Photobiology, photodermatology and sunscreens: A comprehensive overview. Part 2: Topical and systemic photoprotection

Giornale Italiano di Dermatologia e Venereologia

Volumn 148, Issue 1, 2013, Pages 107-133

  Celleno, L ^a   Calzavara Pinton, P ^b   Sala, R ^b   Arisi, M C ^b   Bussoletti, C ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Antioxidants; Photobiology; Skin neoplasms; Sunscreening agents; Ultraviolet rays

Indexed keywords

ANTIOXIDANT; CAROTENOID; COSMETIC; FREE RADICAL; POLYPHENOL DERIVATIVE; PROTEIN P53; SUNSCREEN;

ACTINIC DERMATITIS; ANTIOXIDANT ACTIVITY; BIOMEDICINE; CARCINOGENESIS; CLINICAL ASSESSMENT; CLINICAL EFFECTIVENESS; DERMATITIS; DERMATOLOGIST; DRUG SOLUBILITY; FAT INTAKE; GENODERMATOSIS; HEALTH CARE POLICY; HISTORY OF MEDICINE; HUMAN; IMMUNOSURVEILLANCE; LIPOPHILICITY; PHOTOBIOLOGY; PHOTOCHEMISTRY; PHOTODERMATOLOGY; PHOTODERMATOSIS; PRODUCT SAFETY; REVIEW; SKIN PROTECTION; SOLAR RADIATION; SOLAR URTICARIA; SUN EXPOSURE; VITAMIN D DEFICIENCY;

EID: 84876591859     PISSN: 03920488     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (152)

1. rd ed. Boca Raton, FL: T&F Informa; 2005. p. 71-85.
2. Roelandts R. History of human photobiology in: Lim HW, Honigsmann H, Hawk JLM editors. Photodermatology. New York: Informa Healthcare USA; 2007. p. 1-13.
3. Urbach F, Forbes PD, Davies RE, Berger D. Cutaneous photobiology: past, present, and future. J Invest Dermatol 1976;67:209-24.
4. Shaath NA. Sunscreens: regulations and commercial development. 3rd ed. Boca Raton, FL: Taylor & Francis Group; 2005.
5. Kenet B, Lawler P. Saving Your Skin. New York, NY: Four Walls Eight Windows; 1994.
6. Henne W. In vivo determination of the sunscreen factor of cosmetic preparations, history and the present state of art. Parf Kosm 1983;64:415-23.
7. Schulze R. Einige Versuche und Bemerkungen zum Problem der handelsüblichen Lichtschutzmittel. Praf u Kosm 1956;37:310-5.
8. Greiter F. Sun protection factor-development methods. Parf Kosm 1974;55:70-5.
9. Brown M. SPF testing in Europe: The International SPF Test Method. In: Shaath NA, editor. Sunscreens: regulation and commercial development. 3rd ed. Boca Raton, FL: T&F Informa; 2005. p. 779-806.
10. Food and Drug Administration (FDA). Department of Health, Education and Welfare. USA: Sunscreen drug products for over-the-counter drugs: proposed safety, effective and labeling conditions. Federal Register 43/166. 1978;38206-69.
11. Fitzpatrick TB. The validity and practicability of sun-reactive skin types I through VI. Arch Dermatol 1988;124:869-71.
12. Food and Drug Administration. Department of Health and Human Services, FDA. USA: Sunscreen Drug Products for Over-the-Counter Human use. Proposed Amendment of Final Monograph; Proposed Rule, Federal Register: Vol. 72, No.165/Monday, August 27, 2007 49070-49122.
13. Food and Drug Administration. Department of Health and Human Services, FDA. USA: Sunscreen Drug Product for Over-The-Counter Human Use, Tentative Final Monograph. Federal Register 1993;58:27693-8194.
