-
2
-
-
84862554715
-
Myelodysplastic syndromes: 2012 update on diagnosis, risk-stratification, and management
-
Garcia-Manero G: Myelodysplastic syndromes: 2012 update on diagnosis, risk-stratification, and management. Am J. Hematol 2012;87:692-701.
-
(2012)
Am J. Hematol
, vol.87
, pp. 692-701
-
-
Garcia-Manero, G.1
-
3
-
-
19944427850
-
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
-
Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005;352:254-266.
-
(2005)
N Engl J Med
, vol.352
, pp. 254-266
-
-
Falini, B.1
Mecucci, C.2
Tiacci, E.3
-
4
-
-
0037114829
-
Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
-
Frohling S, Schlenk RF, Breitruck J, et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm. Blood 2002;100:4372-4380.
-
(2002)
Blood
, vol.100
, pp. 4372-4380
-
-
Frohling, S.1
Schlenk, R.F.2
Breitruck, J.3
-
5
-
-
2142675553
-
FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype
-
Beran M, Luthra R, Kantarjian H, et al. FLT3 mutation and response to intensive chemotherapy in young adult and elderly patients with normal karyotype. Leuk Res 2004;28:547-550.
-
(2004)
Leuk Res
, vol.28
, pp. 547-550
-
-
Beran, M.1
Luthra, R.2
Kantarjian, H.3
-
6
-
-
0036720398
-
The roles of FLT3 in hematopoiesis and leukemia
-
Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood 2002;100:1532-1542.
-
(2002)
Blood
, vol.100
, pp. 1532-1542
-
-
Gilliland, D.G.1
Griffin, J.D.2
-
7
-
-
33748467435
-
Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): A Cancer and Leukemia Group B Study
-
Paschka P, Marcucci G, Ruppert AS, et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): A Cancer and Leukemia Group B Study. J Clin Oncol 2006;24:3904-3911.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3904-3911
-
-
Paschka, P.1
Marcucci, G.2
Ruppert, A.S.3
-
8
-
-
33646575624
-
Implications of NRAS mutations in AML: A study of 2502 patients
-
Bacher U, Haferlach T, Schoch C, et al. Implications of NRAS mutations in AML: A study of 2502 patients. Blood 2006;107:3847-3853.
-
(2006)
Blood
, vol.107
, pp. 3847-3853
-
-
Bacher, U.1
Haferlach, T.2
Schoch, C.3
-
9
-
-
0035383768
-
FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
-
Stirewalt DL, Kopecky KJ, Meshinchi S, et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood 2001;97:3589-3595.
-
(2001)
Blood
, vol.97
, pp. 3589-3595
-
-
Stirewalt, D.L.1
Kopecky, K.J.2
Meshinchi, S.3
-
10
-
-
0033014304
-
RAS and leukemia: From basic mechanisms to gene-directed therapy
-
Beaupre DM, Kurzrock R. RAS and leukemia: From basic mechanisms to gene-directed therapy. J Clin Oncol 1999;17:1071-1079.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1071-1079
-
-
Beaupre, D.M.1
Kurzrock, R.2
-
11
-
-
0024990090
-
N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance
-
Radich JP, Kopecky KJ, Willman CL, et al. N-ras mutations in adult de novo acute myelogenous leukemia: Prevalence and clinical significance, Blood 1990;76:801-807.
-
(1990)
Blood
, vol.76
, pp. 801-807
-
-
Radich, J.P.1
Kopecky, K.J.2
Willman, C.L.3
-
13
-
-
34250011216
-
Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: A Cancer and Leukemia Group B study
-
Whitman SP, Ruppert AS, Marcucci G, et al. Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: A Cancer and Leukemia Group B study. Blood 2007;109:5164-5167.
-
(2007)
Blood
, vol.109
, pp. 5164-5167
-
-
Whitman, S.P.1
Ruppert, A.S.2
Marcucci, G.3
-
14
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009;361:1058-1066.
-
(2009)
N Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
-
15
-
-
77952536841
-
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
-
Marcucci G, Maharry K, Wu YZ, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol 28:2348-2355.
-
J Clin Oncol
, vol.28
, pp. 2348-2355
-
-
Marcucci, G.1
Maharry, K.2
Wu, Y.Z.3
-
16
-
-
58249122390
-
TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis
-
Bowen D, Groves MJ, Burnett AK, et al. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis. Leukemia 2009;23:203-206.
-
(2009)
Leukemia
, vol.23
, pp. 203-206
-
-
Bowen, D.1
Groves, M.J.2
Burnett, A.K.3
-
17
-
-
0026578668
-
Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia
-
Nakagawa T, Saitoh S, Imoto S, et al. Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia. Oncology 1992;49:114-122.
-
(1992)
Oncology
, vol.49
, pp. 114-122
-
-
Nakagawa, T.1
Saitoh, S.2
Imoto, S.3
-
18
-
-
0027181645
-
N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome
-
Paquette RL, Landaw EM, Pierre RV, et al. N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome. Blood 1993;82:590-599.
