Analysis of structures and epitopes of surface antigen glycoproteins expressed in bradyzoites of Toxoplasma gondii

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Cong, Hua ^a   Zhang, Min ^a   Zhang, Qingli ^a   Gong, Jing ^a   Cong, Haizi ^a   Xin, Qing ^a   He, Shenyi ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTOZOAL PROTEIN; SURFACE ANTIGEN GLYCOPROTEIN 2C; SURFACE ANTIGEN GLYCOPROTEIN 2D; SURFACE ANTIGEN GLYCOPROTEIN 2X; SURFACE ANTIGEN GLYCOPROTEIN 2Y; UNCLASSIFIED DRUG; EPITOPE; GLYCOPROTEIN; HLA ANTIGEN; MEMBRANE ANTIGEN; PARASITE ANTIGEN; PEPTIDE; SURFACE ANTIGEN P22, TOXOPLASMA;

AMINO ACID SEQUENCE; ARTICLE; BRADYZOITE; COMPUTER PROGRAM; IMMUNE RESPONSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURAL BIOINFORMATICS; TOXOPLASMA GONDII; ANIMAL; CHEMISTRY; HUMAN; IMMUNOLOGY; PARASITOLOGY; PATHOGENICITY; TOXOPLASMA; TOXOPLASMOSIS;

ANIMALIA; PROTOZOA; TOXOPLASMA GONDII;

ANIMALS; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; EPITOPES; GLYCOPROTEINS; HLA ANTIGENS; HUMANS; PEPTIDES; PROTOZOAN PROTEINS; TOXOPLASMA; TOXOPLASMOSIS;

EID: 84876588885     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/165342     Document Type: Article

References (33)