14. Food and Drug Administration [Internet]. Department of Health and Human Services. FDA, USA. Sunscreen Drug Product for Over-The-Counter Human Use, Final Monograph. Federal Register 1999;64:27689-93. [cited 2011 Apr 28]. Available at: www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/DevelopmentResources/ Over-the-CounterOTCDrugs/StatusofOTCRulemakings/ucm090244.pdf
15. COLIPA. Sun protection factor test method. COLIPA Publication. Ref 94/289. October 1994.
16. COLIPA [Internet]. International Sun Protection Factor Test Method, February 2003. [cited 2011 May 05]. Available at: http://www.ncvcosmetica.nl/ upload/File/20030201-Colipa-SPF-methode.pdf
17. COLIPA [Internet].Guidelines. The European Cosmetics Association. International Sun Protector Factor Test Method, May 2006. [cited 2011 Apr 29]. Available at: http://www.colipa.eu/publications-colipa-the-european-cosmetic- cosmeticsassociation/guidelines.html?view=item&id=21
18. Agência Nacional de Vigilância Sanitária (ANVISA) [Internet]. 2002. Regulamento Técnico Sobre Protetores Solares em Cosméticos, Resolução RDC 237. [cited 28 Mar 2011]. Available at:http://e-legis.anvisa.gov.br/leisref/public/showAct.php?id= 18298&word=
19. Schalka S. Influência da quantidade aplicada de protetores solares no fator de proteção solar (FPS): avaliação de dois protetores solares com os mesmos ingredientes em diferentes concentraç ões [Dissertação]. São Paulo, SP: Universidade de São Paulo; 2009. p.152.
20. Schalka S, Silva dos Reis VM. Sun protection factor: meaning and controversies. An Bras Dermato 2011;86:507-15.
21. Azevedo J S, Viana Junior NS, Soares CDV. UVA/UVB sunscreen determination by second-order derivative ultraviolet spectrophotometry. Farmaco 1999;54:573-8. (Pubitemid 29462616)
22. Fourneron JD, Faraud F, Fauneron A. Sur la mesure in vitro de la protection solaire de crèmes cosmétiques. C R Acad Sci II 1999;2:421-7.
23. Pissavini M, Ferrero L, Alaro V, Heinrich U, Tronnier H, Kockott D et al. Determination of the in vitro SPF. Cosmet Toiletries 2003;118:63-72. (Pubitemid 37261244)
24. Mansur JS, Breder MNR, Mansur MCA, Azulay RD. Determinação do fator de proteção solar por espectrofotometria. An Bras Dermatol 1986;6:121-4.
25. Sayre RM, Agin PP, LeVee GJ, Marlowe E. A comparison of In Vivo and in Vitro testing of sunscreening formulas. Photochem Photobiol 1979;29:559-66. (Pubitemid 9117647)
26. Diffey BL, Tanner PR, Matts PJ, Nash JF. In vitro assessment of the broad-spectrum ultraviolet protection of sunscreen products. J Am Acad Dermatol 2000;43:1024-35.
27. Diffey BL. A method for broad spectrum classifications of sunscreens. Int J Cosm Sci 1994;16:47-52. (Pubitemid 24261473)
28. Moyal D, Chardon A, Kallios N. Determination of the UVA protection factor using the PPD as the end point (parts 1) calibrations of the method. Photodermatol Photoimmunal Photomed 2000;16:245-9.
29. Brown S, Diffey BL. The effect of applied thichness on sunscreen protection: In vivo and in vitro studies. Photochem Photobiol 1986;44:509-13.
30. Stenberg C, Larko O. Sunscreen application and its importance for the sun protection factor. Arch Dermatol 1985;121:1400-2. (Pubitemid 16216779)
31. Bech-Thomsen N, Wulf HC. Sunbather's application of sunscreen is probably inadequate to obtain the sun protection factor assigned to the preparation. Photodermatol Photoimmunol Photomed 1992;9:242-4. (Pubitemid 24018006)
32. Gottieb A, Bourget TD, Lowe NJ. Effects of amounts of application of sun protection factor. In: Lowe NJ, Shaath NA, Pathak MA, editors. Sunscreens: development, evaluation, and regulatory aspects. 2nd ed. New York: Marcel Dekker; 1997. p. 583-9.
33. Azurdia RM, Pagliaro JA, Diffey BL, Rhodes LE. Sunscreen application by photosensitive patients is inadequate for protection. Br J Dermatol 1999;140:255-8. (Pubitemid 29111352)
34. Autier P, Boniol M, Severi G, Dore JF. European Organization for Research and Treatment of Cancer Melanoma Co-operative Group. Quantity of sunscreen used by European students. Br J Dermatol 2001;144:288-91.