-
(1993)
Blood
, vol.82
, pp. 590-599
-
-
Paquette, R.L.1
Landaw, E.M.2
Pierre, R.V.3
-
19
-
-
0030986849
-
No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes
-
Mitani K, Hangaishi A, Imamura N, et al. No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes. Leukemia 1997;11:863-865.
-
(1997)
Leukemia
, vol.11
, pp. 863-865
-
-
Mitani, K.1
Hangaishi, A.2
Imamura, N.3
-
20
-
-
17344371122
-
RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: A 10-year follow-up
-
Padua RA, Guinn BA, Al-Sabah AI, et al. RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: A 10-year follow-up. Leukemia 1998;12:887-892.
-
(1998)
Leukemia
, vol.12
, pp. 887-892
-
-
Padua, R.A.1
Guinn, B.A.2
Al-Sabah, A.I.3
-
21
-
-
24744449132
-
RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
-
Bowen DT, Frew ME, Hills R, et al. RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years. Blood 2005;106:2113-2119.
-
(2005)
Blood
, vol.106
, pp. 2113-2119
-
-
Bowen, D.T.1
Frew, M.E.2
Hills, R.3
-
22
-
-
70350438115
-
TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
-
Kosmider O, Gelsi-Boyer V, Cheok M, et al. TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood 2009;114:3285-3291.
-
(2009)
Blood
, vol.114
, pp. 3285-3291
-
-
Kosmider, O.1
Gelsi-Boyer, V.2
Cheok, M.3
-
23
-
-
67649876132
-
Acquired mutations in TET2 are common in myelodysplastic syndromes
-
Langemeijer SM, Kuiper RP, Berends M, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes, Nature genetics 2009;41:838-842.
-
(2009)
Nature genetics
, vol.41
, pp. 838-842
-
-
Langemeijer, S.M.1
Kuiper, R.P.2
Berends, M.3
-
24
-
-
77952426827
-
Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
-
Kosmider O, Gelsi-Boyer V, Slama L, et al. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia 2010;24:1094-1096.
-
(2010)
Leukemia
, vol.24
, pp. 1094-1096
-
-
Kosmider, O.1
Gelsi-Boyer, V.2
Slama, L.3
-
25
-
-
77952421834
-
Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
-
Boultwood J, Perry J, Pellagatti A, et al. Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia. Leukemia 2010;24:1062-1065.
-
(2010)
Leukemia
, vol.24
, pp. 1062-1065
-
-
Boultwood, J.1
Perry, J.2
Pellagatti, A.3
-
26
-
-
84876701610
-
Clinical Characterization and Proteomic Consequences of Mutated Ras in Acute Myeloid Leukemia
-
Kadia T, Kornblau SM, Kantarjian H, et al. Clinical Characterization and Proteomic Consequences of Mutated Ras in Acute Myeloid Leukemia. ASH Annual Meeting, New Orleans Abstracts 2009;114:330.
-
(2009)
ASH Annual Meeting, New Orleans Abstracts
, vol.114
, pp. 330
-
-
Kadia, T.1
Kornblau, S.M.2
Kantarjian, H.3
-
27
-
-
77950980368
-
RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant
-
Ricci C, Fermo E, Corti S, et al. RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant. Clin Cancer Res 16:2246-2256.
-
Clin Cancer Res
, vol.16
, pp. 2246-2256
-
-
Ricci, C.1
Fermo, E.2
Corti, S.3
-
28
-
-
34347236177
-
A comparative study of molecular mutations in 381 patients with myelodysplastic syndrome and in 4130 patients with acute myeloid leukemia
-
Bacher U, Haferlach T, Kern W, et al. A comparative study of molecular mutations in 381 patients with myelodysplastic syndrome and in 4130 patients with acute myeloid leukemia. Haematologica 2007;92:744-752.
-
(2007)
Haematologica
, vol.92
, pp. 744-752
-
-
Bacher, U.1
Haferlach, T.2
Kern, W.3
-
29
-
-
11144358111
-
Prognostically useful gene-expression profiles in acute myeloid leukemia
-
Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 2004;350:1617-1628.
-
(2004)
N Engl J Med
, vol.350
, pp. 1617-1628
-
-
Valk, P.J.1
Verhaak, R.G.2
Beijen, M.A.3
-
30
-
-
61849150985
-
High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients
-
Tyner JW, Erickson H, Deininger MW, et al. High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients. Blood 2009;113:1749-1755.
-
(2009)
Blood
, vol.113
, pp. 1749-1755
-
-
Tyner, J.W.1
Erickson, H.2
Deininger, M.W.3
-
31
-
-
0036260550
-
Ras processing as a therapeutic target in hematologic malignancies
-
Le DT, Shannon KM. Ras processing as a therapeutic target in hematologic malignancies. Curr Opin Hematol 2002;9:308-315.
