Polyhydroxyalkanoic acids from structurally-unrelated carbon sources in Escherichia coli

Applied Microbiology and Biotechnology

Volumn 97, Issue 8, 2013, Pages 3301-3307

  Wang, Qian ^a   Zhuang, Qianqian ^a   Liang, Quanfeng ^a   Qi, Qingsheng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Escherichia coli; Metabolic engineering; PHA; Polyhydroxyalkanoates; Unrelated carbon source

Indexed keywords

4-HYDROXYBUTYRATE; CARBON SOURCE; E. COLI; PHA; POLYHYDROXYALKANOATES; POLYMER CONTENT; PRODUCTION OF; SYNTHETIC BIOLOGY;

BIOCHEMISTRY; CARBON; METABOLIC ENGINEERING; MONOMERS;

ESCHERICHIA COLI;

2 HYDROXYPROPIONATE; 3 HYDROXYALKANOATE; 3 HYDROXYVALARATE; 4 HYDROXYBUTYRIC ACID; HYDRACRYLIC ACID; HYDROXYACID; METHYLMALONYL COENZYME A DECARBOXYLASE; METHYLMALONYL COENZYME A MUTASE; MONOMER; POLYHYDROXYALKANOATE SYNTHASE; POLYHYDROXYALKANOIC ACID; POLYLACTIC ACID; UNCLASSIFIED DRUG;

BACTERIUM; CARBON; POLYMER;

CARBON SOURCE; CUPRIAVIDUS NECATOR; ESCHERICHIA COLI; FED BATCH FERMENTATION; FERMENTED PRODUCT; METABOLIC ENGINEERING; MOLECULAR CLONING; NEGATIVE FEEDBACK; PRECURSOR; REVIEW; SYNTHETIC BIOLOGY;

BIOSYNTHETIC PATHWAYS; BIOTECHNOLOGY; CARBON; ESCHERICHIA COLI; METABOLIC ENGINEERING; ORGANIC CHEMICALS; POLYHYDROXYALKANOATES;

ESCHERICHIA COLI;

EID: 84876667247     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-4809-x     Document Type: Review

References (64)