35. Neale R, Williams G, Green A. Application patterns among participants randomized to daily sunscreen use in a skin cancer prevention trial. Arch Dermatol 2002;138:1319-25.
36. Faurschou A, Wulf HC. The relation between sun protection factor and amount applied in vivo. Br J Dermatol 2007;156:716-9. (Pubitemid 46452341)
37. Bimczok R, Gers-Barlag H, Mundt C, Klette E, Bielfeldt S, Rudolph T et al. Influence of applied quantity of sunscreen products on Sun Protection Factor - A multicenter study organized by the DGK Task force Sun Protection. Skin Pharmacol Physiol 2007;20:57-64. (Pubitemid 46005812)
38. Food and Drug Administration, Department of Health and Human Services, FDA. USA: Sunscreen Drug Product for Over-The-Counter Human Use, Tentative Final Monograph. Federal Register 1993;58(90).
39. Groves GA, Agin PP, Sayre PM. In vitro and In vivo methods to define sunscreen protection. Australas J Dermatol 1979;20:112-9. (Pubitemid 10068156)
40. Osterwalder U, Herzog B. SPF: World Wide Confusion. Br J Dermatol 2009;161(Suppl. 3):13-24.
41. Food and Drug Administration (FDA). Department of Health and Human Services. USA: Sunscreen Drug Product for Over-The-Counter Human Use, Proposed Amendment of Final Monograph, Propose Rule, Federal Register. August 27, 2007:72(165):49070-122.
42. Diffey B. Sunscreens: expectation and realizations. Photodermatol Photoimmunol Photomed 2009;25:233-6.
43. COLIPA UV-A guideline, Method for the in vitro determination of UVA protection provided by sunscreen products. 2007, The European Cosmetic Toiletry and Perfumery Association- COLIPA, Rue de la Loi 223/2, B-1040 Bruxelles, [cited 2012 October 25]. Available at: http://www.colipa.com
44. Young AR. Methods used to evaluate the immune protection factor of a sunscreen: advantages and disadvantages of different in vivo techniques. Cutis 2004;74(5 Suppl):19-23. (Pubitemid 39612329)
45. Herrling T, Jung K, Chatelain E, Langenauer M. Radical skin/sun protection factor RSF- protection against UV-induced free radicals. SOFW-J 2006;132:24-8.
46. Osterwalder U, Jung K, Seifert M, Herrling T. The exceptional importance of UVA sun protection: a comparative analysis of different quality control methods. SOFW-J 2009;135.
47. Kamb A. Sun protection factor p53. Nature 1994;372:730-1.
48. Cesarini JP, Demanneville S. Toward a genotoxic protection factor. Radiat Prot Dosimetry 2000;91:89-91.
49. Direttiva 76/768/CEE del Consiglio, del 27 luglio 1976, concernente il ravvicinamento delle legislazioni degli Stati Membri relative ai prodotti cosmetici. Pubblicata in G.U. 27 Settembre 1976, n. 262.
50. Regolamento CE n. 1223/2009 del Parlamento Europeo e del Consiglio del 30 Novembre 2009 sui prodotti cosmetici. Pubblicato in G.U.U.E. 22 Dicembre 2009, n. L 342/59
51. EU Commission recommendation,2006/647/CE Part 1.
52. Celleno L. I danni del sole: foto-invecchiamento e foto-carcinogenesi. I prodotti di protezione solare in: dermatologia cosmetologica. Milano: Tecniche Nuove Editore; 2008. p. 173-215.
53. EU Commission recommendation, 2006/647/CE Part 2
54. Proserpio G. (con la collaborazione di Premoli R). Fotoprotettori (filtri UV-A e UV-B) pigmentanti e depigmentanti; formulario cosmetico: forme cosmetiche e tecniche preparative. In: Chimica e tecnica cosmetica, vol. II. Milano: Sinerga editore; 1999. p. 297-318. p. 439-609.
