Discovery of a new HIV-1 inhibitor scaffold and synthesis of potential prodrugs of indazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 10, 2013, Pages 2888-2892

  Kim, Se Ho ^a   Markovitz, Benjamin ^a   Trovato, Richard ^a   Murphy, Brett R ^a   Austin, Harry ^a   Willardsen, Adam J ^a   Baichwal, Vijay ^a   Morham, Scott ^b   Bajji, Ashok ^a  

^a Myrexis Inc   (United States)

^b MesaGen LLC   (United States)

Author keywords

HIV Drug target Oxazoles Prodrugs of indazoles

Indexed keywords

ANTIVIRUS AGENT; INDAZOLE DERIVATIVE; OXAZOLE DERIVATIVE; PRODRUG;

AQUEOUS SOLUTION; ARTICLE; DRUG SOLUBILITY; DRUG SYNTHESIS; FOLLOW UP; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIV-1; HUMANS; INDAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84876675337     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.075     Document Type: Article

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