1. Agnew DE, Stevermer AK, Youngquist JT, Pfleger BF (2012) Engineering Escherichia coli for production of C(12)-C(14) polyhydroxyalkanoate from glucose. Metab Eng 14:705-713. doi: 10.1016/j.ymben.2012.08.003
2. Aldor IS, Kim SW, Prather KL, Keasling JD (2002) Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar typhimurium. Appl Environ Microbiol 68:3848-3854
3. Anderson AJ, Dawes EA (1990) Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol Rev 54:450-472
4. Andreeßen B, Lange AB, Robenek H, Steinbüchel A (2010) Conversion of glycerol to poly(3-hydroxypropionate) in recombinant Escherichia coli. Appl Environ Microbiol 76:622-626. doi: 10.1128/AEM.02097-09
5. Byrom D (1987) Polymer synthesis by microorganisms: technology and economics. Trends Biotechnol 5:246-250
6. Chen GQ (2009) A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry. Chem Soc Rev 38:2434-2446. doi: 10.1039/b812677c
7. Chen Q, Wang Q, Wei G, Liang Q, Qi Q (2011) Production in Escherichia coli of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with differing monomer compositions from unrelated carbon sources. Appl Environ Microbiol 77:4886-4893. doi: 10.1128/AEM.00091-11
8. Cho A, Yun H, Park JH, Lee SY, Park S (2010) Prediction of novel synthetic pathways for the production of desired chemicals. BMC Syst Biol 4:35. doi: 10.1186/1752-0509-4-35
9. Choi MH, Yoon SC, Lenz RW (1999) Production of poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid) and poly(4-hydroxybutyric acid) without subsequent degradation by Hydrogenophaga pseudoflava. Appl Environ Microbiol 65:1570-1577
10. Dellomonaco C, Clomburg JM, Miller EN, Gonzalez R (2011) Engineered reversal of the beta-oxidation cycle for the synthesis of fuels and chemicals. Nature 476:355-359. doi: 10.1038/nature10333
11. Doi Y, Kunioka M, Nakamura Y, Soga K (1988) Nuclear magnetic resonance studies on unusual bacterial copolyesters of 3-hydroxybutyrate and 4-hydroxybutyrate. Macromolecules 21:2722-2727
12. Eschenlauer AC, Stoup SK, Srienc F, Somers DA (1996) Production of heteropolymeric polyhydroxyalkanoate in Escherichia coli from a single carbon source. Int J Biol Macromol 19:121-130
13. Felnagle EA, Chaubey A, Noey EL, Houk KN, Liao JC (2012) Engineering synthetic recursive pathways to generate non-natural small molecules. Nat Chem Biol 8:518-526. doi: 10.1038/nchembio.959
14. Fidler S, Dennis D (1992) Polyhydroxyalkanoate production in recombinant Escherichia coli. FEMS Microbiol Rev 9:231-235
15. Fukui T, Abe H, Doi Y (2002) Engineering of Ralstonia eutropha for production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from fructose and solid-state properties of the copolymer. Biomacromolecules 3:618-624
16. Fukui T, Suzuki M, Tsuge T, Nakamura S (2009) Microbial synthesis of poly((R)-3-hydroxybutyrate-co-3-hydroxypropionate) from unrelated carbon sources by engineered Cupriavidus necator. Biomacromolecules 10:700-706. doi: 10.1021/bm801391j
17. Green PR, Kemper J, Schechtman L, Guo L, Satkowski M, Fiedler S, Steinbuchel A, Rehm BH (2002) Formation of short-chain length/medium chain length polyhydroxyalkanoate copolymers by fatty acid beta-oxidation inhibited Ralstonia eutropha. Biomacromolecules 3:208-213
18. Hazer B, Steinbüchel A (2007) Increased diversification of polyhydroxyalkanoates by modification reactions for industrial and medical applications. Appl Microbiol Biotechnol 74:1-12. doi: 10.1007/s00253-006-0732-8
19. Hein S, Söhling B, Gottschalk G, Steinbüchel A (1997) Biosynthesis of poly(4-hydroxybutyric acid) by recombinant strains of Escherichia coli. FEMS Microbiol Lett 153:411-418
20. Jiang X, Meng X, Xian M (2009) Biosynthetic pathways for 3-hydroxypropionic acid production. Appl Microbiol Biotechnol 82:995-1003. doi: 10.1007/s00253-009-1898-7
21. Jung YK, Kim TY, Park SJ, Lee SY (2010) Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers. Biotechnol Bioeng 105:161-171. doi: 10.1002/bit.22548
22. Kang CK, Kusaka S, Doi Y (1995) Structure and properties of poly (3-hydroxybutyrate-co-4-hydroxybutyrate) produced by Alcaligenes latus. Biotechnol Lett 17:583-588
23. Klinke S, Ren Q, Witholt B, Kessler B (1999) Production of medium-chain-length poly(3-hydroxyalkanoates) from gluconate by recombinant Escherichia coli. Appl Environ Microbiol 65:540-548
24. Langenbach S, Rehm BH, Steinbüchel A (1997) Functional expression of the PHA synthase gene phaC1 from Pseudomonas aeruginosa in Escherichia coli results in poly(3-hydroxyalkanoate) synthesis. FEMS Microbiol Lett 150:303-309