55. Singh S, Garg G, Garg V, Gangwar S, Sharma PK. Sunscreen: A introductory review. Journal of Pharmacy Research 2010;3:1857-64.
56. Gaspar LR, Maia Campos PM. Evaluation of the photostability of different UV filter combinations in a sunscreen. Int J Pharm 2006;307:123-8. (Pubitemid 41820404)
57. Tarras-Wahlberg N, Stenhagen G, Larkö O, Rosén A, Wennberg A, Wennerström O. Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation. J Invest Dermatol 1999;113:547-53. (Pubitemid 29489615)
58. nd ed. Cosmetic science and technology series. Vol. 15. New York: Marcel Dekker. Inc.; 1997.
59. Hanno I, Anselmi C, Bouchemal K. Polyamide nanocapsules and nano-emulsions containing Parsol® MCX and Parsol® 1789: in vitro release, ex vivo skin penetration and photo-stability studies. PharmaRes 2012;29:559-73.
60. Yang J, Wiley CJ, Godwin DA, Felton LA. Influence of hydroxypropyl-beta- cyclodextrin on transdermal penetration and photostability of avobenzone. Eur J Pharm Biopharm 2008;69:605-12.
61. Gonzalez H, Farbrot A, Larko O, Wennberg AM. Percutaneous absorption of Benzophenone-3, a common component of topical sunscreens. Clin Exp Dermatol 2002;27:691-4. (Pubitemid 35454233)
62. Scalia S, Simeoni S, Barbieri A, Sostero S. Influence of hydroxypropyl-β-cyclodextrin on photo-induced free radical production by the sunscreen agent, butyl-methoxydibenzoylmethane. J Pharm Pharmacol 2002;54:1 553-8.
63. Foley P, Nixon R, Marks R, Frowen K, Thompson S. The frequency of reactions to sunscreens: The result of a longitudinal population-based study on the regular use of sunscreens in Australia. Br J Dermatol 1993;128:512-8. (Pubitemid 23155947)
64. Francioli M. La protezione solare in rapporto al sistema cosmetico, tesi di dottorato conseguita nell'anno 1997/1998, tutore: Prof.ssa Cecilia Anselmi. [cited 31 October 2012). Available at: http://www.unisi.it/ricerca/ dottorationweb/st-cosm/dotcosmlold.htm.it
65. Brewster B. Seeking homogeneity in UV filter distribution. Cosm Toil 2006;121:7-9.
66. Nikolić S, Keck CM, Anselmi C, Müller RH. Skin photoprotection improvement: synergistic interaction between lipid nanoparticles and organic UV filters. Int J Pharm 2011;414: 276-84.
67. Ziosi P, Manfredini S, Brazzo F, Vaccarelli C, Vertuani S, Reggio S et al. SPF Booster: un nuovo approccio nello sviluppo di prodotti solari- Valutazione di efficacia in vitro e in vivo, [cited 2012 November 9). Available at: http://www.sissproceedings.org/documentes/llziosi-Ms.pdf
68. Scalia S, Casolari A, Iaconinoto A, Simeoni S. Comparative studies of the influence of cyclodextrins on the stability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate. J Pharm Biomed Anal 2002;30:1181-9. (Pubitemid 35284329)
69. Rieger M, Falls T. Sun and Skin Science: a periodical review. C. & T; 2006. p. 121:41-7.
70. Black HS. Systemic photoproective agents. Photodermatol 1987;4:187-95.
71. Rosen CF. Topical and systemic photoprotection. Dermatol Ther 2003;16:8-15. (Pubitemid 36665990)
72. Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H et al. Distinct sets of genetic alterations in melanoma. N Engl J Med 2005;353:2135-47. (Pubitemid 41653105)
73. Li X, Gould SJ. PEX11 promotes peroxisome division independently of peroxisome metabolism. J Cell Biol 2002;156:643-51. (Pubitemid 34839880)
74. Coulomb B, Dubertret L, Bell E, Fosse M, Breton-Gorius J, Frost C et al. Endogenous peroxidases in normal human dermis: A marker of fibroblast differentiation. J Invest Dermatol 1983;81:75-8. (Pubitemid 13072439)
75. Little C. Steroid hydroperoxides as substrates for glutathione peroxidase. Biochimi Biophys Acta 1972;284:375-81.
76. Haenen GRMM, Bast A. Modulation of lipid peroxidation by dihydrolipoate in interplay with vitamin C, vitamin E and glutathione. Proceedings of the Winter meeting of the Free Radical and Cancer Society for Free Radical Research; 1989; Tobingen.