-
(2002)
Curr Opin Hematol
, vol.9
, pp. 308-315
-
-
Le, D.T.1
Shannon, K.M.2
-
32
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev 2007;7:295-308.
-
(2007)
Nat Rev
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
33
-
-
60849083841
-
Oncogenic Kras-induced leukemogeneis: Hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation
-
Zhang J, Wang J, Liu Y, et al. Oncogenic Kras-induced leukemogeneis: Hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood 2009;113:1304-1314.
-
(2009)
Blood
, vol.113
, pp. 1304-1314
-
-
Zhang, J.1
Wang, J.2
Liu, Y.3
-
34
-
-
0345743699
-
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
-
Braun BS, Tuveson DA, Kong N, et al. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci USA 2004;101:597-602.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 597-602
-
-
Braun, B.S.1
Tuveson, D.A.2
Kong, N.3
-
35
-
-
33749320394
-
Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice
-
Parikh C, Subrahmanyam R, Ren R. Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice. Blood 2006;108:2349-2357.
-
(2006)
Blood
, vol.108
, pp. 2349-2357
-
-
Parikh, C.1
Subrahmanyam, R.2
Ren, R.3
-
36
-
-
65949123563
-
Oncogenic Kras initiates leukemia in hematopoietic stem cells
-
Sabnis AJ, Cheung LS, Dail M, et al. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol 2009;7:e59.
-
(2009)
PLoS Biol
, vol.7
-
-
Sabnis, A.J.1
Cheung, L.S.2
Dail, M.3
-
37
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study. Lancet Oncol 2009;10:223-232.
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
-
38
-
-
33846011361
-
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
-
Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007;109:52-57.
-
(2007)
Blood
, vol.109
, pp. 52-57
-
-
Kantarjian, H.1
Oki, Y.2
Garcia-Manero, G.3
-
39
-
-
0019952276
-
Proposals for the classification of the myelodysplastic syndromes
-
Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51:189-199.
-
(1982)
Br J Haematol
, vol.51
, pp. 189-199
-
-
Bennett, J.M.1
Catovsky, D.2
Daniel, M.T.3
-
40
-
-
33745968917
-
Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
-
Cheson BD, Greenberg PL, Bennett JM, et al. Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 2006;108:419-425.
-
(2006)
Blood
, vol.108
, pp. 419-425
-
-
Cheson, B.D.1
Greenberg, P.L.2
Bennett, J.M.3
-
41
-
-
0024998851
-
RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia
-
Hirsch-Ginsberg C, LeMaistre AC, Kantarjian H, et al. RAS mutations are rare events in Philadelphia chromosome-negative/bcr gene rearrangement-negative chronic myelogenous leukemia, but are prevalent in chronic myelomonocytic leukemia. Blood 1990;76:1214-1219.
-
(1990)
Blood
, vol.76
, pp. 1214-1219
-
-
Hirsch-Ginsberg, C.1
LeMaistre, A.C.2
Kantarjian, H.3
-
42
-
-
0030897009
-
International scoring system for evaluating prognosis in myelodysplastic syndromes
-
Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997;89:2079-2088.
-
(1997)
Blood
, vol.89
, pp. 2079-2088
-
-
Greenberg, P.1
Cox, C.2
LeBeau, M.M.3
-
43
-
-
77956237515
-
Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1
-
Kohlmann A, Grossmann V, Klein HU, et al. Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1. J Clin Oncol 2010;28:3858-3865.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3858-3865
-
-
Kohlmann, A.1
Grossmann, V.2
Klein, H.U.3
-
44
-
-
4544358326
-
Chronic myelomonocytic leukemia: Myeloproliferative variant
-
Onida F, Beran M. Chronic myelomonocytic leukemia: Myeloproliferative variant. Curr Hematol Rep 2004;3:218-226.
-
(2004)
Curr Hematol Rep
, vol.3
, pp. 218-226
-
-
Onida, F.1
Beran, M.2
-
45
-
-
57249084078
-
Genome profiling of chronic myelomonocytic leukemia: Frequent alterations of RAS and RUNX1 genes
-
Gelsi-Boyer V, Trouplin V, Adelaide J, et al. Genome profiling of chronic myelomonocytic leukemia: Frequent alterations of RAS and RUNX1 genes. BMC Cancer 2008;8:299.
-
(2008)
BMC Cancer
, vol.8
, pp. 299
-
-
Gelsi-Boyer, V.1
Trouplin, V.2
Adelaide, J.3
-
46
-
-
0026537641
-
Longitudinal analysis of point mutations of the N-ras proto-oncogene in patients with myelodysplasia using archived blood smears
-
van Kamp H, de Pijper C, Verlaan-de Vries M, et al. Longitudinal analysis of point mutations of the N-ras proto-oncogene in patients with myelodysplasia using archived blood smears. Blood 1992;79:1266-1270.
-
(1992)
Blood
, vol.79
, pp. 1266-1270
-
-
van Kamp, H.1
de Pijper, C.2
Verlaan-de Vries, M.3
|