25. Law KH, Chan PL, Lau WS, Cheng YC, Leung YC, Lo WH, Lawford H, Yu HF (2004) Construction of recombinant Escherichia coli strains for production of poly-(3-hydroxybutyrate-co-3-hydroxyvalerate). Appl Biochem Biotechnol 113-116:361-372
26. Lee JW, Na D, Park JM, Lee J, Choi S, Lee SY (2012) Systems metabolic engineering of microorganisms for natural and non-natural chemicals. Nat Chem Biol 8:536-546. doi: 10.1038/nchembio.970
27. Li R, Chen Q, Wang PG, Qi Q (2007a) A novel-designed Escherichia coli for the production of various polyhydroxyalkanoates from inexpensive substrate mixture. Appl Microbiol Biotechnol 75:1103-1109
28. Li R, Zhang H, Qi Q (2007b) The production of polyhydroxyalkanoates in recombinant Escherichia coli. Bioresour Technol 98:2313-2320. doi: 10.1016/j.biortech.2006.09.014
29. Li ZJ, Shi ZY, Jian J, Guo YY, Wu Q, Chen GQ (2010) Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from unrelated carbon sources by metabolically engineered Escherichia coli. Metab Eng 12:352-359. doi: 10.1016/j.ymben.2010.03.003
30. Meng DC, Shi ZY, Wu LP, Zhou Q, Wu Q, Chen JC, Chen GQ (2012) Production and characterization of poly (3-hydroxypropionate-co-4-hydroxybutyrate) with fully controllable structures by recombinant Escherichia coli containing an engineered pathway. Metab Eng 14:317-324
31. Nakamura S, Kunioka M, Doi Y (1991) Biosynthesis and characterization of bacterial poly (3-hydroxybutyrate-co-3-hydroxypropionate). Macromol Rep 28:15-24
32. Nomura CT, Taguchi K, Gan Z, Kuwabara K, Tanaka T, Takase K, Doi Y (2005) Expression of 3-ketoacyl-acyl carrier protein reductase (fabG) genes enhances production of polyhydroxyalkanoate copolymer from glucose in recombinant Escherichia coli JM109. Appl Environ Microbiol 71:4297-4306. doi: 10.1128/AEM.71.8.4297-4306.2005
33. Nomura CT, Taguchi K, Taguchi S, Doi Y (2004) Coexpression of genetically-engineered 3-ketoacyl-ACP synthase III (fabH) and polyhydroxyalkanoate synthase (phaC) genes leads to short-chain-length-medium- chain-length polyhydroxyalkanoate copolymer production from glucose in Escherichia coli JM109. Appl Environ Microbiol 70:999-1007
34. Park SJ, Choi J, Lee SY (2005) Engineering of Escherichia coli fatty acid metabolism for the production of polyhydroxyalkanoates. Enzym Microb Technol 36:579-588
35. Park SJ, Lee TW, Lim SC, Kim TW, Lee H, Kim MK, Lee SH, Song BK, Lee SY (2012) Biosynthesis of polyhydroxyalkanoates containing 2-hydroxybutyrate from unrelated carbon source by metabolically engineered Escherichia coli. Appl Microbiol Biotechnol 93:273-283. doi: 10.1007/s00253-011-3530-x
36. Park SJ, Yang TH, Kang HO, Lee SH, Lee EJ, Kim TW, Lee SY (2008) Mutants of PHA synthase from Pseudomonas sp. 6-19 and method for preparing lactate homopolymer or copolymer using the same. WO Patent 2,008,062,999
37. Qi Q, Rehm BH, Steinbüchel A (1997) Synthesis of poly(3-hydroxyalkanoates) in Escherichia coli expressing the PHA synthase gene phaC2 from Pseudomonas aeruginosa: comparison of PhaC1 and PhaC2. FEMS Microbiol Lett 157:155-162
38. Qiu YZ, Han J, Guo JJ, Chen GQ (2005) Production of poly(3- hydroxybutyrate-co-3-hydroxyhexanoate) from gluconate and glucose by recombinant Aeromonas hydrophila and Pseudomonas putida. Biotechnol Lett 27:1381-1386. doi: 10.1007/s10529-005-3685-6
39. Rathnasingh C, Raj SM, Jo JE, Park S (2009) Development and evaluation of efficient recombinant Escherichia coli strains for the production of 3-hydroxypropionic acid from glycerol. Biotechnol Bioeng 104:729-739. doi: 10.1002/bit.22429
40. Rathnasingh C, Raj SM, Lee Y, Catherine C, Ashok S, Park S (2012) Production of 3-hydroxypropionic acid via malonyl-CoA pathway using recombinant Escherichia coli strains. J Biotechnol 157:633-640. doi: 10.1016/j.jbiotec.2011. 06.008
41. Rehm BH, Mitsky TA, Steinbüchel A (2001) Role of fatty acid de novo biosynthesis in polyhydroxyalkanoic acid (PHA) and rhamnolipid synthesis by pseudomonads: establishment of the transacylase (PhaG)-mediated pathway for PHA biosynthesis in Escherichia coli. Appl Environ Microbiol 67:3102-3109. doi: 10.1128/AEM.67.7.3102-3109.2001
42. Rehm BH, Steinbüchel A (2001) Heterologous expression of the acyl-acyl carrier protein thioesterase gene from the plant Umbellularia californica mediates polyhydroxyalkanoate biosynthesis in recombinant Escherichia coli. Appl Microbiol Biotechnol 55:205-209
43. Renner G, Pongratz K, Braunegg G (1996) Production of poly (3-hydroxybutyrate-co-4-hydroxybutyrate) by Comamonas testosteronii A3. Food Technol Biotech 34:2-3