77. Moysan A, Morliere P, Marquis I, Richard A, Dubertret L. Effects of selenium on UVA-induced lipid peroxidations in cultured human skin fibroblasts. Skin Pharmacol 1995;8:139-48.
78. Tyrrell RM, Pidoux M. Endogenous glutathione protects human skin fibroblasts against the cytotoxic action of UVB, UVA and near visible radiations. Photochem Photobiol 1986;42:561.
79. Wartanowicz M, Panczenko-Kresowska B, Ziemlański S, Kowalska M, Okolska G. The effect of alpha-tocopherol and ascorbic acid on the serum lipid peroxide level in elderly people. Ann Nutr Metab 1984;28:186-91. (Pubitemid 14125833)
80. Stuttgen O, Schaefer E. Vitamine und Haut. In O. Stuttgen E. Schaefer editors. Funktionelle Dermatologie. New York: Springer; 1974. p. 78-9.
81. Stoyanovsky DA, Kagan VE, Packer L. Iron binding to alpha-tocopherol- containing phospholipid liposomes. Biochem Biophys Res Commun 1989;160:834-8.
82. Wolf C, Steiner A, Hönigsmann H. Do oral carotenoids protect human skin against ultraviolet erythema, psoralen phototoxicity, and ultraviolet-induced DNA damage? J Invest Dermatol 1988; 90:55-7. (Pubitemid 18026955)
83. Eberlein-König B, Ring J. Relevance of vitamins C and E in cutaneous photoprotection. J Cosmet Dermatol 2005;4:4-9.
84. Packer JE, Mahood JS, Mora-Arellano VO, Slater TF, Willson RL, Wolfenden BS. Free radicals and singlet oxygen scavengers: reaction of a peroxy-radical with beta-carotene, diphenyl furan and 1,4-diazobicyclo (2,2,2)-octane. Biochem Biophys Res Commun 1981;98:901-6.
85. Ribaya-Mercado JD, Garmyn M, Gilchrest BA, Russell RM. Skin lycopene is destroyed preferentially over beta-carotene during ultraviolet irradiation in humans. J Nutr 1995;125:1854-9.
86. Ross J, Kasum C. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002;22:19-34. (Pubitemid 35221452)
87. Wei H, Saladi R, Lu Y, Wang Y, Palep S, Moore J et al. BIsoflavone genistein: photoprotection and clinical implications in dermatology. J Nutr 2003;133:3811-9.
88. Katiyar S. Silymarin and skin cancer prevention: antiinflammatory, antioxidant and immunomodulatory effects. Int J Oncol 2005;26:169-76.
89. Widyarini S. Protective effect of the isoflavone equol against DNA damage induced by ultraviolet radiation to hairless mouse skin. J Vet Sci 2006;7:217-23. (Pubitemid 44387068)
90. Tong X, Van Dross R, Abu-Yousif A, Morrison A, Pelling J. Apigenin prevents UV-B-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition. Mol Cell Biol 2007;27:283-96. (Pubitemid 46013251)
91. Afaq F, Adhami V, Ahmad N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol Appl Pharmacol 2003;186:28-37. (Pubitemid 36262946)
92. Moehrle M, Dietrich H, Patz C, Hafner H. Sun protection by red wine? J Dtsch Dermatol Ges 2009;7:29-32.
93. Jeon H, Kim J, Kim W, Lee S. Effects of oral epigallocatechin gallate supplementation on the minimal erythema dose and UV-induced skin damage. Skin Pharmacol Physiol 2009;22:137-41.
94. Mnich CD, Hoek KS, Virkki LV, Farkas A, Dudli C, Laine E et al. Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of trascriptional controls. Exp Dermatol 2009;18:69-77.
