A Bobbaers H Thrombocytopenia and prognosis in intensive care Crit Care Med 2000 28 1871-1876 10.1097/00003246-200006000-00031 10890635
9. Furlan M Robles R Galbusera M Remuzzi G Kyrle PA Brenner B Krause M Scharrer I Aumann V Mittler U von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolyticuremic syndrome N Engl J Med 1998 339 1578-1584 10.1056/NEJM199811263392202 9828245
10. Green J Doughty L Kaplan SS Carcillo JA The tissue factor and plasminogen activator type 1 response ion children with sepsis induced multiple organ failure Thromb Haemost 2002 87 218-223 11858480
11. Moake JL Thrombotic microangiopathies N Engl J Med 2002 347 589-600 10.1056/NEJMra020528 12192020
12. Tsai HM Lian EC Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura N Engl J Med 1998 339 1585-1594 10.1056/NEJM199811263392203 9828246
13. Sadler JE Biochemistry and genetics of von Willebrand factor Annu Rev Biochem 1998 67 395-424 10.1146/annurev.biochem.67.1.395 9759493
14. van Mourik JA Boertjes R Huisveld IA Fijnvandraat K Pajkrt D van Genderen PJ Fijnheer R von Willebrand factor propeptide in vascular disorders: A tool to distinguish between acute and chronic endothelial cell perturbation Blood 1999 94 179-185 10381511
15. Levy GG Nichols WC Lian EC Foroud T McClintick JN McGee BM Yang AY Siemieniak DR Stark KR Gruppo R Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura Nature 2001 413 488-494 10.1038/35097008 11586351
16. Asada Y Sumiyoshi A Hayashi T Suzumiya J Kaketani K Immunohistochemistry of vascular lesion in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen Thromb Res 1985 38 469-479 10.1016/0049-3848(85)90180-X 2861671
17. Bell WR Braine HG Ness PM Kickler TS Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients N Engl J Med 1991 325-398 403 2062331
18. Rock GA Shumak KH Buskard NA Blanchette VS Kelton JG Nair RC Spasoff RA Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group N Engl J Med 1991 325 393-397 2062330
19. Brilliant SE Lester PA Ohno AK Carlon MJ Davis BJ Cusher HM Hemolytic uremic syndrome without evidence of microangiopathic hemolysis on peripheral blood smear South Med J 1996 89 342-345 10.1097/ 00007611-199603000-00018 8604470
20. Fava S Galizia AC Thrombotic thrombocytopenic purpura-like syndrome in the absence of schistocytes Br J Haematol 1995 89 643-644 7734369
21. Tsai HM Li A Rock G Inhibitors of von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura Clin Lab 2001 47 387-392 11499801
22. Moore JC Hayward CP Warkentin TE Kelton JG Decreased von Willebrand factor protease activity associated with thrombocytopenic disorders Blood 2001 98 1842-1846 10.1182/blood.V98.6.1842 11535519
23. Veyradier A Obert B Houllier A Meyer D Girma JP Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: A study of 111 cases Blood 2001 98 1765-1772 10.1182/blood.V98.6.1765 11535510
24. Ono T Mimuro J Madoiwa S Soejima K Kashiwakura Y Ishiwata A Takano K Ohmori T Sakata Y Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: Its correlation to development of renal failure Blood 2006 107 528-534 10.1182/blood-2005-03-1087 16189276
25. Busund R Koukline V Utrobin U Nedashkovsky E Plasmapheresis in severe sepsis and septic shock: A prospective, randomised, controlled trial Intensive Care Med 2002 28 1434-1439 10.1007/s00134-002-1410-7 12373468
26. Bernard GR Vincent JL Laterre PF LaRosa JP Dhainaut JF Lopez-Rodriguez A Steingrad JS Garbo GE Heltebrand JD Ely W Fisher CJ Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001 344 699-709 10.1056/NEJM200103083441001 11236773
27. Chauhan AK Motto DG Lamb CB Bergmeier W Dockal M Plaimauer B Scheiflinger F Ginsburg D Wagner DD The metalloprotease ADAMTS13 is a natural anti-thrombotic J Exp Med 2006 203 767-776 10.1084/jem.20051732 16533881
28. Motto D Zhang W Zhu G Additional environmental and/or genetic factors are required to trigger TTP in ADAMTS13-deficient mice (Abstract) Blood 2004 104 258 10.1182/blood-2004-04-1438
29. Motto DG Chauhan AK Zhu G Homeister J Lamb CB Desch KC Zhang W Tsai HM Wagner DD Ginsburg D Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice J Clin Invest 2005 115 2752-2761 1240119 16200209 10.1172/JCI26007
30. Bick RL Disseminated intravascular coagulation: Pathophysiologic mechanisms and manifestations. Semin Thromb Hemost 1998 24 3-18 9515775
