The microtubule-associated protein MAPRE2 is involved in perineural invasion of pancreatic cancer cells

International Journal of Oncology

Volumn 35, Issue 5, 2009, Pages 1111-1116

  Abiatari, Ivane ^a   Gillen, Sonja ^a   DeOliveira, Tiago ^a   Klose, Theresa ^a   Bo, Kong ^a   Giese, Nathalia A ^b   Friess, Helmut ^a   Kleeff, Jörg ^a,c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Invasion; Microtubule; Pancreatic cancer; Perineural

Indexed keywords

MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2;

ACINAR CELL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INVASION; CELL NUCLEUS; CYTOPLASM; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS; NONHUMAN; PANCREAS CANCER; PERINEURIUM; PRIORITY JOURNAL;

AGED; BLOTTING, WESTERN; CELL LINE, TUMOR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; PERIPHERAL NERVES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 70449592221     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000426     Document Type: Article

References (31)

1. Maitra A and Hruban RH: Pancreatic cancer. Annu Rev Pathol 3: 157-188, 2008.
2. Welsch T, Kleeff J and Friess H: Molecular pathogenesis of pancreatic cancer: advances and challenges. Curr Mol Med 7: 504-521, 2007. (Pubitemid 47244895)
3. Ceyhan GO, Michalski CW, Demir IE, Muller MW and Friess H: Pancreatic pain. Best Pract Res Clin Gastroenterol 22: 31-44, 2008.
4. Esposito I, Kleeff J, Bergmann F, Reiser C, Herpel E, Friess H, Schirmacher P and Buchler MW: Most pancreatic cancer resections are R1 resections. Ann Surg Oncol 15: 1651-1660, 2008.
5. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin 58: 71-96, 2008.
6. Abiatari I, DeOliveria T, Kerkadze V, Schwager C, Esposito I, Giese NA, Huber P, Bergman F, Abdollahi A, Friess H and Kleeff J: Consensus transcriptome signature of perineural invasion in pancreatic carcinoma. Mol Cancer Ther 8: 1494-1504, 2009.
7. Su LK and Qi Y: Characterization of human MAPRE genes and their proteins. Genomics 71: 142-149, 2001. (Pubitemid 32165080)
8. Morrison EE: Action and interactions at microtubule ends. Cell Mol Life Sci 64: 307-317, 2007.
9. Musch A: Microtubule organization and function in epithelial cells. Traffic 5: 1-9, 2004. (Pubitemid 38159399)
10. Valiron O, Caudron N and Job D: Microtubule dynamics. Cell Mol Life Sci 58: 2069-2084, 2001.
11. Gimona M, Buccione R, Courtneidge SA and Linder S: Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol 20: 235-241, 2008.
12. Vasiliev JM: Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells. Int J Dev Biol 48: 425-439, 2004.
13. Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler MW, Giese NA and Friess H: Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene 24: 4421-4432, 2005. (Pubitemid 40961765)
14. Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Buchler MW, Giese NA and Friess H: Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology 132: 1447-1464, 2007. (Pubitemid 46627568)
15. Cassimeris L: Accessory protein regulation of microtubule dynamics throughout the cell cycle. Curr Opin Cell Biol 11: 134-141, 1999. (Pubitemid 29084142)
16. Desai A and Mitchison TJ: Microtubule polymerization dynamics. Annu Rev Cell Dev Biol 13: 83-117, 1997.
17. Bu W and Su LK: Regulation of microtubule assembly by human EB1 family proteins. Oncogene 20: 3185-3192, 2001. (Pubitemid 32553671)
18. Lee T, Langford KJ, Askham JM, Bruning-Richardson A and Morrison EE: MCAK associates with EB1. Oncogene 27: 2494-2500, 2008.
19. Vitre B, Coquelle FM, Heichette C, Garnier C, Chretien D and Arnal I: EB1 regulates microtubule dynamics and tubulin sheet closure in vitro. Nat Cell Biol 10: 415-421, 2008.
20. Carvalho P, Tirnauer JS and Pellman D: Surfing on microtubule ends. Trends Cell Biol 13: 229-237, 2003.
21. Broussard JA, Webb DJ and Kaverina I: Asymmetric focal adhesion disassembly in motile cells. Curr Opin Cell Biol 20: 85-90, 2008.
22. Wehrle-Haller B and Imhof BA: Actin, microtubules and focal adhesion dynamics during cell migration. Int J Biochem Cell Biol 35: 39-50, 2003. (Pubitemid 35449172)
23. Hsieh PC, Chang JC, Sun WT, Hsieh SC, Wang MC and Wang FF: p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway. Oncogene 26: 4928-4940, 2007.
24. Liu M, Yang S, Wang Y, Zhu H, Yan S, Zhang W, Quan L, Bai J and Xu N: EB1 acts as an oncogene via activating beta-catenin/TCF pathway to promote cellular growth and inhibit apoptosis. Mol Carcinog 48: 212-219, 2009.
25. Orimo T, Ojima H, Hiraoka N, Saito S, Kosuge T, Kakisaka T, Yokoo H, Nakanishi K, Kamiyama T, Todo S, Hirohashi S and Kondo T: Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma. Hepatology 48: 1851-1863, 2008.
26. Ralhan R, Desouza LV, Matta A, Chandra Tripathi S, Ghanny S, Datta Gupta S, Bahadur S and Siu KW: Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry. Mol Cell Proteomics 7: 1162-1173, 2008. (Pubitemid 351943962)
27. Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q and Xu N: Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway. Oncogene 24: 6637-6645, 2005. (Pubitemid 41486794)
28. Komarova Y, Lansbergen G, Galjart N, Grosveld F, Borisy GG and Akhmanova A: EB1 and EB3 control CLIP dissociation from the ends of growing microtubules. Mol Biol Cell 16: 5334-5345, 2005. (Pubitemid 41566843)
29. Morris PG and Fornier MN: Microtubule active agents: beyond the taxane frontier. Clin Cancer Res 14: 7167-7172, 2008.
30. Jordan MA and Wilson L: Microtubules as a target for anticancer drugs. Nat Rev Cancer 4: 253-265, 2004.
31. Trivedi M, Budihardjo I, Loureiro K, Reid TR and Ma JD: Epothilones: a novel class of microtubule-stabilizing drugs for the treatment of cancer. Future Oncol 4: 483-500, 2008.