95. Siscovick J, Zapolanski T, Magro C, Carrington K, Prograis S, Nussbaum M. Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression. Photodermatol Photoimmunol Photomed 2008;24:134-41. (Pubitemid 351682228)
96. Capote R, Alonso-Lebrero J, García F, Brieva A, Pivel J, González S. Polypodium leucotomos extract inhibits transurocanic acid photoisomerization and photodecomposition. J Photochem Photobiol B 2006;82:173-9. (Pubitemid 43240095)
97. Gonzalez S, Gilaberte Y, Philips N. Mechanistic insight in the use of a Polypodiumm leucotomos extract as an oral and topical photoprotective agent. Photochem Photobiol Sci 2010;9:559-63.
98. Middelkamp-Hup M, Pathak M, Parrado C, García-Caballero T, Rius-Díaz F, Fitzpatrick T et al. Orally administered Polypodium leucotomos extract decreases psoralen-UVA induced phototoxicity, pigmentation, and damage of human skin. J Am Acad Dermatol 2004;50:41-9. (Pubitemid 38095649)
99. Reyes E, Jaen P, de las Heras P, Carrion F, Alvarez-Mon M, de Eusebio E et al. Systemic immunomodulatory effects of Polypodium leucotomos as an adjuvantto PUVA therapy in generalized vitiligo: a pilot study. J Dermatol Sci 2006;41:213-6. (Pubitemid 43246722)
100. Andrés-Lacueva C, Monagas M, Khan N, Izquierdo-Pulido M, Urpi-Sardá M, Permanyer J et al. Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process. J Agric Food Chem 2008;56:3111-7. (Pubitemid 351746036)
101. Kerzendorfer C, O'Driscoll M. UV-B and caffeine: inhibiting the DNA damage response to protect against the adverse effects of UV-B. J Invest Dermatol 2009;129:1611-3.
102. Pilkington SM, Watson RB, Nicolaou A, Rhodes L. Omega-3 polyunsaturated fatty acids: photoprotective macronutrients. Exp Dermatol 2011;20:537-43.
103. Rhodes L, O'Farrell S, Jackson M, Friedmann P. Dietary fish-oil supplementation in humans reduces UV-B-erythemal sensitivity but increases epidermal lipid peroxidation. J Invest Dermatol 1994;103:151-4. (Pubitemid 24234598)
104. Moloney FJ, Collins S, Murphy GM. Sunscreens: safety, efficacy and appropriate use. Am J Clin Dermatol 2002;3:185-91. (Pubitemid 34533778)
105. Green AC, Williams G, Neale R, Hart V, Leslie D, Parsons P et al. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomized controlled trial. Lancet 1999;354:1038.
106. Dennis LK, Beane Freeman LE, Van Beek MJ. Sunscreen use and the risk for melanoma: a quantitative review. Ann Intern Med 2003;139:966-78.
107. Huncharek M, Kupelnick B. Use of topical sunscreens and the risk of malignant melanoma: a meta-analysis of 9067 patients from 11 case-control studies. Am J Public Health 2002;92:1173-7. (Pubitemid 34700987)
108. Green AC, Williams GM, Logan V, Strutton GM. Reduced Melanoma after regular sunscreen use: randomized trial follow up. J Clin Oncol 2011;29:257-63.
109. Van der Pols JC, Williams GM, Pandeva N, Logan V, Green AC. Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use. Cancer Epidemiol Biomarkers Prev 2006;15:2546-8. (Pubitemid 46048320)
110. Barton MK. Sunscreen use in adults is beneficial in preventing melanoma. CA Cancer J Clin 2011;61:137-8.
111. Tsukahara K, Moriwaki S, Hotta M, Fujimura T, Sugiyama-Nakagiri Y, Sugawara S et al. The effect of sunscreen on skin elastase activity induced by ultraviolet-A irradiation. Biol Pharm Bull 2005;28:2302-7. (Pubitemid 41757424)
112. Fourtanier A, Moyal D, Seité S. Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. Photodermatol Photoimmunol Photomed 2008;4:164-74.
113. Schleyer V, Weber O, Yazdi A, Benedix F, Dieu K, Röcken M et al. Prevention of polymorphic light eruption with a sunscreen of very high protection level against UVB and UVA radiation under standardized photodiagnostic conditions. Acta Derm Venereol 2008;88:555-60.
