Cardiac output augmentation during hypoxemia improves cerebral metabolism after hypothermic cardiopulmonary bypass

Annals of Thoracic Surgery

Volumn 81, Issue 2, 2006, Pages 625-633

  Schultz, Jess M ^a   Karamlou, Tara ^a   Shen, Irving ^a   Ungerleider, Ross M ^a,b   Corno, Antonio ^c   Douglas, William ^c   Mayer, John ^c   Jacobs, Marshall ^c   Bradley, Scott M ^c   Brizard, Christian ^c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTICLE; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN PERFUSION; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; DISEASE CLASSIFICATION; HEART OUTPUT MEASUREMENT; HEMATOCRIT; HEMODYNAMICS; HYPOTHERMIA; HYPOXEMIA; INTERMETHOD COMPARISON; NEWBORN; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TENSION; PRIORITY JOURNAL; SWINE;

ANIMALS; ANIMALS, NEWBORN; ANOXEMIA; BRAIN; CARDIAC OUTPUT; CIRCULATORY ARREST, DEEP HYPOTHERMIA INDUCED; OXYGEN CONSUMPTION; RANDOM ALLOCATION; SWINE;

EID: 31044452084     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2005.06.042     Document Type: Article

References (24)

1. W.J. Greeley, F.H. Kern, R.M. Ungerleider The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children J Thorac Cardiovasc Surg 101 1991 783 794
2. W.J. Greeley, V.A. Bracey, R.M. Ungerleider Recovery of cerebral metabolism and mitochondrial oxidation state is delayed after hypothermic circulatory arrest Circulation 84 Suppl 3 1991 400 406
3. D.C. Bellinger, R.A. Jonas, L.A. Rappaport Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass [see comment] N Engl J Med 332 1995 549 555
4. C.D. Kurth, M. Priestley, J. Golden, J. McCann, R. Raghupathi Regional patterns of neuronal death after deep hypothermic circulatory arrest in newborn pigs [see comment] J Thorac Cardiovasc Surg 118 1999 1068 1077
5. D. Wypii, J.W. Newburger, L.A. Rappaport The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment the Boston Circulatory Arrest Trial J Thorac Cardiovasc Surg 126 2003 1397 1403
6. S.M. Langley, P.J. Chai, S.E. Miller Intermittent perfusion protects the brain during deep hypothermic circulatory arrest Ann Thorac Surg 68 1999 4 13
7. J.W. Newburger, R.A. Jonas, G. Wernovsky A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery [see comment] N Engl J Med 329 1993 1057 1064
8. A.J. duPlessis, R.A. Jonas, D. Wypij Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants J Thorac Cardiovasc Surg 114 1997 991 1001
9. 2 and cerebral blood flow in hypoxic hypoxia Acta Physiolog Scand 93 1975 423 432
10. S.L. Tsui, J. Schultz, I. Shen, R.M. Ungerleider Postoperative hypoxemia exacerbates potential brain injury after deep hypothermic circulatory arrest Ann Thorac Surg 2004 In press.
11. M.M. O'Rourke, K.M. Nork, C.D. Kurth Altered brain oxygen extraction with hypoxia and hypotension following deep hypothermic circulatory arrest Acta Neurochirurg 70 Suppl 1997 78 79
12. M.M. O'Rourke, K.M. Nork, C.D. Kurth Neonatal cerebral oxygen regulation after hypothermic cardiopulmonary bypass and circulatory arrest Crit Care Med 28 2000 157 162
13. M. Aoki, F. Nomura, M.E. Stromski Effects of pH on brain energetics after hypothermic circulatory arrest Ann Thorac Surg 55 1993 1093 1103
14. C.P. Reinhardt, S. Dalhberg, M.A. Tries, R. Marcel, J.A. Leppo Stable labeled microspheres to measure perfusion validation of a neutron activation assay technique Am J Physiol Heart Circ Physiol 280 2001 H108 H116
15. W.T. Mahle, R.R. Clancy, E.M. Moss, M. Gerdes, D.R. Jobes, G. Wernovsky Neurodevelopmental outcome and lifestyle assessment in school-aged and adolescent children with hypoplastic left heart syndrome Pediatrics 105 2000 1082 1089
16. D.C. Bellinger, D. Wypij, A.J. duPlesis, L.A. Rappaport, R.A. Jonas, G. Wernovsky, J.W. Newberger Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries the Boston Circulatory Arrest Trial J Thorac Cardiovasc Surg 126 2003 1385 1396
17. L.F. Duebener, I. Hagino, T. Sakamoto Effects of pH management during deep hypothermic bypass on cerebral microcirculation alpha-stat versus pH-stat Circulation 106 Suppl 1 2002 103 108
18. T. Sakamoto, D. Zurakowski, L.F. Duebener Combination of alpha-stat strategy and hemodilution exacerbates neurologic injury in a survival piglet model with deep hypothermic circulatory arrest Ann Thorac Surg 73 2002 180 190
19. J.R. Mault, S. Ohtake, M.E. Klingensmith, J.S. Heinle, W.J. Greeley, R.M. Ungerleider Cerebral metabolism and circulatory arrest effects of duration and strategies for protection Ann Thorac Surg 55 1993 57 64
20. L.F. Duebener, T. Sakamoto, S. Hatsuoka Effects of hematocrit on cerebral microcirculation and tissue oxygenation during deep hypothermic bypass Circulation 104 Suppl 1 2001 260 264
21. H. Kawata, J.C. Fackler, M. Aoki Recovery of cerebral blood flow and energy state in piglets after hypothermic circulatory arrest versus recovery after low-flow bypass J Thorac Cardiovasc Surg 106 1993 671 685
22. O. Barnea, E.H. Austin, B. Richman, W.P. Santamore Balancing the circulation theoretic optimization of pulmonary/systemic flow ratio in hypoplastic left heart syndrome [see comment] J Am Coll Cardiol 24 1994 1376 1381
23. W.A. Cooper, I.G. Duarte, V.H. Thourani Hypothermic circulatory arrest causes multisystem vascular endothelial dysfunction and apoptosis Ann Thorac Surg 69 2000 696 703
24. R.M. Ungerleider, I. Shen, T. Yeh Jr, J. Schultz, R. Butler, M. Silberbach, C. Giacomuzzi Routine mechanical ventricular assist following the Norwood procedure - improved neurologic outcome and excellent hospital survival Ann Thorac Surg 77 2004 18 22