31. Bick RL Disseminated intravascular coagulation: Objective clinical and laboratory diagnosis, treatment and assessment of therapeutic response Semin Thromb Hemost 1996 22 69-88 8711492
32. Kwan HC Thrombotic microangiopathy Semin Hematol 1987 24 69-81 3603058
33. Kwan HC Miscellaneous secondary thrombotic microangiopathy Semin Hematol 1987 24 141-147
34. Nguyen T Hall Y Fiedor M Hasset A Lopez-Plena I Watson S Lum L Carcillo JA Microvascular thrombosis in pediatric multiple organ failure: Is it a therapeutic target? Pediatr Crit Care Med 2001 2 187-196 10.1097/ 00130478-200107000-00001 12793940
35. Dreyfus M Masterson M David M Rivard GE Muller FM Krenz W Beeg T Minard A Allgrove J Cohen JD, et al. Replacement therapy with a monoclonal Ab purified protein C concentrate in newborns with severe congenital protein C deficiency Semin Thromb Hemost 1995 21 371-381 8747700
36. Churchwell KB McManus ML Kent P Gorlin J Galacki D Humphreys D Kevy SV Intensive blood and plasma exchange for treatment of coagulopathy in meningococcemia J Clin Apheresis 1995 10 171-177 8770708
37. Fourrier F Chopin C Huart JJ Runge I Caron C Goudemand J Double blind placebo controlled trial of antithrombin III concentrate in septic shock with disseminated intravascular coagulation Chest 1993 104 882-888 8365305
38. Gross SM Kennan JJ Whole blood transfusion for exsanguinating coagulopathy in a US field surgical hospital in Kosovo J Trauma 2000 49 145-148 10912871
39. Harrison CN Lawrie AS Iqbal A Hunter A Machin SJ Plasma exchange with solvent/detergent treated plasma of resistant thrombotic thrombocytopenic purpura Br J Haematol 1996 94 756-758 10.1046/ j.1365-2141.1996.d01-1836.x 8826906
40. Hattersley PG Kuntel M Cryoprecipitate as a souce of fibrinogen in treatment of disseminated intravascular coagulation Transfusion 1976 16 641-645 10.1046/j.1537-2995.1976.16677060249.x 996924
41. Leclerc F Hazelzet JA Jude B Hofhuis W Hue V Martinot A Van de Vort E Protein C and S deficiency in severe infectious purpura of children: A collaborative study of 40 cases Intensive Care Med 1992 18 202-225 10.1007/BF01709832 1430582
42. McManus ML Churchwell KD Coagulopathy as a predictor of outcome in meningococcal sepsis and systemic inflammatory response syndrome with purpura Crit Care Med 1993 21 706-711 10.1097/00003246-199305000-00014 8482092
43. Riewald M Reiss H Treatment options for clinically recognized disseminated intravascular coagulation Semin Thromb Hemost 1998 24 53-59 9515780
44. Rintala E Kauppila M Seppala O Voipio-Pulkk L Pettila V Rasi V Kotilainen P Protein C substitution in sepsis-associated purpura fulminans Crit Care Med 2000 28 2373-2378 10.1097/ 00003246-200007000-00032 10921567
45. Rock G Shumak KH Sutton DM Buskard NA Nair RC Cryosupernatant as replacement fluid for plasma exchange in thrombotic thrombocytopenic purpura. Members of the Canadian Apheresis Group Br J Haematol 1996 94 383-386 10.1046/j.1365-2141.1996.d01-1800.x 8759902
46. Sagripanti A Carpi A Rosaia B Morelli E Innocenti M D'Acunto G Nicolini A Iloprost in the treatment of thrombotic microangiopathy: report of thirteen cases Biomed Pharmacother 1996 50 350-356 10.1016/ S0753-3322(96)89667-3 8952854
47. Williams CK Fernbach B Cuttner J Hallert JF Essien ER Management of leukemia associated disseminated intravascular coagulation Haematologia (Budap) 1982 15 287-295 7185647
48. Zenz W Bodo Z Zobel G Fanconi S Rettenbacher A Recombinant tissue plasminogen activator restores perfusion in meningococcal purpura fulminans Crit Care Med 1998 26 969-971 10.1097/00003246-199805000-00039 9590330
49. Reeves JH A review of plasma exchange in sepsis Blood Purification 2002 20 282-286 10.1159/000047021 11867876
50. Stegmayr BG Banga R Berggren L Norda R Rydvall A Vikerfors T Plasma exchange as rescue therapy in multiple organ failure including acute renal failure Crit Care Med 2003 31 1730-1736 10.1097/ 01.CCM.0000064742.00981.14 12794412
51. Darmon M Azoulay E Thiery G Ciroldi M Galicier L Parquet N Veyradier A Le Gall JR Oksenhendler E Schlemmer B Time course of organ dysfunction in thrombotic microanguiopathy patients receiveign either plasma perfusion or plasm exchange Crit Care Med 2006 34 2127-2133 10.1097/ 01.CCM.0000227659.14644.3E 16763519