Activities, crystal structures, and molecular dynamics of dihydro-1 h -isoindole derivatives, inhibitors of HIV-1 integrase

ACS Chemical Biology

Volumn 8, Issue 1, 2013, Pages 209-217

  Métifiot, Mathieu ^a   Maddali, Kasthuraiah ^a   Johnson, Barry C ^c   Hare, Stephen ^b   Smith, Steven J ^c   Zhao, Xue Zhi ^c   Marchand, Christophe ^a   Burke, Terrence R ^c   Hughes, Stephen H ^a   Cherepanov, Peter ^b,d   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDRO 1H ISOINDOLE DERIVATIVE; INTEGRASE; INTEGRASE INHIBITOR; RALTEGRAVIR; UNCLASSIFIED DRUG; VIRUS DNA; XZ 115; XZ 116; XZ 259; XZ 89; XZ 90;

ANTIVIRAL ACTIVITY; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; HIV INTEGRASE INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOINDOLES; MOLECULAR DYNAMICS SIMULATION; SULFONAMIDES;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN SPUMARETROVIRUS;

EID: 84872508209     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300471n     Document Type: Article

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