44. Södergård A, Stolt M (2002) Properties of lactic acid based polymers and their correlation with composition. Prog Polym Sci 27:1123-1163
45. Schubert P, Steinbüchel A, Schlegel HG (1988) Cloning of the Alcaligenes eutrophus genes for synthesis of poly-beta-hydroxybutyric acid (PHB) and synthesis of PHB in Escherichia coli. J Bacteriol 170:5837-5847
46. Slater SC, Voige WH, Dennis DE (1988) Cloning and expression in Escherichia coli of the Alcaligenes eutrophus H16 poly-beta-hydroxybutyrate biosynthetic pathway. J Bacteriol 170:4431-4436
47. Söhling B, Gottschalk G (1996) Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri. J Bacteriol 178:871-880
48. Song S, Hein S, Steinbüchel A (1999) Production of poly (4-hydroxybutyric acid) by fed-batch cultures of recombinant strains of Escherichia coli. Biotechnol Lett 21:193-197
49. Song SS, Ma H, Gao ZX, Jia ZH, Zhang X (2005) Construction of recombinant Escherichia coli strains producing poly (4-hydroxybutyric acid) homopolyester from glucose. Wei Sheng Wu Xue Bao 45:382-386
50. Steinbüchel A, Lütke-Eversloh T (2003) Metabolic engineering and pathway construction for biotechnological production of relevant polyhydroxyalkanoates in microorganisms. Biochem Eng J 16:81-96
51. Steinbüchel A, Pieper U (1992) Production of a copolyester of 3-hydroxybutyric acid and 3-hydroxyvaleric acid from single unrelated carbon sources by a mutant of Alcaligenes eutrophus. Appl Microbiol Biotechnol 37:1-6
52. Steinbüchel A, Valentin HE (1995) Diversity of bacterial polyhydroxyalkanoic acids. FEMS Microbiol Lett 128:219-228
53. Steinbüchel A, Aerts K, Babel W, Follner C, Liebergesell M, Madkour MH, Mayer F, Pieper-Furst U, Pries A, Valentin HE, Roman W (1995) Considerations on the structure and biochemistry of bacterial polyhydroxyalkanoic acid inclusions. Can J Microbiol 41(Suppl 1):94-105
54. Taguchi S, Yamada M, Matsumoto K, Tajima K, Satoh Y, Munekata M, Ohno K, Kohda K, Shimamura T, Kambe H, Obata S (2008) A microbial factory for lactate-based polyesters using a lactate-polymerizing enzyme. Proc Natl Acad Sci U S A 105:17323-17327. doi: 10.1073/pnas.0805653105
55. Timm A, Steinbüchel A (1990) Formation of polyesters consisting of medium-chain-length 3-hydroxyalkanoic acids from gluconate by Pseudomonas aeruginosa and other fluorescent pseudomonads. Appl Environ Microbiol 56:3360-3367
56. Valentin HE, Dennis D (1997) Production of poly(3-hydroxybutyrate-co-4- hydroxybutyrate) in recombinant Escherichia coli grown on glucose. J Biotechnol 58:33-38
57. Valentin HE, Mitsky TA, Mahadeo DA, Tran M, Gruys KJ (2000) Application of a propionyl coenzyme A synthetase for poly(3-hydroxypropionate-co-3- hydroxybutyrate) accumulation in recombinant Escherichia coli. Appl Environ Microbiol 66:5253-5258
58. Wang Q, Liu C, Xian M, Zhang Y, Zhao G (2012a) Biosynthetic pathway for poly(3-hydroxypropionate) in recombinant Escherichia coli. J Microbiol 50:693-697. doi: 10.1007/s12275-012-2234-y
59. Wang Q, Tappel RC, Zhu C, Nomura CT (2012b) Development of a new strategy for production of medium-chain-length polyhydroxyalkanoates by recombinant Escherichia coli via inexpensive non-fatty acid feedstocks. Appl Environ Microbiol 78:519-527. doi: 10.1128/AEM.07020-11
60. Yamada M, Matsumoto K, Nakai T, Taguchi S (2009) Microbial production of lactate-enriched poly[(R)-lactate-co-(R)-3-hydroxybutyrate] with novel thermal properties. Biomacromolecules 10:677-681. doi: 10.1021/bm8013846
61. Yang TH, Jung YK, Kang HO, Kim TW, Park SJ, Lee SY (2011) Tailor-made type II Pseudomonas PHA synthases and their use for the biosynthesis of polylactic acid and its copolymer in recombinant Escherichia coli. Appl Microbiol Biotechnol 90:603-614. doi: 10.1007/s00253-010-3077-2
62. Yang TH, Kim TW, Kang HO, Lee SH, Lee EJ, Lim SC, Oh SO, Song AJ, Park SJ, Lee SY (2010) Biosynthesis of polylactic acid and its copolymers using evolved propionate CoA transferase and PHA synthase. Biotechnol Bioeng 105:150-160
63. Zhou Q, Shi ZY, Meng DC, Wu Q, Chen JC, Chen GQ (2011) Production of 3-hydroxypropionate homopolymer and poly(3-hydroxypropionate-co-4- hydroxybutyrate) copolymer by recombinant Escherichia coli. Metab Eng 13:777-785. doi: 10.1016/j.ymben.2011.10.002
64. Zhou XY, Yuan XX, Shi ZY, Meng DC, Jiang WJ, Wu LP, Chen JC, Chen GQ (2012) Hyperproduction of poly(4-hydroxybutyrate) from glucose by recombinant Escherichia coli. Microb Cell Fact 11:54. doi: 10.1186/1475-2859-11-54