Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

Biochemical Pharmacology

Volumn 85, Issue 10, 2013, Pages 1478-1485

  Lin, Kuan H ^a,b   Kuo, Jinn R ^c   Lu, Wan J ^b   Chung, Chi L ^d   Chou, Duen S ^b   Huang, Shih Y ^b   Lee, Hsiu C ^b,e   Sheu, Joen R ^b  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

Hinokitiol; Hydroxyl radical; MAPK; Occlusion time; Platelet activation; PLC 2

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; CALCIUM; COLLAGEN; HYDROXYL RADICAL; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE B; PROTEIN KINASE C; THROMBIN; THUJAPLICIN; TRIFLAVIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CLOTTING; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; EX VIVO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE;

ADENOSINE DIPHOSPHATE; ANIMALS; ARACHIDONIC ACID; BLOOD PLATELETS; CALCIUM; COLLAGEN; GENE EXPRESSION REGULATION; HUMANS; HYDROXYL RADICAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MONOTERPENES; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THROMBIN; THROMBOSIS; TROPOLONE;

EID: 84876681795     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.02.027     Document Type: Article

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