1. McLeod R., Kieffer F., Sautter M., Hosten T., Pelloux H., Why prevent, diagnose and treat congenital toxoplasmosis? Memorias do Instituto Oswaldo Cruz 2009 104 2 320 344 2-s2.0-65549156690
2. Tenter A. M., Heckeroth A. R., Weiss L. M., Toxoplasma gondii: from animals to humans. International Journal for Parasitology 2000 30 12 1217 1258
3. Chew W. K., Wah M. J., Ambu S., Segarra I., Toxoplasma gondii: determination of the onset of chronic infection in mice and the in vitro reactivation of brain cysts. Experimental Parasitology 2012 130 1 22 25
4. Soldati D., Boothroyd J. C., Transient transfection and expression in the obligate intracellular parasite Toxoplasma gondii. Science 1993 260 5106 349 352 2-s2.0-0027310836 (Pubitemid 23160142)
5. Jung C., Lee C. Y., Grigg M. E., The SRS superfamily of Toxoplasma surface proteins. International Journal for Parasitology 2004 34 3 285 296 (Pubitemid 38299179)
6. Manger I. D., Hehl A. B., Boothroyd J. C., The surface of Toxoplasma tachyzoites is dominated by a family of glycosylphosphatidylinositol-anchored antigens related to SAG1. Infection and Immunity 1998 66 5 2237 2244 2-s2.0-0031949214 (Pubitemid 28194126)
7. Lekutis C., Ferguson D. J. P., Boothroyd J. C., Toxoplasma gondii: identification of a developmentally regulated family of genes related to SAG2. Experimental Parasitology 2000 96 2 89 96 2-s2.0-0033759567 10.1006/expr.2000. 4556
8. Machado A. V., Caetano B. C., Barbosa R. P., Salgado A. P. C., Rabelo R. H., Garcia C. C., Bruna-Romero O., Escriou N., Gazzinelli R. T., Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunity. Vaccine 2010 28 18 3247 3256 2-s2.0-77949659658 10.1016/j.vaccine.2010.02.003
9. Saeij J. P. J., Arrizabalaga G., Boothroyd J. C., A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. Infection and Immunity 2008 76 6 2402 2410 2-s2.0-46249083369 10.1128/IAI.01494-07
10. Kim S. K., Karasov A., Boothroyd J. C., Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine. Infection and Immunity 2007 75 4 1626 1634 2-s2.0-34147108730 10.1128/IAI.01862-06 (Pubitemid 46559426)
11. He X. L., Grigg M. E., Boothroyd J. C., Garcia K. C., Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily. Nature Structural Biology 2002 9 8 606 611 2-s2.0-0036315557 10.1038/nsb819 (Pubitemid 34816142)
12. Crawford J., Grujic O., Bruic E., Czjzek M., Grigg M. E., Boulanger M. J., Structural characterization of the bradyzoite surface antigen (BSR4) from Toxoplasma gondii, a unique addition to the surface antigen glycoprotein 1-related superfamily. Journal of Biological Chemistry 2009 284 14 9192 9198 2-s2.0-66149122633 10.1074/jbc.M808714200
13. Crawford J., Lamb E., Wasmuth J., Grujic O., Grigg M. E., Boulanger M. J., Structural and functional characterization of SporoSAG: a SAG2-related surface antigen from Toxoplasma gondii. Journal of Biological Chemistry 2010 285 16 12063 12070 2-s2.0-77951211783 10.1074/jbc.M109.054866
14. Notredame C., Higgins D. G., Heringa J., T-coffee: a novel method for fast and accurate multiple sequence alignment. Journal of Molecular Biology 2000 302 1 205 217 2-s2.0-0034623005 10.1006/jmbi.2000.4042
15. Di Tommaso P., Moretti S., Xenarios I., Orobitg M., Montanyola A., Chang J. M., Taly J. F., Notredame C., T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension. Nucleic Acids Research 2011 39 2 W13 W17 2-s2.0-79959959356 10.1093/nar/gkr245
16. Buchan D. W. A., Ward S. M., Lobley A. E., Nugent T. C. O., Bryson K., Jones D. T., Protein annotation and modelling servers at University College London. Nucleic Acids Research 2010 38 2 W563 W568 2-s2.0-77954287478 10.1093/nar/gkq427 gkq427
17. Sadowski M. I., Jones D. T., The sequence-structure relationship and protein function prediction. Current Opinion in Structural Biology 2009 19 3 357 362
18. Schultz J., Copley R. R., Doerks T., Ponting C. P., Bork P., SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Research 2000 28 1 231 234 2-s2.0-0033957469 (Pubitemid 30047767)
19. Roy A., Xu D., Poisson J., Zhang Y., A protocol for computer-based protein structure and function prediction. Journal of Visualized Experiments 2011 3 57 e3259
20. Zhang Y., I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 2008 9, article 40 2-s2.0-39449115394 10.1186/1471-2105-9-40 (Pubitemid 351267364)
21. Roy A., Kucukural A., Zhang Y., I-TASSER: a unified platform for automated protein structure and function prediction. Nature protocols 2010 5 4 725 738 2-s2.0-77954065271
22. Humphrey W., Dalke A., Schulten K., VMD: visual molecular dynamics. Journal of Molecular Graphics 1996 14 1 33 38 2-s2.0-0029878720 10.1016/0263-7855(96)00018-5 (Pubitemid 26152973)
23. Schwede T., Kopp J., Guex N., Peitsch M. C., SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Research 2003 31 13 3381 3385 2-s2.0-0042622380 10.1093/nar/gkg520 (Pubitemid 37442164)
24. Guex N., Peitsch M. C., SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 1997 18 15 2714 2723 2-s2.0-0031473847 10.1002/elps.1150181505 (Pubitemid 28059943)
25. Guex N., Peitsch M. C., Schwede T., Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective. Electrophoresis 2009 30 1 S162 S173 2-s2.0-69249212321 10.1002/elps.200900140
26. Moutaftsi M., Peters B., Pasquetto V., Tscharke D. C., Sidney J., Bui H. H., Grey H., Sette A., A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nature Biotechnology 2006 24 7 817 819 2-s2.0-33746132748 10.1038/nbt1215 (Pubitemid 44086622)
27. Sidney J., Assarsson E., Moore C., Ngo S., Pinilla C., Sette A., Peters B., Quantitative peptide binding motifs for 19 human and mouse MHC class i molecules derived using positional scanning combinatorial peptide libraries. Immunome Research 2008 4 1, article 2 2-s2.0-39549085122 10.1186/1745-7580-4-2 (Pubitemid 351278399)
28. Lundegaard C., Nielsen M., Lund O., The validity of predicted T-cell epitopes. Trends in Biotechnology 2006 24 12 537 538 2-s2.0-33751205625 10.1016/j.tibtech.2006.10.001 (Pubitemid 44781247)
29. Barragan A., David Sibley L., Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. Journal of Experimental Medicine 2002 195 12 1625 1633 2-s2.0-0037124340 10.1084/jem.20020258 (Pubitemid 34666075)
30. Wallner B., Elofsson A., Can correct protein models be identified? Protein Science 2003 12 5 1073 1086 2-s2.0-0037406141 10.1110/ps.0236803 (Pubitemid 36505441)
31. Graille M., Stura E. A., Bossus M., Muller B. H., Letourneur O., Battail-Poirot N., Sibaï G., Gauthier M., Rolland D., Le Du M. H., Ducancel F., Crystal structure of the complex between the monomeric form of Toxoplasma gondii surface antigen 1 (SAG1) and a monoclonal antibody that mimics the human immune response. Journal of Molecular Biology 2005 354 2 447 458 2-s2.0-27744467202 10.1016/j.jmb.2005.09.028 (Pubitemid 41581679)
32. Cong H., Mui E. J., Witola W. H., Sidney J., Alexander J., Sette A., Maewal A., McLeod R., Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A-0201. Vaccine 2011 29 4 754 762 2-s2.0-78650544437 10.1016/j.vaccine.2010.11.015
33. Cong H., Mui E. J., Witola W. H., Sidney J., Alexander J., Sette A., Maewal A., McLeod R., Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A-1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8+T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii. Immunome Research 2010 6 1, article 12 2-s2.0-78649586807 10.1186/1745-7580-6-12