A 13-week subchronic toxicity study of hinokitiol administered in the diet to F344 rats

Food and Chemical Toxicology

Volumn 49, Issue 8, 2011, Pages 1782-1786

  Cho, Y M ^a   Hasumura, M ^a   Takami, S ^a   Imai, T ^b   Hirose, M ^c   Ogawa, K ^a   Nishikawa, A ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c Food Safety Commission of Japan   (Japan)

Author keywords

F344 rats; Hinokitiol; Subchronic toxicity

Indexed keywords

ALBUMIN; CHOLESTEROL; CREATININE; HEMOGLOBIN; PROTEIN; THUJAPLICIN;

ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; CHOLESTEROL BLOOD LEVEL; CHRONIC TOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG STRUCTURE; ERYTHROCYTE COUNT; FEMALE; FISCHER 344 RAT; HEART WEIGHT; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; LIVER WEIGHT; MALE; MEAN CORPUSCULAR VOLUME; MORTALITY; MYOCARDITIS; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SEX DIFFERENCE; SUBCHRONIC TOXICITY; TOXICITY TESTING; UREA NITROGEN BLOOD LEVEL; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; CHOLESTEROL; CREATININE; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTE COUNT; ERYTHROCYTE INDICES; FEMALE; HEART; KIDNEY; LIVER; MALE; MONOTERPENES; MYOCARDITIS; NITROGEN; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; RATS; RATS, INBRED F344; TOXICITY TESTS, CHRONIC; TROPOLONE;

RATTUS;

EID: 79958762703     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.04.027     Document Type: Article

References (19)

1. Diouf P.N., Delbarre N., Perrin D., Gerardin P., Rapin C., Jacquot J.P., Gelhaye E. Influence of tropolone on Poria placenta wood degradation. Appl. Environ. Microbiol. 2002, 68:4377-4382.
2. Doulias P.T., Nousis L., Zhu B.Z., Frei B., Galaris D. Protection by tropolones against H2O2-induced DNA damage and apoptosis in cultured Jurkat cells. Free Radic. Res. 2005, 39:125-135.
3. Ema M., Harazono A., Fujii S., Kawashima K. Evaluation of developmental toxicity of beta-thujaplicin (hinokitiol) following oral administration during organogenesis in rats. Food Chem. Toxicol. 2004, 42:465-470.
4. Ido Y., Muto N., Inada A., Kohroki J., Mano M., Odani T., Itoh N., Yamamoto K., Tanaka K. Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. Cell Prolif. 1999, 32:63-73.
5. Imai N., Doi Y., Nabae K., Tamano S., Hagiwara A., Kawabe M., Ichihara T., Ogawa K., Shirai T. Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats. J. Toxicol. Sci. 2006, 31:357-370.
6. Inamori Y., Sakagami Y., Morita Y., Shibata M., Sugiura M., Kumeda Y., Okabe T., Tsujibo H., Ishida N. Antifungal activity of Hinokitiol-related compounds on wood-rotting fungi and their insecticidal activities. Biol. Pharm. Bull. 2000, 23:995-997.
7. Morita Y., Sakagami Y., Okabe T., Ohe T., Inamori Y., Ishida N. The mechanism of the bactericidal activity of hinokitiol. Biocontrol Sci. 2007, 12:101-110.
8. Murakami K., Ohara Y., Haneda M., Tsubouchi R., Yoshino M. Prooxidant action of hinokitiol: hinokitiol-iron dependent generation of reactive oxygen species. Basic Clin. Pharmacol. Toxicol. 2005, 97:392-394.
9. Nakagawa Y., Tayama K. Mechanism of mitochondrial dysfunction and cytotoxicity induced by tropolones in isolated rat hepatocytes. Chem. Biol. Interact. 1998, 116:45-60.
10. Nakano, S., 1959. Experimental and clinical studies on unsaturated seven-membered ring compounds. 34th report. The effect of Hinokitiol-natrium and tropolone upon organs of mice through long-term oral administration. Nigata Igaku-kai Zasshi 76 (Suppl. 1), 119-125 (in Japanese).
11. Ogata A., Ando H., Kubo Y., Nagasawa A., Ogawa H., Yasuda K., Aoki N. Teratogenicity of thujaplicin in ICR mice. Food Chem. Toxicol. 1999, 37:1097-1104.
12. Osawa K., Matsumoto T., Maruyama T., Takiguchi T., Okuda K., Takazoe I. Studies of the antibacterial activity of plant extracts and their constituents against periodontopathic bacteria. Bull. Tokyo Dent. Coll. 1990, 31:17-21.
13. Sakagami Y., Inamori Y., Isoyama N., Tsujibo H., Okabe T., Morita Y., Ishida N. Phytogrowth-Inhibitory activities of beta-dolabrin and gamma-thujaplicin, hinokitiol-related compounds and constituents of Thujopsis dolabrata Sieb. Et Zucc. var hondai Makino. Biol. Pharm. Bull. 2000, 23:645-648.
14. Shimizu M., Noda T., Yamano T., Yamada A., Morita S. Acute oral toxicity of natural food additives in mice and rats. Seikatsu Eisei. 1993, 37:215-220. (in Japanese).
15. Sofuni T., Miyabe M., Ishizaki M., Watanabe S., Maita K., Kawamura T. Mutagenicity test on food additives (series II). The collaborative study supported by the Ministry of Health and Welfare of Japan. Jpn. J. Mutagen. Tests Chem. 1993, 2:19-28. (in Japanese).
16. Tanaka T., Muto N., Ido Y., Itoh N., Tanaka K. Induction of embryonal carcinoma cell differentiation by deferoxamine, a potent therapeutic iron chelator. Biochim. Biophys. Acta 1997, 1357:91-97.
17. Tanaka T., Satoh T., Onozawa Y., Kohroki J., Itoh N., Ishidate M., Muto N., Tanaka K. Apoptosis during iron chelator-induced differentiation in F9 embryonal carcinoma cells. Cell Biol. Int. 1999, 23:541-550.
18. Yamato M., Hashigaki K., Kokubu N., Tsuruo T., Tashiro T. Synthesis and antitumor activity of tropolone derivatives. J. Med. Chem. 1984, 27:1749-1753.
19. Yasumoto E., Nakano K., Nakayachi T., Morshed S.R., Hashimoto K., Kikuchi H., Nishikawa H., Kawase M., Sakagami H. Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines. Anticancer Res. 2004, 24:755-762.