114. DeLeo VA, Clark S, Fowler J, Poncet M, Loesche C, Soto P. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis 2009;83:95-103.
115. Hadshiew IM, Stab F, Untiedt S, Bohnsack K, Rippke F, Hölzle E. Effects of topically applied antioxidants in experimentally provoked polymorphous light eruption. Dermatology 1997;195:362-8. (Pubitemid 28017814)
116. Hadshiew IM, Treder-Conrad C, v Bülow R, Klette E, Mann T, Stab F et al. Polymorphous light eruption (PLE) and a new potent antioxidant and UVA-protective formulation as prophylaxis. Photodermatol Photoimmunol Photomed 2004;20:200-4. (Pubitemid 39077016)
117. Jeanmougin M, Peyron JL, Thomas P, Beani JC, Guez E, Bachot N. Polymorphic light eruption: prophylaxis using a topical combination of antioxidants and UVA protection formulations. Ann Dermatol Venereol 2006;133:425-8. (Pubitemid 44270828)
118. Swanbeck G, Wennersten G. Treatment of polymorphous light eruptions with beta-carotene. Acta Derm Venereol 1972;52:462-6.
119. Jancen CT. Oral carotenoid treatment in polymorphous light eruption: a cross over comparison with oxychloroquine and placebo. Photodermatology 1985;2:166-9.
120. Eberlein-König B, Fesq H, Abeck D, Przybilla B, Placzek M, Ring J. Systemic vitamin C and vitamin E do not prevent photoprovocation test reactions in polymorphous light eruption. Photodermatol Photoimmunol Photomed 2000;16:50-2. (Pubitemid 30230384)
121. Neumann R, Rappold E, Pohl-Markl H. Treatment of polymorphous light eruption with nicotinamide: a pilot study. Br J Dermatol 1986;115:77-80. (Pubitemid 16090173)
122. Ortel B, Wechdom D, Tanew A, Honigsmann H. Effect of nicotinamide on the phototest reaction in polymorphous light eruption. Br J Dermatol 1988;118:669-73.
123. Caccialanza M, Recalcati S, Piccinno R. Oral polypodium leucotomos extract photoprotective activity in 57 patients with idiopathic photodermatoses. G Ital Dermatol Venereol 2011;146:85-7.
124. Tanew A, Radakovic S, Gonzalez S, Venturini M, Calzavara-Pinton PG. Polypodium leucotomos extract for the prevention of polymorphic light eruption. J Am Acad Dermatol 2012;66:58-62.
125. Faurschou A, Wulf HC. Synergistic effect of broad-spectrum sunscreens and antihistamines in the control of idiopathic solar urticaria. Arch Dermatol 2008;144:765-9. (Pubitemid 351846877)
126. Beattie PE, Dawe RS, Ibbotson SH, Ferguson J. Characteristics and prognosis of idiopathic solar urticaria: a cohort of 87 cases. Arch Dermatol 2003;139:1149-54. (Pubitemid 37128376)
127. Hawk JL, Lim HW. Chronic actinic dermatitis. In: Lim HW, Hönigsmann H, Hawk JL, editors. Photodermatology. USA: Informa Healthcare; 2007. p. 169-83.
128. Bissonnette R. Update on sunscreens. Skin Therapy Lett 2008;13:5-7.
129. Gallicchio L, Boyd K, Matanoski G, Tao XG, Chen L, Lam TK et al. Carotenoids and the risk of developing lung cancer: a systematic review. Am J Clin Nutr 2008;88:372-83.
130. Al-Wadei HA, Schuller HM. Beta-Carotene promotes the development of NNK-induced small airway-derived lung adenocarcinoma. Eur J Cancer 2009;45:1257-64.
131. Corbett MF, Herxheimer A, Magnus IA, Ramsay CA, Kobza-Black A. The long term treatment with beta-carotene in erythropoietic protoporphyria: a controlled trial. Br J Dermatol 1977;97:655-62.
132. Sanders CJ, Weelden H van, Kazzaz GA, Sigurdsson V, Toonstra J, Bruijnzeel-Koomen CA. Photosensitivity in patients with lupus erythematosus: a clinical and photobiological study of 100 patients using a prolonged phototest protocol. Br J Dermatol 2003;149:131-7. (Pubitemid 36966522)
133. Stege H, Budde MA, Grether-Beck S, Krutmann J. Evaluation of the capacity of sunscreens to photoprotect lupus erythematosus patients by employing the photoprovocation test.Photodermatol Photoimmunol Photomed 2000;16:256-9.
134. Kuhn A, Gensch K, Haust M,Meuth AM, Boyer F, Dupuy P et al. Photoprotective effects of a broad-spectrum sunscreen in ultraviolet-induced cutaneous lupus erythematosus: A randomized, vehicle-controlled, double-blind study. J Am Acad Dermatol 2011;64:37-48.
135. Herzinger T, Plewig G, Rocken M. Use of sunscreens to protect against ultraviolet-induced lupus erythematosus. Arthritis Rheum 2004;50:3045-6. (Pubitemid 39209544)
136. Cusack C, Danby C, Fallon JC, Ho WL, Murray B, Brady J et al. Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus Photodermatol Photoimmunol Photomed 2008;24:260-7.
137. International Agency for research on cancer. Sunscreens. In: IARC Handbooks of Cancer Prevention. Vol. 5. Lyon: IARC press; 2001.
138. Menzies SW. Is sun exposure a major cause of melanoma? Yes. London: BJM; 2009; 337:a763.
139. Nohynek GJ, Antignac E, Re T, Toutain H. Safety assessment of personal care products/cosmetics and their ingredients. Toxicol Appl Pharmacol 2010;243:239-59.
140. Schlumpf M, Cotton B, Conscience M. In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect 2001;109:239-44. (Pubitemid 32331514)
141. Collaris EJ, Frank J. Photoallergic contact dermatitis caused by ultraviolet filters in different sunscreens. Int J Dermatol 2008;47(Suppl 1):35-7.
142. Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henrikensen M, Skakkebaek NE et al. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene)camphor after whole-body topical application and reproductive hormone levels in humans. J Invest Dermatol 2004;123:57-61. (Pubitemid 38833463)
143. Nash JF. Human safety and efficacy of ultraviolet filters and sunscreen products. Dermatol Clin 2006;24:35-51. (Pubitemid 41741819)
144. Filipe P, Silva JN, Silva R, Cirne de Castro JL, Marques Gomes M et al. Stratum corneum is an effective barrier to TiO2 and ZnO nanoparticle percutaneous absorption. Skin Pharmacol Physiol 2009;22:266-75.
145. Stern ST, McNeil SE. Nanotechnology safety concerns revisited. Toxicol Sci 2008;101:4-21. (Pubitemid 350239008)
146. Schilling K, Bradford B, Castelli D, Dufour E, Nash JF, Pape W. Human safety review of 'nano' titanium dioxide and zinc oxide. Photochem Photobiol Sci 2010;9:495-509.
147. Schaefer H, Redelmaier TE. Skin barrier: Principles of percutaneous absorption. Basel: Karger AG; 1996. p. 118-28; 191-3.
148. Benech-Kieffer F, Meuling WJ, Leclerc C, Roza L, Leclaire J, Nohynek G. Percutaneous absorption of Mexoryl SX in human volunteers: comparison with in vitro data. Skin Pharmacol Appl Skin Physiol 2003;16:343-55. (Pubitemid 37256069)
149. Sage RJ, Lim HW. Recommendations on photoprotection and vitamin D. Dermatologie Therapy 2010;23:82-5.
150. Dihel JW, Chiu MW. Effects of ambient sunlight and photoprotection on vitamin D status. Dermatologic Therapy 2010;23:48-60.
151. Matsui MAS, Hsia A, Miller JD, Hanneman K, Scull H, Cooper KD et al. Non-sunscreen photoprotection: antioxidants add a value to a sunscreen. J Investig Dermatol Symp Proc 2009;14:56-9.
152. Darvin ME, Haag S, Meinke M, Zastrow L, Sterry W, Lademann J. Radical production by infrared A irradiation in human tissue. Skin Pharmacol Physiol 2010;23:40-6.